Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-06-10T12:47:07Z No. of bitstreams: 1 lucianafalcithezarodrigues.pdf: 2445948 bytes, checksum: 70c2ecd74aa75b086d89fc80dfb11b06 (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-07-13T13:48:40Z (GMT) No. of bitstreams: 1 lucianafalcithezarodrigues.pdf: 2445948 bytes, checksum: 70c2ecd74aa75b086d89fc80dfb11b06 (MD5) / Made available in DSpace on 2016-07-13T13:48:40Z (GMT). No. of bitstreams: 1 lucianafalcithezarodrigues.pdf: 2445948 bytes, checksum: 70c2ecd74aa75b086d89fc80dfb11b06 (MD5) Previous issue date: 2012-02-23 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / O presente trabalho objetivou conhecer a riqueza e distribuição espacial de oligoquetas em córregos de primeira ordem localizados em áreas preservadas. A dissertação está dividida em duas seções: a primeira trata de um inventário contendo informações sobre a distribuição geográfica e ecologia das espécies de oligoquetas identificadas em oito córregos localizados no Estado de Minas Gerais; a segunda aborda a distribuição espacial de oligoquetas nesses córregos, inseridos em duas fisionomias vegetais de Mata Atlântica (Floresta Estacional Semidecidual e Campos Rupestres); traz também uma abordagem em mesoescala através do estudo dos oligoquetas em mesohabitats de remanso e corredeira. Cento e sessenta amostras de folhiço submerso foram obtidas (oitenta em corredeiras e oitenta em remansos), com amostrador Surber, nos meses de maio, junho, julho e setembro de 2010 e junho de 2011 em oito córregos de primeira ordem, localizados nos municípios de Juiz de Fora e Lima Duarte, Estado de Minas Gerais. Foram inventariados 20 taxa de oligoquetas, dos quais um -Bratislavia (?) sp.- possivelmente é uma espécie nova, totalizando 4.376 espécimes. Em termos de riqueza, o gênero mais representativo foi Pristina, com 10 espécies. Foi encontrado maior valor do índice de diversidade beta entre áreas de fisionomias vegetais diferentes. Quanto aos mesohabitats, a fauna não mostrou separação entre corredeiras e remansos, indicando que fatores ligados às diferenças em menor escala, como velocidade da corrente, largura e profundidade do córrego, não interferiram de forma significativa na distribuição da fauna. Os resultados obtidos nesse estudo vêm contribuir de forma importante para o conhecimento sobre a distribuição das espécies de oligoquetas no Brasil, sobretudo em ambientes lóticos preservados, ambientes para os quais poucos estudos foram realizados. / The present study aimed knows space richness and distribution of oligochaetes on first order streams situated on preserved areas. The dissertation is divided on two sections: the first one treats about a inventory containing information about ecology and geographic distribution of oligochaetes species indentified on eight streams located on State of Minas Gerais; the second one approach oligochaetes distribution in this streams, inserted on two vegetation types of Atlantic Forest ( Semidecidual Estacional Forest and Rupestres Fields); bring too an mesoscale approach through study of oligochaetes in riffles and pools mesohabitats. One hundred and sixty samples of litter was taken (eighty on riffles and eighty on pools), with Surber sampler, at the months of May, June, July and September of 2010 and June of 2011 on eight first order streams, situated on municipalities Juiz de Fora and Lima Duarte, State Minas Gerais. Twenty oligochaetes taxa was inventoried, of witch -Bratislavia (?) sp.- probably is a new specie, adding it up 4376 specimens. In terms of richness, the most representative genus was Pristina, with ten (10) species. Different areas vegetation types had the highest value of beta diversity index. As to mesohabitats, fauna don’t show separation between riffles and pools, indicating that factors related minor scale differences, like running speed, streams spread and depth, don’t affect on significative way on fauna distribution. The results obtained in this study came add to an important form to knowledge about distribution of oligochaetes species on Brazil, mainly on preserved lotic environments, sites with few studies performed.

