The main objective of this thesis Business plan -- Animaland is to create a business plan to establish a company to provide alternative medicine services for animals close to Ostrava and testing the viability of this business plan. The theoretical part focuses on the specifies of small and medium enterprises and the principles of processing a business plan. At the end of the theoretical part are described the alternative methods used in the Czech Republic. In the practical part is already prepared a business plan itself, with all the essentials that business plan should include. These are market analysis, competition analysis, marketing plan, financial plan, risk analysis etc.

The diploma thesis is focused on the analysis of accessability of homes for the elderly people in the Pardubice region. The first part is the definition of terms and evaluation of various types of social assistance and an explanation of who is and who can be a provider of social services under the law. The practical part is focused on the analysis of the provision of residential services for seniors in the region. There are also analysed data of individual regions of this area and proposal how to improve the financial situation and the availability of homes for the elderly.

The thesis focus on fraud management - the detection of fraudulent behavior. In the first part current market situation in finance, telecommunications and healthcare is mapped. Following section contains the review of methods used for data mining which is closely related to detection of fradulent or non-standard behaviour. Part of the thesis is focused on the fraudulent behaviour detection in the procurement area. The whole cycle of deployment and use of the tool for detection is introduced. It covers data collection, identification of suspected cases, outcomes analysis and recommendations how to prevent from fraud.

The goal of this thesis is to evaluate Android in context of other mobile operating system currently available on the market. I will mention history of Android, it's evolution and comparison with other mobile platforms. On the sample application I will introduce the principles of development for the Android operating system. Finally, I will describe monetization on real data provided by developers.

The subject of this thesis is an analysis of various stylistic aspects of Karel Čapek's Povídky z jedné a z druhé kapsy and Devatero pohádek. In the first part, the author deals with a distinctive feature of Čapek's works, which is an attempt to cause an impression of an oral narrative. At first, she studies an influence of this feature on general composition of the chosen writings. Then she analyses particular language means. The second part explores other stylistic and linguistic means, which are typical for chosen material. These are for example accumulations of synonymic expressions, playing with acoustic form of language or utilization of elements from foreign languages. Witnih each topic, the author compares the three texts. Key words Karel Čapek, short prose, literature for children, analysis of language

