Bakgrund: Upplevelsen av ensamhet ökar med en stigande ålder. Det finns ett samband mellan ensamhet och psykisk eller fysisk ohälsa, och detta samtidigt som medellivslängden förväntas öka i Sverige och i andra delar av världen. Situationen medför ett ökat behov av att vårdpersonal ska kunna se lidandet ensamhet skapar och för att kunna ge adekvat vård. Syfte: Att beskriva äldre personers erfarenheter och upplevelse av ensamhet. Metod: Litteraturstudie med 10 vetenskapliga artiklar från databaserna PubMed och Cinahl. Analysen av artiklarna genomfördes med hjälp av Fribergs femstegsmodell och SBUS granskningsmall. Resultat: Analysen resulterade i tre huvudkategorier med sju underkategorier: Ensamhetens konsekvenser, Saknad av betydelsefulla relationer och Att skapa meningsfullhet. Konklusion: Resultatet av litteraturstudien visade på att äldre personer erfarenheter och upplevelser påverkar det psykiska måendet. Ensamhet kan vara kopplat till känslan av utanförskap från samhället. Genom att lyfta fram äldres upplevelse av ensamhet kan sjuksköterskan bidra till en förbättrad vård och ge en djupare förståelse för den ensamma individen. / Background: The feeling of loneliness or exclusion increases with age. And there is a connection between perceived loneliness and mental or physical ill health. At the same time, the average life expectancy is expected to increase in Sweden and other parts of the world. The situation means that there is an increased need for healthcare professionals to see the suffering created by loneliness, to provide adequate care. Aim: To describe older people's experience of loneliness. Methods: Literature review conducted with 10 qualitative articles found in PubMed and Cinahl. Analysis was conducted with help from Friberg's five steps model and SBUS review template. Result: The analysis resulted in three main categories with 7 subcategories: The consequences of loneliness, The lost of meaningful relationships and To create meaningfulness. Conclusion: The result of this literature study showed that elderly peoples experiences of loneliness affects their mental health. Loneliness could be related to feelings of alienation from the society. By highlight elderly peoples experience of loneliness is it possible for the nurse to enable and contribute with a better care and to give a deeper understanding for the lonely individual.

KIF1A is a molecular motor for membrane-bound cargo important to the development and survival of sensory neurons. KIF1A dysfunction has been associated with several Mendelian disorders with a spectrum of overlapping phenotypes, ranging from spastic paraplegia to intellectual disability. We present a novel pathogenic in-frame deletion in the KIF1A molecular motor domain inherited by two affected siblings from an unaffected mother with apparent germline mosaicism. We identified eight additional cases with heterozygous, pathogenic KIF1A variants ascertained from a local data lake. Our data provide evidence for the expansion of KIF1A-associated phenotypes to include hip subluxation and dystonia as well as phenotypes observed in only a single case: gelastic cataplexy, coxa valga, and double collecting system. We review the literature and suggest that KIF1A dysfunction is better understood as a single neuromuscular disorder with variable involvement of other organ systems than a set of discrete disorders converging at a single locus. / National Institutes of Health / Revisión por pares

No description available.

Researchers and publishing guidelines recommend reporting confidence intervals (CIs) not just along with null hypothesis significance testing (NHST), but for many other statistics such as effect sizes and reliability coefficients. Although CI and standard errors (SEs) are closely related, examining standard errors alone in simulation studies is not adequate because we do not always know if a standard error is small enough. Overly small SEs may lead to increased probability of Type-I error and CIs with lower coverage rate than expected. Statistical simulation studies generally examine the magnitude of the empirical standard error, but it is not clear if they examine the properties of confidence intervals. The present study examines confidence interval investigating and reporting practices, particularly with respect to coverage and bias as diagnostics in published statistical simulation studies across eight psychology journals using a systematic literature review. Results from this review will inform editorial policies and hopefully encourage researchers to report CIs.

