“Biosim” is a simulation software which works to simulate the harvesting system.This system is able to design a model for any logistic problem with the combination of several objects so that the artificial system can show the performance of an individual model. The system will also describe the efficiency, possibility to be chosen for real life application of that particular model. So, when any one wish to setup a logistic model like- harvesting system, in real life he/she may be noticed about the suitable prostitution for his plants and factories as well as he/she may get information about the least number of objects, total time to complete the task, total investment required for his model, total amount of noise produced for his establishment in advance. It will produce an advance over view for his model. But “Biosim” is quite slow .As it is an object based system, it takes long time to make its decision. Here the main task is to modify the system so that it can work faster than the previous. So, the main objective of this thesis is to reduce the load of “Biosim” by making some modification of the original system as well as to increase its efficiency. So that the whole system will be faster than the previous one and performs more efficiently when it will be applied in real life. Theconcept is to separate the execution part of ”Biosim” form its graphical engine and run this separated portion in a third generation language platform. C++ is chosenhere as this external platform. After completing the proposed system, results with different models have been observed. The results show that, for any type of plants of fields, for any number of trucks, the proposed system is faster than the original system. The proposed system takes at least 15% less time “Biosim”. The efficiency increase with the complexity of than the original the model. More complex the model, more efficient the proposed system is than original “Biosim”.Depending on the complexity of a model, the proposed system can be 56.53 % faster than the original “Biosim”.

Th.--linguist. afr.--Bruxelles--Université libre, 1980.