Diversas características interferem na aceitabilidade de variedades de feijoeiro (Phaseolus vulgaris L.) no mercado consumidor, como o brilho do tegumento. Geralmente, o feijão com brilho é rejeitado para consumo, pois apresenta difícil cozimento. No entanto, o brilho pode conferir resistência ao ataque de insetos e patógenos à semente, podendo constituir uma vantagem para o melhoramento do feijão. A presença de brilho é devida à expressão do gene Asp (Asper) na forma alélica dominante. Genótipos aspasp, portanto, apresentam tegumento opaco. Outro gene, J (Joker), interfere na expressão da característica, de modo que o alelo recessivo j diminui a intensidade do brilho e altera a coloração do tegumento. J é considerado o precursor de polifenois denominados pró-antocianidinas. Na presença j estes compostos não são sintetizados. No presente trabalho foram genotipadas variedades de feijoeiro crioulas [Serro Azul Brilhante (SAB - tegumento brilhante) e Fosco (SAF - tegumento opaco) e Puebla-152 (P-152 - brilhante)] e a cultivar Diamante Negro (DN - opaco), contrastantes para o brilho do tegumento. Análises fenotípicas, morfológicas e bioquímicas permitiram inferir os genótipos das variedades e avaliar a segregação do brilho em populações derivadas de cruzamentos entre contrastantes: SAF x SAB e P-152 x DN. Os resultados mostraram que as variedades não variam para J, apenas para Asp, sendo que SAB e P-152 carregam Asp e SAF e DN o alelo asp. Em todos os cruzamentos a segregação foi de três brilhantes (Asp) para um opaco (asp) na geração F2 e de cinco brilhantes para três opacos em F3. A partir dos resultados, as variedades foram contrastadas por meio de marcadores de AFLP, analisando-se a similaridade genética e identificando-se bandas diferenciadoras entre as mesmas. A partir disso, foi empregada a metodologia de Bulk Segregant Analysis na população F2 de P-152 x DN, para encontrar marcadores AFLP candidatos ao mapeamento do brilho. Foram encontrados marcadores associados que, no entanto, revelaram serem falsos positivos. Análises utilizando marcadores microssatélites ou análises bioinformáticas de sintenia com a soja poderiam ser realizadas, visando detectar marcadores precisamente ligados à característica / Several characteristics interfere in acceptability of common bean varieties (Phaseolus vulgaris L.) by consumers, like seed coat shininess. Generally, varieties with shiny seed coat are rejected by consumers due to their difficult cooking. However, shininess could confer resistance to insects attak and also pathogens to the seed, giving an advantage for this trait in common bean breeding. The presence of shininess is due the expression of the Asp (Asper) gene in the dominant allelic form. Other gene, J (Joker), interferes on the expression of this characteristic, with j conditioning a less shiny seed coat and changing seed coat color. J is considered the precursor of a class of polyfenols called pro-anthocyanidins. In the presence of j these compounds are not synthesized. In the present work we genotyped common bean landraces [Shiny Serro Azul (SAB shiny seed coat) and Dull Serro Azul (SAF dull seed coat) and Puebla-152 (P-152 shiny)] and the cultivar Diamante Negro (DN dull), contrasting for seed coat shininess. Phenotypic, morphological and biochemical analyses allowed to genotype all varieties and evaluate the segregation of shinines in populations derived from crosses between contrasting genotypes: SAF x SAB and P-152 x DN. Results showed that varieties do not vary for J, only for Asp. SAB and P-152 carry Asp and SAF and DN carry asp. In all crosses segregation was of three shiny (Asp) for one opaque (asp) in F2 and of five shiny for three dull in F3. Based on the results, all varities were contrasted by AFLP markers, analyzing genetic similarity and identifying differencial bands among all of them. Further it was used the Bulk Segregant Analysis method in population F2 of the cross P-152 x DN, aiming to find candidate AFLP markers for shininess mapping. We found markers associated but they revealed to be false positives. Further analyses using microsatellite markers or sinteny comparisons with soybean genome could be done, aiming to find specific markers linked to this trait

