Main goal of graduation theses is analysis possibilities to use logistic technologies in food company Fontea. This analysis is focused on material and informative flows in her logistic chain including analysis of key factors. These factors are important for implementation of chosen technologies. Subsequently were analyzed customer department, sales department, production department, purchasing department and shipping department. There were found several principal problems. Customer department staffs have a problem with finding actual quantity of manufactured finished goods, because up-dating of computer system is provided only once a day. Most of orders are inserted manually in computer system. Staffs are not able to find out charges of manufactured finished goods. Similar problems were discovered also in the next departments. To fix the problem were suggested implementation of Quick Response and automatic identification of barcodes and Radio Frequency Identification (RFID).

Submitted by Alison Vanceto (alison-vanceto@hotmail.com) on 2017-05-15T12:34:48Z No. of bitstreams: 1 TeseAGM.pdf: 2946187 bytes, checksum: 5394dae1eeb0847b3196cbbccb6d3b76 (MD5) / Approved for entry into archive by Ronildo Prado (ronisp@ufscar.br) on 2017-05-18T20:28:06Z (GMT) No. of bitstreams: 1 TeseAGM.pdf: 2946187 bytes, checksum: 5394dae1eeb0847b3196cbbccb6d3b76 (MD5) / Approved for entry into archive by Ronildo Prado (ronisp@ufscar.br) on 2017-05-18T20:28:14Z (GMT) No. of bitstreams: 1 TeseAGM.pdf: 2946187 bytes, checksum: 5394dae1eeb0847b3196cbbccb6d3b76 (MD5) / Made available in DSpace on 2017-05-23T18:21:23Z (GMT). No. of bitstreams: 1 TeseAGM.pdf: 2946187 bytes, checksum: 5394dae1eeb0847b3196cbbccb6d3b76 (MD5) Previous issue date: 2015-11-26 / Não recebi financiamento / In recent decades, the lead time reduction has become crucial to ensure the competition of enterprises. To address this, plus the abandonment of the tradit ional mindset based on efficiency and cost, to a mentality based on the reduction of lead time, companies began to incorporate in production management, principles and practices related, outstandingly, to the Quick Response Manufacturing (QRM) and the Lean Manufacturing (LM). In this context, this work aims, according to companies located in Brazil, Europe, and in the USA: (I) Verify if the degree of knowledge of the exclusive principles of QRM approach is equal to the degree of knowledge regarding common concepts to LM and QRM, (II) Verify if the degree of knowledge of the exclusive principles of QRM is greater due to factors such as training, dissemination, and awareness, (III) Check if the mindset based on economies of scale and cost reduction is still the main obstacle in the degree of knowledge of the companies surveyed, (IV) Verify if the concepts / elements / exclusive practices QRM less adopted by companies are those related to the change of economies of scale and cost-based mindset, still fairly entrenched in enterprises, (V) Verify if there is a significant difference between the degree of implementation of QRM practices due to the region studied, and (VI) Check whether the use of concepts / elements / practices of LM favors the adoption of QRM. For this, it was carried out an exploratory survey with an intentional sample of companies in these regions who wish to reduce the lead time. Data were analyzed using descriptive statistics and non-parametric tests. Concerning to the knowledge of the companies surveyed about the QRM, it was concluded that the level of knowledge about the exclusive practices of QRM is lower than in relation to the common practice at LM and QRM. The companies’ knowledge degree about the exclusive principles of QRM is possibly greater due to training, dissemination, and awareness and such factors are present more at the region of US. The mindset based on economies of scale and cost reduction is possibly the main barrier in the degree of knowledge in the companies surveyed. Concerning to the application of the QRM practices by companies surveyed, it was concluded that the extent of implementation of practices regarding the key concept "power of time" is lower than the other key concepts; there was not observed any statistically significant differences in the degree of implementation of QRM practices due to the region; the LM practices helps and contribute to the effort of implementation of QRM in companies that seek to reduce the lead time and; the concepts, elements and practices of QRM less adopted by companies are those related to the abandonment of the mindset based on economies of scale and cost reduction. / Nas últimas décadas, a redução do lead time se tornou crucial para garantir a competitividade das empresas. Para fazer frente a isso, além do abandono da tradicional mentalidade baseada em eficiência e custo, para uma mentalidade baseada em redução de lead time, as empresas passaram a incorporar na gestão da produção princípios e práticas abordados, destacadamente, pelo Quick Response Manufacturing (QRM) e pelo Lean Manufacturing (LM). Dentro desse contexto, este trabalho objetiva, em função de empresas situadas no Brasil, na Europa e nos EUA: (I) Verificar se o grau de conhecimento dos princípios exclusivos da abordagem do QRM é igual ao grau de conhecimento a respeito de conceitos comuns ao LM e ao QRM; (II) Verificar se o grau de conhecimento dos princípios exclusivos do QRM é maior em função de fatores como treinamento, divulgação e conscientização; (III) Verificar se a mentalidade baseada em economia de escala e redução de custo ainda é o principal obstáculo no grau de conhecimento das empresas pesquisadas; (IV) Verificar se os conceitos/elementos/práticas exclusivos do QRM menos adotados pelas empresas são aqueles relacionados com a mudança de mentalidade baseada em economia de escala e custo, ainda bastante arraigado nas empresas; (V) Verificar se existe diferença significativa entre o grau de implementação de práticas do QRM em função da região estudada e (VI) Verificar se a utilização de conceitos/elementos/práticas do LM favorece a adoção do QRM. Para tanto, realizou-se uma survey exploratória com uma amostra intencional de empresas dessas regiões, que desejam reduzir o lead time. Os dados foram analisados por meio de estatística descritiva e testes não-paramétricos. Com relação ao conhecimento a respeito do QRM nas empresas pesquisadas, concluiu-se que o grau de conhecimento a respeito das práticas exclusivas do QRM é menor do que em relação às práticas comuns ao LM e ao QRM; o grau de conhecimento das empresas a respeito dos princípios exclusivos do QRM possivelmente é maior em função de treinamento, divulgação e conscientização nos EUA e; a mentalidade baseada em economia de escala e redução de custos possivelmente é o principal obstáculo no grau de conhecimento nas empresas pesquisadas. Com relação à aplicação das práticas do QRM nas empresas pesquisadas, concluiu-se que o grau de aplicação das práticas do conceito-chave “o poder do tempo” é menor que dos demais conceitos-chave; não existem diferenças estatisticamente significativas no grau de aplicação das práticas do QRM em função da região; as práticas do LM auxiliam e contribuem para o esforço de implantação do QRM nas empresas que buscam reduzir o lead time e; os conceitos, elementos e práticas do QRM menos adotados pelas empresas são aqueles relacionados ao abandono da mentalidade baseada em economia de escala e redução de custo.

