"This research aimed to explore and better understand intervention protocols and their effect on lower limb control associated with anterior cruciate ligament (ACL) injury. A fundamental and unique aspect of this investigation was to establish a lab-based testing protocol that successfully mimicked actual game play. [...]This research validated a lab-based measure that best mimicked game-play to use as a pre- and post- testing measure for two common methods used in current ACL intervention strategies. In addition, further understanding of the effects of a landing training and dynamic balance training program were found." / Doctor of Philosphy

Includes addendum and corrections (leaves 390-402) / Bibliography: leaves 333-389. / xv, 402 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Analyses the effects of N-acetylcysteine (NAC) alone and in combination with glyceryl trinitrate (GTN) on three models of myocardial ischaemia and reperfusion. A sensitive and specific assay for malondialdehyde (MDA) in plasma was developed in order to assess the extent of oxidative stress in this series of studies. / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1996

This study examined the metabolic and thermal responses of 14 firefighters during four repeated work bouts of treadmill exercise in a thermoneutral laboratory, working at an intensity similar to typical firefighting tasks (30-34 ml·kg-1·min-1), while wearing firefighting protective equipment and breathing from a self-contained breathing apparatus. Each work bout consisted of treadmill walking at 93.8 m·min-1 and 8% grade for 8 min followed by 4 min of passive rest. Oxygen consumption remained unchanged between all four work bouts (p>0.05). Ventilation increased significantly (p<0.05) during the first three work bouts from 57.1 (±3.1) to 68.7 (±2.7) L·min-1. Percent heart rate reserve increased significantly (p<0.05) during each work bout, from 76.0 (±1.8) % HRR during the first to 97.2 (±1.1) % HRR during the fourth work bout. Core temperature increased significantly (p<0.05) during each work bout from 36.87 (±0.07) to 38.87 (±0.10) °C from the first to the fourth work bout, as did some of the psychophysiological measures.

Made available in DSpace on 2014-06-11T19:32:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-13Bitstream added on 2014-06-13T19:03:03Z : No. of bitstreams: 1 sirtoli_lf_dr_botfca.pdf: 818464 bytes, checksum: be591ab3596d134bf54bd99bb5f3c688 (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / A Lippia alba (Mill.) N.E.Br. ex Britt & Wilson é uma importante espécie medicinal de uso popular conhecida como erva cidreira brasileira. Trata-se de um arbusto, cujas folhas frescas ou secas e inflorescências são utilizadas na forma de chás, macerados, compressas, pomadas, banhos e extratos alcoólicos. Suas folhas apresentam ação antiespasmódica, moluscicida, fungicida, calmante e digestiva. Considerando, a) a inexistência de estudos sobre a L. alba em hidroponia b) a utilização de solução nutritiva para atender as necessidades da espécie, fornecendo nutrientes de maneira balanceada e possibilitando a produção de plantas com adequada qualidade e em menor espaço de tempo, c) a necessidade de produção de matéria prima para uso medicinal popular e farmacêutico, o presente estudo objetivou avaliar o desenvolvimento e as trocas gasosas de L. alba submetida à variação das concentrações dos nutrientes a partir da diluição da solução nutritiva de Hoagland e Arnon (1950). Assim, as plantas foram cultivadas em quatro tratamentos, constituídos pela variação de nutrientes na solução nutritiva n°2 de Hoagland e Arnon (1950), ou seja, em solução completa (100%) e diluída à 80%, 60% e 40% em relação à completa. As variáveis avaliadas foram área foliar, massas secas dos diferentes órgãos, razão de área foliar (RAF), área foliar específica (AFE), razão de massa foliar (RMF), taxa de crescimento absoluto (TCA), taxa assimilatória líquida (TAL), taxa de crescimento relativo (TCR), taxa de assimilação de CO2 (A, mmolCO2 m-2 s-1), condutância estomática (gs, mol m-2s-1), transpiração (E, mmol H2O m-2 s-1), concentração intercelular de CO2 na folha (Ci, mmolCO2 mol-1ar) e eficiência de uso da água (EUA). Os resultados obtidos permitem concluir que: 1. As concentrações dos nutrientes na solução nutritiva, de maneira geral, foram excessivas... / The present study aimed to evaluate physiological effects of the boscalida-based fungicide on phytotechnical, physiological and biochemical aspects of grafted and ungrafted Japanese cucumber plants. The experiment was carried out under protected cultivation at São Manuel Experimental Farm, Faculty of Agronomical Sciences (FCA), São Paulo State University (UNESP), Botucatu Campus, São Paulo State, Brazil. Both the cucumber hybrid ‘Tsuyataro’ grafted onto the pumpkin ‘Excite Ikky’ and ungrafted plants were subjected to different levels (0, 25, 50, 75 and 100 g a.i. ha-1) of the boscalida fungicide through leaf application at weekly intervals. Experimental design was in randomized blocks, in a 5x2 factorial arrangement, with four replicates and six plants per plot, so that the four central plants were considered in the evaluation. Higher CO2 assimilation and water use efficiency and lower internal CO2 concentration were observed in grafted plants at 39 DAT. The levels 75 and 100 g a.i. ha-1 favored CO2 assimilation in grafted plants and led to lower internal CO2 concentration in the substomatal chamber. Grafted plants had higher total soluble protein concentration and a linear response to boscalida levels at 81 D.A.T. SOD and CAT activities were higher in ungrafted plants, whereas the highest boscalida levels, especially 100 g a.i. ha-1, led to a decrease in the activity of both enzymes. POD activity was higher in grafted plants and decreased as the fungicide levels increased. Higher activity of nitrate reductase was ... (Complete abstract click electronic access below)

