[pt] Esta dissertação é um estudo sobre o designer empreendedor e os modelos de processo de design e inovação no contexto das startups com base de design. Em um momento em que as tecnologias de manufatura digital e os meios digitais permitem ao designer projetar, produzir e distribuir de forma independente seus produtos, as possibilidades de sua atuação se transformam. O interesse pelo tema deste trabalho e pela relação entre empreendedorismo e design visa contribuir para o campo e preencher uma lacuna existente na formação dos designers no que toca as diferentes maneiras de atuação no mercado hoje. Assim, essa dissertação pesquisou os processos de design e de inovação descritos na literatura e as formas de estruturação de processos utilizados na prática diária do empreendedorismo em design.Esta pesquisa se organizou através de revisão bibliográfica sobre modelos de processo de design e modelos de processo de inovação. Posteriormente, foram realizadas entrevistas semiestruturadas com designers empreendedores para compreender como sua atuação na prática social e a vivência do empreendedorismo em design moldam os processos destes profissionais. Como resultados são elencados modelos de processo de referência e feitas considerações sobre as características deste designer empreendedor e suas formas de estruturação de processos no que toca as formulações de estratégias de negócios, esquemas produtivos, esquemas de viabilização econômica dos projetos e saídas comerciais para os produtos. São assim levantados pontos a serem considerados para uma discussão alicerçada naquilo que guia os designers na realização de seus projetos, os modelos de processo de design de produto no contexto do empreendedorismo. / [en] This dissertation is a study on the entrepreneurial designer and the design and innovation process models in the context of design intensive startups. At a time when digital manufacturing technologies and digital media allow the designer to independently design, produce and distribute their products, the possibilities of their performance are transformed. The interest in the theme of this work and the relationship between entrepreneurship and design aims to contribute to the field and fill a gap in the training of designers in what concerns the different ways of acting in the market today. Thus, this dissertation investigated the processes of design and innovation described in the literature and the forms of process structure used in the daily practice of entrepreneurship in design. This research was organized through a literature review on models of the design process and innovation process models. Subsequently, semi-structured interviews were conducted with entrepreneurial designers to understand how their work in social practice and the experience of entrepreneurship in design shape the processes of these professionals. As results are listed reference process models and made considerations about the characteristics of this entrepreneurial designer and its forms of process structuring in what concerns the formulations of business strategies, productive schemes, schemes of economic feasibility of the projects and commercial outlets for the products . Thus points are raised to be considered for a discussion based on what guides designers in the realization of their projects, the product design process models in the context of entrepreneurship.

Studiens syfte var att undersöka hur upplever Pro-gamers inom FIFA stressorer och vilka copingstrategier som används för att hantera dem. Studiens fokus var på att få fram upplevelser av stressorer hos deltagarna och om de upplever just dessa faktorer, vad de använder sig av för copingstrategier för att hantera dessa situationer. Det deltog totalt åtta stycken intervjupersoner där alla var män i åldrarna 17-34 år (M=22,5) där dessa intervjupersoner befann sig i inklusionskriterie för att medverka i studien där alla var pro-gamers inom FIFA. Studien har utgått ifrån en kvalitativ forskningsmetod och använt sig av semistrukturerade intervjuer för samla in data och intervjuguide som grund har utgått utifrån ett teoretiskt ramverk, McGrath (1970) fyra-stegs stressprocess modellen. I studiens resultat framkommer det totalt två stycken huvudteman, det första huvudtemat som nämns är upplevda stressorer, som totalt har fem stycken underliggande teman. Dessa är krav på sig själv, krav från samhället, krav från föreningen, krav från fans och krav från vänner och familj. Det andra huvudtemat som framkommer i studien är copingstrategier som används för att hantera upplevda stressorer som har totalt fyra stycken underliggande teman. Dessa är stöd från föreningen, stöd från familj, stöd från vänner och copingstrategier i sitt FIFA-utövande. Resultatdelen i studien har olika svarsteman men det var bland annat att intervjupersoner upplever stressorer i sitt FIFA spelande där de bland annat upplever krav på sig själv, samhället, föreningen, fans samt från sina vänner och familj. I resultatdelen framkom det även vilka copingstrategier som intervjupersoner använder sig av för att hantera dessa krav som kan bidra till att deltagarna upplever stressorer. Det som framkom var till exempel att de upplevde att det fanns bra stöd från föreningen och använde sig av den möjligheten, från sin familj och vänner men att de också använde sig av individuella copingstrategier såsom fysisk aktivitet eller att gå ut och promenera. Studiens resultat kan i framtiden vara användbar till framtida forskning för esportföreningar och liknande organisationer. Detta genom att studiens resultat kan forskas vidare kring bland annat vilka copingstrategier som kan användas om man i sitt FIFA-utövande upplever stressorer. / The purpose of the study was to investigate how Pro-gamers within FIFA experience stressors and which coping strategies are used to deal with them. The focus of the study was to bring out experiences of stressors in the participants to write if they experience and lead to any stress and performance anxiety when they are in a competitive context and if they experience these factors what they use for coping strategies to deal with these situations. A total of eight interviewees participated where all were men aged 17-34 years (M=22.5, SD=?) where these interviewees were in the inclusion criteria to participate in the studies where all were pro-gamers within FIFA. The study was based on a qualitative research method and used semi-structured interviews to collect data and an interview guide based on a theoretical framework, McGrath's (1970) four-step stress process model. In the results of the study, a total of two main themes emerge, the first main theme mentioned is perceived stressors, which in total has five underlying themes. These are demands on oneself, demands of society demands of the association, demands of fans and demands of friends and family. The second main theme that emerges in the study is coping strategies used to manage perceived stressors, that have a total of four underlying themes. These are support from the association, support from family, support from friends and coping strategies in their FIFA practice. The results part in the studies has different answers, but it was, among other things, that interviewees experience stressors in their FIFA playing, where they experience demands on themselves, society, the association, fans and from their friends and family, among other things. In the results section, it was also revealed which strategies the interviewees use to deal with these demands, which can contribute to the participants experiencing stressors. What emerged was, for example, that they felt that there was good support from the association and used the opportunity from their family and friends that they also used individual strategies such as physical activity or going out for a walk. The results of the study may in the future be useful to future research for esports associations and similar organizations. This is because the study's results can be further researched on, among other things, which coping strategies can be used if you experience stressors in your FIFA practice.

