Patients returning to sport after anterior cruciate ligament (ACL) reconstruction surgery currently have a high risk for sustaining a second ACL injury and having early signs of knee osteoarthritis. Assessing lower extremity kinetics and kinematics during landing can provide information about a patient's risk for sustaining a second ACL injury and having further joint trauma. However, currently accepted methods to assess kinetics and kinematics are not feasible to use in most non-research settings as they are expensive, time consuming, and take up a lot of space. The goal of this project was to identify methods to assess landing mechanics which are reliable and feasible to use in non-research settings. First, we found that the loadsol®, a wireless force sensing shoe insole, is valid relative to embedded force plates and repeatable between days for assessing kinetics and kinetic symmetry during bilateral and unilateral landing tasks. Second, we developed a new method to collect continuous kinematic data using a low-cost videocamera, disposable markers, and an automated point tracking program. This method was validated against a 3D motion capture system for measuring a fixed angle and for measuring sagittal plane running kinematics. Third, we found that the new video analysis method is valid relative to 3D motion capture and is repeatable between days for assessing frontal and sagittal plane knee kinematics during landing. Finally, we used the loadsol® and automated 2D video analysis to assess landing mechanics in both patients following ACL reconstruction and healthy uninjured control participants in a non-research setting. We found that, relative to controls, patients following ACL reconstruction had reduced kinetic symmetry during bilateral landing, where they offloaded their surgical limb and relied more heavily on their non-surgical limb. Additionally, patients following ACL reconstruction had reduced knee flexion range of motion symmetry during unilateral landing, where they had reduced knee flexion when landing on their surgical limb. Collectively, these projects developed methods to quantitatively assess landing mechanics that are feasible to use in non-research settings, documented the validity and between-day repeatability of these methods, and demonstrated that they could be used to identify kinetic and kinematic deficits in patients following ACL reconstruction. This project is an important step toward being able to assess landing mechanics in patients recovering from an ACL reconstruction. / Doctor of Philosophy / The anterior cruciate ligament (ACL) is a bundle of connective tissue that helps stabilize the knee joint. ACL injuries are common in sport, and ACL reconstruction surgery is the most widely used treatment strategy for patients who wish to return to playing sports. Unfortunately, even after ACL surgery and rehabilitation, many patients who return to sport wind up getting hurt again and developing severe joint pain down the road. Previous research has identified movement and loading patterns which are associated with this increased risk for further injury in patients following ACL reconstruction. For example, patients who have increased asymmetry when landing from a jump, where they shift weight away from their surgical limb and towards their non-surgical limb, have an increased likelihood of sustaining a second ACL injury to either their surgical or non-surgical leg. Assessing movement during rehabilitation could help identify patients who exhibit poor movement mechanics and improve movement to reduce their risk for second injuries. However, there are not currently methods available to reliably assess movement that are feasible for widespread use in non-research settings (i.e. physical therapy clinics). The purpose of this project was to identify and develop methods to assess movement which are accurate and feasible to use in a clinical setting. In this dissertation, we first determined the accuracy of using wireless force sensing shoe insoles to measure how hard and how symmetrically people contact the ground when they land from a jump. Second, we developed a new method to measure knee motion using videos collected with low-cost cameras (e.g. iPad), and determined the accuracy of this method compared to a three-dimensional motion capture system. For the last part of this dissertation we demonstrated that the aforementioned methods could be used to identify deficits in landing mechanics in patients following ACL reconstruction in a non-research setting. When comparing ACL reconstruction patients with uninjured controls, we found movement and loading asymmetries which were expected and which are associated with the risk for second ACL injuries and early onset knee osteoarthritis. This project is an important step towards being able to assess landing mechanics in patients recovering from an ACL reconstruction, which could improve our ability to prevent subsequent injuries in this clinical population.

