Cancer is the second leading cause of death after cardiovascular diseases in the world. Many of the chemical carcinogens need metabolic activation that catalyzed by cytochrome P450 and Phase II enzymes in order to exert their genotoxic and carcinogenic effects. Hence one possible mechanism is that phenolic compounds may alter anticarcinogenic effects is through an interaction with these enzymes either by the inhibition or activation of certain forms, leading to a reduced production of the ultimate carcinogen. Therefore anti-carcinogen activity of tannic acid, a hydrolyzable plant polyphenol, has a crucial importance to prevent conversion of pro-carcinogens to their carcinogenic form. Tannic acid is produced from secondary metabolism of plants and is found in edible vegetables, fruits and nuts, especially tea, cocoa, coffee and wine. In the present work, modulation of rabbit liver and kidney microsomal P450 dependent aniline 4-hydroxylase, N-nitrosodimethylamine N-demethylase and p-nitrophenol hydroxylase activities and cytosolic phase II enzymes / glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase:1 (NQO1) were studied in the presence of tannic acid at concentrations ranging from 0.5 &micro / M to 150 &micro / M in the reaction medium. The results obtained in this study were shown that tannic acid significantly inhibited the activities of p-nitrophenol hydroxylase, aniline 4-hydroxylase, NDMA N-demethylase, glutathione S-transferase, NAD(P)H:quinine oxidoreductase 1. Tannic acid was found to be the most potent inhibitor of cytosolic glutathione S-transferase with IC50 of 0.33 &micro / M and the least potent inhibitor of microsomal aniline 4-hydroxylase.with IC50 of 60.26 &micro / M. Effect of tannic acid on enzyme activities was further studied for both mode and type of inhibition. For this purpose various concentrations of the substrate were examined at various tannic acid concentrations. Lineweaver-Burk and Dixon plots were then generated from the resulting data sets. The Km value and inhibition constants (KI) were determined from double reciprocal and Dixon plot of the enzyme activity versus substrate and inhibitor concentration, respectively. Tannic acid was shown to be a noncompetitive inhibitor for liver cytosolic GST, NQO1 and microsomal aniline 4- hydroxylase enzymes with KI of 0.3 &micro / M, 41 &micro / M and 54.7 &micro / M, respectively. On the other hand, in kidney tissues, tannic acid was an uncompetitive inhibitor of cytosolic GST, while it was noncompetitive inhibitor for cytosolic NQO1 with a KI of 12.6 &micro / M. These results indicate that tannic acid may modulate cytochrome P450 dependent and Phase II enzymes and influence the metabolic activation of xenobiotics mediated by these enzymes.

Listed as federally-endangered in 1990, the Lower Keys marsh rabbit (LKMR, Sylvilagus palustris hefneri) exists as a metapopulation in patches of wetland habitat in Florida’s Lower Keys. This study sought to address 2 priority actions identified by the LKMR Recovery Team: (1) monitoring of populations and (2) reintroduction. Monitoring the distribution and status of LKMR populations is critical for targeting future management actions. Informal transects for rabbit fecal pellets were used to survey habitat patches documented in1988–1995 surveys and to identify additional patches of occupied and potential habitat. Next, a buffer was created around patches to help managers account for uncertainty in rabbit movements and to identify groups of patches that might function as local populations. Surveys included 228 patches of occupied and potential habitat, 102 of which were occupied by rabbits. Patches were arranged in 56 occupied and 88 potential populations. Surveys revealed new patches of both occupied and potential habitat. Considering only areas included in 1988–1995 surveys, however, revealed a net decrease in the number of occupied patches. Many of the recently extirpated populations, which tended to occupy the periphery of larger islands or small neighboring islands, were unlikely to be recolonized without human intervention. Reintroduction provides a means of artificially recolonizing potential habitat. Two pilot reintroductions were conducted to evaluate this conservation strategy for the species. The second reintroduction was postponed, but the first effort met all criteria for short-term success, including survival comparable to a control group, fidelity to release sites, and evidence of reproduction. There are a limited number of potential source populations for translocations. Future efforts should consider using in-situ captive breeding to prevent potential long-term impacts to these populations. Few potential release sites exhibited suitable habitat quality and landscape context. Thus, for reintroduction to be more widely-applied for this species, it must be part of a comprehensive management plan involving land acquisition, control of secondary impacts from development, and habitat restoration and enhancement.