This dissertation focuses on the re-use of business process reference models, available in a business process model warehouse, to enable the definition of more comprehensive business requirements. It proposes a business process model warehouse framework to promote the re-use of multiple business process reference models and the flexible visualisation of business process models. The critical success factor for such a framework is that it should contribute to minimise to some extent the causes of inadequate business requirements. The proposed framework is based on an analogy with a data warehouse framework, consisting of the following components: usage of multiple business process reference models as source models, the conceptual design of a process to extract, load and transform multiple business process reference models into a repository, a description of repository functionality for managing enterprise architecture artefacts, and motivation of flexible visualisation of business process models to ensure more comprehensive business requirements. / Computer Science (School of Computing) / M.Sc. (Information Systems)

The use of computer modeling is fast increasing in almost every scientific, engineering and business arena. This dissertation investigates some challenging issues in design, modeling and analysis of computer experiments, which will consist of four major parts. In the first part, a new approach is developed to combine data from approximate and detailed simulations to build a surrogate model based on some stochastic models. In the second part, we propose some Bayesian hierarchical Gaussian process models to integrate data from different types of experiments. The third part concerns the development of latent variable models for computer experiments with multivariate response with application to data center temperature modeling. The last chapter is devoted to the development of nested space-filling designs for multiple experiments with different levels of accuracy.

In this thesis, a service oriented decomposition approach: Use case Driven Service Oriented Architecture (UDSOA), is introduced to close the gap between business requirements and SOA (Service Oriented Architecture) design by including business use cases and system use cases into decomposition process. The approach is constructed upon Service Oriented Software Engineering (SOSE) modeling technique and aims to fill the deficits of it at the decomposition phase. Further, it aims to involve both business vision and Information Technologies concerns in the decomposition process. This approach starts with functional top-down decomposition of the domain. Then, business use cases are used for further decomposition because of their high-level view. This connects the business requirements and our SOA design. Also it raises the level of abstraction which allows us to focus on business services. Second step of the SOA approach uses system use cases to continue decomposition. System use cases help discovering technical web services and allocating them on the decomposition tree. Service oriented analysis also helps separating business and technical services in tightly coupled architecture conditions. Those two steps together bring quality in to both problem and solution domains.