Although airbags have reduced the incidence of fatal and severe injuries in automobile collisions, they have been shown to increase the risk of less severe injuries. The purpose of this research was to investigate particular occupants and injury types in automobile crashes in order to identify national trends in injury incidence, type, and severity. A statistical analysis was performed in order to determine the effects of airbag deployment on incidence and severity of various injury and occupant types. In addition, a computational modeling study aimed to recreate actual automobile crashes that occurred in order to identify injury mechanisms and occupant kinematics during the crash. The specific studies performed were designed to investigate the effects of frontal airbags on: skin injuries, burn injuries, eye injuries, orbital fractures, severe upper extremity injuries, and pregnant occupant injuries. The statistical analyses revealed several significant findings in injury trends related to occupant exposure to airbag deployment. In particular, occupants in frontal crashes were significantly at a higher risk to sustain a skin injury (p=0.00), a burn injury (p=0.02), a corneal abrasion (p=0.03), and a severe upper extremity injury (p=0.01) when exposed to an airbag deployment, than when not exposed to an airbag deployment. In addition, female occupants were at a statistically higher risk of sustaining an airbag induced skin injury than males (p=0.00). Finally, within a 95% confidence interval, older occupants were at a higher risk for sustaining both airbag induced burn injuries, and severe upper extremity injuries. While occupants in crashes with lower impact velocities were at a higher risk for airbag induced burn injuries, occupants in crashes with higher impact velocities were more likely to sustain a severe upper extremity injury. The airbag increased the incidence of eye injuries for occupants in frontal crashes, however, it also decreased the severity of the associated eye injuries. In particular, occupants who sustained an orbital fracture when exposed to airbag deployment sustained mostly closed, less severe orbital fractures, while occupants not exposed to airbag deployment much more often sustained more severe, open, displaced, or comminuted orbital fractures. While the airbag was shown to increase the risk of some injuries to particular occupants involved in specific crash types, the airbag appears to have provided a beneficial protective effect as it also reduced the severity of all injuries observed. / Master of Science

Stress fractures are common overuse injuries that have plagued athletes for many years. Often referred to as fatigue fractures, they are formed when the skeletal muscles fatigue and can no longer absorb the shock of repetitive pounding activities such as running. Stress fractures are most common in the weight-bearing bones of the lower extremities and are usually preceded by sudden increases or changes in training routines. Because they are most common in athletes who are least fit, it has been hypothesized that freshmen athletes who are not prepared for the increased physical demands of college athletics have the greatest risk for developing stress fractures compared to other academic classes. As of yet however, there have been very few studies that have examined the interaction of different variables such as academic class, on the formation of stress fractures. Therefore, the purpose of this study was to look at the incidence, frequency and pattern of stress fractures among the female athletes at Virginia Polytechnic Institute and State University. A retrospective analysis of 28 injury cases over four years revealed that 67% of the injuries occurred in freshmen athletes. The majority of these were in the lower leg and occurred in mid-season rather than pre-season. There were no relationships found between the variables sport, class, site and season and thus it was concluded that the incidence of injury was not affected by the interaction of these variables. However, the variables themselves did influence the formation of stress fractures. Ultimately, this study provided insight on what factors should be carefully examined in order to prevent future stress fracture injuries in collegiate athletes. / Master of Science

Traumatic brain injury (TBI) remains an important cause of morbidity and mortality within society. TBI may result in both focal and diffuse brain injury. Diffuse traumatic axonal injury (TAI) is an important pathological substrate of TBI, and can be associated with a range of clinical states, ranging from concussion through to death, the clinical severity being associated with a number of factors related to the injury. A retrospective study was conducted using 406 cases with TBI, from the archive of the Academic Department of Pathology (Neuropathology) University of Edinburgh, during the period from1982 and 2005. This cohort was sequential and provided a unique description of the range of pathologies associated with fatal TBI within the Edinburgh catchment area. All the data was collected on a proforma and analysed to provide a description of the incidence in the injury patterns among the Edinburgh cohort. This cohort was then used to provide cases to try and critically assess the mechanisms of axonal injury in TBI. A study was undertaken to investigate TAI in an experimental model of non-impact head injury in a gyrencephalic mammalian model (piglet model) and in human autopsy materials using immunohistochemical analysis of a range of antibodies, and to define the distribution of axonal injury with flow and neurofilament markers in TAI. A further objective was to examine the expression of β-APP as an indicator of impaired axonal transport, three neurofilament markers targeting NF-160, NF-200, and the phosphorylated form of the neurofilament heavy chain (NFH), in different anatomical regions of piglet and human brains. The double immunofluorescence labelling method was then employed to investigate the hypothesis of co-localisation between β-APP and each one of the previous neurofilament markers. The animal studies showed significant differences in NF-160 between sham and injured 3-5 days old piglet cases (6 hour survival) and between 3-5 days sham and injured, when stained with SMI-34 antibody. In 4 weeks old piglet cases (6 hour survival), immunoreactivity of β-APP was significantly higher in injured than control. No other significant differences for any of the antibodies were noted, based on age, velocity, and survival time. Human results suggested that the brainstem had a higher level of β-APP and NF-160 than the corpus callosum and internal capsule. Co-localisation of β-APP with NFs was not a consistent feature of TAI in piglet and human brains, suggesting that markers of impaired axonal transport and neurofilament accumulation are sensitive to TAI, but may highlight different populations involved in the evolution of TAI.

