Mathematics, physics, biology, and computer science are combined to create computational modeling, which studies the behaviors and reactions of complex biomedical problems. Modern biomedical research relies significantly on realistic computational human models or “virtual humans�. Relevant study areas utilizing computational human models include electromagnetics, solid mechanics, fluid dynamics, optics, ultrasound propagation, thermal propagation, and automotive safety research. These and other applications provide ample justification for the realization of the Visible Human Project® (VHP)-Female v. 4.0, a new platform-independent full body electromagnetic computational model. Along with the VHP-Female v. 4.0, a realistic and anatomically justified Dynamic Breathing Sequence is developed. The creation of such model is essential to the development of biomedical devices and procedures that are affected by the dynamics of human breathing, such as Magnetic Resonance Imaging and the calculation of Specific Absorption Rate. The model can be used in numerous application, including Breath-Detection Radar for human search and rescue.

This work focuses on evaluating the parameters of the human operator as the driver of the vehicle simulator. In the first part, the thesis focuses on the examination of human operator parameters evaluation. In the second part of the thesis is a proposal of various scenarios focused on a specific area of measurement. At the end, the work focuses on the processing and evaluation of measured data obtained from the drivers tested.

Humans consume cannabis for the pharmacological effects mediated by the primary psychoactive cannabinoid, delta-9-tetrahydrocannabinol (THC). However, there is little evidence to suggest that THC acts as a primary reinforcer in non-human models because the drug alone does not support robust self-administration. We hypothesized that THC may have more potent reinforcement enhancing effects – meaning that THC may enhance the reinforcing effects of other non-drug rewards in a user’s environment. In the present experiments, we explore the effects of THC on operant responding for saccharin (SACC) or a visual stimulus (VS). In all experiments rats were shaped to respond for their assigned reinforcer. Drug challenge tests were conducted every 72 hours, rats were injected with the assigned dose of THC and responding for each reinforcer was measured. Our initial findings indicated possible sex differences between male and female rats – THC injections increased lever-pressing for SACC in male rats but not female rats. However, in follow-up experiments we used a different response (nose-key press instead of lever press) that facilitated operant responding in rats that were different sizes – adult males are significantly more massive than adult females. In that experiment THC enhanced nose-key presses for SACC in both male and female rats across a range of doses. Moreover, this latter experiment confirmed that the effect of THC was motivational in nature, THC injections increased effort to obtain SACC under a progressively increasing schedule of reinforcement (progressive ratio). Finally, using a third operant response (head entry into a receptacle) we demonstrated that THC increased reinforcement by the VS across a range of doses. The present studies indicate that THC acts as a reinforcement enhancer, increasing motivation in male and female rats to obtain both SACC and VS throughout a range of doses. By demonstrating that THC enhances the reinforcing effects of both gustatory and non-gustatory reinforcers, our evidence supports the hypothesis that THC’s effect on the brain facilitates incentive motivation regardless of sensory modality of the reinforcer.

