English law originally did not provide an action in cases where pure economic loss was caused negligently. From the Middle Ages (i.e. from more or less the 13th century), when there arose a remedy called 'trespass', which was applicable only in cases of direct forcible injury,

Loss systems are of great importance for price optimization and revenue management even after more than a century since their first appearance. In this thesis, we analyze the optimal pricing problem for an M/M/1/1 Erlang-loss systems, and apply the model to inspect the impacts of vacancy tax regulations on short-term rental hosts. We then work on M/M/N/N loss systems while considering both advance reservation and multinomial logit (MNL) choice-model for the customers. We develop a simulation for this system and then train a machine learning (ML) model based on the outputs of this simulation to predict the utilization of each server based on different queueing parameters. Finally, we train another ML model for price optimization when the decision-maker sets the price for all servers to maximize the revenue of the whole system. We show that the presence of advance reservation decreases the utilization, consequently reducing the profit in the corresponding system. / Thesis / Master of Science (MSc)

No description available.

In an attempt to replicate and extend previous research on the validity of food diary records, 18 obese and 16 previously obese individuals from the community were quizzed on food recording and kcalorie estimation in a controlled analogue of self-monitoring. Results of the experimental phase of the study replicate those of previous studies indicating that the food diaries of obese clients are invalid because of poor food descriptions, incorrect quantity estimates, and errors in converting kcalories. The results also indicate that subjects tend to overestimate quantities and kcalories of foods. However, the present study extended previous research by examining the differences between obese and previously obese individuals. It was thought that weight differences might be a function, to some degree, of the person's accuracy at food recording, quantity of portion and kcalorie estimation. The present results suggested no relationship between current weight and accuracy. The implications of this finding suggests that success at weight loss may not be significantly related to an individual's ability at food description, quantity of portion and ability in kcalorie estimation, as was suggested by previous studies. The results of this study strongly question the validity of self-reports in food consumption. Its implications in research and practice were examined. The assessment phase of the study obtained information via a questionnaire on 177 individuals involved in a weight control program. The areas in the questionnaire consisted of: (a) general information, (b) health, (c) environment, (d) emotional aspects of eating, (e) exercise. The findings support past research on obesity, and revealed some areas of interest for future research.

The prevalence of overweight and obesity in the feline population is estimated to be 25.7% and 33.8%, respectively. Feline obesity is associated with comorbidities such as insulin resistance and hepatic lipidosis. Several risk factors are associated with obesity including middle age, neuter status, decreased activity, and diet. Obesity management is multifaceted and includes client education, diet modification, and consistent monitoring. Successful obesity management may be dependent on owner perception of their cat's quality of life during a prescribed weight loss plan. Poor quality of life perception may result in failure to complete the weight loss process. Food toys may be used to enhance environmental enrichment, allow cats to express their natural predatory behavior and overall improve owner-perceived quality of life. Therefore, we set out to investigate the role of food toys in owner-perceived quality of life of obese cats during a prescribed weight loss plan. Fifty-five cats with a BCS > 7 were enrolled in a double-blinded weight loss study and randomized into one of two groups: food toy (n=26) or food bowl (n=29). Each cat was provided a prescribed weight loss diet and instructions. Body weight and body condition score were evaluated monthly. Additionally, owners completed a monthly questionnaire to assess their cat's quality of life. Of the 44 cats in the final analysis, 66% (n=29) successfully completed the study and lost > 2 BCS points and/or achieved an ideal BCS of 5/9. Low-calorie vegetables were offered to the majority of cats (n= 32) due to owner reports of disruptive food seeking behavior. Of the cats offered vegetables, 87.5% (n=28) cats required a commercial palatant to consume the vegetables. All enrolled cats had a higher (p<0.0000) owner-perceive quality of life at the final visit/recheck/end of study (median QOL=110.0), as compared to the initial weight loss appointment (median QOL=126.0). The increase in quality of life was primarily driven by improvement in moving from one place to another, grooming and scratching, engaging in social activities, and playing and hunting. There was no effect (p=0.27) of food toy on owner-perceived quality of life. Prescribed weight loss improves owner-perceived quality of life of obese cats. A single food toy (ball-style) was included in this study and did not appear to influence owner-perceived QOL. However, the role of food toys needs further investigation as there are several food toy styles that have not yet been investigated during a prescribed weight loss plan. We suspect that most/all of the 32 cats fed vegetables would have withdrawn from the study. Therefore, including vegetables in the prescribed weight loss plan appears to improve success of weight loss in obese cats. / Master of Science / About 60% of cats are overweight or obese, which equates to about 56 million cats in the United States. Feline obesity is associated with poor health outcomes such as insulin resistance and fatty liver disease. Risk factors for feline obesity include middle age, neutered, decreased activity, and diet. Obesity is commonly diagnosed via body condition scoring in small companion animals. Owner-perceived quality of life is an important factor for a successful weight loss plan. Low perceived quality of life may result in owners abandoning the weight loss process. Food toys provide environmental enrichment, slow food consumption and may increase activity. However, the impact of food toys on owner-perceived quality of life and the success of a weight loss plan were not previously investigated. Fifty-five cats were enrolled into the weight loss study and randomly placed into one of two groups. Twenty-six cats were placed in the food toy group, and 29 cats were placed in the food bowl group. Monthly follow-up visits consisted of weighing and body condition scoring each cat. In addition, owners completed a questionnaire to evaluate their cat’s quality of life. Food toys did not influence cat owner perception of their cat’s quality of life. However, cat owners perceived their cat’s quality of life to be higher at the end of the study compared to the beginning for all cats. The increase in quality of life was primarily driven by improvement in moving from one place to another, grooming and scratching, engaging in social activities, and playing and hunting. Satiety was an issue for several cats during the study. Low-calorie vegetables were offered to over half of the study cats to decrease hunger and food-seeking behavior. This study indicates quality of life is increased in cats undergoing a prescribed weight loss plan. A single food toy was utilized in the present study although several types of food toys are currently available that have not been investigated in relation to owner-perceived quality of life during a prescribed weight loss plan.