Magister Scientiae (Physiotherapy) - MSc(Physio) / The distressing event of Spinal Cord Injury (SCI) leads to complete or incomplete injury, and results in many complications such as such as neurogenic shock, cardiovascular disease, temperature regulatory problems, respiratory complications, dysphagia, thromboembolism, and pressure ulcers amongst others. These complications limit the individual’s functioning and participation. Participation is fruitful and meaningful when you are actively involved in a specific activity. To understand the lack of participation within a specific setting, it is important to know what the limitations in activities are, and what causes these limitations. The goal of rehabilitation should be to reintegrate patients back into the community so that they can fulfil their roles. Aim: The aim of the study was (1) To determine included participants’ socio-demographic and injury characteristics; (2) To describe healthcare services received by people living with long-term Traumatic Spinal Cord Injury (TCSI) over the past 12 months; (3) To determine the point prevalence of common activity limitations of survivors of TSCI four years after injury; (4) To determine the point prevalence of participation restrictions of survivors of TSCI four years after injury; and (5) To determine factors associated with activity limitations and selected participation restrictions four years after injury.

Background: Lower extremity (LE) musculoskeletal injuries in soccer players are extremely common. These injuries can result in many days of lost time in competition, severely impacting players and their respective teams. Implementation of group injury prevention programs has gained popularity due to time and cost-effectiveness. Though participation in group injury prevention programs has been successful at reducing injuries, programs often target a single injury and all players do not benefit from participation. Players with a greater number of risk factors are most likely to sustain an injury, and unfortunately, less likely to benefit from a group injury prevention program. The purpose of the proposed research is to determine if targeting these high risk players with one-on-one treatment will result in a reduction in the number of risk factors they possess. Objectives: 1) Determine the effectiveness of one-on-one intervention for reducing the number of risk factors for LE musculoskeletal injury in soccer players with 3 or more risk factors; 2) Assess the effectiveness of matched interventions on reducing the magnitude of identified risk factors. Hypothesis: Fifty percent or more of subjects receiving one-on-one intervention will have a reduction of ≥ 1 risk factor(s). Design: Quasi-experimental pretest-posttest design. Subjects: NCAA Division I men’s and women’s soccer players. Methods: All subjects were screened for modifiable risk factors using a battery of tests which assessed mobility, asymmetry in fundamental movement pattern performance, neuromuscular control, and pain with movement. Players with ≥ 3 risk factors (“high risk”) were placed in the treatment group and received one-on-one treatment from a physical therapist. An algorithm was created with interventions matched to specific deficits to determine the treatment each subject received. Subjects in the intervention group were treated twice per week for four weeks. Players with < 3 risk factors (“low risk”) were placed in the control group and did not receive one-on-one intervention. Analysis: The primary outcome measure was proportion of treatment successes, defined as a reduction of ≥ 1 risk factor(s). Secondary outcomes included analysis of within group and between group differences. Results: Thirteen subjects were treated with one-on-one intervention, with twelve having a reduction of at least 1 risk factor at posttest. The proportion of treatment successes in the intervention group was 0.923 (95%CI 0.640-0.998). The proportion of high risk subjects that became low risk at posttest was 0.846, which was statistically significant (p = 0.003). Within group differences were noted in active straight leg raise (left; p = 0.017), hip external rotation (right, p=0.000; left, p = 0.001) thoracic spine rotation (left; p=0.026), and upper quarter neuromuscular control measures (left inferolateral reach, p = 0.003; left composite, p = 0.016). A statistically significant between group difference was noted in risk factor change from pretest to posttest (p = 0.002), with the median risk factor change in the intervention group and control group being -3 and -1, respectively. Conclusion: Utilizing one-on-one interventions designed to target evidence-based risk factors is an effective strategy to reduce LE musculoskeletal injury risk factors in high risk individuals.

