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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Hidrólise de nucleotídeos de adenina em plaquetas de pacientes com diferentes níveis de colesterol e sua relação com o processo inflamatório / Enzymes that hydrolyze adenine nucleotides of patients with different cholesterol levels and inflammatory processesDuarte, Marta Maria Medeiros Frescura 10 October 2006 (has links)
The activity of NTPDase (EC 3.6.1.5, apyrase, CD39) was verified in platelets from patients with increasing cholesterol levels. A possible association between cholesterol levels and inflammatory markers, such as oxidized low density lipoprotein (oxLDL), highly sensitive C-reactive protein (hsCRP) and oxLDL autoantibodies was also investigated. The following groups were studied: group I (< 150 mg/dl), group II (151 to 200 mg/dl); group III: (201 to 250 mg/dl); group IV (> 251 mg/dl) of cholesterol. The results demonstrated that both ATP and ADP hydrolysis were enhanced as a function of cholesterol levels. The LDL levels increased concomitantly with total cholesterol levels. The triglyceride levels were increased in the group with total cholesterol above 251 mg/dl. oxLDL levels were elevated in groups II, III and IV. hsCRP was elevated in the group with cholesterol higher than 251 mg/dl. oxLDL autoantibodies were elevated in groups III and IV. TBARS content was enhanced as a function of cholesterol levels. In summary, hypercholesterolemia is associated with an enhanced of inflammatory response and ATP and ADP hydrolysis. The increase in NTPDase activity is possibly related to a compensatory response to the
inflammatory and pro-oxidative state associated with hypercholesterolemia. / A atividade da NTPDase (EC 3.6.1.5, apyrase, CD39) foi verificada em plaquetas de pacientes com diferentes níveis de colesterol. Uma possível associação entre os níveis de colesterol e os marcadores inflamatórios como LDL
oxidado (oxLDL), proteína C reativa ultrasensível (hsCRP) e anticopos anti-LDL oxidado (Anti-oxLDL) foi investigado. Os seguintes grupos foram estudados: grupo I (< 150 mg/dl), grupo II (151 a 200 mg/dl); grupo III: (201 a 250 mg/dl); grupo IV (> 251 mg/dl) de colesterol. Os resultados demonstraram que a hidrólise dos nucleotídeos (ATP e ADP) aumentou em função dos níveis de colesterol. Os níveis
de LDL aumentaram concomitantemente com os níveis de colesterol total. Os níveis de triglicerídeos foram elevados no grupo com colesterol total acima de 251 mg/dl. Os níveis de oxLDL foram elevados nos grupos II, III and IV. A hsCRP foi elevada no grupo com cholesterol maior que 251 mg/dl. Os Anti-oxLDL foram elevados nos grupos III e IV. O conteúdo de TBARS foi aumentando em função dos níveis de colesterol. Em resumo, a hipercolesterolemia está associada com o aumento da resposta inflamatória e hidrólise de ATP e ADP. O aumento da atividade da NTPDase está possivelmente relacionado com uma resposta compensatória ao estado inflamatório e pró-oxidativo associado com a hipercolesterolemia.
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Veränderungen kardiovaskulärer Risikofaktoren - mit besonderer Betrachtung von Homocystein und hsCRP - unter drei aktuell diskutierten Ernährungsstrategien zur Gewichtsreduktion: Low carb, Low fat und Low fat with reduced glycemic load / Changes in cardiovascular risk factors - with special consideration of homocysteine and hsCRP - while following one of three currently discussed weight-loss strategies: Low carb, low fat and low fat with reduced glycemic loadHönemann, Ines 24 April 2008 (has links)
No description available.
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Der Stellenwert von Biomarkern zur Prognoseabschätzung bei diastolischer Dysfunktion und HFpEF / The prognostic value of neuropeptides in diastolic dysfunction and HFpEFGonschior, Stefan 20 March 2017 (has links)
No description available.
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Diagnostische Wertigkeit einer Kombination von sieben Biomarkern zur Detektion einer echokardiographisch relevanten linksventrikulären Dysfunktion in einem kardiovaskulären Risikokollektiv / Diagnostic value of a combination of seven biomarkers for the detection of echocardiographic relevant left ventricular dysfunction in a cardiovascular risk groupJohann to Büren, Ferdinand 12 April 2018 (has links)
No description available.
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Kardiovaskulární rizika u chronického onemocnění dýchacích cest v dětském věku / Cardiovascular Risks in Chronic Airway Disease in ChildhoodKreslová, Marcela January 2020 (has links)
1 Cardiovascular risks in chronic airway disease in childhood The aim of this thesis was to evaluate cardiovascular risk by using a combined diagnostic approach by measuring RHI and specific biochemical markers in patients with chronic respiratory disease, where we could assume a possible risk of CVD. A total of 119 probands were examined, including 22 patients with cystic fibrosis (CF) and 52 asthma patients. We evaluated RHI using a new plethysmographic method that has a number of advantages over the ultrasonographic methods used in other studies, including non-invasiveness, high sensitivity, low biological variability and objectivity due to automatic processing. Of the biochemical parameters, we measured 4 biomarkers in relation to endothelial dysfunction (ED): hsCRP, ADMA, E-selectin, and VCAM-1. We compared RHI and biomarkers in CF and asthma patients with healthy controls and sought mutual correlations. We did not prove a statistically significant difference in RHI between the test groups with CF children but we confirmed the decreasing trend of RHI since adolescence and significantly lower RHI values in CF adults, confirming the progressive development of atherogenesis and worsening of ED with age. Biochemical parameters showed significantly higher levels of hsCRP, sVCAM-1 and E-selectin in CF...
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Einfluss der LDL-Apherese auf die Plaqueentstehung und -stabilität anhand der Konzentrationsbestimmung von Biomarkern / Effect of LDL-apheresis on plaque formation and plaque stabilization on the basis of biomarker concentrationStrauchmann, Julia 05 March 2012 (has links)
No description available.
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