Background: Sepsis is a condition that can result in death by failure or lack of treatment. Mortality has decreased over the past decade and thus is due to increased awareness and improved management of disease cases. Despite this decline, the death rate is still high and increased knowledge to detect and prevent sepsis in time is needed to reduce the suffering and serious complications. Aim: The aim is to illustrate nursing knowledge of the role in caring for patients with sepsis. Method: A literature review study based on an analysis of eight quantitative and two qualitative articles of research. Results: The result showed that nurses experienced that a lack of knowledge exists, long experience in nurses are valuable and that assessment tools can improve nurses' detection of sepsis. Nurses experienced detection of sepsis as a difficult, defiant and stressful task but it could facilitate trough teamwork. Conclusion Combination of knowledge and exertion of assessment tools improve the quality of care and reduce mortality. The result showed that experience and education among nurses are important for improving the competence to early identification of sepsis. / Sjukdomstillståndet sepsis är ett globalt folkhälsoproblem med högt dödsantal vilket skapar stort lidande. Sepsis framkallar ett stört systemiskt svar av immunförsvaret som utlöser livshotande symtom och ett snabbt utvecklande sjukdomsförlopp. Sjukdomen utvecklar en inflammation i hela kroppen oavsett om infektionen finns i blodet eller inte. Studiens syfte var att belysa sjuksköterskans erfarenheter av att vårda patienter med sepsis. Bristande kunskap påverkar omhändertagandet av patienter med sepsis som leder till förseningar och i värsta fall komplikationer. Sjuksköterskors erfarenheter var att kartläggning av sjukdomsförloppet är utmanande, tidsberoende och att stort ansvar läggs på deras axlar. Det framkom att det inte finns tillräcklig kunskap hos sjuksköterskor och att de inte känner trygghet i hur en patient med sepsis skall handläggas. Utbildning och erfarenhet lyftes fram som stärkande faktorer för att kompensera bristen på kunskap. Genom att utbilda sjuksköterskor om tidiga tecken på sepsis och passande omvårdnadsåtgärder kunde professionen stärkas i vårdandet av dessa patienter. Sjuksköterskans erfarenhet belystes och ansågs vara viktigt för teamarbetet med andra professioner och behandlingen av patienter med sepsis. Lång arbetserfarenhet bland sjuksköterskor kunde effektivisera vården, inge trygghet till kolleger och öka patientsäkerheten. Ett fåtal sjuksköterskor var medvetna om bedömningsverktyg och hur de skulle användas. Resultatet visar på att efter införande av bedömningsverktyg i vårdandet av patienter med sepsis förbättrades handläggningen, vården säkerställdes och dödligheten minskade. Bedömningsverktyg är viktigt för att ställa diagnos och likaså mätning av vitalparametrar. Användning av bedömningsverktygen resulterade i att sjuksköterskor lättare kom ihåg alla omvårdnadsåtgärder och att risken för missar minimerades. Sjuksköterskor upplevde stor arbetsbelastning i vårdandet av patienter med sepsis på grund av högt tempo, stort patientflöde och stressig arbetsmiljö. Patienter fick vänta länge på akutmottagningen innan de fick tillsyn och vårdprioritet som följd av sjuksköterskornas arbetsbelastning. Erfarenheterna var att de inte hade tillräckligt med tid för patienterna och att bedömningarna blev bristfälliga på grund av underbemanning. Det kan leda till komplikationer och ökad dödlighet för patienten vilket medförde att sjuksköterskor upplevde oro och stress. Sjuksköterskor bör ha tillräcklig kompetens att identifiera och handlägga patienter med sepsis då det ofta är de som först möter dessa patienter.

Background: Approximately 25,000 people in Sweden receive a stroke diagnosis annually. Stroke can lead to major consequences such as loss of bodily functions that will affect the daily life of the stroke survivor. Family, and those caregivers who are living closely with the patient play an important role in the stroke survivor’s life and they are often expected to contribute with support. It is important to identify the needs of people close to the patient in an early stage. As well as involving them in their special needs during the process as it increases their sense of manageability. Nurses' area of responsibility is based on enabling participation and seeing both patients and relatives. Relatives have an expectation of contributing support to the patient. Aim: The aim of this study was to describe relatives' experiences of support related to stroke. Method: A literature-based study and an analysis of seven qualitative scientific articles. Results: The analysis resulted in one main theme: the navigation in a new life. The results showed how important information and knowledge is for the relatives to; achieve good support, to not develop an illness as a result of their support efforts, adjusting to their new role and situation in a better way to create a positive environment. Conclusion: Relatives described a difficult situation where they experienced fear and concern. Professional support assisted the relatives in the situation. By observing the situation, a profound understanding can be reached and by involving relatives, thus contributes to an improved health. / Livet efter stroke kan ge omfattande konsekvenser för både patienten och närstående. Ett stort behov av hjälp i hemmet fanns hos patienten, närstående har visat sig vara en stor resurs för den strokedrabbade och i den vårdandeprocessen som följer. Men att stå bredvid en person som drabbats av stroke upplevdes som svårt, eftersom en stroke innebar förändringar i det dagliga livet. Tidigare forskning visade att närstående i samband med stroke ofta upplevde ett sämre mående, de prioriterade patienten och glömde bort sig själva i situationen eftersom patienten hade ett stort behov av hjälp. Från sjuksköterskan kunde de närstående få stöd för att lättare kunna hantera situationen och samtidigt ha en god hälsa själva. Sjuksköterskan har därför en betydelsefull roll gällande att ge god omvårdnad till den drabbade patienten men samtidigt till de närstående. Syftet med detta examensarbete var att beskriva närståendes upplevelser av stöd i samband med strokesjukdom. För att författarna skulle förstå vilka känslor och tankar närstående upplevde användes kvalitativa artiklar. En litteraturbaserad studie utfördes, vetenskapliga artiklar analyserades och bildade resultatet. Resultatet påvisade att närstående som gått igenom denna situation upplevde att stödet var varierat och hade en önskan att vara involverade i mötet tillsammans med patient och sjuksköterska. Huvudtemat kom att bli navigera i det nya livet. Fyra underteman kunde identifieras, bland annat närståendes egna strategier för att kunna hantera vardagen lättare beskrevs i ett undertema. Vidare framkom från resultatet att närståendes behov att vägledas från sjuksköterskan samt hur sjuksköterskor gav information och kunskap och hur detta upplevdes från närstående. Studien visade att närstående upplevde en minskad hälsa och att stödet till närstående varierade, därmed bör närstående involveras i större utsträckning samt att stödet kan preciseras från sjuksköterskor.