Rapid development and urbanization of the Lower Florida Keys in the last 30 years has fragmented the habitat of the Lower Keys marsh rabbit (Sylvilagus palustris hefneri) and threatened it with extinction. Current threats exist at multiple spatiotemporal scales and include threats due to development, invasive species, and global climate change. On Boca Chica Key, the Lower Keys marsh rabbit (LKMR) exists as a metapopulation on Naval Air Station-Key West (NASKW). I conducted a population viability analysis to determine the metapopulation's risk of extinction under multiple management scenarios by developing a spatially-explicit, stage-structured, stochastic matrix model using the programs RAMAS Metapop and ArcGIS. These management scenarios include clearance of airfield vegetation, habitat conversion, and control of feral cats as an invasive species. Model results provided the Navy with relative risk estimates under these different scenarios. Airfield clearance with habitat conversion increased extinction risk, but when coupled with feral cat control, risk was decreased. Because of the potential of sea-level rise due to human-induced global climate change, and its projected impact on the biodiversity of the Florida Keys, I estimated the impacts of rising sea levels on LKMR across its geographic distribution under scenarios of no, low (0.3m), medium (0.6m), and high (0.9m) sea-level rise. I also investigated impacts due to 2 treatments (allowing vegetation to migrate upslope and not allowing migration), and 2 land-use planning decisions (protection and abandonment of humandominated areas). Not surprisingly, under both treatments and both land-use planning decisions, I found a general trend of decreasing total potential LKMR habitat with increasing sea-level rise. Not allowing migration and protecting human-dominated areas both tended to decrease potential LKMR habitat as compared with allowing migration and abandoning human-dominated areas. In conclusion, conservation strategies at multiple scales need to be implemented in order to reduce threats to LKMR, such as development, invasive species, and global climate change.

Abstract: Objective: To compare the long-term viability of percutaneously injected crushed auricular cartilage to surgically implanted cartilage in the rabbit. Methods: Auricular cartilage was harvested bilaterally in 10 New Zealand white rabbits. A 1 cm2 cartilage graft was harvested and implanted surgically on the upper nasal dorsum. The remaining cartilage was crushed and percutaneously injected on the lower nasal dorsum. Volume and mass of each graft were compared between pre-implantation and after 3 months of observation. A histological study was conducted to evaluate chondrocyte viability and degree of fibrosis on the grafts. Results: Mass and volume remained similar for surgically implanted cartilage grafts. Mass and volume diminished by an average of 47% and 40% respectively after 3 months for the injected crushed cartilage grafts. Chondrocyte viability was an average of 25% lower in the injected grafts. Conclusion: Cartilage injection is a promising technique that must be refined to increase long term chondrocyte viability. Developing an appropriate injection apparatus would improve this technique. / Résumé : Objectif: Comparer la viabilité à long-terme de cartilage auriculaire broyé injecté de façon percutanée au cartilage implanté chirurgicalement chez le lapin Méthodes: Prélèvement de cartilage auriculaire bilatéralement chez 10 lapins blancs « New Zealand ». Pour chaque lapin, une greffe de cartilage de 1 cm2 fut prélevée et implantée chirurgicalement au niveau du dorsum nasal supérieur. Le reste du cartilage fut broyé puis injecté de manière percutanée sur le dorsum nasal inférieur. La masse et le volume de chaque greffon furent mesurés lors de la chirurgie initiale et 3 mois plus tard. Une étude histologique a été entreprise afin de comparer la viabilité des greffons et le degré de fibrose. Résultats: La masse et le volume des greffons de cartilage entier sont demeurés semblables suite à l’implantation. La masse et le volume des greffons de cartilage injecté ont diminué en moyenne de 47% et 40% respectivement suite à l’implantation. L’analyse histologique a démontré une diminution moyenne de 25% de la viabilité chondrocytaire pour les greffons de cartilage injecté. Conclusion: L’injection de cartilage est une technique prometteuse devant être raffinée pour augmenter la viabilité chondrocytaire à long-terme. Le développement d’un instrument d’injection approprié faciliterait la technique.