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2015. / Made available in DSpace on 2016-05-24T17:39:35Z (GMT). No. of bitstreams: 1 339419.pdf: 1426935 bytes, checksum: 0d8c0c0486e49626e60185221fcff86b (MD5) Previous issue date: 2015 / Leflunomida e metotrexato são drogas modificadoras do curso da doença classicamente utilizadas por via sistêmica no tratamento da artrite reumatoide e o sucesso clínico está relacionado com a inibição da proliferação de células imunes e de citocinas na cavidade articular. Baseado nestes potenciais efeitos inibitórios, nossa principal hipótese é que a administração direta dessas drogas na medula é capaz de reduzir a infiltração de leucócitos, edema e incapacitação articular em um modelo de artrite induzida por LPS. Ratos Wistar fêmeas, pesando entre 200 e 220 g, receberam as drogas por via intratecal, 2 horas antes da administração de LPS (30 ng/ 50 µl; i.a.) nas articulações de joelho previamente sensibilizadas com carragenina (300 µg/ 20 µl; i.a.). A incapacitação articular foi avaliada pelo tempo de elevação da pata (TEP; s) durante o deambular de 1 min; o edema pelo aumento do diâmetro articular (DA; cm) e a migração celular pela contagem total de leucócitos (CT; cel/mm3) do fluido sinovial coletado ao final de 5 horas de observação dos parâmetros. As administrações por via intratecal de teriflunomida (metabólito ativo da leflunomida) (0,1 e 20 µg/ 10 µl) e metotrexato (25 µg/ 10 µl) foram capazes de reduzir a migração celular para o fluido sinovial, a incapacitação e o edema articular promovidos pelo LPS, ao contrário de quando administrados por via intraperitoneal, sugerindo que o sítio de interação para os efeitos antiartríticos das drogas foi restrito ao ambiente medular. A coadministração com uridina (10 µg) reverteu apenas os efeitos inibitórios produzidos pela menor dose de teriflunomida, sugerindo que apenas em maiores concentrações o mecanismo de ação da droga independe da inibição da síntese de novo de nucleotídeos. A coadministração por via intratecal de teriflunomida (0,1 µg) e bumetanida (60 µg), um bloqueador do reflexo da raiz dorsal, não potencializou o efeito inibitório da teriflunomida na redução da incapacitação, edema e migração celular, sugerindo que a inibição do reflexo da raiz dorsal e consequentemente da inflamação neurogênica estejam envolvidos na ação medular da teriflunomida. A coadministração de teriflunomida (0,1 µg) e metotrexato (25 µg) por via intratecal promoveu um efeito somatório na inibição da inflamação articular, provavelmente pela adição do mecanismo imunomodulador do metotrexato na inibição da síntese de citocinas pelas células gliais. O presente estudo sugere que o tratamento por via intratecal com teriflunomida e metotrexato modula a inflamação periférica provavelmente por reduzir o aumento da quantidade de citocinas inflamatórias na medula, através da inibição da atividade glial que inibea sensibilização dos terminais neuronais medulares envolvidos na sinalização nociceptiva e na indução da inflamação neurogênica. Esta estratégia pode representar uma nova abordagem terapêutica para o tratamento da artrite reumatoide com menos efeitos colaterais sistêmicos.<br> / Abstract : Leflunomide and methotrexate are disease-modifying antirheumatic drugs classically used systemically in the treatment of rheumatoid arthritis and clinical success is related to inhibition of proliferation of immune cells and cytokines in the joint cavity. Based on these potential inhibitory effects, our central hypothesis is that the direct administration of these drugs on the spinal cord is able to reduce articular incapacitation, edema and synovial leukocyte infiltratio induced in a model of LPS-induced arthritis. Female Wistar rats, weighing between 200 and 220 g were given the drugs intrathecally 2 hours before administration of LPS (30 ng/ 50 µl; i.a.) in the knee joints previously sensitized with carrageenan (300 µg/ 20 µl; i.a.). Inflammatory-induced incapacitation was measured hourly by the paw elevation time (TEP; s) in 1-min period of observation, and edema was evaluated by the articular diameter increase (DA; cm) taken just after each incapacitation measurement. After the 5-h period of observation parameters the synovial fluid was collected from articular capsule for total leukocyte count (CT; cells/ mm3). Intrathecal administration of teriflunomide ( active metabolite of teriflunomide) (0.1 and 20 µg/ 10 µl) and methotrexate (25 g/ 10 µl) were able to reduce cell migration to the synovial fluid, incapacitation and joint edema induced by LPS, unlike when given by intraperitoneal route, suggesting that the interaction site for antiarthritic effects of drugs was restricted to spinal cord microenvironment. Co-administration with uridine (10 µg) just reverses the inhibitory effects produced by the lower dose of intrathecal teriflunomide, suggesting that only in the higher concentrations of the drug mechanism of action independent from inhibition of de novo synthesis of nucleotides. Co-administration of intrathecal teriflunomide (0.1 µg) and bumetanide (60 µg), a blocker of the dorsal root reflex did not potentiate the inhibitory effect of teriflunomide on the reduction of incapacitation, edema and cell migration, suggesting that inhibition of dorsal root reflex and neurogenic inflammation are involved in spinal action of teriflunomide. Co-administration of teriflunomide (0,1 µg) and methotrexate (25 µg) intrathecally caused a summation effect on inhibition of joint inflammation, probably due to the addition of methotrexate immunomodulatory mechanism of inhibition on cytokine synthesis released by glial cells. Thus, this study proposes that the intrathecal methotrexate and leflunomide modulates the peripheral inflammation by inhibiting on increase of cytokines in spinal cord that sensitizes neuronal terminals involved in nociceptive signaling andinduction of neurogenic inflammation. This strategy may represent a novel therapeutic approach for the treatment of rheumatoid arthritis with fewer systemic side effects.

This thesis seeks to improve the development process of open source content management system extensions with particular focus on functional extensions of Joomla CMS. It starts by analyzing current open source CMS market to conclude that most of it is dominated by systems implemented in the PHP programming language. Standard tools used throughout the PHP development process are then analyzed to show that fully-featured integrated development environments are not used as often as with compiled languages. It's shown, however, that modern open source IDEs can deliver performance gains even when used for development in a scripting language. The focus is then shifted from general purpose PHP development to the specifics of CMS extension development. Three major open source systems (WordPress, Drupal and Joomla) are presented with focus on their extensibility. It's demonstrated that some features of Joomla's module system, which are not present in the other systems in comparison, are making it much harder to establish an efficient development workflow that would take full advantage of an IDE. Two recommended workflows for Joomla extension development are then presented while pointing out their disadvantages. Based on this analysis, a new development workflow is designed incorporating yet-to-be-developed functional extensions of Eclipse IDE to solve the problems. The Eclipse platform is then described, pointing out some key technologies used to implement these functional extensions. Finally, major components of the implementation are described.

