Införandet av en mobil intensivvårdsgrupp (MIG) har visat sig ha goda resultat utomlands med minskade andningsstopp och mortalitet inom pediatrisk vård. Vid Astrid Lindgrens Barnsjukhus i Solna, Sverige (ALB) finns långt framskridna planer på att starta en MIG-verksamhet. Syftet med denna studie var att beskriva pediatriska patienter som faller in under potentiella MIG-kriterier innan inläggning på barnintensivvårdsavdelningen/barnintermediäravdelningen (BIVA/BIMA) på ALB. Studien gjordes retrospektivt genom journalgranskning av inskrivna pediatriska patienter på BIVA/BIMA under 2009. Totalt inkluderades 148 pediatriska patienter i åldern 0-18 år i studien. Resultat visade att Andningsbesvär var den vanligaste inskrivningsorsaken och att Andning var den vanligast förekommande kontaktorsaken. Provtagning var den mest förekommande åtgärden som utfördes på akutmottagningen/vårdavdelningen innan förflyttning till BIVA/BIMA. Slutsatsen blev att det skulle kunna finnas cirka 300 pediatriska patienter per år på ALB som skulle kunna vara aktuella för MIG-uppdrag. Det är en klar indikation för att starta en MIG-verksamhet på ALB för att minska inläggningar på BIVA/BIMA samt identifiera dessa pediatriska patienter i ett tidigt skede innan akut försämring. / The implementation of Pediatric Medical Emergency Team (PMET) has proven to reduce respiratory arrest and mortality in Pediatric hospitals worldwide. At Astrid Lindgrens Barnsjukhus in Solna, Sweden (ALB) there are advanced plans to start a PMET. The aim of this study was to describe pediatric patients that met potential PMET-criteria before being admitted to pediatric intensive care unit/high demand unit (PICU/HDU) at ALB. The study was a retrospective chart review of admitted pediatric patients at PICU/HDU during 2009. Totally 148 pediatric patients between the age of 0 to 18 years were included in the study. The result showed that respiratory problems were the most common reason for being admitted to the hospital and problems with breathing was the most frequent PMET-criteria. Before the patient moved to the PICU/HDU the most common intervention performed in the emergency department/wards was sample-taking. The conclusion was that around 300 pediatric patients a year could benefit from a PMET at ALB. That is a clear indication that a PMET should be started at ALB to reduce admitted patients to PICU/HDU and identify the patients at risk for acute worsening.

Bakgrund: Intuberade patienter inom intensivvården har en hög risk för att erhålla en ventilator-associerad pneumoni (VAP). Det finns evidensbaserade riktlinjer för vuxna somförebygger VAP. För barn behövs det däremot mer forskning för att klargöra vilka omvårdnadsåtgärder som kan standardiseras. Syfte: Syftet är att beskriva vilka omvårdnadsåtgärder som förebygger VAP hos barn inom intensivvården, en litteraturöversikt. Metod: En deskriptiv litteraturstudie med kvantitativ induktiv ansats valdes. 16 kvantitativa studier analyserades med en innehållsanalys. Det samlade materialet kvalitetsgranskades med hjälp av GRADE. Resultat: Fem huvudteman identifierades utifrån studiernas resultat. Huvudteman var VAP-omvårdnadspaket, munvård med klorhexidin, skötsel av endotrakealtub, olika nutritionssonder, omvårdnadsutbildning. VAP-omvårdnadspaket och omvårdnadsutbildning visade sig statistiskt signifikant sänka VAP-prevalensen hos barn. Munvård med klorhexidin kunde inte sänka VAP-prevalensen. Slutsats: Med rätt evidensbaserad vård kan VAP-prevalensen sänkas. Forskning kring VAP-prevention till barn saknar evidens i nuläget och kan ej anses vara evidensbaserad vård. För att göra vården evidensbaserad, rekommenderas att globala riktlinjer för VAP-prevention till barn tas fram. / Background: Intubated patients admitted to an intensive care unit have a higher risk ofacquiring ventilator-associated pneumonia (VAP). There are evidence-based guidelines for adults that prevent VAP. For children there is a need for more research in this area to clarifywhich nursing methods can be standardized. Aim: The aim was to describe which nursing care measures prevent VAP in children admitted to the intensive care unit, a literature review. Method: A descriptive literature study with a quantitative inductive approach was used. A total of 16 quantitative studies was analysed with a content analysis. A GRADE system was used to assess the quality of the included studies. Results: Five main themes were identified from the study’s results. The main themes where VAP-care bundles, oral care with chlorhexidine, care of endotracheal tube, different nutritional catheters, and nursing care education. VAP-care bundles and nursing care education showed to have statistically and significantly lowered the prevalence of VAP in children. Oral care with Chlorhexidine did not lower the prevalence significantly of VAP. Conclusion: The prevalence of VAP can be lowered with the right evidence-based practice. At the current situation research on preventing VAP in children lack evidence and can’t be considered as evidence-based practice. To make the nursing care evidence based, it´s recommended to create global guidelines of VAP-prevention for children.

