No / To present a computational model mapping visual field (VF) locations to optic nerve head (ONH) sectors accounting for individual ocular anatomy, and to describe the effects of anatomical variability on maps produced. A previous model that related retinal locations to ONH sectors was adapted to model eyes with varying axial length, ONH position and ONH dimensions. Maps (n = 11,550) relating VF locations (24-2 pattern, n = 52 non–blind-spot locations) to 1° ONH sectors were generated for a range of clinically plausible anatomical parameters. Infrequently mapped ONH sectors (5%) were discarded for all locations. The influence of anatomical variables on the maps was explored by multiple linear regression. Across all anatomical variants, for individual VF locations (24-2), total number of mapped 1° ONH sectors ranged from 12 to 90. Forty-one locations varied more than 30°. In five nasal-step locations, mapped ONH sectors were bimodally distributed, mapping to vertically opposite ONH sectors depending on vertical ONH position. Mapped ONH sectors were significantly influenced (P < 0.0002) by axial length, ONH position, and ONH dimensions for 39, 52, and 30 VF locations, respectively. On average across all VF locations, vertical ONH position explained the most variance in mapped ONH sector, followed by horizontal ONH position, axial length, and ONH dimensions. Relations between ONH sectors and many VF locations are strongly anatomy-dependent. Our model may be used to produce customized maps from VF locations to the ONH in individual eyes where some simple biometric parameters are known. / ustralian Research Council Linkage Project LP100100250 (with Heidelberg Engineering GmbH, Germany); Australian Research Council Future Fellowship FT0990930 (AMM); Australian Research Council Future Fellowship FT0991326 (AT)

Thesis (M.A.)--University of South Africa, 2001.

The aim of this one-year master thesis was to examine the principles of arrangement used by the Swedish Royal Office archive from about 1540-1878, and how the principles of arrangement have corresponded with the information needs of that rules the Swedish Royal Office archive. The following theoretical premises were important: Berndt Fredriksson's empirical archival science, JBLD Strömberg's concepts of archive systems and Randolph C. Head's concepts of mirroring. Two questions have been examined. What connections is there between the major reorganizations of the Swedish Royal Office archive, the process for governance of Sweden / the Royal Office, access to / control over archival documents, information needs, the political situation, and changes in how the archive was arranged and inventoried. What sources of inspiration have those responsible for the reorganizations had regarding the reorganizations? My source material consisted primarily of archival inventories. In this inquiry I have used a case study in which document and literature studies were conducted. During this study I have discovered that several principles of arrangement was in use simultaneously during the examined time period. This suggests either that older ideas regarding inventory labor were present at the same time and influenced the inventory labor or that the "archivist" during this time period had great freedom to choose between different principles of arrangement. Arrangement by geographic location were used during the entire time period. The archival inventories arranged by this principle has evolved from larger descriptions over geographic places to titles in Latin over countries. It also seems likely that the countries of this archival inventories represented Sweden's foreign relations. Mirroring has been detected between the reasons for the reorganizations, major political conflicts internally and externally, changes in the governance process, the user groups of the archive, the information needs and archival inventories. Mirroring has also occurred between the principles of arrangement and information access and needs. There are several available sources of inspiration to the reorganizations and hence the principles of arrangement.

Title: Inhibition of interleukin-6 trans-signaling by sgp130Fc is anti-tumorigenic in head and neck squamous cell carcinoma. Background: Head and neck squamous cell carcinoma (HNSCC) is a highly inflammatory cancer type, and interleukin-6 (IL-6) is associated with this phenotype. Elevated expression of IL-6 is linked to tumor progression, recurrence, metastasis, and resistance to therapy in HNSCC. However, targeting IL-6 or IL-6 receptor (IL-6R) has demonstrated little to no clinical efficacy. IL-6 signals through a classical signaling pathway via membrane IL-6R or a trans-signaling pathway via soluble IL-6R (sIL-6R). Recent evidence suggests that classical signaling induces acute, transient inflammation, eventually resulting in homeostasis; whereas trans-signaling may induce chronic, pro-tumorigenic inflammation. Therefore we propose that IL-6 trans-signaling is associated with the pro-inflammatory phenotype observed in HNSCC. We wanted to determine whether inhibition of IL-6 trans-signaling by sgp130Fc would better demonstrate anti-tumor efficacy and increase HNSCC tumor response to radiation, chemotherapy, and targeted therapy (cetuximab) compared to global IL-6 pathway inhibition. Method/Results: Baseline levels of IL-6, IL-6R, sIL-6R, and sgp130 proteins in HNSCC cells were determined using ELISA and flow cytometry. Cisplatin, radiation, and cetuximab treatments each induced HNSCC cell secretion of IL-6 and sIL-6R in vitro, yet adding sgp130Fc to those treatments did not further reduce clonogenic survival. Sgp130Fc treatment significantly suppressed SQ20B tumor growth in nude mice, whereas global IL-6 pathway inhibition by IL-6R antagonist tocilizumab did not; however, cetuximab reduced the efficacy of sgp130Fc in this animal model. Sgp130Fc also sensitized SQ20B xenograft tumors to radiation and chemotherapy in nude mice and suppressed SCCVII tumor growth in male but not female C3H/HeJ mice. Conclusion: Inhibition of IL-6 trans-signaling by sgp130Fc displayed significant anti-tumor effects as a single therapy and sensitized resistant HNSCC tumors to radiation and chemotherapy in vivo; however, sgp130Fc did not reduce survival of HNSCC cells in vitro. These results suggest that the efficacy of sgp130Fc relies on targeting another part of the microenvironment instead of tumor cells directly. Sgp130Fc has promise both as a single therapy and potentially as combined therapy with radiation and chemotherapy in HNSCC.

