Master of Science / Department of Kinesiology / Craig A. Harms / Obesity and asthma often coexist in the same people. Both are characterized by the presence of low-grade systemic inflammation. A high-fat diet may contribute to concurrent development of both conditions by promoting a pro-inflammatory postprandial environment leading to a transient accumulation of blood lipids (postprandial lipemia; PPL) and acute airway inflammation. Previous results from our lab have shown an ~20% increase in airway inflammation two hours after consuming a high-fat meal (HFM) that was significantly associated with increased plasma triglycerides. While acute exercise has been shown to attenuate PPL, it is unknown whether these protective effects will translate to reduced airway inflammation after a high-fat meal. PURPOSE: To determine the effects of an acute bout of exercise on airway inflammation after a HFM. We tested the hypothesis that an acute bout of exercise 12 hours before a high-fat meal would protect against subsequent airway inflammation in healthy men and would be related to the decreased PPL and systemic inflammatory markers. METHODS: In a randomized cross-over study, 12 healthy college-aged men consumed a HFM (1g fat/1kg body weight) 12 hours following exercise (EX; 60 min at 60% VO2max) or without exercise (CON). Exhaled nitric oxide (eNO; measure of airway inflammation), blood lipid profiles (venous sample; total cholesterol, HDL, LDL, triglycerides, glucose), inflammatory markers (hsCRP, TNF-[alpha], IL-6) and pulmonary function tests (PFT) (forced expiratory volume in 1-s,forced vital capacity, forced expiratory flow at 25-75% of vital capacity) were measured pre-HFM, two hours, and four hours post-HFM. RESULTS: Baseline eNO was not different (p>0.05) between trials. eNO increased (p<0.05) post HFM at two hours in the both CON and EX conditions. eNO between trials was not different (p>0.05). Triglycerides were significantly increased two and four hours post HFM but were not different (p>0.05) between conditions. There was no relationship (p>0.05) between eNO and triglycerides or systemic inflammatory markers for any time point in either condition. Pulmonary function did not differ (p>0.05) between any condition. CONCLUSION: These results demonstrate that an acute bout of moderate intensity exercise 12 hours before a HFM does not attenuate postprandial airway inflammation or lipemia in healthy college-aged men.

Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references. Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references. Also available on the Internet.

A lipemia pós-prandial (LPP) se caracteriza pelo aumento das concentrações de lipídeos sanguíneos, provocado por meio de refeição ou jejum e está diretamente relacionada com o sedentarismo e a formação da placa aterosclerótica. A adolescência é um período crítico no controle do peso e a inatividade física está associada com desenvolvimento de doenças cardiovasculares (DCV) prematuras. O exercício atua como um importante agente protetor contra o desenvolvimento e progressão de diversas doenças crônicas. Apesar dos efeitos do exercício sobre a LPP serem relativamente bem descritos, os seus efeitos sobre crianças e adolescentes têm sido negligenciados. Além disso, um dos aspectos intervenientes sobre a LPP é a intensidade de exercício. Dessa forma, o objetivo do estudo foi verificar os efeitos do exercício de intensidade média e alta na lipemia e glicemia pós-prandiais em adolescentes eutróficos saudáveis após refeição hiperlipídica. Treze adolescentes do sexo masculino, com idade entre 12 e 16 anos, foram selecionados e realizaram três protocolos: exercício de média intensidade (MI), exercício de alta intensidade (AI) e repouso (REP). No MI, os participantes pedalaram durante 45 minutos a 10% abaixo do 2° limiar ventilatório, seguidos de 180 minutos de repouso. No AI, os participantes pedalaram a 10% acima do 2° limiar ventilatório até alcançarem o mesmo gasto energético do MI. No REP, os participantes permaneceram em repouso durante todo o período. Foi fornecida uma refeição rica em gordura após cada protocolo. Amostras de sangue foram coletadas nos tempos 0 (jejum), 45min (logo após exercício), 105min (1h após a refeição), 135min, 165min, 195min e 225min em cada protocolo. Os níveis de triglicerídeos (TG), colesterol total (CT), HDL, LDL e glicose foram mensurados. Não houve diferenças entre as condições em relação aos níveis de CT, HDL, LDL e glicose. Foi encontrada uma redução significativa (p<0,05) nos níveis de TG (mg/dl) na condição MI quando comparado ao REP e AI no minuto 105 (70,1 + 10,3 vs. 92,2 + 32,4 e 82,2 +10,4) e 