This master’s thesis deals with the design of the new concept of lifting turntable QHZ 20. The main objective is to reduce the installation depth of table. Part of thesis is background research of individual components of the forging complex with hydraulic press CKW 25. It describes the current structure QHZ table, comparing the advantages and disadvantages of possible solutions of the table. The work also includes design, description and calculation of the chosen solution.

4AbstractA pre-filled syringe consists of a number of different components and materials e.g. glass, polymer and silicone oil, which will, in various degrees, interact with the pharmaceutical protein and excipients contained within. In addition to soluble protein loss due to adsorption to silicone droplets, silicone oil (SO) have also been reported to form complexes with pharmaceutical proteins that potentially provoke early and late-stage immune responses. The objective of this project was to investigate the impact of 10 different syringe barrel and plunger combination on the quality on pharmaceutical X and the performance of the syringe (syringeability). This is an explorative study and the purpose of this study was to investigate what options there were rather than to make firm recommendations. pH measurements indicated all chosen combinations were within acceptance criteria. Similarly, subvisible particle with reference standards and USP <788> tests indicated that all chosen combinations were within acceptance criteria. Analysis of visible particles without reference standards indicated that all combinations except 1B and 1C were within acceptance criteria. In terms of syringeability, functional testing revealed that combination 8A was a very poor choice and combination 1B a very good choice. In all of the tests, the currently used combination 1A was within the acceptance criteria. With respect to both the pharmaceutical quality and syringeability, it was considered to be equally preferred as many other combinations. Therefore, there is no real urgency to exchange the currently used syringe. Further investigation of plunger B, and possible other plunger combinations is recommended as they might play a bigger role than the syringe barrel with regard to the syringeability. Additionally, placebo suspension can only be used as a representative alternative for testing pH. / En förfylld spruta består av många olika komponenter och material så som glas, polymer, silikon olja, vilka, till olika grad, kommer reagera med proteiner och hjälpämnen i läkemedlet. Utöver förlust av protein (som följd av adsorption till silikon droppar), har det även rapporterats att silikon olja (SO) bildar komplex med proteinerna i läkemedlet vilka kan framkalla en immunologisk reaktion. Syftet med detta projekt var att undersöka effekten av 10 olika kombinationer av sprut-höljen samt kolvar på kvalitén på läkemedel X samt sprutans prestationsförmåga. Detta är en explorativ studie och syftet var att undersöka vilka alternativ som finns samt få en indikation för hur de uppför sig snarare än att ge tydliga rekommendationer. pH mätningar indikerade att alla valda kombinationer var inom acceptanskriterier. Liknande, både mätning av synliga och mikroskopiska partiklar med hjälp av referenslösningar samt metod USP 788 indikerade att alla valda kombinationer var inom acceptanskriterier. Mätning av synliga och mikroskopiska partiklar utan referenslösningar indikerade att alla kombinationer utom 1B och 1C var inom acceptanskriterier. Gällande sprutkombinationernas funktionalitet (prestationsförmåga) visade det sig att kombination 8A var ett dåligt val och kombination 1B ett attraktivt val. I alla tester, den nuvarande använda kombinationen (1A) var inom acceptanskriterier. Med avseende på både läkemedlets kvalité samt funktionalitet visade sig 1A vara ett likvärdigt alternativ till de andra kombinationerna. Detta innebär att det i dagsläget inte finns ett akut behov av att byta ut det nuvarande sprutkombinationen. Fortsatt utredning av kolv B, samt andra kolvar, är att rekommendera då de kan ha större påverkan funktionaliteten än höljet. Vidare kan placebolösning enbart användas som ett representativt alternativ för att testa pH.