The aim of this study was to map the prevalence of aeolian sand dunes in Västerbotten, northern Sweden to find dunes formed during earlier deglaciation phases, which was then preserved in cold-based conditions during the youngest stadial of the Weichselian glaciation. These preserved dunes were expected to be covered by a layer of till and have a rather faint morphology compared to dunes formed during the Holocene. Consequently, high resolution LIDAR-derived images from the Swedish mapping, cadastral and land registration authority (Lantmäteriet) was used to detect the dunes throughout an area covering most of Västerbotten, above the highest coastline and below the mountain range. The analysis resulted in several new findings of aeolian dunes compared to the findings in the quaternary soil map created by the Geological Survey of Sweden. Despite the fact some of the dunes at the LIDAR-derived image had a strange faint appearance, it was quickly evident during the fieldwork that the aeolian sand was not covered by till on any of the dunes visited. The common view during the last decades has been that cold-based ice will not erode or alter the morphology of the landscape beneath the ice. However, this study suggests that hypothesis may not be entirely correct, and therefore it can be hard to use geomorphological implications to reconstruct past glacial environments. Thus, it can be concluded that even under cold-based conditions, preservation of aeolian sand dunes in Västerbotten is probably not very common.

No description available.

Cardiovascular diseases (CVD) have been the leading cause of death worldwide for many years, making it a devasting and increasing concern across the globe. The risk factors of CVD include postnatal factors and prenatal factors. For the prenatal CVD risk factors study, we focused on maternal hypothyroidism (MH), which is a common clinical condition. Studies have shown MH progeny have increased susceptibility to both acquired cardiovascular disease in adulthood and congenital heart disease, but the underlying mechanisms are not well understood. The goal of the present experiments was to test the hypothesis that MH reduces early postnatal cardiac myocyte proliferation in the progeny so that their adult hearts have a smaller complement of cardiac myocytes, which leads to adverse cardiac disease responses. MH model was induced by thyroidectomy (TX) with total thyroxine (TT4) under 1ng/dl after surgery. The progeny from mice that underwent Sham or TX surgery was termed WT (wild type) or MH (maternal hypothyroidism) progeny, respectively. Hearts were collected from WT and MH progeny to determine heart weight (HW), CM size, CM proliferation, and cell culture. RNA-seq was performed on heart tissue at postnatal day 5 (P5) and P60. Transverse Aortic Constriction (TAC) was performed to cause pressure overload-induced cardiac hypertrophy and/or heart failure (HF) in adult WT and MH progeny. ECHO (in-vivo) and histological (ex-vivo) studies were performed at specific times after TAC. Thyroid hormone treatment (levothyroxine, T4) for MH mother was administered. The results showed that the Heart weight (HW) to body weight (BW) ratio at P60 was no difference between groups, but the MH progeny had a larger CM size, consistent with fewer CM numbers. MH progeny had lower EdU+, Ki67+, and PH3+ CMs, and fewer mononucleated CMs, which shows they had a decreased CM proliferation capacity. RNA-seq data showed that genes related to DNA replication were downregulated in P5 MH progeny, including Bmp10. Both in vivo and in vitro studies showed Bmp10 treatment increased CM proliferation in the presence of thyroid hormone. In adult progeny, RNA-seq data