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BACKGROUND: Both mood and anxiety disorders are more prevalent in women than men with the onset typically occurring during adolescence or early childbearing years. These disorders are particularly prevalent during pregnancy and the postpartum period. While depression during the perinatal period has received significant attention recently, anxiety has not received the same amount of attention. METHODS: The current study was a secondary analysis of a prospective cohort study that followed 91 women with mood disorders through pregnancy and the postpartum period. Our objective was to determine if a correlation existed between anxiety and suicidality. We hypothesized that pregnant women with a history of a mood disorder and comorbid anxiety are more likely to be suicidal than those without comorbid anxiety. The presence of anxiety was determined using the anxiety subscale of the Edinburgh Postnatal Depression Scale, EPDS; a cut off score of six or greater was used to indicate significant anxiety. Suicidality was determined using three separate measures: question ten on the EPDS, question eighteen on the Inventory of Depressive Symptomatology, and question ten on the Montgomery-Asberg Depression Rating Scale. ANALYSIS: Chi square tests were used to compare the demographics of the anxious and non-anxious women based on both diagnosis of anxiety disorders and symptoms of anxiety. Z proportion tests were then used to compare the proportion women with anxiety versus those without anxiety who were suicidal. Lastly, binary logistic regression was used to determine if patients with anxiety were more likely to be suicidal. RESULTS: Among the women in this study, 62 (68.1%) had a diagnosis of major depressive disorder and 29 (31.9%) had a diagnosis of bipolar disorder based on DSM-IV-TR diagnostic criteria. In addition, 45 (49.5%) had a lifetime history of an anxiety disorder. The prevalence of significant anxiety symptoms, as determined by the anxiety subscale on the EPDS, ranged from 9.1-37.5% depending on the time point. Suicidality prevalence also varied depending on both the time point and the scale used: 0-17.5% using the MADRS, 6.7-24.7% using the EPDS, and 2.4-14.7% using the IDS. Using a binary logistic regression, we determined that anxiety was a risk factor for suicidality at time T3 (OR 2.106; 95% CI 1.274-3.481) and M1 (OR 2.057; 95% CI 1.179-3.586) on the MADRS and at T3 (OR1.758; 95% CI 1.219-2.535) on the EPDS.

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京都大学 / 新制・論文博士 / 博士(医学) / 乙第13600号 / 論医博第2310号 / 新制||医||1072(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 村井 俊哉, 教授 佐藤 俊哉, 教授 永井 洋士 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

In the midst of the youth mental health crisis in the United States, Latinx adolescent females are at particular risk of having a mood disorder while being simultaneously disproportionately less likely to access mental health care due to a multitude of structural barriers. Nature-based social prescribing, increasingly popular in primary care settings, refers to recommending participation in community programs to provide a multitude of beneficial effects, including improved mental health. Gardening is an example of one of these programs that has been well studied in adults with evidence of positive impacts on mental health. However, it is unclear whether gardening has similar positive impacts on high-risk groups such as adolescent Latinx females with mood disorders. Using mixed-methods, this pilot study explored the experiences of adolescent Latinx females with mood disorders as they participated in an 8-week-long gardening club intervention. Quantitative findings demonstrated statistically significant reductions in participant Strengths and Difficulties Questionnaire (SDQ) impact scores and conduct scores after participation in the intervention. Qualitative feedback from participants supported these results and identified additional positive impacts of participation including relational connection, knowledge acquisition, and appreciation of having a safe space to engage with others. / Urban Bioethics

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medicinal Sciences Student: Bc. Eva Hepnerová Supervisor: Doc. MUDr. Josef Herink, DrSc. Title: Temporolimbic dysfunction in persons with sleep disorders Background: The aim is to demonstrate the occurrence of symptoms of the temporolimbic dysfunction in person with sleep disorders using standard psychosocial questionnaires. Methods: The occurrence of symptoms of the temporolimbic dysfunction was detected by means of CPSI and LSCL-33 questionnaires. Correlation of both questionnaires' results was evaluated by Spearman's coefficient. Results: According to CPSI 11 % patients have abnormal score and they have higher occurrence of symptoms of the temporolimbic dysfunction. According to LSCL-33 achieve 32 % of respondents abnormal score and 7 % respondents have pathologic score, which means the presence of the temporolimbic dysfunction. Conclusions: The occurrence of the temporolimbic dysfunction in persons with sleep disorders have been shown, but it haven't been higher in comparison with healthy population. Keywords: mood disorders, sleep disorders, psychosocial questionnaire, sleep, temporolimbic region

