Drug discovery contains many strategies, one of which is the privileged scaffold strategy. This strategy incorporates a similar molecular framework within a collection of drug-like compounds in order to target various receptors. These scaffolds are useful to drug discovery scientists since they assist in developing libraries as well as demonstrating selectivity to a target. Oxazolidinones are 5-membered heterocyclic compound containing an oxygen, a nitrogen, and a carbonyl within the ring system. In this present study, the oxazolidinone structure was utilized as a privileged scaffold to target serotonin receptor 7 (5-HT7), mutated BRAF kinase (BRAFV6000E), Bruton’s tyrosine kinase (BTK), and Cyclin-dependent protein kinase 4 and 6 (CDK4/6). Aryl piperazines and piperidines were integrated as another privileged scaffold to support the selectivity towards 5-HT7, while aminopyrimidines were employed to increase binding against the kinases. The 5-HT7 oxazolidinone series was successfully synthesized and analyzed against 5-HT7; however, the three kinase oxazolidinone series were not successfully synthesized.Candidemia is the most common bloodstream infection in the U.S. and is associated with high patient mortality rates. Due to prolonged and/or repeated clinical use of current antifungal agents, drug-resistant fungi have become an emerging problem. There is a need for new antifungals to assist in overcoming drug resistant fungi. In the second project outlined in this work, a series of ketoconazole analogs were designed and successfully synthesized. The ketoconazole analogs exhibited antifungal activity; however, no clear trends were observed in this series. Overall, the series exhibited less CYP3A4 inhibition than the parent compound, ketoconazole. / Pharmaceutical Sciences

The history of privileged communication and the evolvement of the psychotherapist-patient privilege are explored. The psychotherapist-patient relationship is a relatively modern relationship. New laws concerning child abuse and neglect, and the reporting requirements of child sex offenders have begun to shape the application of privileged communication within the psychotherapist-patient. These laws exist at the federal level and throughout each of the fifty states. The effects of abrogating privileged communication for child sex offenders in the psychotherapist relationship are explored. Withdrawal of the privilege creates distrust and hinders open communication within this relationship and prevents sex offenders from receiving needed treatment. The effectiveness of treatment to sex offenders, and particularly child sex offenders, by a psychotherapist is explored. The research shows that those treated by a psychotherapist have a lower recidivism rate than those who do not receive treatment. Recommendations include a change in current federal and Florida state laws that will allow sex offenders to receive proper treatment by a psychotherapist while still protecting children from harm

This thesis is a qualitative case study that explores bisexual migrants’ experiences of belonging in Sweden. The study employs semi-structured interviews to gain an understanding of the importance of bisexual migrants’ different identities in facilitating belonging both in the context of a new country and within the wider LGBT community. Supported by theoretical concepts such as outside belonging, passing and monosexism, this thesis servers to highlight the complexities of belonging at the intersection of being bisexual and a migrant. The results of this study find that sexual identity is something more fixed than migrant identity which evokes feelings of outside belonging. The perceived LGBT-friendliness of Sweden however, proves significant in allowing participants to live out their bisexuality compared to their respective home countries, but navigating belonging within the LGBT community being bisexual can remain challenging, even in Sweden.

In drug discovery there are several approaches to lead generation and one traditional approach involves the synthesis and screening of a structurally diverse compound library against a number of biological targets to identify high affinity lead compounds. The use of a `privileged' structure-based compound library represents a viable approach that could lead to drug like lead compounds. Privileged structures are defined as those ligand substructures that may be used to generate high affinity leads for more than one type of receptor. Examples of privileged structures include phenyl substituted monocycles such as biphenyls, diphenyl methane derivatives, 1,4-dihydropyridines, fused ring systems such as chromones, quinoxalines, quinazolines, 2-benzoxazolones, indoles, benzimidazoles and benzofurans. There are several instances in the literature describing the development of compound libraries based on privileged structures with reportedly high hit rates. Privileged structure based approaches has been used with notable success in the identification of high affinity ligands especially for G-protein coupled receptors (GPCRs). The scaffold 2-aminothiazole (fused and non-fused) may be considered a privileged structure because of its occurrence in a wide variety of pharmaceuticals. The scaffold is found in antibacterials, anti-inflammatory agents, glutamate transporter (GLT-1) modulators, serotonin and muscarinic ligands. The present study involves the synthesis of a 2-aminothiazole (fused and non-fused) based compound library (60 compounds) by incorporating bioactive fragments shown to produce hits in the biological targets of interest. Microwave assisted organic synthesis (MAOS) has been employed at key steps of scaffold synthesis as well as in Suzuki coupling to generate the target aminothiazoles. Preliminary biological screening has resulted in the identification of some promising lead compounds. Trifluoromethoxy substituted aminothiazoles were found to be potent antimicrobials with MIC values in the range of 4-16 microgram/ml. Furanone based aminothiazoles showed affinity for muscarinic receptors. Piperidine based aminothiazoles showed greater than 90% of control (8-OH-DPAT) specific agonist response at the 5-HT1A receptor subtype. The Clog P values of the most potent antimicrobials were found to be in the range of 4.5-6.2 indicating the high lipophilicity of the compounds. High lipophilicity is known to cause solubility issues that may hamper future development. Therefore in an effort to make compounds with intermediate lipophilicity, the phenyl core of the potent aminothiazoles will be replaced with pyridine core using literature procedures (Pyridine core containing aminothiazoles showed Clog P < 4). Future plans include expanding the library, improving the yields of compounds and to evaluate the compounds as modulators of glutamate transporter (GLT-1). The work could be extended to include other privileged structures such as 2-aminooxazole, 2-aminobenzoxazole, 2-aminoimidazole and 2-aminobenzimidazole. These mono and bicyclic heterocyles may be considered bioisosteres of 2-aminothiazole. / Pharmaceutical Sciences