The syndrome commonly referred to as whiplash injury" resulting from motor vehicle accidents is complex and remains a challenge to clinicians, as is evidenced by the recent report of the Quebec task force on the "whiplash syndrome". The main objective of this prospective randomised study was to evaluate two conservative treatment regimens (early immobilisation-experimental group-1, early active mobilisation experimental group-2) which are based on accepted physiological rationale and then to compare their effectiveness with existing treatment regimens that are commonly practiced (control group) in the management of "whiplash" type of injuries. To this stage, the current study is the only prospective randomised clinical trial of its type conducted with a sufficiently large sample size and over a long study period. The results of the current study clearly demonstrated that the subjects in the immobilised group recovered from their pain-related symptoms and returned to their normal duties sooner than those in the other two treatment groups. In addition to this, those subjects who received the immobilisation regimen did not show adverse effects on either the range of motion or the strength of the neck muscles. Thus, the immobilisation regimen was clearly shown to be the preferred option when compared to the other two treatment methodologies investigated in the current study.Although the primary interest of the current study was to compare the efficacy of three different treatment regimens, a series of statistical analyses were performed to establish the prognostic significance of several factors associated with "whiplash" injury. This showed that factors such as gender, age, speed of the vehicles involved, paraesthesia, intensity of pain at the time of the initial examination, interscapular pain, blurred vision and difficulty in focusing, all had prognostic value. ++ / Similarly, the type of collision, seating position, presence of headache within 24 hours post injury, pre-existing degenerative changes in the cervical spine, loss of lordosis and litigation factors had no prognostic significance. Another major emphasis of the current study has been to concentrate on the pain related symptoms of the neck which are of major concern to "whiplash" subjects and to those clinicians treating them. A paucity of such information is considered to be one of the most notable causes of difficulties encountered in the management of "whiplash" injuries.As an adjunct to the main study, the morphology of the deep pre- and post vertebral muscles of the neck region using embalmed cadavers and fresh post-mortem specimens was investigated, as the literature is deficient in--this regard. Similarly, a longitudinal study of 45 subjects was also performed using Magnetic Resonance Imaging (MRI) technology. The longitudinal nature of the M.R.I. study provided for the first time an account of the details associated with the progressive pathological changes that occurred in some disc lesions, at defined points in time following a MVA. The observations made from the adjunct studies help develop a better understanding of the pathoanatomy associated with the deep muscles of the neck region and the pathological changes that occur following a traumatic disc lesion as evidenced within 2 weeks, after 3 months and 12 months post- injury. On the basis of the observations made in the current study, a classification of the "whiplash" injury has been proposed for the consideration of clinicians. Similarly, the questionnaire used for data collection in the current study, can be readily modified and utilised in a clinical situation for establishing documentation, planning treatment strategies and for evaluation of the treatment outcomes of "whiplash" type of injuries.

Violence and traumatic brain injury (TBI) are two major public health concerns. This thesis is comprised of three different research topics; the epidemiology of intentional TBI in Ontario, discharge against medical advice (DAMA) as an undesirable outcome of acute stage, and functional changes after receiving rehabilitation care. To study these areas, three different datasets from the Canadian Institute for Health Information (CIHI) were used. The first epidemiological study on intentional TBI identified 1,409 (8.0%) intentional TBIs and 16,211 (92.0%) unintentional TBIs. Of the intentional TBIs, 389 (27.6%) were self-inflicted TBI (Si-TBI) and 1,020 (72.4%) were other-inflicted TBI (Oi-TBI). The most common causes of Si-TBI were “jumping from high places” and “firearms”. Major causes of Oi-TBI were ‘fight and brawl” and “struck by objects”. Si-TBI was associated with younger age, female gender, and having a history of alcohol/drug abuse. Oi-TBI was also associated with younger age and having an alcohol/drug abuse history and also with male gender. The second study on discharge against medical advice found that 446 (2.84%) TBI patients left hospitals without medical advice. DAMA was significantly associated with intentional injuries in those with self-inflicted TBI and other-inflicted TBI. DAMA was also associated with younger age and a history of alcohol/drug abuse. Using univariate analyses, the third study found that people with intentional TBI had significantly lower FIM gains in the motor area and significantly lower relative function gains (as measured by Montebello Rehabilitation Factor Score) in the cognitive area. Multivariate analyses of the same data showed that intentional TBI was also associated with lower cognitive relative gains, while controlling for age, gender, alcohol/abuse history, and other demographic and clinical variables. Persons with intentional TBI were found to be less likely to be discharged home, controlling for other relevant confounders. In conclusion, a person who has been injured due to assault or suicidal attempt may need more individualized care as they may be at greater risk for adverse rehabilitation outcomes. These findings regarding people with intentional TBI provide a basis for enhancing efforts on prevention of violence-related TBI and DAMA, and also for improving rehabilitation programs and discharge plans for this vulnerable population.