The current focus of research efforts in the area of the biomechanics of traumatic brain injury is the development of numerical (finite element) models of the human head. A validated numerical model of the human head may lead to better head injury criteria than those used currently in crashworthiness studies. A critical step in constructing a validated finite element model of the head is determining the mechanical threshold, should it exist, for various types of injury to brain tissue. This thesis describes a biomechanical study of axonal injury in the anaesthetised sheep. The study used the measurements of the mechanics of an impact to the living sheep, and a finite element model of the sheep skull and brain, to investigate the mechanics of the resulting axonal injury. Sheep were subjected to an impact to the left lateral region of the skull and were allowed to survive for four hours after the impact. The experiments were designed specifically with the numerical model in mind; sufficient data were collected to allow the mechanics of the impact to be faithfully reproduced in the numerical model. The axonal injury was identified using immunohistological methods and the injury was mapped and quantified. Axonal injury was produced consistently in all animals. Commonly injured regions included the sub-cortical and deep white matter, the hippocampi and the margins of the lateral ventricles. The degree of injury was closely related to the peak impact force and to kinematic measurements, particularly the peak change in linear and angular velocity. There was significantly more injury in animals receiving fractures. A three-dimensional finite element model of the sheep skull and brain was constructed to simulate the dynamics of the brain during the impact. The model was used to investigate different regimes of material properties and boundary conditions, in an effort to produce a realistic model of the skull and brain. Model validation was attempted by comparing pressure measurements in the experiment with those calculated by the model. The distribution of axonal injury was then compared with the output of the finite element model. The finite element model was able to account for approximately thirty per cent of the variation in the distribution and extent of axonal injury, using von Mises stress as the predictive variable. Logistic regression techniques were used to construct sets of curves which related the extent of injury, to the predictions of the finite element model, on a regional basis. The amount of observable axonal injury in the brains of the sheep was clearly related to the severity of the impact, and was related to the predictions of a finite element model of the impact. Future improvements to the fidelity of the finite element model may improve the degree to which the model can explain the variation in injury throughout the brain of the animal and variations between animals. This thesis presents results, and a methodological framework, that may be used to further our understanding of the limits of human endurance, in the tolerance of the brain to head impact. All experiments reported herein conformed with the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes. / Thesis (Ph.D.)--Mechanical Engineering, 2000.

The main objectives of the present thesis were to define the dimension of head injuries in Sweden over a longer period and to present a Finite Element (FE) model of the human head which can be used for preventive strategies in the future. The annual incidence of head injuries in Sweden between 1987 and 2000 was defined at over 22 000, cases most of which were mild head injuries. In contrast to traffic accidents, head injuriy due to fall was the most important etiology. Of special interest was that the number of hematoma cases has increased. A detailed and parameterized FE model of the human head was developed and used to evaluate the effects of head size, brain size and impact directions. The maximal effective stresses in the brain increased more than a fourfold, from 3.6 kPa for the smallest head size to 16.3 kPa for the largest head size using the same acceleration impulse. The size dependence of the intracranial stresses associated with injury is not predicted by the Head Injury Criterion (HIC). Simulations with various brain sizes indicated that the increased risk of Subdural Hematoma (SDH) in elderly people may to a part be explained by the reduced brain size resulting in a larger relative motion between the skull and the brain with distension of bridging veins. The consequences of this increased relative motion due to brain atrophy cannot be predicted by existing injury criteria. From studies of the influence of impact directions to the human head, the highest shear strain in the brain stem is found for a Superior-Inferior (SI) translational impulse, and in the corpus callosum for a lateral rotational impulse when imposing acceleration pulses corresponding to the same impact power. It was concluded that HIC is unable to predict consequences of a pure rotational impulse, while the Head Impact Power (HIP) criterion needs individual scaling coefficients for the different terms to account for differences in intracranial response due to a variation in load direction. It is also suggested that a further evaluation of synergic effects of the directional terms of the HIP is necessary to include combined terms and to improve the injuryprediction. Comparison of the model with experiments on localized motion of the brain shows that the magnitude and characteristics of the deformation are highly sensitive to the shear properties of the brain tissue. The results suggest that significantly lower values of these properties of the human brain than utilized in most 3D FE models today must be used to be able to predict the localised brain response of an impact to the human head. There is a symmetry in the motion of the superior and inferior markers for both the model and the experiments following a sagittal and a coronal impact. This can possibly be explained by the nearly incompressible properties of brain tissue. Larger relative motion between the skull and the brain is more apparent for an occipital impact than for a frontal one in both experiments and FE model. This correlates with clinical findings. Moreover, smaller relative motion between the skull and the brain is more apparent for a lateral impact than for a frontal one for both experiments and FE model. This is thought to be due to the supporting structure of the falx cerebri. Such a parametrized and detailed 3D model of the human head has not, to the best knowledge of the author, previously been developed. This 3D model is thought to be of significant value for looking into the effects of geometrical variations of the human head. / QC 20100428

