Selection strategies to increase productive traits of farm animals have been effective and highly specialized breeds and strains were obtained. At the same time, the effort made to obtain extremely high producing animals was accompanied by undesired effects, such as a reduced ability to sustain production, reproduction and health; especially under constrained conditions. The perception that selection was degrading robustness, lead to selection strategies aiming to improve the ability of animals to perform in a wider range of environmental constrain. However, at the present moment, the physiological mechanisms allowing farm animals to perform well in a wide range of environments, while others succumb, have not been described. The present thesis intended to address this question by describing the evolution of traits related to fitness, survival and to the adaptability to environmental constraints. Two maternal rabbit lines differing in their ability to face the environmental constraints, i.e. a `specialist¿ and a `generalist¿ maternal rabbit line were available. Additionally, two generations (20 generations apart) of the specialized line were simultaneously available. During the first two consecutive reproductive cycles, female rabbits were simultaneously subjected to three environmental conditions differing in the intensity and in the physiological constrain imposed. Digestive capacity, the acquisition of resources and the partitioning of resources into different function (i.e. litter size, milk yield, growth, body reserves, etc.) was also assessed. Results showed a greater acquisition capacity of `generalist¿ females in constrained conditions with respect to `specialist¿ females. Moreover, the greater acquisition capacity was not accompanied by a reduction in the digestive efficiency, allowing the `generalist¿ females a relative greater acquisition of digestible energy. The maintenance of reproductive performance by having a greater acquisition capacity, together with the avoidance of making an intensive use of body reserves were both related to the capacity of `generalist¿ females to sustain reproduction in a wide range of environmental conditions. Twenty generations of selection exclusively for reproduction (specialized line), was not accompanied by a higher acquisition capacity, but by a change in the relative priority between the litter being nursed (actual) and the litter being gestate (future litter). In this sense, females from the actual generation of selection for litter size at weaning had a greater milk yield in the first week of lactation (period of great importance to kits survival), reducing it by the end of lactation. The present thesis also evidenced the importance of the environment where the animals are being selected in the evolution of the interplay between competing functions. / Savietto, D. (2014). Environmental and genetic factors driving robustness in reproductive rabbit does [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/37198 / TESIS / Premios Extraordinarios de tesis doctorales

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mRNA molecules form an intermediate in the transfer of sequences from DNA to ribosomes in order to guide protein production. Errors can be introduced into mRNA, producing aberrant proteins which place a strain on cellular regulatory machinery, causing increased risks of apoptosis, cancer, and decreased fitness. These errors may be introduced due to decreased transcriptional proofreading capabilities, exposure to chemicals, or mistakes in RNA editing machinery. It is important to investigate these causes of transcription errors to better understand the long-neglected area of mRNA fidelity which has such significant impacts on our cellular functions. In this paper, it was determined that addition of adenine opposite from abasic sites, not genomic uracil pairing with adenine, are a probable cause of G-to-A transcription errors. That exposure to Roundup causes increased levels of transcription errors, potentially due to oxidative stress. And finally, that off-target ADAR gene editing of transcripts occurs at high levels.

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This thesis investigates the link between optimal carbon tax and endogenous longevity. It considers an overlapping generation model with clean and dirty intermediate goods. Externality caused by producing dirty intermediate goods damages the final goods productionas well as the agents’ longevity. From the social planner’s problem, the cost of carbon emission is formulated. Then, the Pigouvian carbon tax rate is used to internalize such costs. With the two channels of impact of carbon emission combined, the theoretical results suggest that (i) the current carbon tax may abstract from local health costs of carbon emission, especially in rich economies, (ii) in poor economies, the government may be lowering the carbon tax at the expense of their elderly’s welfare, and (iii) the government in economies transitioning from poverty to richness should raise their carbon tax level above that of poor economies. Deeper investigation into the mechanism and a quantitative analysis would beneeded. Future studies can also include endogenous technological change or extend to amulti-economy model.

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Globally, increased length-of-life trends parallel the rise in reported levels of loneliness. Social connectedness is associated with a 50% reduced risk of premature mortality, and research has shown there is a moderately strong association between people who are lonely and people who have an unmet desire to belong. As so, urban planners and designers continually try to understand place relationships within communities to better the health and welfare of future generations. This thesis acknowledges there is a gap of understanding how the built and natural environment play a role in an increased sense of belonging, thus contributing to an alleviation of reported feelings of loneliness and potentially increasing length and quality of life. Utilizing the ‘Blue Zone’ island of Ikaria as a case study, where residents commonly live well beyond 90 and 100 years, this thesis aims to better understand connections between longevity and the physical environment for the longest-lived, cataloguing how these connections influence feelings of belonging. The research consists of a site visit to Ikaria, Greece, where data was collected over the period of five days, employing interview and field observation methods. Drawing from key concepts within environmental psychology and placemaking, the work critically explores the perceptions of Ikarian elders and the public space they regularly inhabit, as well as their role in contributing to sense of place and feelings of belonging. The conclusion offers suggestions on how urban planners might take these findings into consideration, as it is of great importance for planning professionals to better understand individual perceptions of their environment, which may help prevent alienation and increase overall wellbeing.

京都大学 / 新制・課程博士 / 博士(理学) / 甲第23744号 / 理博第4834号 / 新制||理||1691(附属図書館) / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 工藤 洋, 准教授 本庄 三恵, 教授 松下 智直 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

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