Made available in DSpace on 2016-03-22T17:26:17Z (GMT). No. of bitstreams: 1 Ana Carolina Zago.pdf: 345353 bytes, checksum: e4bed43d321cd813fa25d30871e48a86 (MD5) Previous issue date: 2009-09-09 / Objective. To identify the prevalence of factors associated with the lack of adherence to psychopharmacs among Psychosocial Care Units users in Pelotas with mood disorders and schizophrenia. Methods. Cross-sectional study gathered by a prospective cohort with 563 users of PCU in Pelotas, among which 201 had been diagnosed with schizophrenia and 362 with mood disorders. Home interviews were accomplished and two questionnaires were applied, one to obtain demographic, socioeconomic and patient s disorder-related information, and another one on the use of medication and Morisky test to verify the lack of adherence. Results. The prevalence of the lack of adherence was 32%, with no significant difference according to gender, per capita income, period of the disorder, diagnostics and kind of medication. Younger individuals, with higher education, with a partner, with less frequency to PCU and that showed adverse effects were less adhering to treatment. In the stratified analysis, only adverse effects remained associated with the lack of adherence. Conclusion. The lack of adherence in individuals with mental disorders linked to PCU is mainly related to adverse effects and health policies should be dedicated to facing this issue, since it is known that the adherence to treatment helps avoid relapse and the necessity of hospitalization, in order to optimize public resources / Objetivo. Identificar a prevalência e fatores associados à não adesão a medicamentos psicofármacos entre usuários dos Centros de Atenção Psicossocial em Pelotas com transtornos de humor e com esquizofrenia. Métodos. Estudo transversal aninhado a uma coorte prospectiva com 563 usuários dos CAPS de Pelotas, dos quais 201 com diagnóstico de esquizofrenia e 362 com transtorno do humor. Foram realizadas entrevistas domiciliares e aplicados dois questionários, um para obter informações demográficas, socioeconômicas e relacionadas ao transtorno do paciente e outro com informações sobre o uso de medicamentos e o teste de Morisky para verificar a falta de adesão. Resultados. A prevalência de falta de adesão foi de 32%, sem diferença significativa de acordo com o gênero, a renda per capita, o tempo de doença, o diagnóstico e o tipo de medicamento. Indivíduos mais jovens, com maior escolaridade, com companheiro, com menor tempo de frequência aos CAPS e que apresentaram efeitos adversos foram menos aderentes ao tratamento. Na análise estratificada, somente os efeitos adversos permaneceram associados à falta de adesão. Conclusão. A falta de adesão em indivíduos com transtornos mentais vinculados aos CAPS está principalmente relacionada aos efeitos adversos e as políticas de saúde deveriam dedicarse ao enfrentamento deste problema, sabendo-se que a adesão ao tratamento ajuda a evitar recaídas e a necessidade de internações hospitalares, otimizando assim os recursos públicos

Made available in DSpace on 2016-03-22T17:26:55Z (GMT). No. of bitstreams: 1 l1.pdf: 71453 bytes, checksum: 9470f9e45a5664bf7e48ddccf6576547 (MD5) Previous issue date: 2012-01-12 / Aim: To identify the relationship between childhood trauma and the maternal depression in a sample of young people with mood disorders and without mood disorders. Methods: Cross sectional study with 164 young people and their mothers. Ninety-eight young people were in the group with mood disorders and 66 were without mood disorders group. The diagnosis of mood disorder was conducted through the Structured Clinical Interview for DSM-IV (SCID) and childhood trauma was assessed using the Childhood Trauma Questionnaire (CTQ). Maternal depression was identified by the Mini International Psychiatry Interview (MINI). Results: Young people with mood disorders, were 4.52 (95% CI: 1.05, 7.99) points higher on average decreased as the socioeconomic classification, and those who were children of depressed mothers were 5.36 (CI 95% CI: 1.20, 10.17) points higher than average childhood trauma than those who were not depressed mothers. Young people without mood disorders who were working were -5.94 (95% CI: -10.75, -1.13) points in the middle of the CTQ compared those who were not working. Conclusion: There was a relationship between childhood trauma and maternal depression in young people with mood disorders. The prevention and treatment of maternal psychiatric illness may decrease the risk of adverse effects on young people / Objetivo: Verificar a relação entre trauma na infância e a presença de depressão materna em uma amostra de jovens com e sem transtornos de humor. Métodos: Estudo transversal com 164 jovens e suas mães. Noventa e oito jovens fizeram parte do grupo com transtornos de humor e 66 do grupo sem transtorno de humor. O diagnóstico de transtorno de humor dos jovens foi realizado através da Structured Clinical Interview for DSM-IV (SCID) e o trauma na infância foi avaliado através do Childhood Trauma Questionnaire (CTQ). A depressão materna foi identificada pela Mini International Psychiatry Interview (MINI). Resultados: Jovens com transtorno de humor, tiveram 4,52 (IC 95%:1,05; 7,99) pontos a mais na média conforme diminuía a classificação socioeconômica, e, aqueles que eram filhos de mães deprimidas tiveram 5,36 (IC 95%:1,20; 10,17) pontos a mais na média de trauma na infância do que aqueles que não tinham mães deprimidas. Os jovens sem transtornos de humor que estavam trabalhando tiveram -5,94 (IC 95%:-10,75; -1,13) pontos na média do CTQ comparado aqueles que não estavam trabalhando. Conclusão: Verificou-se a relação entre trauma na infância e depressão materna em jovens com transtornos de humor. A prevenção e tratamento de doenças psiquiátricas materna podem diminuir o risco de efeitos negativos nos jovens