Lower back disorders due to whole-body vibration (WBV) are the most common injuries reported by professional drivers. Such injuries often have long-term complications leading to significant personal and societal costs. An improved mathematical model of the whole human body would contribute to a better understanding of the mechanisms of lower back injury and be valuable in injury prevention research. Current biodynamic human models reported in the literature lack detailed information for predicting the non-linearity due to vibration amplitude of transmission of vibration from seat to a human. Therefore, one of the primary objectives of this research has been to develop and validate a detailed threedimensional biodynamic human model, with special attention given to the incorporation of active trunk muscles with non-linear stiffness properties. These muscles have been incorporated into an existing spine and neck model of a MADYMO 50th percentile male occupant model. A detailed multi-body human model has been developed, called MODEL ONE. This thesis shows that incorporating non-linear stiffness functions and energy dissipation using hysteresis or damping into a human model is appropriate for predicting non-linear biodynamic responses in arbitrary excitation functions. A major advantage of MODEL ONE compared to other multi-body models and lumped mass models is its ability to predict nonlinear seat-to-human transmissibility. However MADYMO 50th male occupant models use simplified geometry and rigid bodies to represent the lower lumbar spine. These simplified spinal models have no ability to simulate the internal stresses and deformations of soft tissues, even if these are the apparent cause of lower back pain (LBP). Therefore a detailed finite element human lower lumbar spine model - with appropriate material properties and capable of simulating internal stresses⎯is necessary, in order to better understand spinal injuries under WBV. A three-dimensional finite element model of a lower lumbar spine motion segment - called MODEL TWO - has thus been developed for the present study. MODEL TWO comprises a detailed geometric description of vertebrae, nucleus pulposus, endplates, and intervertebral discs. The intervertebral discs lump together the annulus fibrosus, ground substance and ligaments. The vertebrae have been assumed to be rigid. The material properties of the intervertebral discs of MODEL TWO were obtained from test matrices and from various parameter data reported in the literature. MODEL TWO has been validated against cadaveric experiments reported in the literature. The mechanical behaviour and stress distribution within the MODEL TWO intervertebral disc agree reasonably well with the cadaveric experiments. MODEL TWO was integrated into MODEL ONE to form a new human model, called MODEL THREE, which was subsequently dynamically validated against volunteers� responses to WBV reported in the literature. MODEL THREE, as presented in this thesis, consists of a multi-body human model with detailed representation of a finite element (FE) lower lumbar spine. As far as the author is aware, MODEL THREE is the first model with detailed representation of a FE lower lumbar spine to successfully demonstrate that it is capable of simulating the stress profile of the entire intervertebral disc and endplate region due to WBV. The simulated results revealed abnormal stress concentrations in both the posterior and xviii the posterolateral annulus. The stresses increased most in the posterolateral intervertebral discs region during WBV, suggesting a possible mechanism for disc mechanical overload leading to fatigue fracture and degeneration. The results from MODEL THREE are promising and lead to a more comprehensive understanding of the behaviour of the intervertebral disc under WBV. MODEL THREE has also provided a good foundation for the development of a bio-fidelity human model. However, implementation of currently unavailable and/or inadequate in vitro and in vivo experimental studies is needed to further validate and develop MODEL THREE. A better understanding of injury mechanisms and the clinical significance of LBP will ultimately be arrived at using a combination of analytical models with in vitro and in vivo experimental data.

Ce travail de thèse s’inscrit dans le cadre du développement des mannequins numériques pourl’évaluation ergonomique de la conception de véhicule, plus particulièrement des commandesautomobiles. Il vise à développer des modèles biomécaniques permettant la prise en comptede la dynamique du mouvement et de la force exercée lors d’une tâche pour prédire lemouvement et l’inconfort associé. Ce travail s’est focalisé sur la pédale d’embrayage.Concernant le développement des critères d’inconfort, le concept du mouvement neutre estexploré. Une méthode, basée sur la comparaison entre des mouvements avec desconfigurations imposées et ceux moins contraintes, est proposée. Elle a permis l’identificationde paramètres biomécaniques pertinents et de proposer des indicateurs d’inconfort pour laconception de la pédale d’embrayage.Les relations entre la posture et la force d’appui ont été étudiées expérimentalement en faisantvarier le niveau d’effort exercé sur une pédale statique. Nos résultats montrent que la directiond’effort et l’ajustement postural suivent le principe de minimisation des couples articulaires.Par ailleurs l’utilisation d’un critère de minimisation de l’activité musculaire a montré uneamélioration de la prédiction de la direction d’effort pour les efforts peu élevés.Les indicateurs d’inconfort proposés dans cette étude fournissent des informations objectivespermettant aux ingénieurs de conception de comparer des solutions alternatives de design. Letravail sur les mécanismes de contrôle de l’effort et de la posture constitue, quant à lui, unepremière étape dans l’optique de prendre en compte la force exercée dans la simulation deposture. / This thesis takes place in the context of the development of digital human models forergonomic assessment of vehicle design, particularly automotive controls. It aims to developbiomechanical models that can take into account the dynamics of movement and the forceexerted during a task to predict the movement and the associated discomfort. This workfocused on the clutch pedal.For the development of the discomfort criteria, the concept of neutral movement is explored.An approach, based on comparing imposed pedal configurations and less constrained pedalconfigurations movements, has been proposed. It allowed the identification of relevantbiomechanical parameters and to propose indicators of discomfort for the design of the clutchpedal.The relationships between posture and force exertion were studied experimentally by varyingthe level of force exerted on a static pedal. Our results show that the direction of forceexertion and the postural adjustment follow the principle of minimization of joint torques.Furthermore, the use of a criterion for minimizing muscle activity showed an improvement inpredicting the direction of effort for the low and intermediate force levels.Discomfort indicators proposed in this study provide objective information that allows designengineers to compare design alternatives. Work on the control mechanisms of force exertionand posture is, in turn, a first step towards the simulation of posture/movement by taking intoaccount force exertion.