135 (68,4 + 14,4 vs. 97,3 + 15,6 e 91,54 + 24,9), respectivamente, e no minuto 165 entre REP e MI (103,14 + 24,2 vs. 82,4 + 18,8). A área sob a curva de TG (mg/dl/min) no MI foi 17,19% significativamente inferior quando comparado ao REP (16.437 vs 19.848) e 12,82% inferior quando comparado ao AI (16.437 vs 18.856). Em conclusão, o exercício de MI mostrou-se eficaz na redução dos triglicerídeos pós-prandiais em adolescentes saudáveis, quando comparado ao repouso e ao exercício de AI. / Postprandial lipemia (PPL) is characterized by increased concentrations of blood lipids, caused by meal or fasting and is directly related to a sedentary lifestyle and the formation of atherosclerotic plaque. Adolescence is a critical period in weight and physical inactivity is associated with premature cardiovascular disease (CVD) development. Exercise acts as an important protective mediator against the development and progression of several chronic diseases. Despite the effects of exercise on LPP are relatively well described, its effects on children and adolescents have been neglected. Moreover, one of the factors on aspects LPP is the intensity of exercise. Thus, the aim of this study was to investigate the effects of exercise of medium and high intensity on postprandial lipemia and glycemia in healthy normal adolescents after a high fat meal. Thirteen male adolescents, aged between 12 and 16 years, were selected and performed three protocols: exercise of moderate intensity (MI), high-intensity exercise (HI) and rest (RES). In MI, participants cycled for 45 minutes at 10% below 2nd ventilatory threshold, followed by 180 minutes of rest. In HI, participants cycled at 10% above the 2nd ventilatory threshold in order to achieve the same energy expenditure MI. RES, the participants remain at rest during the entire period. A high fat meal was provided after each protocol. Blood samples were collected at 0 (fasting), 45min (after exercise), 105min (1h after the meal), 135min, 165min, 195min and 225min in each protocol. Triglycerides (TG), total cholesterol (TC), HDL, LDL and glucose were measured. There were no differences between conditions in relation to the levels of TC, HDL, LDL and glucose. A significant reduction (p <0.05) was found in the levels of TG (mg / dL) in the condition MI when compared to the REP and HI at 105 minutes (70.1 ± 10.3 vs. 92.2 + 32.4 and 82.2 +10.4) and 135 (14.4 vs. 68.4 +. 97.3 + 15.6 + 24.9 and 91.54), respectively, and at 165 minutes between REP and MI (24.2 vs 103.14 +. 82.4 + 18.8). The area under the curve of TG (mg / dl / min) in MI was 17.19% significantly lower when compared to REP (16,437 vs 19,848) and 12.82% lower when compared to HI (16,437 vs 18,856). In conclusion, the MI exercise was effective in reducing the postprandial triglyceride levels in healthy adolescents, when compared at rest and during HI exercise.

Introdução: O extrato seco de Solanum melongena (berinjela) vem sendo utilizado pela população como um tratamento alternativo para dislipidemia. Ela é um vegetal rico em flavonóides que são antioxidantes polifenólicos encontrados nos alimentos. Estudos demonstram relação inversa entre o consumo de alimentos ricos em flavonóides e a mortalidade por doença arterial coronariana. O objetivo deste estudo foi avaliar o efeito da administração de cápsulas de extrato de berinjela no perfil lipídico de indivíduos saudáveis após um teste de sobrecarga lipídica via oral . Métodos: Após consentimento informado 58 voluntários saudáveis foram randomizados para receber cápsulas contendo 450 mg extrato seco de berinjela ou placebo. As cápsulas de berinjela ou placebo foram administradas na quantidade de duas cápsulas duas vezes ao dia durante 14 dias. No 14º dia os voluntários foram submetidos a um teste de sobrecarga lipídica, logo após a ingestão de 900 mg de extrato de berinjela ou placebo conforme randomização anterior. A análise nutricional da refeição continha 361 kcal, 22,5 g de gorduras totais, sendo destas 14,5g de gordura saturada e 251mg de colesterol. O perfil lipidico foi aferido em jejum nos dias 0 e 14 e neste último dia aferido em jejum e 2 horas após a sobrecarga lipidica. Resultados: Os níveis de trigliderídeos, expressos em mediana (amplitude interquartílica), encontrados nos voluntários do grupo berinjela foram 69mg/dl (51 - 102), 69 mg/dl (56 - 94) e 92 (64 - 120), antes do tratamento, no 14º dia pré e pós prandial, respectivamente. No grupo placebo os resultados foram 92mg/dl (77 - 128), 79 (60 - 108) e 98 (73 - 142), respectivamente. Não houve interação estatisticamente significativa entre tempo e grupo quanto ao nível de triglicerídeos (P=0,208). Também