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Les noyaux riches en neutrons de masse A=100-110 constituent une région de grand intérêt pour l'étude de la structure nucléaire loin de la stabilité. De précédentes études de cette région de masse ont déjà révélé la complexité de l'évolution de la collectivité et de la déformation dans les chaînes isotopiques de Zr, Mo, Ru et Pd. Afin d'étendre les données expérimentales sur la collectivité à des états de plus haut spin et à des noyaux plus riches en neutrons, des temps de vie d'états excités ont été mesurés dans des noyaux produits par une réaction de fusion-fission en cinématique inverse au GANIL. Les fragments de fission étaient séparés et identifiés en A et Z grâce au spectromètre magnétique de grande acceptance VAMOS tandis que le rayonnement gamma était détecté dans l'ensemble de détecteurs germanium EXOGAM. Environ vingt temps de vie d'états 2+, 4+ et 6+ ont été extraits à l'aide du plunger de Cologne. Cette expérience représente la première mesure RDDS dans des fragments de fission identifiés évènement par évènement à la fois en A et Z.Cette étude des noyaux de masse A=100-110 est complétée par des calculs auto-cohérents de champ moyen et au-delà avec la force de Gogny (D1S). La structure des états fondamentaux et excités est décrite dans le cadre du modèle de Hartree-Fock-Bogoliubov avec des contraintes sur les déformations axiale et triaxiale. Les excitations individuelles sont étudiées par des calculs bloqués et les états de haut spin sont décrits dans l'approximation du champ tournant. Enfin, la méthode de la coordonnée génératrice approchée par un hamiltonien collectif en cinq dimensions (5DCH) est appliquée aux états collectifs de basse énergie. Les résultats sont comparés aux mesures de la collectivité. / Neutron-rich nuclei of mass A=100-110 are of great interest for the study of nuclear structure far from stability. Previous experimental and theoretical studies suggest a complex evolution of deformation and collectivity in the isotopic chains of Zr, Mo, Ru and Pd.In order to extend information on the evolution of the collectivity towards higher spin states and more neutron-rich nuclei, lifetimes of excited states were measured in nuclei produced through a fusion-fission reaction in inverse kinematic at GANIL. Fission fragments were separated and identified in both A and Z with the high acceptance magnetic spectrometer VAMOS while the EXOGAM germanium detectors array was used for the coincident gamma-ray detection. Lifetimes of about twenty excited states were extracted using the plunger device of Cologne. This is the first RDDS measurement on fission fragments which are identified in A and Z on an event-by-event basis. The study of this mass region is completed by theoretical calculations using self consistent mean field and beyond mean field methods implemented with the Gogny force (D1S). The structure of the ground states and the excited states is described with Hartree-Fock-Bogoliubov calculations with constraints placed on the axial and triaxial deformations. Individual excitations are investigated through blocking calculations and the high spin states are studied through cranking calculations. Finally, an approximated generator coordinate method (GCM+GOA) using the 5DCH hamiltonian is used to describe the low energy collective states and to interpret the experimental evolution of the collectivity.

Made available in DSpace on 2015-03-03T15:08:47Z (GMT). No. of bitstreams: 1 FernandoCM_TESE.pdf: 4237848 bytes, checksum: 00e7cb467e7c1cded76198b12c9e6e82 (MD5) Previous issue date: 2013-08-23 / This work has as main objective to find mathematical models based on linear parametric estimation techniques applied to the problem of calculating the grow of gas in oil wells. In particular we focus on achieving grow models applied to the case of wells that produce by plunger-lift technique on oil rigs, in which case, there are high peaks in the grow values that hinder their direct measurement by instruments. For this, we have developed estimators based on recursive least squares and make an analysis of statistical measures such as autocorrelation, cross-correlation, variogram and the cumulative periodogram, which are calculated recursively as data are obtained in real time from the plant in operation; the values obtained for these measures tell us how accurate the used model is and how it can be changed to better fit the measured values. The models have been tested in a pilot plant which emulates the process gas production in oil wells / Este trabalho teve como objetivo principal encontrar modelos matem?ticos baseados em t?cnicas de estima??o param?trica lineares aplicado ao problema do c?lculo da vaz?o de g?s em po?os de petr?leo. Em particular se concentrou na obten??o de modelos de vaz?o aplicados ao caso de po?os que produzem pela t?cnica de plunger-lift em plataformas de petr?leo, pois nesse caso, ocorrem picos elevados nos valores da vaz?o que dificultam sua medi- ??o direta atrav?s de instrumentos. Para isso, desenvolveram-se estimadores baseados em m?nimos quadrados recursivos e fez-se uma an?lise das medidas estat?sticas tais como autocorrela??o, correla??o cruzada, variograma e o periodograma acumulado, que s?o calculadas recursivamente ? medida que dados s?o obtidos em tempo real da planta em opera??o; os valores obtidos para essas medidas indicaram o qu?o exato ? o modelo utilizado e de que forma ele pode ser alterado para melhor se adequar aos valores medidos. Os modelos obtidos foram testados em uma planta piloto que emula o processo de produ??o de g?s em po?os de petr?leo