Prédire précisément la posture adoptée par un conducteur est primordial dans la conception d'un véhicule, surtout quand un mannequin numérique est utilisé. De plus, le marché automobile en Chine est en pleine expansion et devient le plus gros marché automobile. L'adaptation de la conception des véhicules aux spécificités de ce marché est un enjeu majeur pour de nombreux constructeurs automobiles. Le conducteur chinois se distingue du conducteur Européen par une anthropométrie différente, non seulement en taille mais aussi en proportion du corps. L'adaptation de la conception de la voiture au marché chinois devient un enjeu majeur pour de nombreux constructeurs automobiles. Cette thèse vise à (1) étudier l'effet des paramètres anthropométriques et des paramètres véhicule sur la posture de conduite, (2) développer un modèle statistique de prédiction de posture de conduite, (3) quantifier la variabilité intra- (i.e. la variabilité pour un même conducteur) et interindividus (variabilité entre différents conducteurs) des postures de conduite confortables. Les postures de conduite de soixante et un sujets ont été recueillies à l'aide de deux maquettes de véhicule multi-réglable sous quatre conditions d'essai en ajoutant progressivement le nombre de paramètres de contrôle (contraintes), de la configuration with "contraintes minimum" aux configurations proches des véhicules existants. En plus de la hauteur du siège, les effets des positions longitudinales de la pédale d'embrayage et du volant ainsi que l'angle de coussin de siège ont été étudiés. Les sujets ont été divisés en trois groupes de taille (petite, moyenne et grande). Un sous-échantillon (27 « nés française »et 21« nés Chinois») a été constitué avec une distribution de taille similaire et de ratios hauteur du buste / taille, longueur bras / taille et longueur jambe / taille différents / Accurate prediction of driving posture is essential for vehicle interior design, especially when a digital human model (DHM) is used. Meanwhile, the car market is booming in China. Chinese drivers are different from those of European in terms of anthropometry, not only in stature but also in body proportion. How to adapt car design to the Chinese market is becoming a major issue for many car manufacturers. The present PhD thesis aims at (1) studying the effects of key vehicle interior design dimensions and anthropometric variables on driving posture, (2) developing a statistical driving posture prediction model (3) quantifying intra-(i.e. variability of the same driver) and inter-individual (variability between different drivers) variability of comfortable driving postures. The driving postures of sixty-one subjects were collected using two multi-adjustable vehicle mock-ups under four test conditions by gradually adding the number of control parameters (constraints), from the “least constrained” driving condition to the configurations close to currently existing vehicles. In addition to seat height, the effects of the longitudinal positions of clutch pedal and steering wheel as well as seat cushion angle were investigated. The subjects were divided into three stature groups (short, average and tall). A sub-sample (27 ‘French-born’ and 21 ‘Chinese born’) was constituted with similar stature distribution and quite different in the sitting stature/stature, arm length/stature and thigh length/stature ratios

Yes / For decades, animals have been widely used in advertisements, and yet little is known about the effects on consumer reactions along the entire purchase decision process. This study disentangles the effects of using animal stimuli in isolation or jointly with a human model in print advertisements. Empirical evidence is derived from 126,220 consumer evaluations of 302 actual print advertisements across 18 product categories. Animals do not only support a positive attitude change, they also influence how products integrate into consumers´ relevant set and the purchase intention by itself. By comparison, female consumers react more pronounced than their male counterparts on animal stimuli. However, it should be avoided to combine an animal stimulus with a human model to preserve a better influence over consumer reaction.

