Loin des automates du début du XVIIe siècle, le traitement automatique de la langue connaît dernièrement une évolution rapide notamment dans le domaine de l'analyse de corpus. Dans le cadre de la génération, les travaux restent cependant plus rares, principalement en raison de la complexité de leur implémentation. En plus des difficultés propres à la création de phrases ou de textes, un tel outil doit être en mesure d'effectuer une analyse du thème de l'interaction afin d'y conformer sa production. L'objectif de mon mémoire est la génération de phrases aléatoires, donc sans analyse de thème, syntaxiquement et sémantiquement correctes. Pour le côté syntaxique, j'ai décidé de construire mon programme autour d'une ontologie syntaxique basée sur un corpus du journal « Le Monde ». Le but de cette ontologie syntaxique est de permettre la génération de phrases ayant une structure syntaxique correcte. Le côté sémantique devait s'effectuer par l'ajout à cette structure d'un lexique marqué et permettre la génération de phrases sémantiquement correctes. Ce lexique devait être marqué à l'aide des structures de traits des grammaires syntagmatiques guidées par les têtes. Malheureusement, certains problèmes logistiques m'ont obligé à utiliser un vocabulaire marqué catégoriellement et, par là même, à abandonner la partie sémantique de la génération. Mon projet de mémoire traite donc de la création d'un générateur de phrases, de sa conception à sa réalisation. ______________________________________________________________________________

This thesis addresses the reliability of Goldmann-type applanation tonometers (GAT). It deals with the investigation of the relation between predicted intraocular pressure, IOPG and true pressure, IOPT. The problem of the accuracy of GAT readings has acquired special importance over the last two decades as new types of surgical procedures to correct vision disorders are being explored and gain universal acceptance. The overall aim of the present study is to assess the effects of individual variations in the corneal central thickness (CCT), material properties of the involved tissues and paracentral applanation on the accuracy of IOPG. Two finite element models have been constructed: a two-dimensional axisymmetric model of the cornea and a three-dimensional model of the whole corneoscleral envelope. Various material descriptions were adopted for the cornea in 2D, whereas the 3D model accounted for collagen microstructure and represented a hyperelastic ber reinforced material. Nonlinear analyses were carried out using the commercial general-purpose finite element software ABAQUS. An extensive literature survey and consultations with ophthalmologists and clinicians were the platform for establishing relevant modelling procedures. The results reveal a clear association between all considered parameters and measured IOPG. The effect of assumed CCT is highly dependent on the corneal material properties. Material model alone has a profound effect on predicted IOPG. Variations in tonometer tip application produce clinically signi cant errors to IOPG measurements. Potential effects of corneal stiffness and paracentral applanation on GAT readings are larger than the impact of CCT. The behaviour of the models is broadly in agreement with published observations. The proposed procedures can be a useful tools for suggesting the magnitudes of corrections for corneal biomechanics and possible human errors. The present modelling exercise has an ability to reproduce the behaviour of human cornea and trace it under IOP and GAT, providing potentially useful information on the distribution of stresses and strains. Some recommendations can be drawn in pursuit of the clinical imperatives of ophthalmologists. / QC 20100729

Ce projet se décline en deux parties. Dans un premier temps, il s’agit de développer une méthode de conversion automatique des textes annotés selon la sémantique des cadres dans FrameNet en représentations sémantiques de la Théorie Sens-Texte, afin de développer davantage de ressources informatiques pour assurer le développement de différents projets, notamment le réalisateur de textes GenDR. Dans un second temps, cette conversion sera mise à profit pour effectuer une analyse comparative entre les deux formalismes. Nous retiendrons que ces formalismes ne sont pas incompatibles, mais diffèrent par leurs niveaux de granularité et leurs objectifs propres. Nous tracerons quelques parallèles entre les fonctions lexicales et les relations entre cadres, et proposerons une mise en commun des formalismes afin de les enrichir. / This project is divided in two main parts. Firstly, a method allowing for an automatic conversion of FrameNet's Semantics-based text annotations into semantic representations, according to the Meaning-Text Theory framework, will be presented. This method will lead to an increased set of data usable to develop and improve various Meaning-Text Theory-based projects, including GenDR, a text realizer. Secondly, the conversion task will be used to do a comparative analysis of the two frameworks. We will conclude that the two frameworks are not incompatible, but differ in their granularity and goals. We will also draw parallels between the lexical functions and frame- to-frame relationships, and make some suggestions regarding changes to the frameworks in order to enrich them.