Violence and traumatic brain injury (TBI) are two major public health concerns. This thesis is comprised of three different research topics; the epidemiology of intentional TBI in Ontario, discharge against medical advice (DAMA) as an undesirable outcome of acute stage, and functional changes after receiving rehabilitation care. To study these areas, three different datasets from the Canadian Institute for Health Information (CIHI) were used. The first epidemiological study on intentional TBI identified 1,409 (8.0%) intentional TBIs and 16,211 (92.0%) unintentional TBIs. Of the intentional TBIs, 389 (27.6%) were self-inflicted TBI (Si-TBI) and 1,020 (72.4%) were other-inflicted TBI (Oi-TBI). The most common causes of Si-TBI were “jumping from high places” and “firearms”. Major causes of Oi-TBI were ‘fight and brawl” and “struck by objects”. Si-TBI was associated with younger age, female gender, and having a history of alcohol/drug abuse. Oi-TBI was also associated with younger age and having an alcohol/drug abuse history and also with male gender. The second study on discharge against medical advice found that 446 (2.84%) TBI patients left hospitals without medical advice. DAMA was significantly associated with intentional injuries in those with self-inflicted TBI and other-inflicted TBI. DAMA was also associated with younger age and a history of alcohol/drug abuse. Using univariate analyses, the third study found that people with intentional TBI had significantly lower FIM gains in the motor area and significantly lower relative function gains (as measured by Montebello Rehabilitation Factor Score) in the cognitive area. Multivariate analyses of the same data showed that intentional TBI was also associated with lower cognitive relative gains, while controlling for age, gender, alcohol/abuse history, and other demographic and clinical variables. Persons with intentional TBI were found to be less likely to be discharged home, controlling for other relevant confounders. In conclusion, a person who has been injured due to assault or suicidal attempt may need more individualized care as they may be at greater risk for adverse rehabilitation outcomes. These findings regarding people with intentional TBI provide a basis for enhancing efforts on prevention of violence-related TBI and DAMA, and also for improving rehabilitation programs and discharge plans for this vulnerable population.

La patología de origen traumático, cuarta causa de mortalidad y primera en cuanto a años perdidos, es un relevante problema de salud, que ocasiona además una elevada morbilidad e incapacidad y un alto coste sanitario y social. El conocimiento de su abordaje se ha realizado mediante el análisis de bases de datos de pacientes y encuestas a profesionales. El presente trabajo de investigación va dirigido a conocer si la asistencia al paciente adulto con TCE en las UCI catalanas de referencia para esta patología es comparable en cuanto a epidemiología, abordaje y resultados, a los que muestra la literatura referente a otros países de nuestro entorno. Se planteó un estudio con un objetivo principal doble, por un aparte describir las características demográficas y clínicas de los pacientes y por otro analizar el abordaje terapéutico y la monitorización. Como objetivos secundarios se plantearon conocer la variabilidad de los apartados anteriores según la gravedad del TCE, conocer si la práctica clínica se adhería a las principales recomendaciones de las Guías de Práctica Clínica vigentes y conocer el resultado neurológico final de los pacientes, identificando las posibles variables epidemiológicas estudiadas que pudieran influir en el resultado neurológico y la presencia de de insultos secundarios que se producen. Se realizó un estudio observacional, multicéntrico y prospectivo en las 7 UCIs catalanas de referencia para esta patología. Se recogieron datos demográficos, clínicos, radiológicos, monitorización, terapéuticos, complicaciones y de resultado de los pacientes que ingresaban en una UCI afectos de un TCE, con o sin politraumatismo durante los primeros 15 días de estancia. Se incluyeron pacientes 370 pacientes durante un año.Los principales resultados muestran un predomina el sexo masculino, edad media de 40 años, causa principal el accidente de tráfico. Un 36% de los casos ingresaron directamente en el centro de referencia pero únicamente el 26% en los primeros 60 minutos. El perfil de gravedad del TCE fue un 