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This thesis presents a Bayesian approach to incorporate historical data. Usually, in statistical inference, a large data size is required to establish a strong evidence. However, in most bioassay experiments, dataset is of limited size. Here, we proposed a method that is able to incorporate control groups data from historical studies. The approach is framed in the context of testing whether an increased dosage of the chemical is associated with increased probability of the adverse event. To test whether such a relationship exists, the proposed approach compares two logit models via Bayes factor. In particular, we eliminate the effect of survival time by using poly-k test. We test the performance of the proposed approach by applying it to six simulated scenarios. / Thesis / Master of Science (MSc) / This thesis presents a Bayesian approach to incorporate historical data. Usually, in statistical inference, a large data size is required to establish a strong evidence. However, in most bioassay experiments, dataset is of limited size. Here, we proposed a method that is able to incorporate control groups data from historical studies. The approach is framed in the context of testing whether an increased dosage of the chemical is associated with increased probability of the adverse event. To test whether such a relationship exists, the proposed approach compares two logit models via Bayes factor. In particular, we eliminate the effect of survival time by using poly-k test. We test the performance of the proposed approach by applying it to six simulated scenarios.

Obstacles sometimes limit enrollment in randomized clinical trials of an exper- imental product versus an active control, making it desirable to augment the ran- domized control group with historical control groups. However, bias between control groups with respect to the mean outcome could lead to spurious conclusions. Meth- ods are necessary that allow for the combination of control groups while controlling for bias. Pocock (1976) developed a Bayesian test to address this need, but it requires sub- jective specification of the variance of the bias between the randomized and historical control groups and is designed to include only a single historical control group. In the context of an actively controlled non-inferiority trial, we extend his method on three fronts. First, we replace subjective specification of the variance of the bias with empirically driven estimates. Second, we develop an adaptive design that re-powers a trial based on an interim estimate of the variance of the bias using observed data. Third, we modify the test to include multiple historical control groups. When including a single historical control group, simulations show that the true bias, if known, can be used in place of the variance of the bias, and that this estimate ivmaintains Type I Error with no loss in power as compared to using the true variance of the bias. Further, we show that using an empirical estimate of the bias to estimate the variance of bias may result in moderately inflated Type I Error, but that using a conservative estimate of the bias (the upper bound of a 90% confidence interval) maintains Type I Error. Simulations also demonstrate that using an estimate of the bias at the interim and conclusion provides designed power but may result in moder- ately inflated Type I Error. Therefore, a conservative estimate of the bias should be used at trial end when using this approach. Lastly, it is shown that if an adequate number of multiple historical control groups are available, the modified test maintains Type I Error when using bias estimates. These methods provide objective guidance on parameter estimation, but further research is necessary in order to improve power.

Li Ho Yin, Leo. / "Architecture Department, Chinese University of Hong Kong, Master of Architecture Programme 2010-2011, design report." / Includes bibliographical references. / ABSTRACT --- p.3 / INTRODUCTION --- p.5 / Issues & Context / Statement of Intent / Overall Context / PART 1 --- p.8 / Chapter Chapter 1 : --- Identity --- p.9 / Hong Kong Identity / Self Esteem / Chapter Chapter 2 : --- Collective Memory --- p.11 / Memories and Human / Collecthe Memory / Collective Episodic Memory / Collective Semantic Memory / Collective Procedural Memory / Collective Anaemias / Architecture & Memory Recalling / Chapter Chapter 3 : --- Meaning within Architecture --- p.13 / Architecture & Memory Recalling / Chapter Chapter 4 : --- Kowloon Walled City --- p.14 / Background History / Form of City / Facade / Street / Roof scape / PART 2 --- p.16 / Chapter Chapter 5 : --- Museum of absent memory --- p.17 / Re- imprint the memory / Project description / Conclusion / BIBLIOGRAPHY --- p.20

In contemporary American society, the nonprofit board is accountable for ensuring that an organization has sufficient resources to carry out its mission. Filling the gap between demands for services and the resources to meet them is often a struggle for small, local nonprofit organizations. This hermeneutic phenomenological study examined how board members of small, local nonprofits in the focal community perceive organizational effectiveness. Understanding the nature of nonprofit organization effectiveness according to board members contributes to understanding how those accountable meet their organizational objectives. A review of the literature revealed that nonprofit effectiveness involves the action of contributing and the motivation behind the action, both of which are associated with trust and reciprocity. Guided by social constructivism, this study employed a qualitative analysis of repeated iterations of semiotic data from board members (n = 30) and text analysis of organizational mission statements (n = 21), generating thick descriptions of the board members' understanding of effectiveness. Findings were derived from successive coding iterations starting with the raw data, through locating text related to specific codes, to verifying relationships among codes, and incorporating researcher reflection. The analysis revealed that strategies focused on developing reciprocity and mitigating mistrust among board members contribute to board members' perceiving their organizations as effectively achieving their objectives. The study's findings support positive social change by informing social scientists and members of local nonprofit boards of the perceived gap between services demands and the resources to meet them among board members.

Thesis (Ph. D.)--University of Chicago, 2002. / Includes bibliographical references (p. 240-254). Also available on the Internet.

Thesis (Ph. D.)--University of Chicago. / Includes bibliographical references (p. 85-93) and index. Also available on the Internet.

Thesis (Ph. D.)--University of Chicago. / Includes bibliographical references (p. 85-93) and index.

This study focus is on pupils historical understanding of the Holocaust. The main purpose and question in this study is to answer what types of work methods and materials pupils used in Holocaust education in historical class. The method used is an survey on 136 high school’s pupils in Sweden for receiving a better understanding of what historical use of Holocaust pupils meet in historical class. The analyze of the material from the survey focused on four out of seven historical uses based on the historian Klas-Göran Karlsson’s typology on the uses of history, those are ideological, moral, political-educational and scientific use. The theory is used for analysing how pupils encounter the holocaust in the historical classroom. Results from the survey show that pupils meet a variation of historical information and facts is used throw how and what pupils work with the Holocaust. All four of the historical use of history could be seen in the results, but above all the scientific use and the ideological use. The scientific use of the Holocaust focuses on factors and relationship between causal factor and outcome. The ideological use of the Holocaust focuses on the understanding of democratic and human values. The study reveals that no historical use is dominant in the different classes, that means the individual meeting whit information about the Holocaust and pupil has an important value in what type of understanding and historical use the pupil have of the Holocaust.