[pt] A presente dissertação buscou, por meio da análise de casos concretos e do estudo da evolução histórica das Constituições brasileiras, apresentar como as controvérsias sobre o instituto do foro por prerrogativa de função determinam e são determinadas pelas decisões do Supremo Tribunal Federal. Embora costumeiramente o debate público associe o foro distintivo à impunidade e ao incentivo à corrupção, o que pode ser muito bem resumido pelo frequente uso não técnico da expressão foro privilegiado, é possível enxergar esse instituto como importante ferramenta de essencial proteção dos mandatos eletivos. Elaborado para ser um obstáculo às perseguições contra autoridades políticas, também atua para evitar que a influência dessas mesmas autoridades seja revertida em indevida proteção pelo Poder Judiciário. A ausência de soluções fáceis para os dilemas processuais penais relativos ao tratamento jurisdicional em matéria criminal dispensado às autoridades políticas é um fato e, não por acaso, identificou-se a existência de soluções originais e particulares para a questão em diferentes países latino-americanos e potências globais. O recorte da dissertação se revela pela análise de ações penais julgadas ou em transcurso no Supremo Tribunal Federal e permite observar como a oscilação da interpretação da Corte sobre as regras desse instrumento legal reduz o grau de certeza e previsibilidade nas delicadas acusações criminais contra as autoridades políticas do país. Essa incerteza que, incentivada pelas decisões da própria Suprema Corte, acaba por configurar significativa insegurança ao regime democrático, poderia ser sanada com a edição de norma constitucional mais clara e com a cessação das reiteradas tentativas da Suprema Corte de reformar normas constitucionais e infraconstitucionais por meio de ampliações expansivas de sua interpretação. A mais importante e recente decisão da Suprema Corte para a matéria, oferecida nos autos da Questão de Ordem na Ação Penal 937, propiciou uma série de novidades nos seus regramentos. Na visão do autor, embora tais nuances tenham atingido a meta principal de reduzir os trabalhos do Supremo em sua competência criminal originária, não ofereceram esclarecimentos suficientes para que se considerem seguras as interpretações sobre o tema. / [en] This paper aims at presenting, by the analyzes of actual cases and the study of the historical evolution of Brazilian constitutions, the ways the controversial disputes around the legal instrument known as privileged jurisdiction due to public function prerogatives impact the Brazilian Supreme Court (STF) participation in the country s democratic political process. The public has usually related this constitutional safeguard to impunity and incentive to corruption, which has been summarized over the years by the popular usage of the non-technical, shortened term privileged jurisdiction (foro privilegiado). However, it is possible to acknowledge it as an important tool for the essential protection of elected mandates. Designed to be an obstacle to the persecution of political authorities, the instrument is also intended to avoid authorities misuse of their rights against Justice. The absence of easy solutions for criminal processual dilemmas related to the jurisdictional treatment of criminal matters concerning political authorities is a fact. It is no coincidence there are various examples of original and special solutions dealing with the matter throughout Latin America as well as in other global powers. The time frame of the study presents criminal procedures recently tried or in process at the Federal Supreme Court. These court actions allow us to notice the oscillation in the Court’s interpretation of the rules of the legal instrument which in turn allows less certainty and predictability concerning the delicate criminal accusations against political authorities in the country. This uncertainty, which is encouraged by the Court s decisions, ends up establishing a significant level of insecurity for the democratic regime in Brazil. That could be easily avoided by the setting of a more objective constitutional rule for the subject and by the ceasing of STF’s repetitive attempts to reform constitutional ruling or other legislation by means of expanded interpretations on the matter. The most recent decision on the subject by STF is found in the Question of Order in Criminal Procedure 937, which brought changes for the ruling of the matter. In the author s opinion, the changes reached their goal of lowering the number of cases reaching the Supreme Court, more accordingly with its original competence, however, they did not clarify important issues so as to guarantee consensus about their interpretation.

