Introduction: The thesis deals with the relationship between substance use and eating disorder. In particular, it focuses on the phenomenon of self-medication substance abuse among women who have experienced an eating disorders. The theoretical part provides a comprehensive picture of the studied issue, supported by Czech and international research in the area. The empirical part is based on qualitative data collection and consists of a combination of short case studies and thematic analysis. Objectives: The main aim of the thesis is to map out and find out whether women who suffer from eating disorders use addictive substances, including alcohol, for the purpose of self-medication. The thesis also aims to find out whether there is a difference between the different forms of eating disorders and the pattern of substance use. Sample: The research sample consisted of 10 women aged 19 - 38 years who have had experiences with eating disorders. Methods: The method of semi-structured interview was chosen for the purpose of the research. The data obtained were presented using short case reports. The case studies were supplemented by a timeline and a test battery, which consisted of AUDIT, DAST and FTND questionnaires for better orientation of the researcher. The data were subsequently analyzed through...

The thesis focuses on knowledge of eating disorders by students of University of South Bohemia. The theoretical part defines particular types of eating disorders and the causes related with this problems. There are possible treatment methods for eating disorders mentioned at the end of this part. The practical part deals with students? awareness of eating disorders. It focuses on students? knowledge of eating disorders and orthorexia nerovosa. The research is based on questionnaire construction. The students of selected faculties of University of South Bohemia were the respondents. The results of the research were statistically processed.

Aim of this thesis was mapping of diet and eating habits of children from primary school through survey. Chosen respondents were pupils in 4th and 5th grades in microregion Blatná. It took part 279 pupils aged 9 - 11. The results are processed in the form of graphs, tables and discussions. Children´s nutrition is very discussed topic lately. It all comes with the food machines where children have access to unhealthy junk food.

1 Abstract Body weight changes have been described in the course of Parkinson's disease (PD) as well as following bilateral deep brain stimulation of the subthalamic nucleus (STN DBS) performed in advanced PD. According to the literature weight changes occur in 50-100% of patients who undergo STN DBS. In the last 15 years extensive efforts have been put in understanding the underlying mechanisms behind the weight changes following STN DBS in advanced PD patients however many sources still report conflicting evidence. Improved motor status, reduction in dyskinesias, decrease in energy expenditure, dopaminergic medication reduction, modification of food intake, hormonal factors, regional effects of stimulation were all speculated to cause this weight gain. We hypothesized that patients who underwent STN DBS procedure in our center would gain weight as reported in the literature (study 1, study 2). The etiology of post STN DBS weight gain has not been fully elucidated up to date, in our second study we further hypothesized that the weight changes are due to dysregulation of food related hormones and parameters (study 2). In the third study we hypothesized that weight gain is associated with position of active electrode contact (study 3). Aims of the study: The primary aims of our studies were to assess body...

This work is focused on physical activity, diet, daily routine and dietary habits of adolescents at two high schools in České Budějovice. In selected folder also finds occurence of obesity and anorexia. Research was attended by a total of 311 students aged 15 to 19 years. Each of the students has filled a questionnaire on nutrition and exercise and was subject to measure body weight, height and subcutaneous fat. Collected data were processed by BMI and BIA methods and then compared with data from measurements made in 2008. The results indicate 16% of overweight students and only 1% with obesity according to BMI method. BIA method measured 4% with obesity and 9% overweight. Compared to 2008 research there is decrease of students with obesity, but increased numbers with overweight.

The diploma dissertation involves dilemma of self-perception of one´s body in teenagers related to their self-concept. It consists of the theoretical and the practical part. The theoretical part of dissertation defines personality in general and it also describes the teenage period and its typicall physical and psychical characters including the point of view of some theories of evolution. It also describes dilemma of changes of the body and different points of view of slef-perception of one´s body. The practical part of dissertation demonstrates results of evaluation of self-perception one´s body as well as information about content with physiognomy of one´s body and outer effects which influence the self-perception of one´s body mainly by using the quantitative method. The conclusions pointed to that evaluation of one´s body in connection with self-concept is notable and demonstrate differences and specificities between girl´s and boy´s self-perception of one´s body.

Our diploma thesis entitled ?The system of prevention of social and pathological phenomena and its implementation at elementary schools? engages in the analysis of possibilities and conditions for and approaches to the implementation of primary pre-vention at elementary schools. The objective of the present diploma is to describe how systems of primary prevention work on the regional and school levels; accordingly, we have performed a comparison of different approaches to this issue at selected schools in the regions of South Bohemia and Pardubice. We have analyzed programmes of the aforesaid regions on the conceptual level, observing the implementation of preventive programmes at particular schools (such as elementary or special). Furthermore, we have examined the assistance as actually pro-vided to schools during the formation of school preventive programmes and their influ-ence on pupils or students as such. We are also interested in how the possibilities that are on offer for the cooperation among schools are utilized and how schools make use of grant programmes provided by regional authorities. The present thesis is divided into two parts, theoretical and practical. The theo-retical part first characterizes and defines basic terms, explaining the most common so-cial and pathological phenomena with the largest impact on the young. Second, a men-tion is made of the system of prevention at both the school and regional levels. Accord-ingly, the practical part focuses on the analysis of school activities in the area of preven-tion, particularly the methodology of prevention, the support of the formation of preven-tive programmes and the influence such programmes have on children. The conclusion summarizes presuppositions and hypotheses which are men-tioned in the introduction. A sociological survey has been conducted at selected schools by means of questionnaires, which will be evaluated at the end of our thesis.

