Fear generalization, the generalization of fear to innocuous stimuli, is a characteristic component of pathological anxiety. For example, after returning from war, a person might begin to experience fear in response to the sound of fireworks, a stimulus typically regarded as safe. When excessive, “overgeneralization” serves as a core feature of fear and anxiety-related disorders, such as PTSD. The present collection of studies sought to investigate the neural correlates and temporal dynamics of fear generalization in humans. The first study sought to investigate the causal role of the ventromedial prefrontal cortex (vmPFC) and hippocampus in the generalization of fear. Contrary to hypotheses, individuals with focal damage to the vmPFC (N=8) or hippocampus (N=12) did not demonstrate significantly increased fear generalization relative to individuals with brain damage outside of these regions (N=16) or normal comparison participants (N=20). Potential explanations for this finding are explored. The second study sought to investigate the time course of fear generalization in humans. Participants (N = 107) completed a fear generalization task over the course of two sessions. Results indicate that fear generalization significantly increased as the duration of time between training and testing increased. This suggests that a stimulus may elicit a generalized fear response at one arbitrarily selected time point, but not another. This study establishes a novel paradigm that can be used in future work to investigate changes in the neural correlates of fear generalization over time. Fear generalization is found across an array of anxiety disorders, making it a compelling area of study. The present work highlights the dynamic nature of fear generalization in humans. Further, the present study leads to a number of questions for future research.

Children with social skills deficits in verbal and nonverbal communication can face a variety of social challenges in many aspects of their lives. Given the increasing social needs of many students in today's classrooms, there is a need for increased social skills instruction and support in public schools. Inclusion opportunities in public schools can have a positive impact on the development of social skills and can increase peer understanding and empathy for students with special needs. Although there is research in the area of inclusion and its benefits, there is little known about the impact of the instructional setting on the ability of children to generalize social skills to other school settings. Based on social development theory and social learning theory, this quantitative study used secondary data (N = 129) from 2 primary schools in Connecticut to determine whether elementary age children are more likely to generalize social skills if they are taught social skills in the general education classroom setting compared to those who are taught social skills in the resource room setting or receive no instruction in social skills controlling for natural social skills growth. The result of an ANCOVA revealed that children who were taught social skills in the general education setting were more likely to generalize social skills across settings. The results of this study contribute to positive social change by helping inform school administrators and teachers about how to best support children with social deficits in reaching their academic and social potential. The findings may also help to create an environment that is more accepting of the varying needs of students and as a result can help to create a positive school climate and increase acceptance and friendships among elementary age students that can last into adulthood.

Typically developing children learn from play. For example, play serves as a foundation for children to acquire early language and social skills. Children with autism tend to have deficits in play, and often engage in rigid or repetitive behaviors during play. Such rigid play behavior can limit opportunities for these children to learn from play. Researchers have shown that it is possible to increase the variety of play behaviors that children with autism engage in. But, research has not yet shown whether these gains in play behavior will transfer to other play environments and situations. Therefore, the purpose of this study was to investigate methods for promoting the transfer of varied and appropriate play to other play situations with three children with autism. In this study, we increased varied play behavior by providing rewards for playing in a varied manner (and not providing rewards for playing in an inappropriate or rigid manner). We did this with multiple different play situations to help the participants learn to engage in varied play in different situations. We then tested to see if the participants would vary their play with completely new play situations. We found that, following some modifications, our procedures were successful at increasing varied play behavior for all three participants, and that their varied play transferred to other play situations.

Socially withdrawn children are at increased risk for various maladaptive outcomes. One intervention suggested to mediate these outcomes is the use of peermediated social skills training. However, little research supports its use with socially withdrawn children; even less research has investigated the role of peer mediators in the generalization of treatment effects. The purpose of this study was to evaluate a generalization training package on the generalization of socially withdrawn students and their peer mediators' interactions. This study compared the effectiveness of various procedures in a peer-mediated intervention on the generalization of prosocial interactions with socially withdrawn students and examined how students' perceptions of social support, bullying experiences, and intervention acceptability changed as a result of the peer-mediated social skills training intervention. Results indicated that the socially withdrawn participants engaged in more prosocial behavior following the intervention and that it generalized to a highly unstructured, novel setting with multiple students.

The purpose of this study is to demonstrate the effects of awareness on experimentally induced anxiety. Forty college undergraduates were conditioned with a mild electric shock as the UCS (unconditioned stimulus) and a tone a s the CS (conditioned stimulus). After conditioning, the experimental group was taught to discriminate between the CS and six other tones which were both higher and lower in frequency than the CS. The control group was not given these learning trials. After learning to discriminate the tones, the experimental subjects had a higher GSR (Galvanic Skin Response) to the seven tones as compared to the control group. The discrimination process thus facilitated an association among the tones. This increase in anxiety was relatively greater with the passage of time as the experimental subjects also had a higher GSR to the seven tones 24 hours after conditioning compared with 30 minutes after conditioning. These increases, however, were not significant in all cases.