Thesis (MTech Biomedical Technology)--Cape Peninsula University of Cape Town, 2005 / In clinical radiotherapy, experiments are performed to determine optimal conditions of the radiation prior to radiotherapy. These experiments focus on the relative biological effectivness(RBE) determination and are predominantly applied in high linear energy transfer (LET) radiations i.e. fast neutrons, as the RBE values for such radiations vary greatly. In general, the RBE of a certain radiation relative to a given reference radiation flCo gamma) varies widely with the energy, dose, dose rate, fractionation, type of tissue and end-point used. Experience with neutron therapy at iThemba LABS has shown that treatment with more fractions and lower doses per fraction may be beneficial for some patients. To calculate the iso-effective treatment dose needed, an appropriate alp ratio for early effects is needed. In this study, the repair of mouse jejunum was measured for split-dose irradiations to determine if a suitable alP ratio for neutrons could be estimated using the known value for gamma rays and the applicable RBE.. Crypt stem cell survival was measured 3.5 days after split-dose exposures to p(66)/Be neutrons and 6OCo gamma rays. Dose response curves for both treatment modalities and for both acute and fractionated exposures were constructed by counting crypts of Leiberkhiin at the base of the villi in haematoxylin and Eosin-stained sections of mouse jejunum. Using a RBE value of 1.64 and an alP ratio of 7Gy noted for tbe fractionated photon exposures, an alP ratio of 11.5 IV could be estimated for neutrons.