Made available in DSpace on 2016-06-02T19:51:45Z (GMT). No. of bitstreams: 1 3196.pdf: 1584882 bytes, checksum: e87305ed1643450b13fc00d6bac58c63 (MD5) Previous issue date: 2010-08-20 / The approach Quick Response Manufacturing (QRM) has been proposed in the late ninety, and since then, has been successfully deployed in many companies, achieving promising results in reduction of lead time in environments with high product variety. This approach, although already established abroad, mainly in the United States, is poorly known in Brazil as not to have official records of its practice, thus providing a vast new area of research. From this context that this dissertation aims to explore and understand the general ways to reduce lead time based on QRM and propose a practical application of this approach. For this objective to be achieved, we sought, first, the comprehensive review of the literature concerning the reduction of lead time, describing the tools and principles to reduce lead time in the QRM approach and then propose to implement some of the principles and tools of QRM in the production area in a business of writing. This proposed implementation of QRM is analyzed and validated by simulations that visualize the interactions of variables from the factory floor and the effects of these variables in the percentage of use of sectors in the intermediate level of inventory (WIP) and lead time. It is hoped that the practical implementation of the proposals to reach a 55% reduction from the current level of WIP company and up to 77% in the average lead time of its products. Thus, this research contributes to the theory and practice in management of manufacturing systems, showing the importance of reducing lead time and the effects and benefits of implementing QRM in a Brazilian company. / A abordagem Quick Response Manufacturing (QRM) foi proposta no final da década de noventa e, desde então, vem sendo implementada com sucesso em inúmeras empresas, atingindo promissores resultados na redução de lead time em ambientes com alta variedade de produtos. Essa abordagem, embora já estabelecida no exterior, principalmente nos Estados Unidos, ainda é pouco conhecida no Brasil a ponto de não possuir registros oficiais de sua aplicação prática, proporcionando, assim, uma nova e vasta área de pesquisa. A partir desse contexto que surge essa dissertação que tem como objetivo geral explorar e entender as formas para a redução de lead time com base no QRM e propor a aplicação prática dessa abordagem. Para que este objetivo fosse alcançado, buscou-se, primeiramente, a revisão integral da literatura a respeito de redução do lead time, descrevendo as ferramentas e os princípios para a redução de lead time na abordagem QRM; em seguida, propô-se a implementação de alguns dos princípios e ferramentas do QRM na área de produção em uma empresa de materiais de escrita. Essa proposta de implementação do QRM é analisada e validada por simulações que permitem visualizar as interações das variáveis do chão-de-fábrica e os efeitos dessas variáveis no percentual de utilização dos setores, no nível de estoque intermediário (WIP) e no lead time. Espera-se que a implementação na prática das propostas apresentadas atinja uma redução de 55% do nível atual de WIP da empresa e de até 77% no lead time médio de seus produtos. Dessa forma, essa pesquisa pretende contribuir com a teoria e a prática em gestão de sistemas de manufatura, mostrando a importância da redução do lead time e os efeitos e benefícios da implementação do QRM em uma empresa brasileira.