Cette thèse traite de stratégies d'évaluation séquentielle et batch-séquentielle de fonctions à valeurs réelles sous un budget d'évaluation limité, à l'aide de modèles à processus Gaussiens. Des stratégies optimales de réduction séquentielle d'incertitude (SUR) sont étudiées pour deux problèmes différents, motivés par des cas d'application en sûreté nucléaire. Tout d'abord, nous traitons le problème d'identification d'un ensemble d'excursion au dessus d'un seuil T d'une fonction f à valeurs réelles. Ensuite, nous étudions le problème d'identification de l'ensemble des configurations "robustes, contrôlées", c'est à dire l'ensemble des inputs contrôlés où la fonction demeure sous T quelle que soit la valeur des différents inputs non-contrôlés. De nouvelles stratégies SUR sont présentés. Nous donnons aussi des procédures efficientes et des formules permettant d'utiliser ces stratégies sur des applications concrètes. L'utilisation de formules rapides pour recalculer rapidement le posterior de la moyenne ou de la fonction de covariance d'un processus Gaussien (les "formules d'update de krigeage") ne fournit pas uniquement une économie computationnelle importante. Elles sont aussi l'un des ingrédient clé pour obtenir des formules fermées permettant l'utilisation en pratique de stratégies d'évaluation coûteuses en temps de calcul. Une contribution en optimisation batch-séquentielle utilisant le Multi-points Expected Improvement est également présentée.

Submitted by Lukas Riehl Figueiredo null (lukas_rf@hotmail.com) on 2018-06-05T16:44:30Z No. of bitstreams: 1 Dissertacao-Lukas-Riehl-Figueiredo.pdf: 2667513 bytes, checksum: ea70d94af0366189c71508909d5f3ba7 (MD5) / Rejected by Elza Mitiko Sato null (elzasato@ibilce.unesp.br), reason: Solicitamos que realize correções na submissão seguindo as orientações abaixo: Problema 01) Na folha de aprovação deve constar a data(dia, mês e ano) da defesa, no seu arquivo está somente o ano. Lembramos que o arquivo depositado no repositório deve ser igual ao impresso, o rigor com o padrão da Universidade se deve ao fato de que o seu trabalho passará a ser visível mundialmente. Agradecemos a compreensão. on 2018-06-06T15:51:03Z (GMT) / Submitted by Lukas Riehl Figueiredo null (lukas_rf@hotmail.com) on 2018-06-06T21:57:37Z No. of bitstreams: 1 Dissertacao-Lukas-VF.pdf: 2667598 bytes, checksum: 032e5b83677ed9c2b780bd1c8401aa2e (MD5) / Approved for entry into archive by Elza Mitiko Sato null (elzasato@ibilce.unesp.br) on 2018-06-08T13:33:19Z (GMT) No. of bitstreams: 1 figueiredo_lr_me_sjrp.pdf: 2667598 bytes, checksum: 032e5b83677ed9c2b780bd1c8401aa2e (MD5) / Made available in DSpace on 2018-06-08T13:33:19Z (GMT). No. of bitstreams: 1 figueiredo_lr_me_sjrp.pdf: 2667598 bytes, checksum: 032e5b83677ed9c2b780bd1c8401aa2e (MD5) Previous issue date: 2018-02-01 / Modelos de processos de negócio têm sido utilizados em ambientes organizacionais para o entendimento da cadeia de processos, visando melhorias técnicas, gerenciais e estratégicas. Esses modelos abrangem variadas informações sobre os recursos utilizados e interações entre diferentes setores e pessoas, evidenciando interdependências entre os processos. Contudo, esses modelos podem apresentar problemas de legibilidade e dificuldades de navegação à medida em que se tornam extensos. A representação do conhecimento implícito é complexa e não está padronizada; as interdependências nem sempre são fáceis de serem compreendidas. O uso de ontologias tem aberto uma perspectiva complementar para mitigar esses problemas e prover processos com semânticas acessíveis por máquina. As ontologias contribuem para a conceituação e organização da informação embutida e desestruturada que se encontra presente nos processos de negócio e que deve ser explorada. As ontologias são utilizadas para estruturar o conhecimento implícito que está presente nos processos de negócio, possibilitando a compreensão desse conhecimento por máquina. As ontologias também contribuem para o alinhamento das visões das equipes de negócio e de Tecnologia da Informação da organização. Nesse contexto, este trabalho apresenta um processo sistemático para gerar uma ontologia a partir de um modelo de processos de negócio em BPMN v2.0, permitindo consultar informações sobre o modelo. Uma ferramenta denominada PM2ONTO foi então desenvolvida, visando gerar a ontologia em OWL automaticamente e disponibilizar uma interface para consultas predefinidas, elaboradas na linguagem SPARQL. Os modelos de processos de negócio devem ser exportados para arquivos em XPDL v2.2, os quais serão as entradas do sistema PM2ONTO. As ontologias resultantes ficam disponíveis em um banco de dados para consultas e também podem ser manipuladas por outras diferentes ferramentas. A avaliação do processo sistemático apresentado neste trabalho foi feita com base em estudos de caso, usando modelos de processos de negócio de diferentes áreas e diferentes níveis de complexidade. / Aiming technical, managerial and strategic improvements, business process models have been used in organizational environments to understand the process chain. Although these models may present readability problems and navigation difficulties as they become extensive, they can cover many information about resources and interactions between different sectors and people, showing interdependencies among the processes. Interdependencies are not always easy to understand because of its complex and not standardized knowledge. The use of ontologies has opened a complementary perspective to mitigate these problems and to provide processes with machine-accessible semantics. Also, they contribute in the conceptualization and organization of the embedded and unstructured information that is present in the business processes and that must be explored. In order to ease machine knowledge, ontologies are used to structure the implicit knowledge in business processes. They also contribute to the alignment of the organization's business and IT teams. In this context, this work presents a systematic process to generate an ontology from a business process model in BPMN v2.0, allowing to query information about the model. In this way, PM2ONTO tool was developed aiming to generate the ontology in OWL automatically and to provide an interface for predefined queries elaborated in the SPARQL language. Business process models should be exported to files in XPDL v2.2, which will be the inputs of the PM2ONTO system. The resulting ontologies stay available in a database for queries and can also be manipulated by other different tools. The systematic process evaluation presented in this work was made based on case studies, using business process models of different areas and different levels of complexity.