Introduction One out of five reported motor vehicle collision injuries occur to the upper extremities. Certain parts of The Total HUman Model for Safety (THUMS) lack validation against experimental data, including the elbow. The aim of this project is to refine and validate the elbow joint of THUMS, with focus on anatomical response of the elbow during axial impact applied to the wrist. Methods Internal contacts in the elbow were modified and new contacts assigned between bones and ligaments of the elbow. The posterior part of the radial- and ulnar collateral ligaments, and joint capsule was implemented to the model. Elasticmodulus of the cortical bones of the elbow was increased as well as the shell thickness of the humeral cortical bone. The updated model was validated against an experiment where an axial load was applied to the wrist of a female cadaver. The experimental resultant force in the wrist was then compared with the wrist force obtained from the simulations. Results The correlation between the experimental and simulation resultant wrist force for the updated model resulted in a CORA score of 0.882. This gave a 6.7% higher CORA score compared with the original model. Hourglass energy was reduced from 63.52% of internal energy to 0.78%. Energy ratio and contact energies indicated that the simulation was stable. Discussion Movement of elbow bones was assessed to be more anatomically correct, by accounting for the posterior ligament and elbow capsule support. The contact peak force in the humerus was lower and occurred earlier in the simulation in the updated model compared to the original. This is believed to be due to the reduced gap between the elbow bones after increasing the shell thickness of the humeral cortical bone. The model setup resembled the experiment in a good manner. Conclusion The upper extremity of THUMS was refined for improved biofidelity, with focus on the anatomical response of the elbow joint under an axial impact. However, further model improvements are suggested as well as extended validated against other experimental impact results. / Introduktion En av fem rapporterade krockskador med motorfordon förekommer i de övre extremiteterna. Vissa strukturer hos Total HUman Model for Safety (THUMS) saknar validering gentemot experimentell data, där armbågen är ett av dem. Syftet med detta projekt är att förfina och validera armbågsleden hos THUMS, med fokus på dess anatomiska respons under axiellt islag applicerad på handleden. Metod Interna kontakter i armbågen modifierades och nya kontakter tilldelades mellan ben och ligament. De posteriora delarna av kollateral ligament hos radius och ulna implementerades i modellen, så även armbågens ledkapseln. Elasticitetsmodulen hos de kortikala benen i armbågen höjdes och skalets tjocklek idet humerala kortikala benet utökades. Den uppdaterade modellen validerades mot ett experiment där en axiell belastning hade applicerats mot en kvinnlig kadavers handled. Den resulterande kraften i handleden från experimentet jämfördes sedan med erhållen kraft i handleden från simuleringarna. Resultat Korrelationen mellan den experimentella kraften och simulerade kraften hos den uppdaterade modellen resulterade i ett CORA-poäng på 0,882. Detta är en ökning med 6,7% jämfört med den ursprungliga modellen. Hourglassenergin reducerades från 63,52% av inre energi till 0,78%. Energiförhållandet och kontaktenergier indikerade stabil simulering. Diskussion Rörelsen av armbågens ben bedömdes vara mer anatomiskt korrekt, med hänsyn till stödet från de posteriora ligamentet och armbågens ledkapsel. Den maximala islagskraften i humerus minskade och uppträdde tidigare i simuleringen hos den uppdaterade modellen jämfört med originalet. Detta tros bero på reducerat avstånd mellan armbågens ben genom ökandet av skaltjockleken hos det humeralakortikala benet. Modelluppställningen motsvarade experimentets uppställning. Konklusion De övre extremiteterna av THUMS förfinades i syfte att förbättra biofideliteten. Fokus låg på armbågens anatomiska respons under ett axielltislag. Både ytterligare förbättringar av modellen och utökad validering mot andra experimentella islag rekommenderas. / Technology