There is an ever-increasing usage of mobile data with global traffic having reached 115 exabytes per month at the end of 2022 for mobile data traffic including fixed wireless access. This is projected to grow up to 453 exabytes at the end of 2028, according to Ericssons 2022 mobile data traffic outlook report. To meet the increasing demand radio access networks (RAN) used for mobile communication are continuously being improved with the current generation enabling larger virtualization of the network through the Cloud RAN (C-RAN) architecture. This facilitates the usage of commercial off-the-shelf servers (COTS) in the network replacing specialized hardware servers and making it easier to scale up or down the network capacity after traffic demand. This thesis looks at how we can efficiently identify servers needed to meet traffic demand in a network consisting of both COTS servers and specialized hardware servers while trying to reduce the energy consumption of the network. We model the problem as a network where the antennas and radio heads are connectedto the core network through a C-RAN and a specialized hardware layer. The network is then represented using a graph where the nodes represent servers in the network. Using this problem model as a base we then generate problem instances with varying topologies, server profiles, and traffic demands. To find out how the traffic should be passed through the network we test two different methods: A mixed integer linear programming (MILP) method focused on energy minimization and a graph attention network (GAT) predictor combined with the energy minimization MILP. To help evaluate the results we also create three other methods: a MILP model that tries to spread the traffic as evenly as possible, a random predictor combined with the energy minimization MILP and a greedy method. Our results show that the energy optimization MILP method can be used to create optimal solutions, but it suffer from a slow computation time compared to the other methods. The GAT model shows promising results in making predictions regarding what servers should be included in a network making it possible to reduce the problem size and solve it faster with MILP. The mean energy cost of the solutions created using the combined GAT/MILP method was 4% more than just using MILP but the time gain was substantial for problems of similar size as the GAT was trained on. With regards to computation time the combined GAT/MILP method used was 85% faster than using only MILP. For networks of almost double the size than the ones that the GAT model was trained on the solutions of the combined GAT and MILP methods had a mean energy cost increase of 7% while still showing a strong speedup, being 93% faster than when only using MILP.

