The electro-optic technique of measuring the cardiovascular pulse wave known as photoplethysmography (PPG) is clinically utilised for noninvasive characterisation of physiological components by dynamic monitoring of tissue optical absorption. There has been a resurgence of interest in this technique in recent years, driven by the demand for a low cost, compact, simple and portable technology for primary care and community-based clinical settings, and the advancement of computer-based pulse wave analysis techniques. PPG signal provides a means of determining cardiovascular properties during the cardiac cycle and changes with ageing and disease. This thesis focuses on the photoplethysmographic signal for cardiovascular assessment. The contour of the PPG pulse wave is influenced by vascular ageing. Contour analysis of the PPG pulse wave provides a rapid means of assessing vascular tone and arterial stiffness. In this thesis, the parameters extracted from the PPG pulse wave are examined in young adults. The results indicate that the contour parameters of the PPG pulse wave could provide a simple and noninvasive means to study the characteristic change relating to arterial stiffness. The pulsatile component of the PPG signal is due to the pumping action of the heart, and thus could reveal the circulation changes of a specific vascular bed. Heart rate variability (HRV) represents one of the most promising quantitative markers of cardiovascular control. Calculation of HRV from the peripheral pulse wave using PPG, called pulse rate variability (PRV), is investigated. The current work has confirmed that the PPG signal could provide basic information about heart rate (HR) and its variability, and highly suggests a good alternative to understanding dynamics pertaining to the autonomic nervous system (ANS) without the use of an electrocardiogram (ECG) device. Hence, PPG measurement has the potential to be readily accepted in ambulatory cardiac monitoring due to its simplicity and comfort. Noncontact PPG (NPPG) is introduced to overcome the current limitations of contact PPG. As a contactless device, NPPG is especially attractive for physiological monitoring in ambulatory units, NICUs, or trauma centres, where attaching electrodes is either inconvenient or unfeasible. In this research, a prototype for noncontact reflection PPG (NRPPG) with a vertical cavity surface emitting laser (VCSEL) as a light source and a high-speed PiN photodiode as a photodetector is developed. The results from physiological experiments suggest that NRPPG is reliable to extract clinically useful information about cardiac condition and function. In summary, recent evidence demonstrates that PPG as a simple noninvasive measurement offers a fruitful avenue for noninvasive cardiovascular monitoring. Key words: Photoplethysmography (PPG), Cardiovascular assessment, Pulse wave contour analysis, Arterial stiffness, Heart rate (HR), Heart rate variability (HRV), Pulse rate variability (PRV), Autonomic nervous system (ANS), Electrocardiogram (ECG).

Submitted by Filipe dos Santos (fsantos@pucsp.br) on 2018-10-19T11:51:51Z No. of bitstreams: 1 Rafael Emídio Murata Rodrigues.pdf: 1071545 bytes, checksum: 468e0f7e27e278e12eed0dd52f4198cc (MD5) / Made available in DSpace on 2018-10-19T11:51:51Z (GMT). No. of bitstreams: 1 Rafael Emídio Murata Rodrigues.pdf: 1071545 bytes, checksum: 468e0f7e27e278e12eed0dd52f4198cc (MD5) Previous issue date: 2018-08-30 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / In our lives, we constantly move in streets and neighborhoods. In general, we consider time and (or distance) when planning the route. However, their solutions may face complex problems arising from the different possibilities of solutions. Similar to route planning, the Vehicle Routing Problem was introduced by George B. Dantzig and John H. Ramser in 1959 and consists of delivering gasoline to several fuel stations; at first a mathematical proposal, later became an algorithmic approach, for planning of routes of delivery of products in an optimized way (searching the "shortest path"). Although, during the search of shortest path, they are limited to the use of the streets. In this context emerges the Human Routing Problem, such an approach is not limited to streets, but makes use of all possible paths, by vehicles and humans. Such a problem can be observed in route planning at airports, museums and a supply chain company that wants to optimize the route of delivery of its products and increase customer satisfaction. Based on the Vehicle Routing Problem, the Human Routing Problem will be proposed. Its problematic will be demonstrated in a prototype, capable of assisting in the planning of human routes and three use cases. Ideas of Human Routing Problem had inspiration in the collective foraging insects / Na nossa vida, nos locomovemos constantemente em ruas e bairros. Em geral, consideramos o tempo e (ou a distância), ao planejar a rota. Contudo, suas soluções podem enfrentar problemas complexos, decorrentes das diversas possibilidades de soluções. Semelhante a planejamento de rotas, o Problema de Roteamento de Veículos foi introduzido por George B. Dantzig, e John H. Ramser em 1959 e consiste em entregar gasolina diversos postos de combustível; a princípio uma proposta matemática, mais tarde tornou-se uma abordagem algorítmica, para planejamento de rotas de entrega de produtos de forma otimizada (buscando o “menor caminho”). Embora, durante a busca de menor caminho, limitam-se ao uso de ruas. Neste contexto emerge o Problema de Roteamento Humano, tal abordagem não se limita a ruas, mas faz uso de todos os caminhos possíveis, por veículos e humanos. Tal problemática, pode ser observada nos planejamentos de rotas em aeroportos, museus e em uma empresa de supply chain que deseja otimizar a rota de entrega dos seus produtos, e aumentar a satisfação dos seus clientes. Tomando como base central, o Problema de Roteamento de Veículos será proposto o Problema de Roteamento Humano. Sua problemática, será demonstrado em um protótipo, capaz de auxiliar no planejamento de rotas humanas e três casos de uso. As ideias do Problema de Roteamento Humano tiveram inspiração no forrageamento dos insetos coletivos