não foram encontradas diferenças nos valores de colesterol total (P=0,973), HDL colesterol (P=0,059) e LDL colesterol (P=0,611). Conclusão: Nossos resultados demonstram que a utilização de cápsulas de extrato seco de S. Melongena por 14 dias não produziu nenhum efeito no perfil lipidico em jejum e pós-prandial em indivíduos normais. / Introduction: Dry Solanum melongena (eggplant) extract is being used by the population as an alternative treatment for dyslipidemia. It is a vegetable rich in flavonoids, which are polyphenol anti-oxidants found in foods. Studies reveal an inverse relationship between the consumption of foods rich in flavonoids and mortality from coronary artery disease. The objective of this study was to assess the effect of administering eggplant extract capsules on the lipid profile of healthy individuals after an oral lipid overload test. Methods: After informed consent, 59 healthy volunteers were randomized to take capsules containing 450 mg of dry eggplant extract or placebo. The eggplant or placebo capsules were administered in quantities of two capsules, twice a day, for 14 days. On the 14th day, the volunteers were submitted to a lipid overload test immediately after ingesting 900 mg of eggplant extract or placebo as per prior randomization. The nutritional analysis of the meal contained 361 kcal, 22.5 g of total fat, 14.5 g of which was saturated and 251mg of cholesterol. The lipid profile was checked during fasting on days 0 and 14 and on this last day it was checked during fasting and after a lipid overload. Results: Triglyceride levels, expressed as median (interquartile range), found in eggplant group volunteers were 69mg/dl (51 -102), 69 mg/dl (56 - 94) and 92 (64 - 120), before treatment, on the 14th day pre- and postprandial, respectively. In the placebo group, the results were 92mg/dl (77 - 128), 79 (60 - 108) and 98 (73 - 142), respectively. There was no statistically significant interaction between the time and the group as to triglyceride levels (P=0.208). No difference was found in total cholesterol (P=0.973), HDL cholesterol (P=0.059) and LDL cholesterol (P=0.611) levels either. Conclusion: Our results reveal that the use of dry S. Melongena extract capsules for 14 days did not produce any effect on the lipid profile during fasting and postprandial in normal individuals.

Made available in DSpace on 2015-07-22T20:50:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-08-26 / TEDE / BV UNIFESP: Teses e dissertações

A lipemia pós-prandial (LPP) se caracteriza pelo aumento das concentrações de lipídeos sanguíneos, provocado por meio de refeição ou jejum e está diretamente relacionada com o sedentarismo e a formação da placa aterosclerótica. A adolescência é um período crítico no controle do peso e a inatividade física está associada com desenvolvimento de doenças cardiovasculares (DCV) prematuras. O exercício atua como um importante agente protetor contra o desenvolvimento e progressão de diversas doenças crônicas. Apesar dos efeitos do exercício sobre a LPP serem relativamente bem descritos, os seus efeitos sobre crianças e adolescentes têm sido negligenciados. Além disso, um dos aspectos intervenientes sobre a LPP é a intensidade de exercício. Dessa forma, o objetivo do estudo foi verificar os efeitos do exercício de intensidade média e alta na lipemia e glicemia pós-prandiais em adolescentes eutróficos saudáveis após refeição hiperlipídica. Treze adolescentes do sexo masculino, com idade entre 12 e 16 anos, foram selecionados e realizaram três protocolos: exercício de média intensidade (MI), exercício de alta intensidade (AI) e repouso (REP). No MI, os participantes pedalaram durante 45 minutos a 10% abaixo do 2° limiar ventilatório, seguidos de 180 minutos de repouso. No AI, os participantes pedalaram a 10% acima do 2° limiar ventilatório até alcançarem o mesmo gasto energético do MI. No REP, os participantes permaneceram em repouso durante todo o período. Foi fornecida uma refeição rica em gordura após cada protocolo. Amostras de sangue foram coletadas nos tempos 0 (jejum), 45min (logo após exercício), 105min (1h após a refeição), 135min, 165min, 195min e 225min em cada protocolo. Os níveis de triglicerídeos (TG), colesterol total (CT), HDL, LDL e glicose foram mensurados. Não houve diferenças entre as condições em relação aos níveis de CT, HDL, LDL e glicose. Foi encontrada uma redução significativa (p<0,05) nos níveis de TG (mg/dl) na condição MI quando comparado ao REP e AI no minuto 105 (70,1 + 10,3 vs. 92,2 + 32,4 e 82,2 +10,4) e 135 (68,4 + 14,4 vs. 97,3 + 15,6 e 91,54 + 24,9), respectivamente, e no minuto 165 entre REP e MI (103,14 + 24,2 vs. 82,4 + 18,8). A área sob a curva de TG (mg/dl/min) no MI foi 17,19% significativamente inferior quando comparado ao REP (16.437 vs 19.848) e 12,82% inferior quando comparado ao AI (16.437 vs 18.856). Em conclusão, o exercício de MI mostrou-se eficaz na redução dos triglicerídeos pós-prandiais em adolescentes saudáveis, quando comparado ao repouso e ao exercício de AI. / Postprandial lipemia (PPL) is characterized by increased concentrations of blood lipids, caused by meal or fasting and is directly related to a sedentary lifestyle and the formation of atherosclerotic plaque. Adolescence is a critical period in weight and physical inactivity is associated with premature cardiovascular disease (CVD) development. Exercise acts as an important protective mediator against the development and progression of several chronic diseases. Despite the effects of exercise on LPP are relatively well described, its effects on children and adolescents have been neglected. Moreover, one of the factors on aspects LPP is the intensity of exercise. Thus, the aim of this study was to investigate the effects of exercise of medium and high intensity on postprandial lipemia and glycemia in healthy normal adolescents after a high fat meal. Thirteen male adolescents, aged between 12 and 16 years, were selected and performed three protocols: exercise of moderate intensity (MI), high-intensity exercise (HI) and rest (RES). In MI, participants cycled for 45 minutes at 10% below 2nd ventilatory threshold, followed by 180 minutes of rest. In HI, participants cycled at 10% above the 2nd ventilatory threshold in order to achieve the same energy expenditure MI. RES, the participants remain at rest during the entire period. A high fat meal was provided after each protocol. Blood samples were collected at 0 (fasting), 45min (after exercise), 105min (1h after the meal), 135min, 165min, 195min and 225min in each protocol. Triglycerides (TG), total cholesterol (TC), HDL, LDL and glucose were measured. There were no differences between conditions in relation to the levels of TC, HDL, LDL and glucose. A significant reduction (p <0.05) was found in the levels of TG (mg / dL) in the condition MI when compared to the REP and HI at 105 minutes (70.1 ± 10.3 vs. 92.2 + 32.4 and 82.2 +10.4) and 135 (14.4 vs. 68.4 +. 97.3 + 15.6 + 24.9 and 91.54), respectively, and at 165 minutes between REP and MI (24.2 vs 103.14 +. 82.4 + 18.8). The area under the curve of TG (mg / dl / min) in MI was 17.19% significantly lower when compared to REP (16,437 vs 19,848) and 12.82% lower when compared to HI (16,437 vs 18,856). In conclusion, the MI exercise was effective in reducing the postprandial triglyceride levels in healthy adolescents, when compared at rest and during HI exercise.

Introdução: O extrato seco de Solanum melongena (berinjela) vem sendo utilizado pela população como um tratamento alternativo para dislipidemia. Ela é um vegetal rico em flavonóides que são antioxidantes polifenólicos encontrados nos alimentos. Estudos demonstram relação inversa entre o consumo de alimentos ricos em flavonóides e a mortalidade por doença arterial coronariana. O objetivo deste estudo foi avaliar o efeito da administração de cápsulas de extrato de berinjela no perfil lipídico de indivíduos saudáveis após um teste de sobrecarga lipídica via oral . Métodos: Após consentimento informado 58 voluntários saudáveis foram randomizados para receber cápsulas contendo 450 mg extrato seco de berinjela ou placebo. As cápsulas de berinjela ou placebo foram administradas na quantidade de duas cápsulas duas vezes ao dia durante 14 dias. No 14º dia os voluntários foram submetidos a um teste de sobrecarga lipídica, logo após a ingestão de 900 mg de extrato de berinjela ou placebo conforme randomização anterior. A análise nutricional da refeição continha 361 kcal, 22,5 g de gorduras totais, sendo destas 14,5g de gordura saturada e 251mg de colesterol. O perfil lipidico foi aferido em jejum nos dias 0 e 14 e neste último dia aferido em jejum e 2 horas após a sobrecarga lipidica. Resultados: Os níveis de trigliderídeos, expressos em mediana (amplitude interquartílica), encontrados nos voluntários do grupo berinjela foram 69mg/dl (51 - 102), 69 mg/dl (56 - 94) e 92 (64 - 120), antes do tratamento, no 14º dia pré e pós prandial, respectivamente. No grupo placebo os resultados foram 92mg/dl (77 - 128), 79 (60 - 108) e 98 (73 - 142), respectivamente. Não houve interação estatisticamente significativa entre tempo e grupo quanto ao nível de triglicerídeos (P=0,208). Também não foram encontradas diferenças nos valores de colesterol total (P=0,973), HDL colesterol (P=0,059) e