Este trabalho propõe criar uma metodologia para a padronização de atividades de células de manufatura e de montagem. A metodologia compreende a seleção de algumas ferramentas de produção enxuta e de uma aplicação das mesmas. O desenvolvimento da metodologia ocorre em conjunto com a aplicação, caracterizando desta forma uma pesquisa-ação, uma vez que conceitos e ferramentas são revisados e adequados durante as aplicações. A metodologia é baseada no evento kaizen e sua aplicação tem duração de dois meses. O evento kaizen é utilizado na primeira semana e as demais semanas são dedicadas para acompanhamento das ações de melhorias. As duas últimas semanas são dedicadas à avaliação de resultados. Publicações na literatura científica relacionadas à padronização são poucas, por esta razão pode-se afirmar que este trabalho tem uma contribuição academicamente relevante com o tema e que empresas podem conhecer os requisitos básicos para aplicação da metodologia, podendo explorar seus benefícios. Um dos passos importante da metodologia é a definição das melhores práticas. A participação dos operadores na validação da distribuição das atividades para cada operador e na definição do ritmo de produção é um dos requisitos para o sucesso da implementação. Um processo padronizado permite distinguir uma situação normal de uma anormal. Desta forma ações corretivas podem ser definidas e implementadas. Esta metodologia apresenta um método simples para definição da capacidade instalada e de utilização de operador e máquina de uma célula de manufatura. A aplicação acontece em uma empresa de autopeça. Durante a aplicação, conceitos de manufatura enxuta são disseminados e as pessoas são instigadas a encontrar os desperdícios dentro do processo a ser padronizado. Esta metodologia é resultado de mais de quatorze aplicações e uma delas é utilizada neste trabalho para descrever a metodologia de padronização. / This research proposes to build a methodology for standardization activities of a manufacturing process. The methodology consists of a selection of tools from lean manufacturing systems and of application method. The development of this methodology occurred in parallel with his application, when conceptions and tools are revised and adapted. The standardization methodology is based on kaizen event and whole application takes two months. The kaizen event is used at the first week, when the bets practice are defined and implemented. The rest of the schedule is used for follow up and improvement action implementation. The two last week are dedicated for results analyzes. At science literature, publications about manufacturing activities standardization are not much available. Considered that, it might affirm this research has academic contributions for the theme and organization can find some basic requirement for standardization work application. One of the important phases of the methodology is to define the best practice. The labor participation is one of the requirements for implementation successes. Their participation at the validation of task operator distribution and cycle time definition, ensure the maintenance of standardized work. A standardize process enable distinguish one normal condition of abnormal one. Then corrective action can be defined and implemented. This methodology presents a simple method to define the real install capacity andthe labor and machine utilization of the manufacturing cells. The application occurs at assembly supplier company. During the application, lean manufacturing concepts are disseminated and the people are instigated to find the waste into the process. This methodology is result of more than fourteen applications and one of then is used in this dissertation to describe the methodology.