The goal of this thesis is to explore tools for using the C# programming language to create scripts - short programs for quick and easy solving of small, usually one-time temporary tasks that usually arise during the work on larger projects. In the thesis we analyze existing tools and identify their advantages and disadvantages, formulate requirements for our own tool, and develop our own tool. The result of the thesis is a small integrated development environment (IDE) for quick and easy authoring of scripts in the C# language. The IDE offers sufficient features to allow easy authoring and debugging of programs consisting primarily of a single C# source code file. In the work we make heavy use of the NRefactory library for syntactic and semantic analysis of the C# source code. Powered by TCPDF (www.tcpdf.org)

Made available in DSpace on 2014-06-12T15:55:21Z (GMT). No. of bitstreams: 2 arquivo6248_1.pdf: 847551 bytes, checksum: 8ceaa2bed7b099a42d33baab297abaf3 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2004 / A enzima que degrada a insulina (IDE) é uma proteína intracelular, cuja função mais caracterizada in vitro tem sido sua atividade proteolítica, com alta especificidade para a insulina. Contudo, além da insulina, a IDE também metaboliza outros substratos, como vários fatores de crescimento, e possui outras funções, como a de proteína ligadora e a de proteína regulatória. A IDE se relaciona com várias funções celulares, como a diferenciação e crescimento celulares, e sua expressão é regulada de acordo com o período de desenvolvimento do animal. Também foi referido que a IDE facilita a união dos receptores de esteróides ao DNA nuclear. Por outro lado, sabe-se que o estradiol (E2) estimula o crescimento do epitélio uterino. Para examinar se a IDE é regulada em relação a estímulo de crescimento celular, o presente estudo avaliou na fração citosólica de homogeneizados de útero de ratos, se a IDE é modificada em quantidade e atividade em diferentes status estrogênicos, ou seja, em situação de proliferação celular (proestro e castração +E2) e apoptose (metaestro e castração). Os resultados mostraram que a quantidade e a atividade da IDE aumentam nos animais em fase de proestro ou nos castrados e tratados com E2 e diminuem nos animais em fase de metaestro ou nos castrados. Foi encontrada correlação linear entre a degradação da insulina (atividade da IDE) e o peso relativo do útero, indicando ainda mais o envolvimento da IDE com o crescimento celular. Dessa forma, em condições de proliferação celular (induzida pelo estradiol) observamos aumento na quantidade e atividade da IDE e aumento do peso uterino. Esses dados sugerem que a IDE deve ser considerada um requerimento importante para o crescimento do endométrio induzido pelo estradiol