Submitted by William Justo Figueiro (williamjf) on 2015-07-03T13:41:57Z No. of bitstreams: 1 33.pdf: 1124727 bytes, checksum: 13f67fb58a5e7f4f1395960e55e270ff (MD5) / Made available in DSpace on 2015-07-03T13:41:57Z (GMT). No. of bitstreams: 1 33.pdf: 1124727 bytes, checksum: 13f67fb58a5e7f4f1395960e55e270ff (MD5) Previous issue date: 2013-06-20 / Nenhuma / O presente trabalho teve como objetivos, discutir o papel das lideranças empresariais na implementação de um Plano de Remuneração Variável (PRV) e as repercussões de âmbito pessoal e profissional deste processo. Para tanto, foi realizado um estudo de caso em uma organização do segmento de comercialização de commodities que passou recentemente por uma joint venture e implementou o PRV. O referencial teórico desenvolvido abordou os seguintes tópicos: 1) remuneração variável e desempenho; 2) a motivação e comprometimento no trabalho; 3) aspectos da cultura e clima organizacional; 4)comunicação organizacional. A coleta de dados foi feita através de entrevistas semiestruturadas e presenciais, com 10 lideranças que atuam na empresa estudada e pesquisa documental, que teve tratamento de dados pela análise de conteúdo, sendo utilizada na análise das categorias para corroborar e/ou confrontar os dados oriundos das entrevistas. Os dados foram analisados pela técnica da Análise Textual Discursiva (MORAES, 2003), sendo identificadas as seguintes categorias de análise: 1) processo de implementação (HANASHIRO, TEIXEIRA e ZACCARELLI, 2010); 2) principais desafios na implementação do PRV (ROSSI, 2004); 3) necessidade de ajustes (BARBOSA, 1999); 4) a liderança e o papel do líder (BASS e AVOLIO, 1994); 5) sentimentos das lideranças no processo de implementação do PRV (DESSLER, 1996); 6) o mais fácil e o mais difícil na implementação do PRV (FLEURY e FLEURY, 2004); 7) o que se faria diferente na implementação do PRV (WRIGHT, 2000); 8) repercussões profissionais da implementação do PRV nas equipes (KOHN, 1998); 9) reflexões a respeito de consequências da implementação do PRV na vida pessoal dos participantes (GOMES e AMORIM, 2008); 10) alinhamento entre estratégias de crescimento da empresa e a implementação do PRV (WOOD Jr. e PICARELLI, 2004); 11) mudanças percebidas nos profissionais das equipes (HANASHIRO, TEIXEIRA e ZACCARELLI, 2010); 12) recomendações às lideranças que pretendem implementar um PRV (HANASHIRO, TEIXEIRA e ZACCARELLI, 2010). Os principais resultados apontam para a necessidade de líderes engajados no processo de implementação e conhecedores do PRV, o entendimento de que se trata de uma ferramenta estratégica de gestão e indutora de cultura organizacional, da importância de uma comunicação clara e correta para a devida compreensão do PRV nos mais diversos níveis hierárquicos e a absoluta necessidade de alinhamento entre os alvos individuais e as estratégias da organização. / The main objectives of this project are to discuss the leadership role in industrial corporations which are implementing a Variable Compensation Plan (VCP), and the personal and professional repercussions of this process. This searching project utilized an international corporation of commodities, formed recently by a joint venture, which implemented a new VCP on the last year. In the theoretical foundation of this work are appointed the following topics: 1) variable contribution and performance; 2) motivation and work engagement; 3) cultural and organizational climate; 4) communication. Data collection was performed by semi structured and present interviews, with 10 leaderships of the corporation studied. Complementary information was collected through documental search, treated by data analysis, and utilized as subject of comparison with information from interviews. These data was analyzed through Discursive Textual Analyzes method (MORAES, 2003), which determined the following categories: 1) VCP implementation process (HANASHIRO, TEIXEIRA and ZACCARELLI, 2010); 2) main challenges on VCP implementation (ROSSI, 2004); 3) adjustments identified on process (BARBOSA, 1999); 4) the leadership and its roles (BASS and AVOLIO, 1994); 5) leaderships feelings about VCP implementation process (DESSLER, 1996); 6) most difficult and easiest procedures identified on VCP implementation (FLEURY and FLEURY, 2004); 7) what should be different on VCP implementation (WRIGHT, 2000); 8) professional repercussions on work teams during VCP implementation (KOHN, 1998); 9) personal life consequences generated by VCP implementation (GOMES and AMORIM, 2008); 10) VCP and organization growth strategies alignment (WOOD Jr. and PICARELLI, 2004); 11) changes on professional behavior of work team (HANASHIRO, TEIXEIRA and ZACCARELLI, 2010); 12) recommendations to leaders wich intend to implement a VCP (HANASHIRO, TEIXEIRA and ZACCARELLI, 2010). Main results appoint to the importance of engagement and knowledge of leaders about VRP implementation; the understanding that VRP is a strategic management tool; the importance of a clear and correct communication to the right comprehension of VRP in all hierarchic levels; and the necessity of alignment between individual targets and the organization strategies.