Le but de ce projet était d'identifier de manière méthodique et standardisée les partenaires interagissant avec la protéine dystrophine dans les cellules musculaires squelettiques humaines différenciées et découvrir de nouveaux rôles de la dystrophine. Des cellules immortalisées ont été obtenue en sur-exprimant de manière stable hTERT / CDK4. Nous avons réalisé une analyse transcriptomique comparant des lignées immortalisées avec leurs populations primaires correspondantes, à l’état de prolifération et de différentiation. Nous avons constaté que l'immortalisation n'a pas d'effet mesurable sur le programme myogénique ou sur tout autre processus cellulaires, et qu'elle avait un effet protecteur contre le processus de sénescence. Les lignées de cellules musculaires humaines constituent donc de bon model in vitro pour l’étude de l’interactome de la dystrophine. Nous avons déterminé l’interactome de la dystrophine en utilisant l’approche proteomique ‘QUICK’. Nous avons identifié 18 nouveaux partenaires directs de la dystrophine, partenaires étant impliqués dans le transport vésiculaire ou étant des protéines d'adhésion. Ces résultats renforcent les données précédemment publiées suggérant un lien entre la dystrophine et le trafic vésiculaire, ainsi que dystrophine et adhesion cellulaire. Ces nouveaux partenaires ont été ajoutés à l’interactome de la dystrophine, interactome accessible sur le Web: sys-myo.rhcloud.com/dystrophin-interactome. Ce site web est dédié à être un outil facile d’utilisation permettant d’explorer et de visualiser l’interactome de la dystrophine du muscle squelettique. / The aim of this project was to systematically identify new interaction partners of the dystrophin protein within differentiated human skeletal muscle cells in order to uncover new roles in which dystrophin is involved, and to better understand how the global interactome is affected by the absence of dystrophin. hTERT/cdk4 immortalized myogenic human cell lines represent an important tool for skeletal muscle research however, disruption of the cell cycle has the potential to affect many other cellular processes to which it also linked. A transcriptome-wide analysis of healthy and diseased lines comparing immortalized lines with their parent primary populations in both differentiated and undifferentiated states testing their myogenic character by comparison with non-myogenic cells found that immortalization has no measurable effect on the myogenic cascade or on any other cellular processes, and that it was protective against the senescence. In this context the human muscle cell lines are a good in vitro model to study the dystrophin interactome. We investigated dystrophin’s interactors using the high-sensitivity proteomics ‘QUICK’ approach. We identified 18 new physical interactors of dystrophin which displayed a high proportion of vesicle transport related proteins and adhesion proteins, strengthening the link between dystrophin and these roles. The proteins determined through previously published data together with the newly identified interactors were incorporated into a web-based data exploration tool: sys-myo.rhcloud.com/dystrophin-interactome, intended to provide an easily accessible and informative view of dystrophins interactions in skeletal muscle.

Quick Response code opens possibility to convey data in a unique way yet insufficient prevention and protection might lead into QR code being exploited on behalf of attackers. This thesis starts by presenting a general introduction of background and stating two problems regarding QR code security, which followed by a comprehensive research on both QR code itself and related issues. From the research a solution taking advantages of cloud and cryptography together with an implementation come after. We also give an objective evaluation on the outcome in comparison to existing QR products. They are based on the purpose of enhancing QR code security and aim to interpret how we have tackle the specified problems meanwhile to suggest possible further work for bringing security of QR code to a higher level.