Aborder le thème de l’attractivité des investissements directs étrangers (IDE) relève d’une préoccupation essentielle pour la Tunisie. Depuis les années 1970, les IDE sont devenus un vecteur clef dans la croissance du pays, en témoignent les différentes mesures législatives et réglementaires qui ont été prises afin de préparer un cadre attractif pour les investisseurs. Cependant, au regard des efforts consentis et des avantages accordés, les résultats sont plutôt décevants et restent loin des attentes. Dés lors, il est intéressant d’étudier les déterminants des IDE en Tunisie et leurs effets sur l’économie locale en particulier sur la croissance économique. A cette fin le capital humain est mis au cœur du mécanisme en analysant son impact sur la croissance et la manière dont il interagit avec les flux d’IDE. C’est autour de cette thématique que notre thèse est axée. L’analyse statistique et économétrique menée au cours de ce travail montre que durant les deux dernières décennies, les IDE en Tunisie s’expliquent par la réalisation des projets ponctuels de prospections pétrolières et des opérations de privatisation de grandes entreprises publiques. Ce sont principalement les secteurs rentiers (hydrocarbures) et les opérations non reconductibles de privatisation qui ont attiré le plus d’IDE, alors que les IDE manufacturiers restent toujours polarisés par le textile et l’habillement. Il apparaît aussi, que l’IDE, hors énergie et privatisations, est faible. De plus, ces opérations n’ont pas déclenché une dynamique d’entrée d’IDE dans ces secteurs. Pour conclure, les résultats attestent clairement de l’effet peu significatif de l’évolution des flux d’IDE et des taux de scolarisation (capital humain) sur la croissance économique en Tunisie. Il ressort aussi que les IDE pris isolément affectent positivement la croissance mais sans crée autant des externalités positives (effets spillovers). / Addressing the issue of the attractiveness of foreign direct investment is a major concern for countries like Tunisia. Since the 1970s, the attractiveness of FDI became a key variable in the country’s economic growth, as shown by the adoption of different legislative and regulatory measures meant to create a favorable environment for investors. However, given the amount of efforts invested and benefits granted, the results come across as being pretty disappointing and all remain far from the goals and hopes initially raised. In this context, it is interesting to study the FDI determinants in Tunisia and their impact on the local economy especially in terms of national growth. To this end, we will focus on the important role played by the human capital, its effects on growth and the way it interacts with the flows of FDI. The core of the thesis will indeed revolve around this theme. The statistical and econometric analysis undertaken in the dissertation will show that for the past two decades, FDI in Tunisia have been the result of a few oil exploration projects and privatization of big public companies. It is mainly the annuitant sector (hydrocarbon) and the non-renewable privatization projects that have attracted the most FDI, whereas industrial FDI remain polarized by the textile-Apparel industries. It also appears that, privatizations and energy sector set aside, FDI remain weak. Not only that, these operations have not triggered a dynamic input on FDI for these sectors. In conclusion, the results clearly prove that progress in FDI and school enrollment ratio (human capital) in Tunisia has had little effect on the Tunisian economic growth. It also has been brought to our attention that, taken alone, FDI have a positive impact on growth; however they fail to create spillover effects.

Title: Projectional editor for domain-specific languages Author: Ondřej Dvořák Department: Department of Distributed and Dependable Systems Supervisor: RNDr. Michal Malohlava Abstract: Programming is a craft requiring a good tooling. One of tools selected as crucial for software development is an integrated development environment (IDE) that allows to maintain most of the general-purpose languages. Domain-specific languages grow in a popularity last years, thus it is necessary to support them by IDE as well. Not just a textual or graphical form of DSL sources is suitable for their maintenance, so does the combination of them. One of the promising approaches is represented by a novel method called a projectional editing. Its objective is to show different visualization forms of program source code, combine and manipulate with them at one place. The thought is typically realized by a projectional editor. In this thesis we design a projectional editor for domain-specific languages and provide its experimental implementation. It analyzes potential approaches to a projectional editing and designs their suitable realization in Microsoft Visual Studio. It provides a universal implementation of a projectional editor on the top of Visual Studio as well as on the top of a standalone application. Moreover, it supports...