No / Hair loss can be a psychologically devastating adverse effect of chemotherapy, but satisfactory management strategies for chemotherapy-induced alopecia remain elusive. In this Review we focus on the complex pathobiology of this side-effect. We discuss the clinical features and current management approaches, then draw upon evidence from mouse models and human hair-follicle organ-culture studies to explore the main pathobiology principles and explain why chemotherapy-induced alopecia is so challenging to manage. P53-dependent apoptosis of hair-matrix keratinocytes and chemotherapy-induced hair-cycle abnormalities, driven by the dystrophic anagen or dystrophic catagen pathway, play important parts in the degree of hair-follicle damage, alopecia phenotype, and hair-regrowth pattern. Additionally, the degree of hair-follicle stem-cell damage determines whether chemotherapy-induced alopecia is reversible. We highlight the need for carefully designed preclinical research models to generate novel, clinically relevant pointers to how this condition may be overcome.

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Class of 2010 Abstract / OBJECTIVES: The objective was to compare differences in weight loss data presented in published orlistat studies on orlistat to their corresponding studies submitted to the FDA. METHODS: This meta-­‐analysis compared one-­‐year weight loss data reported in six published orlistat 120 mg studies to data reviewed by the FDA in the New Drug Application (NDA). The primary dependent variables were the percentage of subjects achieving 5% and 10% weight loss. Prior to analysis, weight loss data was stratified into placebo and orlistat groups. Potential for bias was assessed with a funnel plot and by calculating Kendall’s tau. The a priori alpha level was 0.05. RESULTS: Corresponding FDA reviews were located for 6 published orlistat trials. The pooled odds ratio of published vs. FDA 5%weight loss data for the placebo arm was 2.18 (95% CI: 1.83 to 2.60; p < 0.001) and 1.95 (95% CI: 1.70 to 2.24; p < 0.001) for the orlistat arm. The pooled odds ratio of published vs. FDA for 10% weight loss data for the placebo arm was 2.25 (95% CI: 1.74 to 2.91; p < 0.001) and 2.20 (95% CI: 1.88 to 2.57; p < 0.001) for the orlistat arm. The p-­‐values for Kendall’s tau for the 5% and 10% weight loss data were 0.054 and 0.34, respectively. CONCLUSIONS: Published orlistat trials presented 5% and 10% weight loss data that were twice of that reported in the FDA-­‐reviewed trials, and there was potential for bias in the 5% weight loss data.

<p>Fetma och övervikt är ett hot mot folkhälsan. Många med övervikt och fetma försöker gå ner i vikt, men få lyckas bibehålla viktminskningen. Studiens syfte var att ta reda på erfarenheter av betydelsefulla faktorer och strategier för en bestående viktminskning, samt motivation för bibehållandet av vikten. Enligt Self-determination theory (SDT) blir beteendeförändringar bestående om de är autonoma och om motivationen är intern. Åtta kvinnor som deltagit i Itrims viktminskningsprogram intervjuades. Resultatet visade att förändringar i kost, motion och förhållningssätt var för egen vinning och viktiga för en bibehållen vikt. Andra faktorer var kunskap, psykiskt och fysiskt välmående samt vilja. Bibehållandet av viktminskningen var ett självständigt arbete där kunskaper från programmet och från inre reflektion införlivades i livsstilen, vilket överrensstämmer med SDT.</p>