Head mounted projection display (HMPD) technology, as an alternative to conventional head mounted displays (HMD), offers a potential of designing wide field-of-view (FOV), low distortion optical see-through HMDs (OST-HMDs). Existing HMPD designs, however, suffer from problems of low luminance and low image resolution, which limits the applications of such information displays for the scenarios which require high luminance and high image fidelity. The design of a polarized head mounted projection display (p-HMPD) was recently proposed to overcome the challenge of low luminous efficiency in existing HMPD designs. Polarization management was employed to reduce the light loss caused by beamsplitting in an HMPD.The work in this dissertation focuses on the development and evaluation of an SXGA resolution, high efficiency p-HMPD system. The main contributions are as follows. First, the key elements in the polarization management scheme of a p-HMPD were selected and their polarization performances were characterized by measuring their Mueller matrices, based on which the overall display performance of a p-HMPD was analyzed.Second, based on a pair of ferroelectric liquid-crystal-on-silicon (FLCoS) microdisplays, a compact illumination unit and a light-weight projection system were designed, from which a p-HMPD prototype was built. Following the prototype implementation, a series of calibrations were performed to obtain correct color presentation, desired focusing setting, and optical system characteristics necessary for achieving accurate registration between virtual objects and their counterparts in the real world.Third, the imaging properties of a retroreflective screen which is an essential part of a p-HMPD or HMPD were studied and its effects on the image resolution of an HMPD system were further characterized.Finally, the performance of the system was evaluated through two objective user experiments, including a visual acuity assessment and a depth perception accuracy assessment.