Accurate smoltification and disease management in Atlantic salmon (Salmo salar) are key issues for the aquaculture industry. Due to their anadromous lifecycle the transfer of salmon from fresh water (FW) to seawater (SW) is crucial to their survival; too early can cause mortality, too late can cause desmoltification and long-term health problems. Both scenarios can increase susceptibility to four viral diseases: Salmon alphavirus (SAV), Infectious salmon anemia virus (ISAV), orthoreovirus (PRV), and Piscine myocarditis virus (PMCV). They all show similar clinical and histopathological symptoms and can easily spread throughout farms. Understanding the initial innate immune response to these viruses may provide biomarkers that could help identify and monitor infections. An in house and onsite Na+/K+ ATPase (NKA) qRT-PCR assay was developed for the salmon biomarker ATPase to test smoltification readiness in salmon smolts. Tested against NKA enzymatic assays it showed a similar success rate over 3 years: NKA qRT-PCR (57%), NKA activity assay (60%). Onsite tests confirmed that the ATPase mRNA transcript is a useful biomarker for smoltification detection. An in-lab and mobile multiplex qRT-PCR assay was developed for detection of SAV, PRV and PMCV. The analytical sensitivity of the SAV (86.5% SE 0.11), PRV (90.94%, SE 0.09) and PMCV (100.46%, SE 0.19) assays was 102 copies for PMCV and 103 for SAV and PRV. Initial results suggest individual assays could be run on site at farms. Addition of an internal control, probit analysis and viral positive tests are still required for multiplex assay integration. Salmon erythrocytes were infected with ISAV, SAV and Poly I:C to investigate whether they induce and up-regulate innate immune response genes. All genes were expressed at low levels in all parameters investigated including non-infected control erythrocytes. These findings suggest erythrocytes act as an initial buffer to viral infections and may help stimulate the innate immune response.

This diploma thesis is focused on determining of investment subsidies influence on the economic performance of the chosen sample of companies. This findings are further enhanced by analysis of Common Agriculture Policy which should give readers the information about its changes and also give them a basic overview of the influence of the changes on the companies performance. Moreover, the theoretical part is focused also on differences among modern methods of performance measurement. In the practical part of this diploma thesis were analyzed three chosen companies and part of the agriculture sector with the help of traditional and modern metrics of performance measurement. To analyze the influence of investment subsidies and key financial factors on economic value added were used regression and correlation analysis. By doing that, author was able to suggest the areas of improvement for each economic entity, in order the companies could reach significant increase in economic value added.

The work focuses on the analysis of EU funds. Described is also the general functioning of the European community in terms of politics, economics, geographical kontext, regional policy and economics and social cohesion. Subsequently, the theoretical part of the work is devoted to tourism and choosing suitable program for derive financial resources for tourism development. The aim of this work is to draft a specific project based on information obstained from the analysis of the Rural Development Program in the Czech republic. Another objective is to assess the effects and benefits resulting from the project. The project proposal is developed in the practical part of the thesis. Finances are drawn from the European Agricultural Fund for Rural Development (EAFRD) through the Rural Development Program (RDP). The entire project is analyzed and evaluated in particular in economic and financial terms. Social and development aspect, creating new jobs and the overall of the project are evaluated too.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第24884号 / 医博第5018号 / 新制||医||1068(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 鈴木 実, 教授 小濱 和貴, 教授 中島 貴子 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

This thesis focuses on support of tourism, namely grants of private entities. There are described ex post assessments of Rural Development Programme (RDP) 2007-2013 impacts in this thesis. The programme focused on accommodation and sports devices in the region Jihočeský kraj (CZ). The influence of the support and the utilization range of new services are analysed here. There is measured a success rate of support in conclusion and there is also given an advice, how to improve the support efficiency.

No description available.

The thesis analyzes and compares the selected information systems on industrial property focused on trademarks and industrial designs. These are the selected systems of the Industrial Property Office of the Czech Republic, the Office for Harmonization in the Internal Market, the World Intellectual Property Organization, the US Patent and Trademark Office and the Swedish Patent and Registration Office. The work is divided into seven parts. The first part describes the terminology and the environment of trademarks and industrial designs. The second part lists the types of international classification, which is followed by the third part, which describes the international treaties and agreements. The fourth part presents selected institutions and their analyzed systems. The fifth part deals with the analysis and the sixth section summarizes trends in the disclosure of trade marks and industrial designs. The last seventh part of the work shows an impact of the protection of trademarks and industrial designs in the business. The analysis showed that the national databases of the Industrial Property Office of the Czech Republic were top rated. The worst evaluation acquired databases of the US Patent and Trademark Office. Key words Industrial property, trademark, industrial design, information system,...