LDL colesterol (P=0,611). Conclusão: Nossos resultados demonstram que a utilização de cápsulas de extrato seco de S. Melongena por 14 dias não produziu nenhum efeito no perfil lipidico em jejum e pós-prandial em indivíduos normais. / Introduction: Dry Solanum melongena (eggplant) extract is being used by the population as an alternative treatment for dyslipidemia. It is a vegetable rich in flavonoids, which are polyphenol anti-oxidants found in foods. Studies reveal an inverse relationship between the consumption of foods rich in flavonoids and mortality from coronary artery disease. The objective of this study was to assess the effect of administering eggplant extract capsules on the lipid profile of healthy individuals after an oral lipid overload test. Methods: After informed consent, 59 healthy volunteers were randomized to take capsules containing 450 mg of dry eggplant extract or placebo. The eggplant or placebo capsules were administered in quantities of two capsules, twice a day, for 14 days. On the 14th day, the volunteers were submitted to a lipid overload test immediately after ingesting 900 mg of eggplant extract or placebo as per prior randomization. The nutritional analysis of the meal contained 361 kcal, 22.5 g of total fat, 14.5 g of which was saturated and 251mg of cholesterol. The lipid profile was checked during fasting on days 0 and 14 and on this last day it was checked during fasting and after a lipid overload. Results: Triglyceride levels, expressed as median (interquartile range), found in eggplant group volunteers were 69mg/dl (51 -102), 69 mg/dl (56 - 94) and 92 (64 - 120), before treatment, on the 14th day pre- and postprandial, respectively. In the placebo group, the results were 92mg/dl (77 - 128), 79 (60 - 108) and 98 (73 - 142), respectively. There was no statistically significant interaction between the time and the group as to triglyceride levels (P=0.208). No difference was found in total cholesterol (P=0.973), HDL cholesterol (P=0.059) and LDL cholesterol (P=0.611) levels either. Conclusion: Our results reveal that the use of dry S. Melongena extract capsules for 14 days did not produce any effect on the lipid profile during fasting and postprandial in normal individuals.

Master of Science / Department of Human Nutrition / Sara K. Rosenkranz / Background: High-fat meals (HFM) have been shown to increase postprandial lipemia (PPL) and inflammation. Acute exercise both pre and post-meal has been shown to attenuate PPL and inflammation. However, studies examining the interaction of HFMs and exercise on PPL and inflammation have used meal and exercise conditions more extreme than typical for average adults. The purpose of this study was to determine if moderate intensity exercise following a "true-to-life" HFM would attenuate PPL and inflammation. Methods: Participants were thirty-nine young adults (18-40 years) with no known metabolic disease. Inclusion criteria consisted of participants meeting physical activity guidelines of ≥ 150 min/week of moderate-to-vigorous physical activity or ≥ 75 min/week of vigorous activity, or < 30 min of planned physical activity per week. Participants were block randomized to EX or CON groups. Participants consumed a HFM of 10 kcal/kgbw. The EX group walked at 60% VO[subscript 2peak] to expend ≈ 5 kcal/kgbw beginning one-hour following the HFM. The CON group remained sedentary during the postprandial period. Blood samples were collected at baseline and 2, and 4hrs postprandially. Results: At baseline, there were no differences between EX and CON groups for any metabolic or inflammatory markers (p>0.05). Postprandial TRG increased ≈ 100% (p<0.001) in both groups, with no differences between groups. HDL concentrations decreased across time in both groups (p<0.001) with no differences between groups (p=0.338). HDL was higher in the EX group at 2hrs (p=0.047), but not 4hrs (p=0.135). IL-6 and TNF-α concentrations did not change over time with no differences between groups (p>0.05). The EX group increased sVCAM-1 from baseline to 4hr (p=0.003), while the CON group did not. Change in TRG was associated with change IL-6, IL-8, IL-10 and TNF-α from baseline to 2hrs when controlling for VO[subscript 2peak] and body fat%. No other associations were seen between change scores for TRG and inflammatory markers. Conclusions: Despite significant increases in PPL following a HFM, moderate intensity exercise in the postprandial period did not mitigate the PPL nor the inflammatory response to the HFM. These results indicate PPL and inflammation following a HFM are not directly related in a young, healthy population with low metabolic risk.