ABSTRACT Eating disorders (mental anorexia and bulimia) and obesity entail grave health, social and economic problems, and lead to detrimental health consequences, often irreversible consequences. Currently the disorders affect about 6% of population, with young girls particularly vulnerable and 16% of women obese. As the relevant surveys reveal, these figures are constantly on the rise. Apart from producing somatic symptoms, both the disorders, anorexia and bulimia, have been observed to bring about typical negative emotions and maladaptive cognition, first and foremost a distorted (negative) self-image focused on inappropriate perception of own body also known as the body image. The paper aims to find out and mutually compare features characteristic of the body image issues as they relate to the eating disorders and obesity / excessive weight. The paper is based on a survey combining qualitative and quantitative research strategies. To collect data, both strategies employed the technique of inquiry - the qualitative part relied on the theory of semi-structured interviews while the quantitative part used a questionnaire. The data thus acquired were processed by quantitative and qualitative procedures. Building on the previous Bachelor paper intended to map the issues of body image in persons with eating disorders, this paper expands the previous survey set of women suffering the condition and adds a new set of obese females. Results of the qualitative part of the survey brought about hypotheses on how the mentioned disorders affected the body image. The quantitative part of the survey revealed similar characteristics in the perceived body image in both the sets, but disclosed also some differences. Significant differences were found when the body image of the diseased persons was compared with that encountered in healthy population. This paper can boost the awareness of this subject in lay public but also in professional community, primarily where psychotherapy and prevention are regarded.

The presented thesis deals with problems of eating disorders (hereinafter abbreviated to EDs). The theoretical framework is the Social Construction of Reality; a concept saying that the individual perceives reality - as a phenomenon formed and determined socially - in the way it is presented by the "power structures" of the society. The thesis pays special attention to the aetiology of these disorders, laying emphasis on family factors. The aim of the thesis refers to one of the topics resulting from my Bachelor thesis, when it appeared worthwhile to work up in detail the problem of subjectively seen factors substantial for onset of EDs. Thus the aim of the thesis was to map which factors the persons suffering from EDs as well as members of their families consider to be significant for onset of the disease - either their own or their daughter´s /sister´s on one hand and EDs generally on the other hand - and what led them to take their stand, in so doing two ranges of time were mapped. The set of persons under review was represented by the same respondents as in case of research for the Bachelor thesis. In order to ensure mapping of the above-mentioned problem in the most possible complex way, a qualitative research strategy was chosen. The necessary data was obtained by employing the technique of deep semi-structured interviews, then the data was processed using qualitative analysis of the respondents´ statements. Part of the research work was also confrontation of the collected and processed data with specialised resources. On the basis of the results of our research it is evident that the factor causing onset and development of the respondents´ or their daughter´s/sister´s EDs mentioned most often is family background. Unlike the Bachelor thesis, this factor was rather mentioned as one of many; it is not so dominant any longer. This may be explained by the fact that the patients spoke about their situations under the influence of other factors that experts had been emphasising. As for EDs generally, then the respondents mostly mentioned desire to be slim, which, however, has now substantially fallen into the shade. This may be explained by the respondents´ experience with EDs. It may be said that in taking their standpoints, family members were much more influenced by information from specialised resources than the persons suffering from EDs themselves, who mostly took their stand on the basis of their own conviction. Our research shows that for persons suffering from EDs, family background was not a source of information on the problem of these disorders. The research pointed out the importance of engaging the family in solving the problem of EDs as well as the necessity of individual approach to each case of this disease. The presented thesis may be a helpful source of information not only for people interested in the problem of EDs; it may also serve as materials for instruction in the medical social field, and last but not least it can be used to bring more information to the general public.

The thesis is focused on the effect of ghrelin receptor (GHS-R1a) agonists and antagonist on food intake regulation. Ghrelin is the only known periferally produced orexigenic hormone and the only known acylated hormone. GHS-R1a agonists and antagonists could be useful in the treatment of cachexia and obesity, respectively. In the first part of the thesis, newly designed peptidic GHS-R1a agonists were characterized. The agonists were stabilized by replacing octanoylated Ser3 with a fatty acid coupled to diaminopropionic acid by a stable amide bond. Other noncoded amino acids were also incorporated. Ghrelin analogs were modified by replacing the octanoyl group with another fatty acid, incorporation of the second fatty acid or shortening the peptide chain. Most of the tested GHS-R1a agonists were found to possess high affinities for GHS-R1a (Ki = 10-9 - 10-10 nM) and to activate signaling pathways of ghrelin. After subcutaneous (SC) administration to mice, agonists showed significant and prolonged orexigenic effect. In the second part of the thesis, acute and long-term effects of pseudopeptide GHS-R1a agonist JMV1843 were tested in lean C57BL/6 mice. Acute SC administration of JMV1843 to fed mice increased food intake in a dose-dependent manner (ED50 = 1.94 mg/kg). JMV1843 was stable in blood serum in...