Orientador: Eduardo Tavares Costa, Rosana Almada Bassani / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Elétrica e de Computação / Made available in DSpace on 2018-08-20T23:52:29Z (GMT). No. of bitstreams: 1 Coiado_OliviaCampos_D.pdf: 1523563 bytes, checksum: 0c49e56163206a06aa60778d17bb44bc (MD5) Previous issue date: 2012 / Resumo: Nos últimos anos, o uso do ultrassom em diagnóstico e terapia vem crescendo e novas técnicas vêm sendo aprimoradas e desenvolvidas para novos tipos de aplicações, como por exemplo, em tratamento alternativo de insuficiência cardíaca. O objetivo deste trabalho foi investigar efeitos biológicos (in vitro e in vivo) em decorrência de exposição do coração de ratos a ondas ultrassônicas (frequência central 1 MHz), a fim de identificar padrões de estimulação que possam ser deletérios ou que possam ser usados terapeuticamente para distúrbios do ritmo cardíaco. Nos experimentos in vitro 7 corações isolados perfundidos de ratas, foram estimulados por 30 s com bursts de intensidade variando entre 0,6 até 8,00 W. Foi observado efeito cronotrópico negativo (sem efeito inotrópico) mais consistente (15-20%) na frequência de estimulação de 3 Hz e intensidades entre 0,62 até 5,54 W, porém este efeito foi transitório e não dependeu do duty cycle utilizado. Observaram-se arritmias na presença do ultrassom, mas não houve variação significativa de temperatura. Nos experimentos in vivo foram utilizadas 20 ratas, os corações foram estimulados por 10 s com bursts de 2-3 MPa. Os experimentos in vivo foram divididos em 5 grupos cada um composto de 5 animais: 1) preliminar; 2) controle ultrassom; 3) ultrassom; 4) controle vagotomizado e 5) ultrassom vagotomizado. No grupo preliminar dos experimentos observou-se o efeito cronotrópico negativo do ultrassom (redução de ~7 % da frequência cardíaca basal logo após a aplicação do ultrassom), relatado previamente. Para os demais grupos, em que se tentou determinar uma possível variação na pressão arterial e a influência do sistema parassimpático sobre o efeito cronotrópico negativo, não foram observadas variações significativas das variáveis estudadas. Estudos adicionais são necessários para esclarecimento dos efeitos da aplicação do ultrassom de alta potência sobre o coração de ratos / Abstract: In recent years, the use of ultrasound in diagnosis and therapy is increasing and new techniques have been improved and developed for new applications as, for instance, in alternative treatment of heart failure. The goal of this study was to investigate the biological effects (in vitro and in vivo) on rat heart of ultrasound waves (1 MHz center frequency) in order to identify stimulatory patterns that may be damaging or that may be used therapeutically for heart rhythm disturbances. In the in vitro experiments, 7 isolated perfused rat hearts, were stimulated with ultrasound bursts for 30 s and intensity ranging from 0.6 to 8 W. Negative chronotropic effect was observed (without inotropic effect) more consistently (15-20%) at the stimulatory frequency of 3 Hz with intensities of 0.62 to 5.54 W but this effect was transient and not dependent on the duty cycle used. We observed arrhythmia in the presence of ultrasound, but no significant variation in temperature. In the in vivo experiments 20 rat hearts were stimulated for 10 s with ultrasound bursts of 2-3 MPa. The experiments were divided into five groups each consisting of 5 animals: 1) preliminary, 2) ultrasound control, 3) ultrasound, 4) vagotomy, control and 5) vagotomy, ultrasound. The preliminary group of experiments, we observed the negative chronotropic effect of ultrasound (~ 7% decrease in heart rate immediately after application of ultrasound), previously reported. In the other groups, in which we have tried to determine the possible variation in blood pressure and the influence of the parasympathetic system on the negative chronotropic effect, there were no significant changes in the variables studied. Additional studies are needed to clarify the effects of high power ultrasound application on rat heart / Doutorado / Engenharia Biomedica / Doutora em Engenharia Elétrica