showed that MH mice had genes upregulated in the inflammatory response before TAC surgery. Six weeks after TAC, the MH progeny had a greater HW/BW ratio, larger CM size, and more severe LV fibrosis consistent with more severe cardiac pathological remodeling compared with WT progeny. T4 supplemented treatment for MH mothers preserved progeny’s early postnatal CM proliferation capacity and the excessive pathological remodeling after TAC. Concluding, CM proliferation during the early postnatal development stage was significantly attenuated in MH progeny, which results in fewer CMs and CM hypertrophy in adult MH progeny. These changes are associated with worse cardiac disease responses under pressure overload in adult MH progeny. For the postnatal CVD risk factors study, we focused on calcium overload and metabolic disorder, which play a critical role in heart failure with preserved ejection fraction (HFpEF). HFpEF is defined as HF with an EF ≥50% and elevated cardiac diastolic filling pressures. The underlying causes of HFpEF are multifactorial and not well-defined. A transgenic mouse with low levels of cardiomyocyte (CM)-specific inducible Cavβ2a expression (β2a-Tg mice) showed increased cytosolic CM Ca2+, and modest levels of CM hypertrophy and fibrosis. This study aimed to determine if β2a-Tg mice develop an HFpEF phenotype when challenged with two additional stressors, a high-fat diet (HFD) and L-NAME (LN). Four-month-old wild-type (WT) and β2a-Tg mice were given either normal chow (WT-N, β2a-N) or HFD and/or L-NAME (WT-HFD, WT-LN, WT-HFD-LN, β2a-HFD, β2a-LN, and β2a-HFD-LN). Some animals were treated with the HDAC (hypertrophy regulators) inhibitor suberoylanilide hydroxamic acid (SAHA) (β2a-HFD-LN-SAHA). Echocardiography was performed monthly. After four months of treatment, terminal studies were performed, including invasive hemodynamics and organ weight measurements. Cardiac tissue was collected. Our results showed that four months of HFD plus L-NAME treatment did not induce a profound HFpEF phenotype in FVB WT mice. β2a-HFD-LN (3-Hit) mice developed features of HFpEF, including increased natriuretic peptide (ANP) levels, preserved EF, diastolic dysfunction, robust CM hypertrophy, increased M2 macrophage population, and myocardial fibrosis. SAHA reduced the HFpEF phenotype in the 3-Hit mouse model by attenuating these effects. Concluding, the 3-Hit mouse model induced a reliable HFpEF phenotype with CM hypertrophy, cardiac fibrosis, and an increased M2 macrophage population. This model could be used for identifying and preclinical testing of novel therapeutic strategies. / Biomedical Sciences

Medical-grade ultrasound devices are now pocket sized and can be easily transported to underserved parts of the world, allowing health care providers to have the tools to optimize diagnoses, inform management plans, and improve patient outcomes in remote locations. Other great advances in technology have recently occurred, such as artificial intelligence applied to mobile health devices and cloud computing, as augmented reality instructions make these devices more user friendly and readily applicable across health care encounters. However, broader awareness of the impact of these mobile health technologies is needed among health care providers, along with training on how to use them in valid and reproducible environments, for accurate diagnosis and treatment. This article provides a summary of a Mayo International Health Program journey to Bwindi, Uganda, with a portable mobile health unit. This article shows how point-of-care ultrasonography and other technologies can benefit remote clinical diagnosis and management in underserved areas around the world.