Tendon transfer surgery is used to improve the hand function of patients with nerve injuries, spinal cord lesions, cerebral palsy (CP), stroke, or muscle injuries. The tendon of a muscle, usually with function opposite that of the lost muscle function, is transferred to the tendon of the deficient muscle. The aim is to balance the wrist and fingers to achieve better hand function. The position, function, and length at which the donor muscle is sutured is essential for the outcome for the procedure. In these studies the significance of the transferred muscle’s morphology, length and apillarization was investigated using both animal and human models. Immunohistochemical, biochemical, and laser diffraction techniques were used to examine muscle structure. In animal studies (rabbit), the effects of immobilization and of tendon transfers at different muscle lengths were analyzed. Immobilization of highly stretched muscles resulted in fibrosis and aberrant regeneration. A greater pull on the tendon while suturing a tendon transfer resulted in larger sarcomere lengths as measured in vivo. On examination of the number of sarcomeres per muscle fiber and the sarcomere lengths after 3 weeks of immobilization and healing time, we found a cut-off point up to which the sarcomerogenesis was optimal. Transfer at too long sarcomere lengths inhibited adaptation of the muscle to its new length, probably resulting in diminished function. In human studies we defined the sarcomere lengths of a normal human flexor carpi ulnaris muscle through the range of motion, and then again after a routinely performed tendon transfer to the finger extensor. A calculated model illustrated that after a transfer the largest force was predicted to occur with the wrist in extension. Morphological studies of spastic biceps brachii muscle showed, compared with control muscle, smaller fiber areas and higher variability in fiber size. Similar changes were also found in the more spastic wrist flexors comparing with wrist extensors in children with CP. In flexors, more type 2B fibers were found. These observations could all be due to the decreased use in the spastic limb, but might also represent a specific effect of the spasticity. In children and adults with spasticity very small fibers containing developmental myosin were present in all specimens, while none were found in controls. These fibers probably represent newly formed fibers originating from activated satellite cells. Impaired supraspinal control of active motion as well as of spinal reflexes, both typical of upper motor syndrome, could result in minor eccentric injuries of the muscle, causing activation of satellite cells. Spastic biceps muscles had fewer capillaries per cross-sectional area compared to age-matched controls, and also a smaller number of capillaries around each fiber. Nevertheless, the number of capillaries related to the specific fiber area was normal, and hence the spastic fibers are sufficiently supplied with capillaries. This study shows that the length of the muscle during tendon transfer is crucial for optimization of force output. Laser diffraction can be used for accurate measurement of sarcomere length during tendon transfer surgery. Wrist flexor muscles have more morphological alterations typical of spasticity compared to extensors.

It is widely recognised that security is a concern in the design of a wide range of embedded systems. However, security for embedded systems remains an unsolved problem, which could create greater challenges in the future than security for mainstream computers today. The promise of universal connectivity for embedded systems creates increased possibilities for malicious users to gain unauthorised access to sensitive information. All modern security protocols use private-key and public-key algorithms. This thesis investigates three important cryptography algorithms (RC4, AES, and RSA) and their relevance to networked embedded systems. Limitations in processing power, battery life, communication bandwidth, memory and costs constrain the applicability of existing cryptography standards for small embedded devices. A mismatch between wide arithmetic for security (32 bit word operations) and embedded data bus widths (often only 8 or 16 bits) combined with a lack of certain operations (e. g., multi precision arithmetic) highlight a gap in the domain of networked embedded systems security. The aim of this thesis is to find feasible security solutions for networked embedded system applications. The above mentioned cryptography algorithms have been ported to three hardware platforms (Rabbit RCM3000, Xilinx Virtex 4 FPGA with MicroBlaze softcore, and a Linux desktop machine) in order to simulate several real world scenarios. Three applications – bidirectional transmission with encryption and decryption for various payload length, unidirectional transmission with very short payload, and encrypted data streaming – were developed to meet the simulation requirements. Several timing results were collected and used for calculating the achieved throughput. The Rabbit hardware platform, which represents the lower end in this thesis, was able to perform the RC4 crypto algorithm with a throughput of about 155 kbit/s. Thus the RC4 crypto algorithm was proven to outperform the AES crypto algorithm by a factor of 5, with AES achieving a throughput of about 32 kbit/s with the same hardware platform. The throughput was similar with the streaming application and UDP data transport. Without performing a cryto algorithm, the streaming application was able to process up to 1.5 Mbit/s. RSA was not implemented on the Rabbit hardware platform. The MicroBlaze hardware platform outperformed the Rabbit system by a factor of 5 – 10. It reached a throughput up to 1.5 Mbit/s with RC4 and up to 130 kbit/s with AES. The RSA algorithm reached up to 0.8 kbit/s on this hardware platform, showing that public-key ciphers are only suitable for short payload data, such as the exchange of a session key. The Linux machine was included in this test only to provide a reference to a non embedded system. The Linux performance was better than the MicroBlaze system by a factor of between 67 – 770, and better than the Rabbit platform by a factor of between 645 – 3125. Both the RC4 and the AES crypto algorithm reached a throughput of up to 100 Mbit/s on the Linux machine, with a throughput of up to 130 kbit/s reached with RSA. Hence, the Rabbit platform combined with the RC4 algorithm is suitable, for example, for MP3 streams with up to 150 kbit/s. The Rabbit platform with the AES algorithm could be used for low quality audio streams, for example for speech announcements. If a higher throughput is required, for example for video streams, the MicroBlaze could be an appropriate platform with throughput of up to 1.5 Mbit/s. Low cost embedded systems like Atmel AVR are not suitable for processing cipher algorithms developed in C. It is widely recommended that assembly language is used to develop such platforms.