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-02-17T22:37:29Z No. of bitstreams: 1 ThiberioDeSouzaCastelo_TESE.pdf: 2616733 bytes, checksum: 7ec74d06a9aa91a8661ccee8c3a034fe (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-02-19T22:29:56Z (GMT) No. of bitstreams: 1 ThiberioDeSouzaCastelo_TESE.pdf: 2616733 bytes, checksum: 7ec74d06a9aa91a8661ccee8c3a034fe (MD5) / Made available in DSpace on 2016-02-19T22:29:56Z (GMT). No. of bitstreams: 1 ThiberioDeSouzaCastelo_TESE.pdf: 2616733 bytes, checksum: 7ec74d06a9aa91a8661ccee8c3a034fe (MD5) Previous issue date: 2015-02-26 / O objetivo foi estabelecer protocolos para obten??o e conserva??o de espermatozoides de cutias (Dasyprocta leporina) criadas em cativeiros no semi-?rido brasileiro, visando sua explora??o sustent?vel. Para tanto tr?s experimentos foram realizados. No primeiro, foi avaliada a influ?ncia da intera??o entre dois tipos de sonda (ondas senoidais e quadr?ticas) e dois protocolos de estimula??o (cont?nuo e seriado) sobre a efici?ncia da colheita de s?men de cutias por eletroejacula??o. A intera??o mais eficiente na obten??o de ejaculados com espermatozoides foi a que utilizou eletrodos em aneis associado com est?mulos em s?rie (4/7; 57%, P<0,05). No segundo, foi realizada a compara??o da a??o crioprotetora de diferentes subst?ncias (glicerol, etilenoglicol, dimetilsulf?xido, dimetilformamida) na criopreserva??o de espermatozoides epididim?rios. Relativo a isso, os maiores valores de motilidade (39,5?4,6%), vigor (2,9?0,2) e integridade de membrana (30,6?4,5%) foram obtidos nas amostras criopreservadas com glicerol quando comparada as amostras contendo etilenoglicol e dimetilformamida, contudo, sem diferen?a (P>0,05) quando comparada as criopreservadas com dimetilsulfoxido. Finalmente, foi analisado o efeito dos m?todos de obten??o de espermatozoides (eletroejacula??o vs colheita epididim?ria) sobre a qualidade dos espermatoz?ides criopreservados. Como resultado as amostras obtidas por lavagem epididm?ria apresentaram motilidade de 25,0?10,9% e vigor 2,4?0,8 e as obtidas por eletroejacula??o obtiveram 31,2?14,2% de motilidade e 2,2?0,7 de vigor, por?m sem diferen?as significativas (P>0,05), denotando a possibilidade de aplicar diretamente, com sucesso, o protocolo de criopreserva??o de espermatozoides epididimarios de cutias (Dasyprocta leporina) para ejaculados da mesma esp?cie. Na presente tese, foram alcan?ados avan?os significativos na obten??o e processamento de espermatozoides de cutias, possibilitando a forma??o de bancos de germoplasmas a partir de amostras oriundas tanto dos epid?dimos quanto por eletroejacula??o. / The general objective of this thesis was to stablish protocols to obtain and conserve agouti (Dasyprocta leporina) sperm bred in captivity in the Brazilian semi-arid, aiming its sustainable production. The thesis was divided in three experiments. In the first one, we studied the influence of the interaction between two probes (quadratics and sine waves) and two stimulation protocols (continuous and in series) on the agouti sperm collection by electroejaculation efficiency. The most efficient interaction on this obtainment was the one with probes with rings associated with stimuli in series (4/7; 57%, P<0.05). In the second experiment we compared the cryoprotectant effects of different substances (glycerol, ethyleneglycol, dimethylsulfoxide, dimethylformamide) on epididymis sperm cryopreservation. The highest values on motility (39.5?4.6%), vigor (2.9?0.2) and membrane integrity (30.6?4.5%) were observed on the samples cryopreserved using glycerol when compared to those with ethyleneglycol and dimethylformamide, but there was no difference (P>0.05) when compared to the samples cryopreserved with dimethylsulfoxide. At last, we studied the effects of the methods to obtain sperm (electroejaculation vs epididymal collection) on post thawing sperm quality. The samples obtained by epididymal retrograde flushing showed values for motility of 25.0?10.9% and vigor 2.4?0.8, and those obtained by electroejaculation had 31.2?14.2% of motility and vigor of 2.2?0.7, however, without statistical difference (P>0.05), which shows the possibility to successfully use the epididymal sperm cryopreservation protocol on agouti ejaculated sperm. In conclusion, significant advances on obtainment and processing of agouti sperm were made, allowing the establishment of germplasm banks from sperm samples obtained from the epididymis or by electroejaculation.

Webbintegrerade utvecklingsmiljöer (också kallat moln-IDE) är en tjänst som erbjuds på internet där en programmerare erbjuds hela sin utvecklingsplattform i molnet. Vad finns det för fördelar och begränsningar med att använda en sådan utvecklingsplattform istället för den traditionella lokala utvecklingsmiljön? Tycker de professionella webbutvecklare som använt moln-IDE att det är en bra idé att använda en denna plattform istället för en lokal miljö? För att svara på detta har olika moln-IDE utforskats och testats. En enkätstudie har även gjorts för att utvärdera de erfarenheter som webbutvecklare haft med moln-IDE. Resultatet var som förväntat mestadels positivt, de flesta respondenterna gillar att använda moln-IDE för sin webbutveckling. Ett flertal fördelar med moln-IDE har uppmärksammats, samt några begränsningar.