O PP é descartado em grande quantidade no meio ambiente, tendo em vista seu consumo muito elevado derivado de suas excelentes propriedades químicas e físicas, boa processabilidade e baixo custo. As radiações ionizantes, não ionizantes (UV e infravermelho), bem como o oxigênio e os poluentes podem causar a degradação do polipropileno (PP). A exposição à radiação ionizante pode causar na molécula de PP cisão de cadeia principal, reticulação e peroxidação (na presença de ar) entre outras. Este estudo tem como objetivo, o desenvolvimento de um PP oxidegradável por meio do controle da degradação induzida por radiação ionizante. As amostras foram processadas por injeção e expostas ao envelhecimento natural durante 180 dias e ao envelhecimento acelerado em estufa á 100°C por 192 dias e depois caracterizadas por avaliação visual, ensaios mecânicos, FTIR, SEM, DSC, TGA e DRX. As amostras de PP Grão 20 kGy, após o envelhecimento natural, apresentaram maior oxidação com presença de fissuras superficiais mais intensamente do que o PP d2w&reg. A resistência a tração do PP irradiado foi superior ao PP d2w&reg e os resultados do alongamento na ruptura mostraram uma diminuição intensa se compararmos o PP irradiado e o PP d2w&reg com o PP. Após a exposição natural espécies os índices de vinila e carbonila aumentaram ligeiramente devido as reações Norrish. O grupo carbonila promove uma oxidação contínua, junto à superfície fazendo com que o polímero diminua sua massa molar. O efeito da degradação natural foi evidente na ordem PP Grão 20 kGy > PP Grão 12,5 kGy = PP d2w&reg > PP. Por conseguinte, este conceito pode ser utilizado para produzir um PP com propriedades oxi-degradáveis de uma forma controlável. / UV light, heat, and pollutants can interact with Polypropylene (PP) molecules, mainly with the tertiary carbon producing free radicals which can react with oxygen producing changes in its properties. PP has outstanding chemical and physical properties and a good processability at very low market price. In addition, PP is extensively used for manufacturing various kinds of products, however due to its large-scale consumption a lot of waste is generated at the end of their life cycle to the environment with low rate degradation. Controlled degradation of PP can be achieved by exposing the polymers to well defined parameters, such as absorbed dose, intemperies, oxygen, etc. In this study, structural changes in PP macro-molecule are created upon exposure to ionizing radiation such as: main chain scission, crosslinking and peroxidation (in presence of air). This study has the objective of comparing the environmental and accelerated exposures of PP neat, PP irradiated with 12,5 kGy and 20 kGy and the incorporation of the commercial pro-degradant d2w&reg. Dumbbell samples were manufactured by injection molding and exposed to the environment during 180 days and to accelerated aging to 192 days. The samples were characterized by Mechanical Testing, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X-ray Diffraction (DRX) and Differential Scanning Calorimetry (DSC). The samples previously irradiated, PP 20 kGy, after environmental aging showed higher oxidation and presence of surface cracks than the PP d2w&reg and PP neat. They also showed presence of carbonyl groups, decreases in elongation at break, increase in Strength Modulus and decrease of melting temperature corroborating with degradation.