Introduction : La mortalité associée à l’insuffisance rénale aiguë (acute kidney injury ‘’AKI’’) aux soins intensifs pédiatriques (SIP) dépasse les 50%. Des études antérieures sur la thérapie de remplacement rénal (TRR) ont fait ressortir plusieurs facteurs de risque de mortalité dont le syndrome de défaillance multiviscérale (SDMV) et la surcharge liquidienne ≥ 10 à 20% avant l’initiation de la TRR. L’objectif de cette étude était d’identifier les principaux facteurs de risque de mortalité à 28 jours après l’initiation de la TRR chez les patients atteints d’AKI aux SIP. Méthode : Il s’agit d’une étude de cohorte rétrospective aux SIP d’un centre tertiaire. Tous les enfants ayant reçus de la TRR continue ou de l’hémodialyse intermittente pour AKI, entre janvier 1998 et décembre 2014, ont été inclus. Les facteurs de risque de mortalité ont été préalablement identifiés par quatre intensivistes et deux néphrologues pédiatres et analysés à l’aide d’une régression logistique multivariée. Résultats : Quatre-vingt-dix patients ont été inclus. L’âge médian était de 9 [2-14] ans. La principale indication d’initiation de la TRR était la surcharge liquidienne (64,2%). La durée médiane d’hospitalisation aux SIP était de 18,5 [8,0-31,0] jours. Quarante patients (44,4%) sont décédés dans les 28 jours suivant l’initiation de la TRR et quarante-cinq (50,0%) avant la sortie des SIP. Le score de PELOD ≥ 20 (OR 4,66 ; 95%CI 1,68-12,92) et la surcharge liquidienne ≥ 15% (OR 9,31; 95%CI 2,16-40,11) à l’initiation de la TRR étaient associés de façon indépendante à la mortalité. Conclusion : Cette étude a permis de faire ressortir deux facteurs de risque de mortalité à 28 jours à l’initiation de la TRR : la surcharge liquidienne et la sévérité du SDMV mesurée par le score de PELOD. / Introduction: Mortality rate associated with acute kidney injury (AKI) in pediatric intensive care units (PICU) exceeds 50%. Prior studies on renal replacement therapy (RRT) have highlighted different mortality risk factors including the presence of a multiple organ dysfunction syndrome (MODS) and fluid overload ≥ 10 to 20% before starting RRT. The aim of this study was to identify most important risk factors of 28-day mortality in patients with AKI at RRT initiation in PICU. Methods: We conducted a retrospective cohort study in a tertiary care pediatric center. All critically ill children who underwent acute continuous RRT or intermittent hemodialysis for AKI between January 1998 and December 2014 were included. A case report form was developed and specific risk factors were identified by a panel of four pediatric intensivists and two nephrologists. Risk factors analysis was made using logistic regression in SPSS and SAS software. Results: Ninety patients were included. The median age was 9 [2-14] years. The most common indication for RRT initiation was fluid overload (FO) (64.2%). The median PICU length of stay was 18.5 [8.0-31.0] days. Forty of the 90 patients (44.4%) died within 28 days after RRT initiation and forty-five (50.0%) died before PICU discharge. In a multivariate logistic regression analysis, a PELOD score ≥ 20 (OR 4.66; 95%CI 1.68-12.92) and percentage of FO ≥ 15% (OR 9.31; 95%CI 2.16-40.11) at RRT initiation were independently associated with mortality. Conclusion: This study suggests that fluid overload and severity of MODS measured by PELOD score are two risk factors of 28-day mortality in PICU patients on RRT.