<p>Oxygen (O2) plays a crucial role in the energy metabolism of complex multicellular life on earth. Due to the small and finite energy stores in the body, fine-tuned changes within the body are required to meet metabolic demand during skeletal muscle contractions, such as during exercise and activities of daily living. The skeletal muscle microcirculation is one of the last steps in the O2 transport pathway from the lungs to muscle cells and represents the largest surface area for O2 and substrate exchange. When skeletal muscle O2 uptake increases during contractions to meet metabolic demand, there must be an increase in muscle O2 delivery. To achieve these elevations in O2 delivery, vessel (arteriole) diameter in the microcirculation is increased, known as vasodilation. This process in the skeletal muscle microcirculation is regulated by several factors, such as neurohumoral, mechanical, endothelial, paracrine, and metabolic influences, which are imperative in properly regulating O2 delivery at rest and during muscular contractions. Two vasodilatory pathways of interest in this dissertation are the cyclooxygenase (COX) and nitric oxide (NO) vasodilatory pathways.</p> <p>The primary aim of my dissertation studies was to determine the mechanisms that modulate skeletal muscle oxygenation in health and to define the impact of a potentially effective intervention, whole-body chronic heat therapy (HT), to treat heart failure with preserved ejection fraction (HFpEF). In Chapter 2, we report that acute selective COX-2 inhibition had no effect on resting or exercising skeletal muscle microvascular oxygenation, pulmonary oxygen uptake, or exercise tolerance in healthy young humans. In Chapter 3, we report that NO, via phosphodiesterase type 5 inhibition, regulates myocyte O2 transport at rest and during recovery from muscle contractions in healthy young rats. In Chapter 4, we show that whole-body chronic HT promotes central and peripheral adaptations, which impact positively exercise tolerance in a pre-clinical rat model of HFpEF. Specifically, whole-body chronic HT had beneficial influences on exercise tolerance, skeletal muscle oxygenation from rest to contractions (driven, at least in part, by enhanced NO bioavailability), body composition, and cardiac function. Chapter 5 is a summary of the results and limitations of the projects presented in Chapters 2-4, with a brief discussion of potential future research directions. </p>

<p>  </p> <p><strong>Background: </strong></p> <p>Torsades de pointes (TdP) is a polymorphic ventricular tachycardia (VT) associated with heart rate-corrected QT interval (QTc) prolongation on the electrocardiogram (ECG). TdP can cause sudden cardiac arrest (SCA), a catastrophic outcome. The antiarrhythmic drugs dofetilide and sotalol can cause QTc prolongation and arrhythmias, as can more than 200 other medications available on global markets. Heart failure (HF) with reduced ejection fraction (HFrEF) is a risk factor for drug-induced TdP, and HFrEF heightens sensitivity to drug-induced QTc lengthening. However, ~55% of patients with HF have preserved, rather than reduced, ejection fraction. It remains unknown whether patients with HF with preserved ejection fraction (HFpEF) are at increased risk for drug-induced VT/SCA. Assessment of the risk of drug-induced VT/SCA in HFpEF patients is important, so that recommendations can be made regarding the safety of QTc-prolonging drugs and need for enhanced ECG monitoring in this population. </p> <p><strong>Objective:</strong></p> <p>In aim 1, we sought to determine the risk of VT and SCA associated with dofetilide and sotalol in patients with HFpEF. In aim 2, we were able to use QTc interval to determine the odds of dofetilide/sotalol-associated QT interval prolongation in patients with HFpEF. In Aim 3, we investigated the influence of HFpEF on VT and SCA associated with a broader group of drugs known to cause TdP (“known “TdP drugs”), as designated by the QT drugs list at www.crediblemeds.org. </p> <p><strong>Methods:</strong></p> <p>In aim 1, we used Medicare claims (2014-2016) and ICD-9/10 codes to identify patients taking the QT interval-prolonging drugs dofetilide or sotalol, which are used commonly in patients with HF and atrial fibrillation, as well as non-dofetilide or sotalol users among 3 groups: HFpEF, HFrEF, and no HF. Multinomial propensity score-matching was performed. Cochran–Mantel–Haenszel statistics and standardized differences were used to compare baseline characteristics. A generalized Cox proportional hazards model was used to estimate hazard ratios (HRs) and test the association of VT and SCA among dofetilide/sotalol users, HFpEF, HFrEF, and no HF.