This dissertation analyzes narratives of queer partner migration, that is, a family-tie migration in which one of the partners of a relationship has migrated in order for the partners to be together, and where the partners queer the migration in the sense that they have a non-normative sexuality and/or gender identity. The purpose of the study is to examine how queer partner migrants and their Swedish partners experience the migration process – which continues also once the administrative process has been completed – by analyzing the emotions and feelings that emerge in the process. The study is a contribution to research on privileged migration as well as intimate migration. The focus is the queer partner migration relationship, and what emotions and feelings ‘do’ to this relationship, but also how emotions and feelings structure the migration process. The study analyzes the work three different emotions – love, loss, and belonging – do in these migration processes, and how this work is described in the participant narratives. Migrant participants have migrated from different parts of the world (Africa, Europe, Latin America, and North America), making it possible to analyze what emotions and feelings do in this particular migration process from the point of view of nationality and, in particular, proximity to ‘Western-ness,’ race, and language as well as how privileges connected to these positions come to matter in the process. The dissertation is an ethnographic interview study in which both migrants and Swedish partners have been interviewed. The interview material consists of a combination of couple interviews and individual interviews. By using affect theories and the concept of queer phenomenology, the dissertation shows how the work that emotions and feelings do in migration processes is connected to gender identity, sexual identity, race and whiteness, nationality, perceived proximity to Western-ness, class, language, and the migration narrative the migrating partner is (or is not) written into by way of the country they have migrated from. This is analyzed in relation to the theoretical frameworks of entanglement, homonationalism, and intimate citizenship. The analysis shows that emotions and feelings structure the migration process for both more privileged and less privileged migrants, but in different ways. The understanding of who ‘is’ a migrant, and the preparedness for the feelings that arise in a migration process, are tied to the positions mentioned above and the privileges these positions give, or do not give, the migrant access to. By focusing on emotions and feelings and what these do, the study also illustrates how the migration process affects the non-migrating partner as this partner engages in emotional labour to ‘make’ the migrating partner ‘Swedish.’ Through their the migrating partner, the non-migrating partner is also aligned in a way that makes them a little bit less ‘Swedish,’ contributing to the non-migrating partner being ‘stopped’ in ways they have usually not experienced before. The study further shows how migration processes produces inequality, and the difficulties that arise when the couples try to live up to the Swedish ideal of the equal relationship. The interviews are analyzed as narratives, and both narratives and storytelling are important throughout the dissertation, not only as the method used in the analysis but as the form of the dissertation, making it a kind of super structure organizing the writing. Writing (how to write accessibly and interesting) and reading (how to write in order to invite an open and active reading) are important aspects of the dissertation. / Avhandlingen analyserar narrativ om queer partnermigration, dvs en familjebandsmigration i vilken en av de två personerna i ett parförhållande migrerar för att de två ska kunna leva i samma land och i vilken de två individerna queerar migrationen på så sätt att de har en icke-normativ sexualitet och/eller könsidentitet. Syftet med studien är att undersöka hur queera partnermigranter och deras svenska partners upplever migrationsprocessen – vilken pågår även efter att den administrativa processen är avslutad – genom att analysera de känslor som uppstår i processen. Studien är ett bidrag till forskning om så väl privilegierad migration som intim migration. I fokus står det queera partnermigrationsförhållandet och vad känslor ”gör” med detta förhållande, men också hur känslor strukturerar migrationsprocessen på olika sätt. Studien analyserar det arbete tre olika känslor – kärlek, förlust och tillhörighet – gör i migrationsprocessen och hur detta arbete beskrivs i deltagarnas narrativ. Migrantdeltagarna i studien kommer från olika delar av världen (Afrika, Europa, Latinamerika och Nordamerika), vilket gör det möjligt att analysera vad känslor gör i den här specifika migrationsprocessen utifrån nationalitet, och specifikt närhet till västerländskhet, ras och språkbakgrund samt hur privilegier kopplade till dessa positioner spelar in i processen. Avhandlingen är en etnografisk intervjustudie där både migranter och svenska partners har intervjuats. Intervjumaterialet består av en blandning av parintervjuer och enskilda intervjuer. Genom att använda affektteorier och queer fenomenologi visar avhandlingen hur det arbete känslor utför i migrationsprocesser är kopplat till könsidentitet, sexuell identitet, ras och vithet, nationalitet, upplevd närhet till västerländskhet, klass, språk och det migrationsnarrativ den migrerande partnern är inskriven i (eller inte) genom det land den migrerat från. Detta analyseras i relation till de teoretiska ramverken trassel (entanglement), homonationalism och intimt medborgarskap. I analysen framkommer att känslor strukturerar migrationsprocessen för både mer privilegierade och mindre privilegierade migranter men på olika sätt. Förståelsen av vem som ”är” en migrant och beredskapen för de känslor som uppstår i migrationsprocessen är till stor del kopplade till de positioner som nämns ovan samt de privilegier migranten har tillgång till genom dessa. Genom att fokusera på känslor och vad dessa gör visar studien också att migrationsprocessen påverkar den icke-migrerande partnern genom att denna förutsätts utföra känsloarbete för att ”göra” den migrerande partnern ”svensk.” Samtidigt blir den icke-migrerande partnern själv, genom sin migrerande partner, riktad på ett sätt som gör den lite mindre ”svensk”, vilket bidrar till att också den icke-migrerande partnerns liv ”stoppas” på sätt den vanligtvis inte tidigare upplevt. Studien visar vidare på hur migrationsprocesser producerar ojämlikhet och de svårigheter som då uppstår när paren försöker leva upp till det jämlika svenska idealförhållandet. Intervjuerna är analyserade som narrativ och både narrativ och berättande är genomgående viktiga i avhandlingen, inte bara som metod utan också som avhandlingens form och en slags struktur som organiserar texten. Skrivande (att skriva tillgängligt och intressant) och läsande (att skriva på ett sätt som inbjuder till öppet och aktivt läsande) är viktiga aspekter i avhandlingen.