This study evaluated the speed of acquisition and level of generalization of tacts across three different stimulus modes: picture-flashcard, video clip, and 3D object. Three young children diagnosed with autism participated in this study. The acquisition of tacts was evaluated during Discrete Trial Training sessions (DTT). Two of the three participants learned the tacts more rapidly in the video clip condition in contrast with the picture condition. All three participants generalized the three tacts learned through a specific stimulus mode to the remaining stimulus modes. One week after the generalization test, all participants generalized to all novel 3D objects.

<p>Working memory (WM) is essential for our ability to function cognitively. In this thesis we set out to examine the effects of computerized WM training in adults, through a randomized, comparison group controlled and double blind design. We measured this using a neuropsychological test called Paced Auditory Serial Addition Task (PASAT), which measures executive functions. The participants (N106), divided into four groups, young (20-30), old (60-70) and training-low dose. They trained with a computerized WM training program called Rememo© at home for five days a week during a period of five weeks. Before and after training they took the test, and then again after three months. The training gave significant improvement on PASAT performance in both young and old, and that the effect was significant at follow up. In conclusion, WM training has an effect even outside the specific tasks trained, which gives strong support to the theory of generalization and also support findings of plasticity in the aging brain.</p>

Working memory (WM) is essential for our ability to function cognitively. In this thesis we set out to examine the effects of computerized WM training in adults, through a randomized, comparison group controlled and double blind design. We measured this using a neuropsychological test called Paced Auditory Serial Addition Task (PASAT), which measures executive functions. The participants (N106), divided into four groups, young (20-30), old (60-70) and training-low dose. They trained with a computerized WM training program called Rememo© at home for five days a week during a period of five weeks. Before and after training they took the test, and then again after three months. The training gave significant improvement on PASAT performance in both young and old, and that the effect was significant at follow up. In conclusion, WM training has an effect even outside the specific tasks trained, which gives strong support to the theory of generalization and also support findings of plasticity in the aging brain.

The aim of this paper is to analyse the ways in which a Swedish translation of an English text intended as a manual for health practitioners needs to be adapted in order to function as an informative text aimed at patients, their families and other laymen interested in the subject. Focus lies on adaption of terminology, style, and target reader perspective. For this paper, selected parts of an English source text were translated into Swedish, and different adaptions prompted by the change in genre, intended target reader and purpose of the text were noticed and subsequently analysed. In the analysis, it became clear that translation of terminology can be treated through addition, omission or generalization where subject specific terms are not relevant for the intended readers. Under the subject of style, formality level defined through the usage of nominalizations and passives was analysed, and here, modulation and transposition proved useful for adapting the formality level to better fit the purpose of the text. Under the category of target reader perspective, omission, generalization and modulation of different kinds were translation strategies used to turn the focus from the intended ST reader to the intended TT reader. Defining or re-defining the subject of different actions was also necessary to shift the perspective from one intended group of readers to another. Finally, the analysis showed that different kinds of adaption may be purposeful in different situations.

<p>An inescapable component to survival in a dynamic environment is detecting and reacting to signals of danger. One of the most elegant processes animals possess to handle this complex task is classical conditioning, wherein stimuli associated with an aversive event acquire the capacity to elicit defensive behaviors. This process helps ensure quick reactions prior to the occurrence of an imminent threat. A problem of living in a dynamic environment, however, is that reliable signals of danger are rarely re-encountered in the exact same form from one situation to the next. Thus, to be truly adaptive it is imperative for defensive responses to extend beyond a specific instance towards other exemplars that might portend the same negative outcome. While the phenomenon of stimulus generalization was recognized in the earliest studies of conditioning from Pavlov's laboratory, a century of conditioning research has not resolved how humans and other animals actually meet this challenge. The research presented herein employs a combination of psychophysiological and functional imaging methods to examine how humans recruit neurocognitive systems to determine what stimuli do (and do not) pose a threat. Results show that human fear generalization is a complex phenomenon affected by the perceptual and conceptual nature of the stimulus. Brain regions and functional networks involved in fear generalization comprise cortical areas involved in coding the representation of conditioned stimuli and subcortical regions involved conditioned learning and the production of behavioral responses, most notably the amygdala. These results reveal the importance of stimulus-specific factors in fear learning and generalization, provide support for anatomically constrained models of fear generalization, and contribute to the development of model systems of fear generalization processes in human anxiety disorders.</p> / Dissertation