O manganês (Mn) é um elemento químico abundante na natureza, principalmente em minérios e presente também em alimentos e na água. É o cofator de enzimas importantes, como a superóxido dismutase mitocondrial. Entretanto, mineradores e outras pessoas expostas a produtos manufaturados de Mn podem apresentar uma concentração excessiva desse metal no cérebro, adquirindo uma desordem neurológica similar ao mal de Parkinson conhecida por manganismo. Basicamente a neurotoxicidade do Mn pode estar associada com os vários estados de oxidação que ele pode alcançar, gerando espécies reativas de oxigênio durante a interconversão dessas espécies. Dessa forma, neste trabalho sintetizamos e avaliamos as propriedades pró-oxidantes e neurotóxicas de complexos de Mn(III) com desferrioxamina, [Mn(dfb)]; acetohidroxamato, [Mn(aha)3]; citrato, [Mn(cit)]; cloro-salen, EUK 8; e aceto-salen, EUK 108. Tais compostos são propostos como miméticos da SOD e/ou catalase, entretanto podem apresentar atividade pró-oxidante. Estes complexos foram caracterizados espectrofotometricamente (UV/Vis e IV) e por voltametria cíclica. Foram determinadas as absortividades molares dos complexos [Mn(aha)3], EUK 8 e EUK 108. Os EUK\'s apresentaram dois processos redutivos, sendo apenas um reversível, enquanto o [Mn(cit)] apresentou apenas um processo redutivo reversível e os hidroxamatos [Mn(dfb)] e [Mn(aha)3] não apresentaram processos redox na faixa de potenciais utilizada. Em teste de lipofilicidade todos os complexos apresentaram maior afinidade pela fase aquosa, sendo muito pouco particionados para a fase orgânica. Através do ensaio de supressão de fluorescência de calceína foi possível estabelecer que os EUK\'s são relativamente mais estáveis do que os outros complexos, sendo o [Mn(aha)3] o menos estável dos compostos estudados. Nas análises de atividade pró-oxidante, o [Mn(dfb)] oxidou fortemente a sonda mesmo na ausência de outros cofatores, mas este processo é dependente da concentração de O2 no meio. Os EUK\'s atuaram como pró-oxidantes em função da concentração de peróxido no meio. A atividade pró-oxidante foi suprimida por ascorbato, glutationa e Trolox®, que agiram como antioxidantes, sugerindo implicações para a terapia do manganismo. O teste de toxicidade aguda em paulistinhas (Danio rerio) adultos resultou na mortalidade de alguns animais quando expostos a [Mn(dfb)] e [Mn(aha)3]. Comparando o telencéfalo de peixes expostos ao [Mn(dfb)] com um controle em microscópio, não se visualizou nenhuma alteração morfológica na região do núcleo dorsal, indicando que o complexo não causou nenhum dano visível nessa região. / Manganese (Mn) is an abundant element which is present also in food and water. It is the cofactor of important enzymes such as mitochondrial superoxide dismutase. However, miners and other occupationally exposed individuals may present an excessive load of Mn in brain and develop manganism, a neurological disorder akin to Parkinson Disease. Basically, Mn neurotoxicity may stem from its wide redox cycle, generating reactive oxygen species in the process of converting from one oxidation state to another. Thus, in this work we synthesized and evaluated the pro-oxidant and neurotoxic characteristics of Mn(III) complexes with desferrioxamine, [Mn(dfb)]; acetohydroxamate, [Mn(aha)3]; citrate, [Mn(cit)]; chlorosalen, EUK 8; and aceto-salen, EUK 108. Such compounds are proposed as mimetics of superoxide dismutase and/or catalase, however they may also be prooxidant. These complexes were characterized spectrophotometrically (UV/Vis and IR) and by cyclic voltammetry. Molar absorptivities were determined for [Mn(aha)3], EUK 8 and EUK 108. EUK\'s displayed two reductive processes, only one of which was reversible, while [Mn(cit)] displayed only one (reversible) reductive process and hydroxamates [Mn(dfb)] and [Mn(aha)3] did not display redox processes in the working range of potentials. Lipophilicity tests showed that all complexes have very low partition to the organic phase. Calcein fluorescence quenching studies showed that both EUK complexes are relatively more stable than the others, while [Mn(aha)3] is the least stable. In the pro-oxidant activity studies, [Mn(dfb)] strongly oxidized the fluorescent probe even in the absence of ancillary substances such as peroxide. However, this effect was dependant on O2 saturation in the solution. Both EUK acted as pro-oxidants with a linear dependence on peroxide concentration. Pro-oxidant activity was eliminated by the treatment with antioxidants such as ascorbate, glutathione and Trolox®, which is of interest for the therapy of manganism. In the acute toxicity tests induced some mortality in adult Danio rerio exposed to [Mn(dfb)] or [Mn(aha)3]. Comparison of the telencephalus of [Mn(dfb)]-exposed individuals with controls failed to indicate morphological alterations in the dorsal nucleus area, indicating that the complex did not affect visibly this brain region.

Syftet med mitt arbete var att jag ville ta reda på hur jag kunde effektivisera min skapandeprocess för att kunna färdigproducera en hiphoplåt om dagen.  Jag producerade fyra låtar. Genom att kartlägga mina beteenden i min skapandeprocess kunde jag med hjälp av litteraturstudier plocka fram metoder för att öka min kreativitet och effektivitet.

Pro-anorexia content, or content that promotes the development and sustainment of eating disorders, is an important topic that has been understudied in the literature. Previous research has primary examined the content featured on pro-anorexia websites, but few researchers have conducted experimental studies examining the direct impact viewing pro-anorexia content has on individuals struggling with an eating disorder. The current study was an experimental study that exposed participants to three conditions: proanorexia content, pro-recovery content, and a control group. The researcher examined the impact that viewing the three levels of content for 10 minutes had on individuals who met criteria and who did not meet criteria for an eating disorder on the Eating Disorder Diagnostic Scale. Participants were examined using the Eating Attitudes Test to examine eating disorder symptomology and the Body Assessment Scale to examine body satisfaction after every condition. The results of this study showed that participants who met criteria for an eating disorder reported increased eating disorder symptomology after viewing the pro-anorexia condition.