Introduction: La ventilation non invasive (VNI) est un outil utilisé en soins intensifs pédiatriques (SIP) pour soutenir la détresse respiratoire aigüe. Un échec survient dans près de 25% des cas et une mauvaise synchronisation patient-ventilateur est un des facteurs impliqués. Le mode de ventilation NAVA (neurally adjusted ventilatory assist) est asservi à la demande ventilatoire du patient. L’objectif de cette étude est d’évaluer la faisabilité et la tolérance des enfants à la VNI NAVA et l’impact de son usage sur la synchronie et la demande respiratoire. Méthode: Étude prospective, physiologique, croisée incluant 13 patients nécessitant une VNI dans les SIP de l’hôpital Ste-Justine entre octobre 2011 et mai 2013. Les patients ont été ventilés successivement en VNI conventionnelle (30 minutes), en VNI NAVA (60 minutes) et en VNI conventionnelle (30 minutes). L’activité électrique du diaphragme (AEdi) et la pression des voies aériennes supérieures ont été enregistrées pour évaluer la synchronie. Résultats: La VNI NAVA est faisable et bien tolérée chez tous les enfants. Un adolescent a demandé l’arrêt précoce de l’étude en raison d’anxiété reliée au masque sans fuite. Les délais inspiratoires et expiratoires étaient significativement plus courts en VNI NAVA comparativement aux périodes de VNI conventionnelle (p< 0.05). Les efforts inefficaces étaient moindres en VNI NAVA (résultats présentés en médiane et interquartiles) : 0% (0 - 0) en VNI NAVA vs 12% (4 - 20) en VNI conventionnelle initiale et 6% (2 - 22) en VNI conventionnelle finale (p< 0.01). Globalement, le temps passé en asynchronie a été réduit à 8% (6 - 10) en VNI NAVA, versus 27% (19 - 56) et 32% (21 - 38) en périodes de VNI conventionnelle initiale et finale, respectivement (p= 0.05). Aucune différence en termes de demande respiratoire n’a été observée. Conclusion: La VNI NAVA est faisable et bien tolérée chez les enfants avec détresse respiratoire aigüe et permet une meilleure synchronisation patient-ventilateur. De plus larges études sont nécessaires pour évaluer l’impact clinique de ces résultats. / Introduction: The need for intubation after noninvasive ventilation (NIV) failure is frequent in the pediatric intensive care unit (PICU). One reason is patient-ventilator asynchrony during NIV. Neurally adjusted ventilatory assist (NAVA) is a mode of ventilation controlled by the patient’s neural respiratory drive. The aim of this study was to assess the feasibility and tolerance of NIV-NAVA in children and to evaluate its impact on synchrony and respiratory effort. Methods: This prospective, physiologic, crossover study included 13 patients requiring NIV in the PICU of Sainte-Justine’s Hospital from October 2011 to May 2013. Patients were successively ventilated in conventional NIV as prescribed by the physician in charge (30 minutes), in NIV-NAVA (60 minutes), and again in conventional NIV (30 minutes). Electrical activity of the diaphragm (EAdi) and airway pressure were simultaneously recorded to assess patient-ventilator synchrony. Results: NIV-NAVA was feasible and well tolerated in all patients. One patient asked to stop the study early because of anxiety related to the leak-free facial mask. Inspiratory trigger dys-synchrony and cycling-off dys-synchrony were significantly shorter in NIV-NAVA versus initial and final conventional NIV periods (both p< 0.05). Wasted efforts were also decreased in NIV-NAVA (all values expressed as median and interquartile values): 0 (0 - 0) in NIV-NAVA versus 12% (4 - 20) and 6% (2 - 22) in initial and final conventional NIV, respectively (p< 0.01). As a whole, total time spent in asynchrony was reduced to 8% (6 - 10) in NIV-NAVA, versus 27% (19 - 56) and 32% (21 - 38) in initial and final conventional NIV, respectively (p= 0.05). No difference in term of respiratory effort was noted. Conclusion: NIV-NAVA is feasible and well tolerated in PICU patients and allows improved patient-ventilator synchronization. Larger controlled studies are warranted to evaluate the clinical impact of these findings.