Introdução: O extrato seco de Solanum melongena (berinjela) vem sendo utilizado pela população como um tratamento alternativo para dislipidemia. Ela é um vegetal rico em flavonóides que são antioxidantes polifenólicos encontrados nos alimentos. Estudos demonstram relação inversa entre o consumo de alimentos ricos em flavonóides e a mortalidade por doença arterial coronariana. O objetivo deste estudo foi avaliar o efeito da administração de cápsulas de extrato de berinjela no perfil lipídico de indivíduos saudáveis após um teste de sobrecarga lipídica via oral . Métodos: Após consentimento informado 58 voluntários saudáveis foram randomizados para receber cápsulas contendo 450 mg extrato seco de berinjela ou placebo. As cápsulas de berinjela ou placebo foram administradas na quantidade de duas cápsulas duas vezes ao dia durante 14 dias. No 14º dia os voluntários foram submetidos a um teste de sobrecarga lipídica, logo após a ingestão de 900 mg de extrato de berinjela ou placebo conforme randomização anterior. A análise nutricional da refeição continha 361 kcal, 22,5 g de gorduras totais, sendo destas 14,5g de gordura saturada e 251mg de colesterol. O perfil lipidico foi aferido em jejum nos dias 0 e 14 e neste último dia aferido em jejum e 2 horas após a sobrecarga lipidica. Resultados: Os níveis de trigliderídeos, expressos em mediana (amplitude interquartílica), encontrados nos voluntários do grupo berinjela foram 69mg/dl (51 - 102), 69 mg/dl (56 - 94) e 92 (64 - 120), antes do tratamento, no 14º dia pré e pós prandial, respectivamente. No grupo placebo os resultados foram 92mg/dl (77 - 128), 79 (60 - 108) e 98 (73 - 142), respectivamente. Não houve interação estatisticamente significativa entre tempo e grupo quanto ao nível de triglicerídeos (P=0,208). Também não foram encontradas diferenças nos valores de colesterol total (P=0,973), HDL colesterol (P=0,059) e LDL colesterol (P=0,611). Conclusão: Nossos resultados demonstram que a utilização de cápsulas de extrato seco de S. Melongena por 14 dias não produziu nenhum efeito no perfil lipidico em jejum e pós-prandial em indivíduos normais. / Introduction: Dry Solanum melongena (eggplant) extract is being used by the population as an alternative treatment for dyslipidemia. It is a vegetable rich in flavonoids, which are polyphenol anti-oxidants found in foods. Studies reveal an inverse relationship between the consumption of foods rich in flavonoids and mortality from coronary artery disease. The objective of this study was to assess the effect of administering eggplant extract capsules on the lipid profile of healthy individuals after an oral lipid overload test. Methods: After informed consent, 59 healthy volunteers were randomized to take capsules containing 450 mg of dry eggplant extract or placebo. The eggplant or placebo capsules were administered in quantities of two capsules, twice a day, for 14 days. On the 14th day, the volunteers were submitted to a lipid overload test immediately after ingesting 900 mg of eggplant extract or placebo as per prior randomization. The nutritional analysis of the meal contained 361 kcal, 22.5 g of total fat, 14.5 g of which was saturated and 251mg of cholesterol. The lipid profile was checked during fasting on days 0 and 14 and on this last day it was checked during fasting and after a lipid overload. Results: Triglyceride levels, expressed as median (interquartile range), found in eggplant group volunteers were 69mg/dl (51 -102), 69 mg/dl (56 - 94) and 92 (64 - 120), before treatment, on the 14th day pre- and postprandial, respectively. In the placebo group, the results were 92mg/dl (77 - 128), 79 (60 - 108) and 98 (73 - 142), respectively. There was no statistically significant interaction between the time and the group as to triglyceride levels (P=0.208). No difference was found in total cholesterol (P=0.973), HDL cholesterol (P=0.059) and LDL cholesterol (P=0.611) levels either. Conclusion: Our results reveal that the use of dry S. Melongena extract capsules for 14 days did not produce any effect on the lipid profile during fasting and postprandial in normal individuals.