</p> <p>In Aim 2, the data source was electronic health records from the Indiana Network for Patient Care (February 2010 to May 2021). After removing patients with overlapping diagnoses of HFpEF and HFrEF, no diagnosis code, absence of QT interval records, and no validated record of using dofetilide or sotalol, we identified patients taking dofetilide or sotalol among three groups: HFrEF, HFpEF, and no HF. Cochran–Mantel–Haenszel statistics were used to compare baseline characteristics. QT interval prolongation was defined as heart rate-corrected QT (QTc) > 500 ms during dofetilide/sotalol therapy. Unadjusted odds ratios (OR) of QT interval prolongation were determined by univariate analysis, and adjusted ORs were determined by generalized estimating equations (GEE) with logit link to account for an individual cluster with different times of hospitalization and covariates.</p> <p>In aim 3, we used Medicare enrollment in fee-for-service medical and pharmacy benefits (2014 to 2016) and ICD-9/10 codes, we identified patients taking drugs known to cause torsades de pointes (TdP drugs; www.crediblemeds.org) and non-TdP drug users among three groups: HFrEF, HFpEF, and no HF. Multinomial propensity score-matching was performed to minimize baseline differences in covariates (patient demographics, comorbidities, health care utilization and drug history). Cochran–Mantel–Haenszel statistics and standardized differences were used to compare baseline characteristics. A generalized Cox proportional hazards model was used to estimate HRs and test the association of VT and SCA among TdP drug users with HFpEF, HFrEF, and no HF.</p> <p><strong>Results:</strong></p> <p>In Aim 1, VT and SCA occurred in 166 (10.68%) and 16 (1.03%), respectively, of 1,554 dofetilide/sotalol users with HFpEF, 543 (38.76%) and 40 (2.86%) of 1,401 dofetilide/sotalol users with HFrEF, and 245 (5.06%) and 13 (0.27%) of 4,839 dofetilide/sotalol users with no HF. The adjusted HR for VT in patients with HFrEF was 7.00 (95% CI 6.12-8.02) and in patients with HFpEF was 1.99 (1.71-2.32). The risk of VT associated with dofetilide/sotalol was increased across the overall study population (HR: 2.47 [1.89-3.23]). Use of dofetilide/sotalol increased the risk of VT in patients with HFrEF (HR: 1.53 [1.07-2.20]) and in those with HFpEF (HR: 2.34 [1.11-4.95]). However, while the overall risk of SCA was increased in patients with HFrEF (HR: 5.19 [4.10-6.57]) and HFpEF (HR: 2.53 [1.98-3.23]) compared to patients with no HF, dofetilide/sotalol use was not significantly associated with an increased risk of SCA.</p> <p>In Aim 2, QTc prolongation associated with dofetilide/sotalol occurred in 51.2% of patients with HFpEF, 70.1% of patients with HFrEF, and 29.4% of patients with no HF. After adjusting for age, sex, race, serum potassium and magnesium concentrations, kidney function, concomitant drug therapy, and comorbid conditions, the adjusted odds of having QTc interval larger than 500ms during the hospital stay were 5.23 [3.15-8.67] for HFrEF and 1.98 [1.17-3.33] for HFpEF with no HF as the reference group. </p> <p>In Aim 3, of 23,910 known TdP drug users with HFrEF, VT and SCA occurred in 4,263 (17.8%) and 493 (2.1%) patients, respectively. In comparison, among 31,359 known TdP drug users with HFpEF, VT and SCA occurred in 1,570 (5.0%) and 340 (1.1%) patients. VT and SCA occurred in 3,154 (0.8%) and 528 (0.1%) of 384,824 known TdP drug users without HF. The overall HR of both VT and SCA was increased in patients with HFrEF (HR: 7.18 [6.13-8.40])  and in those with HFpEF (HR: 2.09 [1.80-2.42]). The risk of VT associated with known TdP drugs was increased across the overall population (HR: 1.34 [1.20-1.51]). Use of known TdP drugs significantly increased the risk of VT and SCA in patients with HFrEF (HR: 1.34 [1.07-1.67]), but not in patients with HFpEF.</p> <p><strong>Conclusion:</strong></p> <p>HFpEF may exhibit an enhanced response to drug-associated VT, and is associated with a higher risk of drug-associated QTc interval prolongation. Further study is needed to identify methods to minimize this risk for patients with HFpEF requiring therapy with dofetilide, sotalol, or drugs known to cause TdP. </p>