M.Ing. (Transportation) / This reseach focused on a quick response transportation planning software package called QRS II which was developed by A J Horowitz at the Centre for Urban Transportation Studies, University of Wisconsin, United states of America. The programme achieves its quick response by incorporating, inter alia, a large number of default parameters within its formulation. Several of these parameters define the typical travel characteristics of the population within a study area and as such, suggest a particular socioeconomic, political, cultural and behavioral profile as existing in that area. These typical conditions may be representative of the behavior in many areas in the United States but may not adequately reflect conditions beyond that. This study has set out to determine whether the default parameters used in QRS II are different to those that would be appropriate in Black towns in areas such as the East Rand Metropolitan Transport Area (ORMET) in South Africa. Local parameter values were identified and compared with the default values in QRS II. It was found that these values were significantly different. More research is required before QRS II can be considered fully adapted to conditions in Black urban areas within a Metropolitan area such as ORMET. However, the new values suggested in this study will go a long way to improving the appropriateness of QRS II applications in South Africa.

This thesis project was carried out by two students on behalf of SMA Mineral AB, which owns the lime plant in Rättvik, where there was need to establish a sampling method for the local quick lime product. The aim was to ensure a maximum concentration of impurities in the product—primarily carbon and sulphur. The mean value of sulphur found in the input material varied over time. Consequently, a suitable statistical method was needed to ensure product quality for the prospective customer as they required that the sulphur content of the proposed product never exceed 500 ppm.The aim was, on the one hand, to process and compile the sampling results in accordance with a suitable statistical method which enabled reasonable conclusions about the product quality and, on the other hand, to answer three key queries that SMA Mineral AB posed:• to investigate whether the product’s sulphur content was affected during conveyance through the lime plant;• to investigate whether sampling at various time intervals may have been a factor which affected the product’s sulphur content;• to investigate whether there was, or were, any particular times of day at which the sulphur content always maintained the correct level.A number of phases were required to find answers to these questions. The planning phase was initiated by a visit to Rättvik, with the purpose of gaining an overall picture of how work at the plant was conducted as well as which guidelines and regulations were in effect. After this visit, a project plan was drawn up in order to serve as support for further work.The sampling campaign took place during the period of 13–16 April 2015 and analysis of the collected material was carried out the following week at the company’s laboratory in Persberg, Sweden. However, the results from the sampling campaign did not provide sufficient basis for answering the company’s questions, which is why data from SMA Mineral AB’s own data collection was used. Data collected during the sampling campaign proved to follow normal distribution. Subsequently, the statistical analysis of variance method, ANOVA, was applied in order to investigate whether the sulphur content changed with respect to the time interval and the sampling site. The test results demonstrated p-values under 0.005, which meant that neither the sampling site nor the sampling time intervals had an effect on the product’s sulphur content. The company’s question, whether there were daily time intervals of acceptable sulphur content in the product, was answered with the assistance of the company’s own data collection, which demonstrated that it did not follow normal distribution. For that reason, the bootstrap method was used to create confidence intervals for the different points in time. The result showed that there were no points in time during which acceptable material was produced. One reason for this is the occurrence of a set of deviating values that were observed to have a sulphur content that exceeded 1,000 ppm. This report presents recommendations for various measures independently of any opinions SMA Mineral AB may have concerning the source of these values and whether they can possibly be avoided. / <p>Validerat; 20160612 (global_studentproject_submitter)</p>

The subject of this diploma thesis is to analyse the Dolkam Šuja Company, a.s. Through the selected methods, described in the first part, the company’s current situation is evaluated and on its basis the measures for improving the current state of the company are proposed.

This diploma thesis includes analysis of the INTERMONT s.r.o. company based on account statements and information given by the firm. It is focusing on an overall review of the firm standing and tries to assess its internal situation and the environment as well. SWOT analysis and Quick test is elaborated in the conditions of the firm. From these points of view proposals improving the firm position are presented.