This dissertation focuses on the re-use of business process reference models, available in a business process model warehouse, to enable the definition of more comprehensive business requirements. It proposes a business process model warehouse framework to promote the re-use of multiple business process reference models and the flexible visualisation of business process models. The critical success factor for such a framework is that it should contribute to minimise to some extent the causes of inadequate business requirements. The proposed framework is based on an analogy with a data warehouse framework, consisting of the following components: usage of multiple business process reference models as source models, the conceptual design of a process to extract, load and transform multiple business process reference models into a repository, a description of repository functionality for managing enterprise architecture artefacts, and motivation of flexible visualisation of business process models to ensure more comprehensive business requirements. / Computer Science (School of Computing) / M.Sc. (Information Systems)

Depuis le Baby-Boom d'après guerre, la France, comme d'autres pays, est confrontée à un vieillissement de la population et à des pathologies qui deviennent de plus en plus chroniques. Ces nouveaux problèmes de santé impliquent des prises en charge plus fréquentes, plus complexes et plus transversales. Cependant, plusieurs freins liés à l'évolution de la société où à l'organisation interne du système de santé, viennent entraver le développement de prises en charge adaptées pour répondre aux nouveaux besoins. Dans un contexte de réduction des dépenses, il est nécessaire d'avoir une meilleure maîtrise des processus de santé.L'objectif de nos travaux est de proposer un ensemble de méthodes pour une meilleure compréhension du parcours de santé de la personne âgée en Auvergne. Pour cela, une description des parcours des personnes âgées est nécessaire pour avoir cette vue d'ensemble aujourd'hui manquante. De plus, cela permettra d'identifier les intervenants, les interactions ou encore les contraintes impliquées dans les différents parcours. Les travaux présentés dans ce manuscrit s'intéressent à deux problématiques. La première consiste à mettre au point des méthodes pour modéliser rapidement et efficacement les parcours de santé. Ces modèles permettront d'analyser comment les différents segments d'une prise en charge s'enchaînent. La seconde problématique consiste à proposer des méthodes pour extraire des informations pertinentes à partir des données selon un point de vue métier prédéfini, propre à la personne qui souhaite analyser ce modèle. Ces informations permettront par exemple de détecter des segments de parcours fréquents, ou encore anormaux.Pour répondre à ces problématiques, les méthodes que nous proposons dans ce manuscrit sont issues du process mining et du data mining. Ces disciplines ont pour objectif d'exploiter les données disponibles dans les systèmes d'information pour en extraire des connaissances pertinentes. Dans un premier temps, nous proposons une méthodologie qui se base sur le pouvoir d'expression des modèles de processus pour extraire des connaissances intéressantes. Dans un second temps, nous proposons des techniques pour construire des modèles de processus partiels, dont l'objectif est de permettre l'extraction de fragments de comportements intéressants.Les expérimentations effectuées démontrent l'efficacité des méthodes proposées. De plus, différentes études de cas ont été menées dans divers domaines pour prouver la généricité des techniques développées. / Ever since the post-World War II baby-boom, France has had to cope with an aging population and with pathologies that have become chronic. These new health problems imply more reccurent, more complex and multidisciplinary medical care. However, multiple obstacles related to the evolution of the society or to the internal organization of the healthcare system hinder the development of new and more adapted health procedures to meet new medical needs. In a context where health expanses have to be reduced, it is necessary to have a better management of health processes.Our work aims at proposing a set of methods to gain an understanding of the elderly health path in the Auvergne region. To this end, a description of the elderly health path is necessary in order to have this missing overview. Moreover, this will enable the identification of the stakeholders, their interactions and the constraints to which they are submitted in the different health procedures.The work presented in this thesis focuses on two problems. The first one consists in developing techniques to efficiently model health paths. With these models, we will be able to analyze how the different segments of a medical care are ordered. The second problem consists in developing techniques to extract relevant information from the data, according to a predefined business point of view, specific to the user who analyzes the model. This knowledge will enable the detection of frequent or abnormal parts of a health path.To resolve these problems, the methods we propose in this thesis are related to process mining and data mining. These disciplines aim at exploiting data available in today's information systems in order to discover useful knowledge. In a first part, we propose a methodology that relies on the expressive power of process models to extract relevant information. In a second part, we propose techniques to build local process models that represent interesting fragments of behavior.The experiments we performed show the efficiency of the methods we propose. Moreover, we analyze data from different application domains to prove the genericity of the developed techniques.

