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Antikanzerogene Effekte von Belamcanda chinensis in Zelllinien maligner Keimzelltumoren des Hodens / Anticancer activities of Belamcanda chinensis in cell lines of malignant testicular germ cell tumorsHasibeder, Astrid 06 November 2013 (has links)
No description available.
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The susceptibility of primordial germ cells to malignant transformation and isolation and characterization of members of a new gene family differentially expressed in invasive and non-invasive immortalized male germ cells / Die Potenz der Primordialen Keimzellen zur malignen Transformation und Isolierung und Charakterisierung von Mitgliedern einer neuen Genfamilie, die in invasiven immortalisierten Keimzellen überexprimiert sindAhmed, Manal Bayomi Mahmoud 29 January 2002 (has links)
No description available.
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Role genu WT1 a dalších molekulárně-biologických abnormalit u germinálních nádorů varlat / The role of WT1 gene and other molecular biological abnormalities in testicular germ cell tumorsBakardjieva - Mihaylova, Violeta January 2020 (has links)
Testicular germinal tumors (TGCT) are relatively rare solid tumors in adults. Even so, they affect more than 700 men a year in the Czech Republic, mostly young patients aged 18- 45 years. A large number of patients are curable by a combination of surgery and chemotherapy, yet about 50 men a year in the Czech Republic succumb to this tumor, in the vast majority of cases due to the development of resistance to chemotherapy containing cisplatin. The rare occurrence and high curability are probably the cause of infrequent molecular and clinical studies carried out in these tumors, and our understanding of the biological processes leading to primary tumor development and the development of cisplatin resistance (CDDP) is still limited. At present, no specific molecular markers that could be used as prognostic or predictive factors and improve patient stratification or treatment tailoring are available in TGCT management. In this work, we studied the molecular-genetic background of TGCT development and CDDP resistance at several levels. To comprehensively study the development of cisplatin resistance, we prepared and analyzed CDDP-exposed TGCT cell lines. Long-term exposure to CDDP increased resistance 10-fold in the NCCIT cell line, while no significant resistance was achieved with Tera-2. The...
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Immunhistochemischer Algorithmus zur Diagnostik maligner Keimzelltumoren des Hodens / Immunohistochemical algorithm for the diagnosis of malignant germ cell tumors of the testisMayer-Eichberger, Katharina 28 March 2011 (has links)
No description available.
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