Aims In heart failure with preserved ejection fraction (HFpEF), the reduction of nitric oxide (NO)-bioavailability and consequently endothelial dysfunction leads to LV stiffness and diastolic dysfunction of the heart. Besides shear stress, high-density lipoprotein (HDL) stimulates endothelial cells to increased production of NO via phosphorylation of endothelial nitric oxide synthase (eNOS). For patients with heart failure with reduced ejection fraction, earlier studies demonstrated a positive impact of exercise training (ET) on HDL-mediated eNOS activation. The study aims to investigate the influence of ET on HDL-mediated phosphorylation of eNOS in HFpEF patients. Methods and results The present study is a substudy of the OptimEx-Clin trial. The patients were randomized to three groups: (i) HIIT (high-intensity interval training; (ii) MCT (moderate-intensity continuous training); and (iii) CG (control group). Supervised training at study centres was offered for the first 3 months. From months 4–12, training sessions were continued at home with the same exercise protocol as performed during the in-hospital phase. Blood was collected at baseline, after 3, and 12 months, and HDL was isolated by ultracentrifugation. Human aortic endothelial cells were incubated with isolated HDL, and HDL-induced eNOS phosphorylation at Ser1177 and Thr495 was assessed. Subsequently, the antioxidative function of HDL was evaluated by measuring the activity of HDL-associated paraoxonase-1 (Pon1) and the concentration of thiobarbituric acid-reactive substances (TBARS). After 3 months of supervised ET, HIIT resulted in increased HDL-mediated eNOS-Ser1177 phosphorylation. This effect diminished after 12 months of ET. No effect of HIIT was observed on HDL-mediated eNOS-Thr495 phosphorylation. MCT had no effect on HDL-mediated eNOS phosphorylation at Ser1177 and Thr495. HIIT also increased Pon1 activity after 12 months of ET and reduced the concentration of TBARS in the serum after 3 and 12 months of ET. A negative correlation was observed between TBARS concentration and HDL-associated Pon1 activity in the HIIT group (r = −0.61, P < 0.05), and a trend was evident for the correlation between the change in HDL-mediated eNOS-Ser1177 phosphorylation and the change in peak V̇O2 after 3 months in the HIIT group (r = 0.635, P = 0.07). Conclusions The present study documented that HIIT but not MCT exerts beneficial effects on HDL-mediated eNOS phosphorylation and HDL-associated Pon1 activity in HFpEF patients. These beneficial effects of HIIT were reduced as soon as the patients switched to home-based ET.

L'élevage de la chèvre « Baladi » au Liban souffre d'un problème de disponibilité alimentaire responsable des faibles performances établies de la race, du fait de sa dépendance majoritaire des zones de pâturage naturel et de la rareté des terrains fourragers ou de l'adoption du système intensif. Dans ce contexte agroclimatique particulier, cette étude se propose d'identifier la conduite optimale, à mi-chemin entre système extensif compromettant la production et la durabilité de l'élevage et système hors-sol qui ne saurait valoriser les aptitudes de la race et les parcours de la région. En effet, les conditions climatiques difficiles de la région d'étude impliquent l'insertion d'une dimension temporelle dans la conceptualisation de la conduite optimale, prenant en considération les fluctuations saisonnières non négligeables des ressources alimentaires naturelles. Comparée à la conduite extensive traditionnelle et à la complémentation largement moins adoptée, une conduite où les chèvres laitières seraient mises au pâturage durant les mois de printemps caractérisé par la prolifération des espèces végétales en vert et enfermées durant la sécheresse estivale paraît a priori adaptée aux conditions du milieu et aux objectifs zootechniques et socioéconomiques. Le cas échéant, le système intensif étant rarement prisé par les éleveurs de la région, l'efficacité des parcours à résidus agricoles ou fourragers aura également été évaluée afin de trouver un optimum zootechnique et économique. Par la suite, il a fallu mettre en place un outil d'évaluation des caractéristiques nutritives des parcours de la région d'étude, des quantités ingérées par les animaux lors du pâturage ou à l'auge et finalement de leur impact direct sur la production laitière et la satisfaction des besoins. L'évaluation des différentes conduites se reflétant dans un nombre de réponses en cours de lactation, un suivi d'analyse continu a été instauré permettant d'apprécier l'état corporel des animaux (poids, note d'état