Codakia orbicularis est un mollusque bivalve appartenant à la famille des Lucinidae et établissant des symbioses avec des bactéries sulfo-oxydantes (symbiotes) au sein de ses branchies. Dans l’hypothèse où toute symbiose nécessite une régulation par des molécules de dialogue, une étude chimique exhaustive pourrait aboutir à la mise en évidence des métabolites impliqués. Le travail de ce manuscrit porte donc sur l'isolement de métabolites secondaires à partir des branchies de ce bivalve et sur l'évaluation de l'activité antibactérienne des molécules isolées. Douze composés ont été isolés des branchies de Codakia orbicularis et leurs structures ont été déterminées par les méthodes spectroscopiques usuelles. Parmi ces molécules, une seule est nouvelle et a été nommée orbicularisine. Elle présente un squelette indolone spirotetracyclique inédit. Parmi les molécules isolées, seules quatre d’entre elles présentent une activité antibactérienne à savoir le soufre S8, la 4-hydroxybenzaldéhyde et deux monoglycérolipides. L'orbicularisine est inactive contre un panel de lignées cellulaires cancéreuses et de kinases. Le nouveau squelette de l’orbicularisine pourrait permettre d'aboutir à une nouvelle famille de molécules par synthèse organique et ainsi d'accroître la diversité moléculaire autour de ce motif inédit. Il sera également intéressant de déterminer l'origine des molécules isolées (procaryote ou eucaryote), particulièrement pour l’orbicularisine, et leurs rôles dans le cadre de la symbiose. Les résultats chimiques obtenus sur C. orbicularis et sur les Lucinidae en général sont intéressants puisque les espèces côtières appartenant aux bivalves ont été peu exploitées en chimie jusqu’à ce jour. / Codakia orbicularis is a bivalve mollusk belonging to the family Lucinidae harboring sulfur-oxidizing bacterial endosymbionts within its gills. Considering that any symbiosis is most likely regulated by dialogue molecules, an exhaustive chemical study could lead to identify the involved metabolites. Thus, the aim of this thesis focuses on the isolation of secondary metabolites from the gills of this bivalve and the evaluation of the antibacterial activity of the isolated molecules. Twelve compounds were isolated from the gills of Codakia orbicularis and their structures were determined by usual spectroscopic methods. Among these molecules, only one presented a new structure and has been named orbicularisine. The latter presents an undescribed spirotetracyclic indolone skeleton. Regarding the biological activities, among the isolated molecules, only four of them identified as S8 sulfur, 4-hydroxybenzaldehyde and two monoglycerolipids presented an antibacterial activity. Orbicularisine was inactive against a panel of cell lines and kinase. The orbicularisine new skeleton is an interesting start for the synthesis of new family of molecules, thus enhancing its molecular diversity. It will be interesting to determine the origin of the isolated molecules (prokaryotic or eukaryotic), especially for the new orbicularisine, and their roles in the frame of the symbiosis. The chemical results obtained on C. orbicularis and on lucinids in general are interesting since the coastal species belonging to Bivalves have not been chemically explored.