La presente tesis doctoral titulada “Materiales de sílice funcionales para la liberación controlada, detección y eliminación de moléculas de interés” se centra en el diseño y desarrollo de materiales híbridos orgánico-inorgánicos mediante la aplicación de los conceptos de Química Supramolecular. Durante el desarrollo de la presente tesis doctoral se han preparado y caracterizado diferentes materiales de base silícea para distintas aplicaciones. La primera parte de la tesis se centra en el desarrollo de materiales de base silícea capaces de variar su comportamiento fluorescente en función de la presencia o ausencia de un cierto analito en el medio. Estos materiales emplean como soporte nanopartículas de sílice que se funcionalizan superficialmente con dos unidades diferentes, una coordinante y una indicadora (un fluoróforo). La interacción del analito de interés (en nuestro caso aniones) con la unidad coordinante modificará las propiedades emisivas del fluoróforo. Así, se han preparado dos materiales en los cuales el grupo fluorescente es rodamina mientras que el grupo coordinante es un imidazolato o una sal de guanidinio respectivamente. Una vez caracterizados ambos materiales se estudió su comportamiento frente a diferentes especies aniónicas a diferentes concentraciones resultando selectivos a la presencia de benzoato (el material funcionalizado con imidazolatos), dihidrógeno fosfato e hidrógeno sulfato (el material funcionalizado con sales de guanidinio). El tercer capítulo de la tesis se centra en la aplicación de materiales híbridos orgánico-inorgánicos para la detección y eliminación de especies altamente tóxicas como son los agentes neurotóxicos. Estos son compuestos organofosforados capaces de causar graves lesiones en el sistema nervioso central. En una primera aproximación se emplea el concepto de puerta molecular para la detección de agentes neurotóxicos. Para ello, se utiliza como soporte inorgánico un material mesoporoso de sílice (MCM-41) cuyos poros se cargan con un colorante que actúa de indicador mientras que la superficie externa del mismo se funcionaliza con una molécula capaz de reaccionar con dichos agentes neurotóxicos. Dicha molécula es capaz de interaccionar entre sí (mediante enlaces de hidrógeno) formando una red que mantiene bloqueada la salida de los poros. En presencia de DCP (dietilclorofosfato, un simulante de agente neurotóxico), y después de que este reaccione con dicha molécula, se produce una reorganización espacial que permite la liberación del colorante. De este modo, la presencia de los agentes neurotóxicos está señalizada mediante un cambio de color. En una segunda aproximación se aborda el uso de soportes inorgánicos de tipo MCM-41 como materiales para la eliminación de agentes neurotóxicos. Para ello se modificaron químicamente las superficies de estos materiales silíceos mediante tratamiento con distintas bases. Como consecuencia de este tratamiento básico los silanoles de la superficie se desprotonan dando lugar a los correspondientes silanolatos (nucleófilos fuertes). Estos silanolatos son capaces de reaccionar con los agentes neurotóxicos descomponiéndolos y favoreciendo su eliminación de un medio contaminado. Por último, se estudia la aplicación de materiales híbridos orgánico-inorgánicos funcionalizados con puertas moleculares en aplicaciones de liberación controlada, concretamente, en liberación controlada intracelular de fármacos de interés. El material híbrido consta de un soporte de sílice mesoporosa cuyos poros se cargan con un compuesto citotóxico (camptotecina) y su superficie externa se funcionaliza con una gluconamida. La presencia de una monocapa densa de gluconamidas por el exterior del material inhibe la liberación del compuesto citotóxico. Al añadir enzimas con capacidad para hidrolizar enlaces amida (amidasa y pronasa) se produce la liberación de la camptotecina. El correcto funcionamiento del material se comprobó in vitro e in vivo (en células HeLa). / Candel Busquets, I. (2014). Functional silica materials for controlled release, sensing and elimination of target molecules [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/39101

The purpose of this study is to understand what future role archive institutions have for genealogists as a result of genetic ancestry testing. To answer the purpose of this study, three additional research questions have been given. The research questions are as follows (1) what type of information genealogists search for when using genetic ancestry testing (2) what kind of information genealogists are able to retrieve by performing a genetic ancestry test (3) how the archive institutions perceive genealogists who perform genetic ancestry testing. Three different methods have been used to retrieve relevant source material. The methods used are netnography, introspective action research and interviews. The source material has been retrieved by analysing three different discussion forums, interviewing representatives of archive institutions as well as performing genetic ancestry testing ourselves. The theories used in the analyses is based on the theoretical framework established by Martin Saar that involves three dimensions of genealogy, and a secondary framework based on Lisa M. Givens and Donald O. Case’s particular understanding of information behaviour, as well as information seeking. The results of the study have enabled us to conclude three different future scenarios on how the archive institution’s role for genealogists will change. The first conclusion is that the DNA-services will slowly phase out the primary role archives play for the genealogists today. Instead, the commercial DNA-services will become the primary source of information. The second conclusion is that the definition of “value” in regard to the material generated by a genealogist will change, and their research will in the future be seen as valuable by the archive institutions. The third and final conclusion is that the archive institutions will begin to facilitate information and knowledge regarding different aspects of genetic ancestry testing, due to demand of archival users. This is a two-year master’s thesis in Archival Science.