The learning using privileged information paradigm has allowed support vector machine models to incorporate privileged information, variables available in the training set but not in the test set, to improve predictive ability. The consequent introduction of the knowledge transfer method has enabled a practical application of support vector machine models utilizing privileged information. This thesis describes a modified knowledge transfer method inspired by cross-validation, which unlike the current standard knowledge transfer method does not create the knowledge transfer function and the approximated privileged features used in the support vector machines on the same observations. The modified method, the robust knowledge transfer, is described and evaluated versus the standard knowledge transfer method and is shown to be able to improve the predictive performance of the support vector machines for both binary classification and regression.

It is widely believed that we have immediate, introspective access to the content of our own thoughts. This access is assumed to be privileged in a way that our access to the thought content of others is not. It is also widely believed that, in many cases, thought content is individuated according to properties that are external to the thinker's head. I will refer to these theses as privileged access and content externalism, respectively. Though both are widely held to be true, various arguments have been put forth to the effect that they are incompatible. This charge of incompatibilism has been met with a variety of compatibilist responses, each of which has received its own share of criticism. In this thesis, I will argue that a contrastive account of self-knowledge is a novel compatibilist response that shows significant promise.

One of the countries where the basic academic education is problematic to achieve is Tanzania. Despite the multiple attempts to increase enrolments and decrease dropouts through new partnerships and organizations, high level of drop out still occur in the country. Two research questions were composed in aim to understand why this drop out phenomenon still occur. First question: “Which individual/ collective factors contribute to that girls and boys in the age group between 7 and 13 drop out of  primary schools?” and the second question: “What differences are there in the drop out causes between two more “privileged” and one more “marginalized” school?”.  The answers to these questions were found through the field work in Babati Town Council, Tanzania. There primary data was gathered in form of semi-structured interviews with three headteachers from three different schools. Two privileged schools; Maisaka Primary School and Primary School Oyster bay, and one marginalized school; Kiongozi Primary School. Also interviews with nine parents/other guardians of dropouts were conducted. Gathered data was summarized in short case stories, narratives which later on were analyzed with in a theoretical framework. This theoretical framework consisted of six different theories. These theories are; Academic Mediation theory, General Deviance theory, Deviant Affiliation theory, Poor Family Socialization theory, Structural Strains theory and lastly a theory of Institutional Departure. The conclusion of the study is that, even though the schools are located in the same area a major difference in dropout rates and its causes are existing. At the marginalized school there is a high level of drop out and at more privileged schools no dropouts occur. Factors which play a major role for this existing difference are; childrens and parents commitment to school, family structure and background, family's socio-economic status, relationships in the family and of course quality of the school.

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