Globally, approximately 1.2 million people die each year due to traffic accidents. Upper extremity injuries account for 18% to 25% of all car accident injuries. In order to be able to analyze these crash-related injuries, Human body models(HBMs) are used as a complement to FE simulations. An example of a HBM is the THUMS SAFER that is based on a 50 percentile American male. The aim of this study was to improve the upper extremity of the THUMS SAFER with respect to Autoliv's requirements to better predict fractures. In addition, this was validated against the Forman experiment(Forman, et al., The journal of trauma and acute care surgery, vol. 77, 2014) where human cadavers of the upper extremity were axially impacted to replicate a car collision. This was done by generating the upper extremity geometry with segmentation of medical images of a right human hand in combination with the complete STL-geometry of the forearm from the Piper project. The STL-geometry of the segmented human hand and Piper forearm was integrated and a complete STL-geometry of the upper extremity was obtained. Based on the complete STL-geometry, the FE-arm HEX 4.0 was built with modelling of bones, ligaments, soft tissue and skin with corresponding material choice in accordance with Autoliv's requirements. The model HEX 4.0 was improved considering an increased mesh density from an average of 94% to 98%. HEX 4.0 was also validated against the data from the Forman experiment for experiments 5, 6 and 15. It showed a good correlation with the acceleration curves between the simulated and experimental values for the three experiments. The reaction force in the elbow was compared for experiment 15, where the simulated value 5.7 kN divided by a factor of 1.4 from 4 kN for the experiment. Furthermore, the fi rst principal strains that occurred in HEX 4.0 were analysed by 17 ms were the highest acceleration was achieved for experiments 5 and 6. Both experiments were shown to be close to the failure threshold of bones. However, the highest value e5=9.8E-03 occurred in the radius for experiment 5, while e6=9.3E-03 in a ligament for experiment 6. In addition, the failure threshold for experiment 15 exceeded 5 ms in lunate, schapoid and triquetrum. This indication of fractures is in good agreement with the experimental results where the corresponding bones resulted in fractures in experiment 15. HEX 4.0 was an improved upper extremity of the THUMS SAFER considering an increased mesh density. It is also capable of indicating fractures and corresponding positions in the form of analyzes of occurring stresses and strains. Nevertheless, improvements and further validation of HEX 4.0 has been proposed in the future work section. / Globalt, dör varje år ungefär 1.2 miljoner personer på grund av trafi kolyckor. Skador på övre extremitet utgör 18% till 25% av alla skador inom bilolyckor. För att kunna analysera dessa krockrelaterade skador används humanmodeller(HBM) som komplement för FE-simuleringar. Ett exempel på en HBM är THUMS SAFER som är baserad på en "50 percentile" amerikans man. Målet med denna studie är att förbättra över extremiten av THUMS SAFER med avseende på Autolivs krav för att bättre kunna förutspå frakturer. Dessutom validerades detta mot Forman experiment(Forman, et al., The journal of trauma and acute care surgery, vol. 77, 2014) där övre extremitet av människokadaver blev axiellt påverkade för att replikera en bilkollsion. Detta gjordes genom att generera STL-geometrin av en övre extremitet med segmentering av medicinska bilder av en höger människohand i kombination med färdig STL-geometri av underarmen från Piper projektet. STL-geometrin av den segmenterande människohanden och Piper underarmen integrerades och en komplett STL-geometri av övre extremiteten erhölls. Baserad på den kompletta STL-geometrin byggdes FE-armen HEX 4.0 med modellering av ben, ligament, mjukvävnad samt hud med motsvarande materialval i enighet med Autolivs krav. Modellen HEX 4.0 förbättrades i form av en ökad mesh densitet från medelvärdet 94% till 98%. Den validerades även gentemot data från Forman experimentet för experiment 5, 6 och 15. Det påvisade en god korrelation på accelerations kurvorna mellan de simulerade och experimentella värdena för de tre experimenten. Reaktionskraften i armbågen jämfördes för experiment 15 där den simulerade värdet 5.7 kN skiljde sig med en faktor 1.4 från 4 kN för experimentet. Ytterligare analyserades första huvudtöjningarna som uppkom i HEX 4.0 vid 17 ms, då den högsta accelerationen uppnådes för experiment 5 och 6. Det visades att båda experimenten låg nära gränsen för benfraktur, däremot uppkom det högsta värdet e5=9.8E-03 i radius för experiment 5, samt e6=9.3E-03 i ett ligament för experiment 6. Dessutom överskred gränsen för benfrakturer för experiment 15 efter 5 ms i lunate, schapoid och triquetrum. Denna indikation av frakturer stämmer väl med resultatet av experimentet där motsvarande benen resulterades i frakturer i experiment 15. HEX 4.0 är en förbättrad övre extremitet av THUMS SAFER i form av förbättrad meshdensitet. Den är även kapabel att indikera frakturer och motsvarande position i form av analyser på förekommande spänningar och töjningar. Förbättringar och ytterligare validering av HEX 4.0 föreslås för framtida arbete.

The Manikin / Manikin Analysis modules have been included in the basic Creo Parametric package for several years - do you know the possibilities of the 'digital human model'? / Die Module Manikin / Manikin Analysis sind seit einigen Jahren im Basispaket von Creo Parametric enthalten - kennen Sie die Möglichkeiten des 'digitalen Menschmodells'?