Made available in DSpace on 2016-01-26T18:56:24Z (GMT). No. of bitstreams: 1 Jose Gustavo Vieira Dissertacao.pdf: 479320 bytes, checksum: 15ff52b9288962a0f41adcd4577eb4d7 (MD5) Previous issue date: 2011-10-27 / The bean crop (Phaseolus vulgaris) is an annual crop of the Fabaceae family. Beans are an important component in the diet of humans and due to its nutritional composition it is an important source of carbohydrates and minerals. The national production of beans is estimated at 3.98 million hectares with an average yield of 38.5 bags per hectare. Higher plants develop in response to environmental characteristics to which they are exposed acquiring metabolic changes to adapt to biotic and abiotic stresses. Salicylic Acid (AS) is an endogenous growth regulator of phenolic nature, which participates in the regulation of physiological processes in plants and is also related to the induction of defense mechanisms. Besides the action of AS as an important regulator of several plant physiological processes, including photosynthesis, this acid also acts as a potential non-enzymatic antioxidant involved in the activation of defense responses in plant under stress conditions. The drought has an effect on several plant physiological processes that result in decreases in productivity levels. Lack of water is harmful to plants when it occurs in specific stages of its development, when it occurs in the pre flowering and grain filling period it causes a drop in productivity levels. / A cultura do feijão (Phaseolus vulgaris) é uma cultura anual da família Fabacea, é um importante componente alimentar na dieta dos seres humanos, devido a sua composição nutricional sendo uma importante fonte de carboidratos e minerais. As plantas superiores se desenvolvem em resposta as características ambientais em que são expostas. O Ácido Salicílico (AS) é um regulador de crescimento endógeno de natureza fenólica, o qual participa da regulação de processos fisiológicos nas plantas e também está relacionado com a indução de mecanismos de defesa. Além da atuação do AS como um importante regulador de diversos processos fisiológicos da planta, incluindo a fotossíntese, este ácido atua também como um potencial agente antioxidante não enzimático, estando envolvido na ativação das respostas de defesa no vegetal sob condições de estresse. O déficit hídrico tem efeito em diversos processos fisiológicos das plantas, os quais acarretam diminuição nos níveis de produtividade. A falta de água é prejudicial às plantas quando ocorre em fases específicas de seu desenvolvimento sendo que quando a mesma ocorre na fase de pré floração e enchimento de grãos acarretam queda nos níveis de produtividade.

Made available in DSpace on 2016-07-18T17:51:08Z (GMT). No. of bitstreams: 1 Jose Gustavo Vieira Dissertacao.pdf: 479320 bytes, checksum: 15ff52b9288962a0f41adcd4577eb4d7 (MD5) Previous issue date: 2011-10-27 / The bean crop (Phaseolus vulgaris) is an annual crop of the Fabaceae family. Beans are an important component in the diet of humans and due to its nutritional composition it is an important source of carbohydrates and minerals. The national production of beans is estimated at 3.98 million hectares with an average yield of 38.5 bags per hectare. Higher plants develop in response to environmental characteristics to which they are exposed acquiring metabolic changes to adapt to biotic and abiotic stresses. Salicylic Acid (AS) is an endogenous growth regulator of phenolic nature, which participates in the regulation of physiological processes in plants and is also related to the induction of defense mechanisms. Besides the action of AS as an important regulator of several plant physiological processes, including photosynthesis, this acid also acts as a potential non-enzymatic antioxidant involved in the activation of defense responses in plant under stress conditions. The drought has an effect on several plant physiological processes that result in decreases in productivity levels. Lack of water is harmful to plants when it occurs in specific stages of its development, when it occurs in the pre flowering and grain filling period it causes a drop in productivity levels. / A cultura do feijão (Phaseolus vulgaris) é uma cultura anual da família Fabacea, é um importante componente alimentar na dieta dos seres humanos, devido a sua composição nutricional sendo uma importante fonte de carboidratos e minerais. As plantas superiores se desenvolvem em resposta as características ambientais em que são expostas. O Ácido Salicílico (AS) é um regulador de crescimento endógeno de natureza fenólica, o qual participa da regulação de processos fisiológicos nas plantas e também está relacionado com a indução de mecanismos de defesa. Além da atuação do AS como um importante regulador de diversos processos fisiológicos da planta, incluindo a fotossíntese, este ácido atua também como um potencial agente antioxidante não enzimático, estando envolvido na ativação das respostas de defesa no vegetal sob condições de estresse. O déficit hídrico tem efeito em diversos processos fisiológicos das plantas, os quais acarretam diminuição nos níveis de produtividade. A falta de água é prejudicial às plantas quando ocorre em fases específicas de seu desenvolvimento sendo que quando a mesma ocorre na fase de pré floração e enchimento de grãos acarretam queda nos níveis de produtividade.

