Zugl.: Mannheim, Staatliche Hochsch. für Musik und Darstellende Kunst, Diss.

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DNA photosensitizers are compounds that are capable of binding in to DNA strands through groove binding, intercalation, or electrostatic interactions. Excitation of these agents by light generates reactive oxygen species which causes extensive photo-oxidative damage to genomic DNA. Physiological concentrations of NaCl and KCl are ~ 150 mM and 260 mM within the cell nucleus where DNA is contained. Unfortunately, the ability of most photosensitizers to bind to double-helical DNA is reduced and photocleavage yields are diminished as concentrations of salt increase. The aim of this project is to observe the photocleavage of pUC19 plasmid DNA induced by N1,N1-bis(9-anthrymethyl)triethylenetetraamine tetrahydrochloride (AL-VIII 23) 1 or N,N-dimethyl-N’-(9-methylanthracenyl)ethylenediamine (NMEA) 2 in presence of salt. Spectroscopic titrations and DNA melting assays were used to study binding modes and affinities of both dyes to the helix upon the addition of salt.

In Squeeze Film Dampers, (SFD), grooves (deep or shallow) are used to feed oil into the damper and prevent oil starvation within the fluid film lands. In oil seals with film land of clearance c, short shallow grooves (depth ≤ 15c, length ≤ 30c) are machined to reduce the cross-coupled stiffness coefficients, and thus improve the seal stability characteristics. Moreover, test stands for these devices can also incorporate grooves or recesses as part of oil feeding/ discharge arrangements. A common assumption is that these grooves do not influence the test system forced response. However, unexpected large added mass coefficients are reported in these configurations and not adequately predicted. In the case of grooved oil seals, experimental results also show that circumferential grooves do aid to reduce cross-coupled force coefficients but to a lesser extent than predictions otherwise indicate. A linear fluid inertia model for analysis of multiple-groove SFD or oil seal configurations is advanced. A perturbation analysis for small motion about a journal centered and off-centered position yields zeroth and first order flow equations defined at each individual flow region (land and grooves) of constant clearance ( c ).The analysis considers both the circumferential and axial dynamic pressure variations across the groove and land regions. At the groove regions, an effective groove depth ( dη ) and effective clearance (c d c η η = + ) are defined based on qualitative observations of the laminar flow pattern through annular cavities. This depth differs from the actual physical groove depth. The boundary conditions at the inlet and exit plane are a function of the geometric configuration. Integration of the resulting dynamic pressure fields on the journal surface yields the force coefficients (stiffness, damping, and inertia). Comparisons between predicted and experimental force coefficients for a grooved oil seal and a SFD show excellent correlation over a narrow range of effective groove depths. The results confirm that large added mass coefficients are associated to the feed/discharge grooves in the scrutinized test configurations. Furthermore, predictions, benchmarking experimental data, corroborate that short inner land grooves in an oil seal do not isolate the pressure field of the adjacent film lands, and hence contribute greatly to the force response of the seal.

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<p>Bilaga 1 CD</p>

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We synthesize polyamide compounds containing bithiophene functional group and lexitropsin analogs and study their biological activity.

In every construction project, there is involvement of multiple team-players and their individual efforts have to be coordinated in a timely manner. Sharing and synchronizing information exchange among diverse team players requires a comprehensive project management and collaboration system that is easily accessible and manageable. Web-based or web-enabled project management and collaboration software offer several opportunities for this purpose. In the last decade, the construction industry has realized the necessity of adopting project management and collaboration systems but experienced adaptation and implementation problems. The major reasons were the required software knowledge, training and comfort level of the users. These issues can be addressed by utilizing a software package that provides a familiar user interface and flexible customization options. Microsoft Groove provides an alternative for web-enabled project management and collaboration with comprehensive and customizable tools, while maintaining the familiar Microsoft Office look and feel. This thesis compares the features of Groove software to commonly used project management and collaboration systems in the construction industry. A sample Groove workspace is developed and demonstrated with customized modules and templates for a typical construction project.