Introduction-Physical activity can reduce the risk of contracting many of the 'diseases of the sedentary', such as coronary heart disease and cancer (Blair et al., 1996). Recognition of this protective effect has led to the development of many programmes designed to promote the benefit of participation in sport and physical exercise (Hillary Commission, 1993; Nicholl et aI., 1995). With participation in sport, especially contact sport, the risk for injuries increases, including injuries to the head and neck (Wilberger, 1993; Wekesa et al., 1996; Pettersen, 2002). Mild traumatic brain injuries (MTBI) or concussion as used interchangeably in the literature (Maroon et al., 2000; Wills & Leathem, 2001) are an important public health concern, due to the high incidence and frequently persisting symptomatology (Evans, 1992). Mild traumatic brain injury is defined as a complex patho-physiological process affecting the brain induced by traumatic biomechanical forces (Aubry et al., 2002; McCrory et al., 2004). A sub-concussive injury or very mild traumatic brain injury (vMTBI) may be defined as an apparent brain insult with insufficient force to cause hallmark symptoms of concussion (Jordan, 2000; Webbe & Bath, 2003). The high incidence of sport related head injuries in South Africa is alarming, although the prevalence thereof is unknown and difficult to assess, as the seemingly trivial injuries frequently remain unreported (Roux et al., 1987). This is especially applicable in sport where a milder form of head injury is common. This is cause for concern as cumulative head injuries traditionally regarded as trivial or 'minor' may result in players running the risk of increasingly negative consequences following repetitive 'minor' head injuries. In contact sport such as rugby, players are at great risk of sustaining repetitive mild traumatic brain injuries. The negative outcome following these repetitive minor head injuries has been demonstrated by numerous studies on boxers and other athletes exposed to repeated MTBI and vMTBI (McLatchie et aI., 1987). The incidence of vMTBI has not yet been researched in school rugby and this study is the first to report the incidence of vMTBI in a secondary school rugby team. Obiectives - The objectives of this study were to determine the incidence, the neuropsychological consequences and the effect on the academic performance of repeated mild (MTBI) and very mild traumatic brain injuries (vMTBI) in a secondary school rugby team during one playing season. Methods - A cohort of 35 secondary school male rugby players divided into a vMTBI (group 1) (n=26) and a MTBI (group 2) (n=9) from a local secondary school's first and second team, was followed for a full competitive season by a trained Biokineticist, who was present at all the games and contact sessions played. All vMTBI and MTBI and the severity of these injuries were documented. A control (group 3) that consisted of 10 secondary school non-rugby players were compared with the vMTBI and MTBI groups. The incidence of repeated MTBI and vMTBI in a secondary school rugby team were gathered by questionnaires and observation next to the field by a trained Biokineticist. Pre-season and post-season neuropsychological tests were conducted on the research groups and the control group. The neuropsychological tests that were conducted on the three groups were the Colour Trial Test 1 and 2 (CTT 1 + 2), the Symbol Digit Modalities Test (SDMT), the Wechsler Memory Scale-Revised (WMS-R) and the Standardised Assessment of Concussion (SAC). After each match played throughout the season the research group also completed a SAC test. The academic results of the final examination (year 1) of the year of the specific rugby season were obtained, as well as the academic results of the final examination of the preceding two years (year 2 and 3). The programme STATISTICA (version 7.0, Stat soft, Tulsa, OK) was used to analyse the data. Descriptive statistics, one-way ANOVA's, two-way repeated measures ANOVA's, Post-hoc Tuckey HSD analysis and Pearson's product moment correlation were used for all the statistical analyses. Results - This study of a secondary school rugby team has shown 726 vMTBI's and 18 MTBI's throughout one rugby season. This relates to 1951 vMTBI's per 1000 player hours and 48 MTBI's per 1000 player hours. Reductions in delayed memory (p=O.O1)from preseason to post-season in a group of players with repetitive vMTBI's during a single rugby season were found. This was the first evidence of possible neurocognitive deficits towards delayed memory in very mild traumatic brain injuries at secondary school level. Statistically significant (p<=0.05)results of the SAC test totals between both the vMTBI and MTBI groups were documented in the different games throughout the rugby season and compared with the baseline test. No statistically significant differences (p<=0.05) between the pre-season and post-season's scores of the SAC test totals were documented. A decrease in academic performance in the subject Afrikaans (year 1 compared with year 2) with a p-value of p=O.O17(group 1) and p=O.O16(group 2) respectively was found. Conclusion - The findings of this study indicate a high incidence of vMTBI in a cohort of secondary school rugby players in one season, a statistically significant reduction (p=O.O1 )in delayed memory of the vMTBI rugby players and a statistically significant decrease in academic performance p=O.O17 (group 1) and p=O.O16 (group 2) in the subject Afrikaans from year 1 to year 2 final examinations. / Thesis (Ph.D. (Human Movement Science))--North-West University, Potchefstroom Campus, 2006.

No description available.

Augmented reality (AR) systems that use head mounted displays to overlay synthetic imagery on the user's view of the real world require accurate viewpoint tracking for quality applications. However, achieving accurate registration is one of the most significant unsolved problems within AR systems, particularly during dynamic motions in unprepared environments. As a result, registration error is a major issue hindering the more widespread growth of AR applications. The main objective for this thesis was to improve dynamic orientation tracking of the head using low-cost inertial sensors. The approach taken within this thesis was to extend the excellent static orientation sensing abilities of accelerometers to a dynamic case by utilising a model of head motion. Head motion is modelled by an inverted pendulum, initially for one degree of rotational freedom, but later this is extended to a more general two dimensional case by including a translational freedom of the centre of rotation. However, the inverted pendulum model consists of an unstable coupled set of differential equations which cannot be solved by conventional solution approaches. A unique method is developed which consists of a highly accurate approximated analytical solution to the full non linear tangential ODE. The major advantage of the analytical solution is that it allows a separation of the unstable transient part of the solution from the stable solution. The analytical solution is written directly in terms of the unknown initial conditions. Optimal initial conditions are found that remove the unstable transient part completely by utilising the independent radial ODE. Thus, leaving the required orientation. The methods are validated experimentally with data collected using accelerometers and a physical inverted pendulum apparatus. A range of tests were performed demonstrating the stability of the methods and solution over time and the robust performance to increasing signal frequency, over the range expected for head motion. The key advantage of this accelerometer model-based method is that the orientation remains registered to the gravitational vector, providing a drift free solution that outperforms existing, state of the art, gyroscope based methods. This proof of concept, uses low-cost accelerometer sensors to show significant potential to improve head tracking in dynamic AR environments, such as outdoors.