corporel, métabolites énergétiques), la production laitière (rendement, durée de lactation et composition du lait) et les performances reproductives (prolificité et croissance des chevreaux). Les capacités d'adaptation des animaux aux restrictions alimentaires dans les différentes conduites ont ainsi été testées. Ces expérimentations réalisées sur deux ans de suite ont montré que ces chèvres manifestent de réelles capacités adaptatives aux aléas alimentaires. En particulier, à chaque fois que l'alimentation le permet, l'énergie disponible est orientée préférentiellement vers la production laitière avec des rebonds relativement importants. Ces rebonds se produisent quel que soit le niveau de production laitière et pendant pratiquement toute la lactation. Parallèlement, on observe une reconstitution lente et régulière des réserves adipeuses qui s'accélère en fin de lactation à un moment où les femelles sont généralement mises à la reproduction, alors que les productions laitières baissent inexorablement. Cette thèse a donc abouti à l'acquisition de connaissances originales sur un modèle animal peu étudié caractérisé par des capacités adaptatives remarquables qui ne se manifestent pas de façon aussi marquée chez les chèvres sélectionnées des zones tempérées / Adaptives capacities of Baladi goats fed on semi-arid rangelands of Bekaa valley (Lebanon)ABSTRACTThe Lebanese Baladi goat dairy production sector suffers from a problem of food availability which is responsible of the animal's poor performances, due to its dependence towards natural rangelands and the scarcity of crop residues and forage pastures as well as of the adoption of intensive systems.In this particular agroclimatic context, this study aims to identify the optimal conduct for this goat, half-way between an extensive system where production and durability are compromised and an intense one where the aptitudes of the breed and the variety of the region's pastures are not valorized. In fact, the region's difficult climatic conditions require the insertion of a temporal dimension in the conceptualization of the optimal conduct, considering the important seasonal fluctuations of the natural feed resources. Compared to the traditional extensive conduct and to the much less adopted supplementation, a conduct where the goats were pasture driven during the spring characterized by the proliferation of green plants and kept indoors during the summer season seems a priori adapted to the local conditions and to the technical and economic objectives. However, the intensive system being rarely considered by the local farmers, the efficiency of agricultural pastures such as crop residues and forages would also have been tested in order to find an optimum between production and feasibility. Thus, an evaluation tool of the pastures' nutrition values, the quantities ingested by the animals during grazing and indoors and finally of their impact on the milk production and satisfaction of feed requirements was implemented. The evaluation of the different tested conducts were reflected on a number of physiological responses during lactation such as the animals' body reserves (body weight, body condition score, NEFA), milk production (quantities, duration and milk composition: milk fat and milk protein contents) and reproductive performances (kids' number, birth weights and growth). The animals' adaptive capacities to different food restrictions situations are hence here tested.These trials realized on two subsequent years showed that this breed demonstrates clear adaptive capacities facing feed fluctuations. A particular adaptation is the orientation of the available extra energy towards milk production with relatively important rebounds whenever allowed by refeeding. These rebounds occurred whatever the initial milk production level and during practically the whole lactation period. In parallel, we observed a slow and regular reconstitution of the body reserves which accelerates at the end of lactation, when the females are getting ready for reproduction, while the milk production suddenly breaks down. In consequent, this study has collaborated in acquiring new original information about an original animal breed characterized by special adaptive capacities which don't generally show in selected high production breeds.Kewords : Baladi goat, feeding conduct, pasture, indoors, adaptive capacities, feeding behaviour, body reserves, milk production, reproductive performances

No description available.