No description available.

Multiple sclerosis is a commonly diagnosed neurological disease that currently has no cure. Due to the significant physical and emotional impact that this disease has on the course of life, depressive symptoms frequently occurs among its sufferers. Many interventions have been developed and studied in an effort to reduce the depressive symptoms without the use of traditional antidepressant medications. This integrated literature review examines empirical evidence regarding non-pharmacologic interventions for depression published between 2003 and 2008. Cognitive behavioral therapy, complementary therapy, and support interventions were examined. Although no single intervention was shown to completely alleviate depressive symptoms, most interventions had a favorable impact.

Minority-girl education in China is a new field of research. This study seeks to explore into this field through reviewing and analyzing the available studies that have been done. This literature has been collected through searching library holdings, Computer Assisted Research Search, and online searching. The criteria against which the literature is to be reviewed and analyzed are in the form of questions and are divided into six categories of introduction, theoretical framework, method, results, discussion (conclusion/recommendations), and abstract or summary; so that all the aspects of a study can be examined. The research filed of minority-girl education in China is found to be improving. A summary of the current educational practices concerning minoirty-girl education in China and the challenges the minority-girl faces when it comes to education is made after the literature collected has been reviewed. Recommendations on future research orientations are made based on the findings.

The scientific evidence required to make policy decisions that protect human health can be challenging to organize. Primary research is often silo-ed between different agency repositories, the pace of publication is unflagging and wide-spread interdisciplinary collaboration can be logistically difficult. Since 2012, the Organisation for Economic Co-operation and Development (OECD) adverse outcome pathway (AOP) framework has provided solutions for some of the challenges of supplying relevant and accessible scientific data for evidence-based decision-making. Development of AOPs is guided by a crowd-sourced approach in which progressions of adverse outcomes (AO) are distilled into pathways containing only the essential key events (KEs) and the causal key event relationships (KERs) that connect them. The framework has widely been adopted in the toxicology community and more recently projects have applied it to the radiation safety field. Presently, a collaborative effort aims to further expand the use of AOPs through creating a network linking exposure to the space exposome with resulting human health outcomes. The network contains four adverse non-cancer outcomes for which participants of future long-range space missions will be at risk. The work of this thesis has contributed to the construction of the space-health AOP network by accomplishing two main objectives. The first was the creation of a novel protocol for collecting a weight of evidence (WOE) that included the benefits of scoping review and artificial intelligence (AI) tools for literature screening. The scoping review WOE collection strategy was then deployed for collecting data across all four outcomes in the space-health network. The second objective was to identify KEs and KERs and summarize the WOE linking space exposure to one of the four AOs: vascular remodeling. In addition to summarizing the pathway, we have also highlighted important modulating factors and knowledge gaps in the WOE. This thesis work contributes to the future of the AOP framework by formulating a new development protocol and employing it in a novel regulatory context. Using the new protocol, this thesis has furthered biological understanding of the effects of space exposure on the cardiovascular system by collating mechanistic information across scientific disciplines to identify KEs and KERs in occurrence of vascular remodeling.