Orientador: João Domingos Rodrigues / Resumo: Dois experimentos foram conduzidos em 2018 e 2019 para avaliar os efeitos de diferentes fungicidas de dois importantes grupos: estrobilurinas e carboxamidas, sobre a eficácia fotossintética e produtividade de plantas de tomate, inoculadas com Alternaria sp., em ambiente protegido na Fazenda Ituaú, Salto - SP, Brasil. O delineamento experimental aplicado em ambos os experimentos foi de blocos ao acaso, com oito tratamentos e cinco repetições: testemunha inoculada (água + inóculo), testemunha absoluta (água), azoxystrobina (50,0 g ha-1), boscalida (50,0 g ha-1), azoxystrobina (50,0 g ha-1) + boscalida (50,0 g ha-1), mandestrobina (194 g ha-1), impirfluxam (30 g ha-1), mandestrobina (194 g ha-1) + impirfluxam (30 g ha-1), aplicados em intervalos de 15 dias, totalizando 7 a 8 aplicações no ciclo da cultura. O efeito no desenvolvimento das plantas foi medido pela altura das plantas e produção dos cinco primeiros cachos. A eficiência fotossintética foi calculada pela medição das trocas gasosas, fluorescência da clorofila a, teores de pigmentos fotossintéticos, e produtividade. Os fungicidas apresentaram algumas melhorias nos parâmetros analisados, como melhorando os componentes da eficiência fotossintética e da produção de frutos comerciais, porém sem apresentar diferenças significativas em relação às testemunhas. Os resultados demonstram eficácia no controle de Alternaria sp. aplicando os fungicidas em tomateiro, e também apontam para efeitos adicionais em componentes da eficiênci... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Two experiments were carried out in 2018 and 2019 to evaluate the effects of the application of different fungicides from two important groups: strobilurins and carboxamides, on the photosynthetic efficiency and yield of tomato plants, inoculated with Alternaria sp., grown in greenhouse at Fazenda Ituaú, Salto - SP, Brazil. The experimental design applied in both trials was randomized blocks with eight treatments and five replicates: inoculated control (water + inoculum), absolute control (water), azoxystrobin (50,0 g ha-1), boscalid (50,0 g ha-1), azoxystrobin (50,0 g ha-1) + boscalid (50,0 g ha-1), mandestrobin (194 g ha-1), inpyrfluxam (30 g ha-1), mandestrobin (194 g ha-1) + inpyrfluxam (30 g ha-1), applied at intervals of 15 days, totalizing 7 or 8 applications in the crop cycle. The effect on plant development was measured by plant height and the production of the five initial bunches. The photosynthetic efficiency was calculated from measurements of gas exchange, chlorophyll a fluorescence, content of photosynthetic pigments, and tomato productivity were evaluated. All fungicides positively affected some evaluated parameters, improving photosynthetic efficiency components and commercial fruit production, however without significant difference to the controls. The results demonstrate the efficacy of the use of these fungicides in controlling Alternaria sp. in tomato and also appoint to some additional effects on photosynthesis efficiency components and antioxidant enzym... (Complete abstract click electronic access below) / Doutor

Laboratory and feral lineages of mice were subjected to cephalad (+GZ) accelerations, for 1.8 seconds, aboard a solid fuel rocket. Spectrophotometric analysis of bronchoalveolar lavage retrieved post launch revealed significant (p < .001) elevations of protein in the lungs of experimental mice. Sudden transient imposition of a mean +GZ acceleration of 6.22 ± .47 (SD) G, at lift-off, may have induced hypervolemia of basilar pulmonary microvasculature with concomitant migration of fluid and protein from intravascular to juxta-alveolar perivascular compartments. Exudates may have entered bronchiolar airways subsequently gravitating toward alveoli.