53% Graves, 27% Moderados y 20% Leves, con una lesión encefálica predominante tipo II de Marshall (39%). La presencia de HSA fue del 49%. Se monitorizó la PIC en el 69% de los TCE grave, la SjO2 en el 27% y el DTC en el 50%. La intensidad de la monitorización y el uso de la terapéutica se incrementa de acuerdo a la mayor gravedad del paciente. Hay una alta adherencia para las recomendaciones de las guías de práctica clínica en lo que hace referencia a la utilización de monitorización sistémica y neurológica, la utilización de barbitúricos, y menor en cuanto a la utilización de corticoides, e hiperventilación. La tasa global de mortalidad en UCI fue del 22%, un 31 % para los graves. Las variables explicativas de "éxitus" fueron el estado de las pupilas, el tipo de lesión radiológica, el sexo y la gravedad del TCE. La presencia de complicaciones prehospitalarias (hipoxia, hipotensión, broncoaspiración, paro cardiorrespiratorio, hipotermia o convulsiones) se constata en el 15% de los pacientes y se asocia de forma acumulativa con un mal resultado.Como conclusión general este trabajo de investigación apoya la hipótesis inicial de que la atención al TCE en las UCI catalanas estudiadas es comparable en cuanto a epidemiología, abordaje y resultados, a los que muestra la literatura referente a otros países de nuestro entorno. Palabras clave:Head injury, traumatic brain injury, neurocritical care. / Trauma disease represents the fourth cause of mortality in frequency and the first one in terms of lifetime waste. It constitutes a significant health problem that provokes a high morbidity and incapacity in addition to striking health and social costs. Since now, its management approach has been done through patient data bases analysis and surveys directed to professionals. This research report attempts to elucidate epidemiologic, management and clinical results' comparability between actual adult BTI clinical practice in Catalan ICU's, which are of reference for this pathology, and practice shown in medical literature in our environment. The study was planned with a double main objective; for one part, to describe demographic and clinical patient characteristics, and for the second part, to analyse patient monitoring and therapeutic management. As secondary objectives we proposed to explore variability by BTI clinical severity, adherence rate to recommendations addressed in Clinical Practice Guidelines in force, and patient neurological outcome, identifying those epidemiologic parameters probably influencing neurological outcome, apart from secondary insults incidence. An observational and prospective study was conducted in 7 reference ICU's in Catalonia. Patient data collected covered demographic, clinical, radiological, monitoring and therapeutic aspects, besides complications and outcome variables for patients that were admitted in the ICU with a BTI diagnosis, with or without multiple trauma, that were followed in their length of stay for a 15-day period. A total of 370 patients were included in the study period of 1 year.Main results show a predominance of males with a mean age of 40, being traffic accident the main cause of BTI. 36% were directly admitted to the reference hospital, but only 26% were admitted in the first hour after the accident. The BTI severity profile was: 53% severe, 27% moderate and 20% mild, being the highest prevalence (39%) type II Marshall encephalic injury. The existence of SH was 49%. ICP was monitored in 69% of severe patients and SjO2 in 27% and TCD in 50%. Monitoring and therapeutic use was shown to increase depending on the higher patient severity. Close adherence to clinical guidelines recommendations was proven for systemic and neurological monitoring and barbiturate use, and was lesser the adherence for hyperventilation and corticoid utilization. ICU mortality rate was 22%, raising 31% for severe patients. Dependent variables for mortality were found to be pupil status, type of radiological finding, sex and BTI severity. Pre-hospital complications (hypoxia, hypotension, bronchial aspiration, cardiac arrest, hypothermia, convulsions) were found in 15% of patients, and are cumulative associated with a worse outcome.As a general conclusion, this research report supports the initial hypothesis that BTI clinical practice reviewed in reference Catalan ICU's, is comparable to practice in other countries of our environment, as is shown from the medical literature published.