Orientador: José Luiz Laus / Banca: Aline Adriana Bolzan / Banca: Cristiane dos Santos Honsho / Banca: Alexandre Lima de Andrade / Banca: Paola Castro Moraes / Resumo: Estudaram-se os efeitos da morfina 1% sobre a reparação corneal, avaliando-se a expressão das metaloproteinases-1, -2, -9, do colágeno tipo IV e da interleucina 10 (IL-10), em coelhos submetidos à ceratectomia lamelar. Dois experimentos foram concebidos, empregando-se 56 animais. No primeiro, 6 coelhos foram tratados com 50μl de morfina 1% (GM), a cada 4 horas, totalizando 4 aplicações diárias. Outros 6 coelhos receberam solução fisiológica (GC) nas mesmas condições adotadas para o GM. Após as ceratectomias, as córneas foram avaliadas até sua epitelização. No segundo, 40 animais foram empregados e as córneas colhidas decorridos 1, 3, 6, 9 e 12 dias das ceratectomias para histologia, imunoistoquímica (MMP-1, MMP-9 e colágeno tipo IV), zimografia (MMP-2 e MMP-9) e ELISA (IL-10). Mais 4 coelhos saudáveis foram utilizados para como controle negativo.O tempo médio de reetitelização não diferiu entre os grupos. Após a ceratectomia, observou-se elevação significativa quanto ao limiar de sensibilidade corneal da 6ª até 96a hora da avaliação. Não se observaram alterações histológicas e quanto ao índice de imunomarcação da MMP-1, -9 e do colágeno do tipo IV entre os grupos estudados . À zimografia, níveis mais elevados de MMP-2 e de MMP-9 foram observados no GM, ao 6º e ao 9º dias após as ceratectomias. Observou-se decréssimo das formas latente e ativa da MMP-9 ao 12º dia. Observou-se, ao 1º dia de avaliação, redução nos níveis de IL-10, comparativamente às córneas saudáveis, mas sem significância estatística entre os grupos, em qualquer dos períodos estudados. O uso local de morfina 1% promoveu analgesia corneal de 4 dias em coelhos submetidos à ceratectomia lamelar e não retardou a epitelização. Elevação do quantitativo da metaloproteinase-1, -2 e -9, em córneas tratadas com morfina 1%, não contraindica seu uso... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: This study aimed evaluate the effects of continual topical administration of 1% morphine on corneal analgesia in rabbits subjected to lamellar keratectomy until completion of the corneal wound healing and to assess the expression of matrix metalloproteinases (MMPs)-1, -2 and -9, type IV collagen and interleukin-10 (IL-10) during the treatment. Fifty-six animals were used. In the first experiment, 12 rabbits were divided into two groups, one (n=6) received 50 μl of topical 1% morphine (MG) every 4 hours while the other group (n=6) received 0.9% NaCl instead (CG). After keratectomies, corneas were evaluated until healing. In the second experiment, 40 animals were divided, 4 rabbits of each group were euthanized 1, 3, 6, 9, and 12 days after keratectomy and corneal samples were processed for histology, immunohistochemistry (MMP- 1, -9 and IV collagen), zymography (MMP-2 and -9) and ELISA (IL-10). Other 4 healthy rabbits were used as negative control. In healthy corneas, CTT did not differ significantly before and after morphine instillation. Mean corneal reepithelization rate did not differ between groups. Following keratectomy, CTT increased from the 6h to 96h time points. Scores of leukocyte infiltration, MMP-1, MMP-9 and type IV collagen expression did not differ between groups at any time point. Zymography indicated that levels of the active forms of MMP-2 and MMP-9 increased on days 6 and 9 in the MG. The levels of both latent and active forms of MMP-9, as well as of the latent form of MMP-2 decreased to values close to those of healthy corneas on day 12. IL-10 levels measured on days 1 to 6 were reduced as compared to those of healthy corneal tissue and returned to levels close to those of healthy corneas. Topical application of 1% morphine promoted corneal analgesia for up to 4 days and did not delay corneal reepithelization... (Complete abstract click electronic access below) / Doutor

For several centuries following their introduction into the British Isles by the Normans, rabbits were farmed on man-made warrens. The right to hunt rabbits during the medieval period was restricted to the highest strata of society and warrens, and rabbit products, carried connotations of wealth and exclusivity. During the post-medieval period, as rabbits became less expensive, their exclusivity declined and access to the species increased across a wider spread of the population. Consequently, later warrens tended to be purely commercial ventures that in places lingered as a form of animal husbandry up until the early twentieth century. Evidence of these warrens is particularly common across England and Wales and typically, although not exclusively, takes the form of pillow mounds, earthworks created to encourage rabbits to burrow. Despite their longevity and high numbers, warrens remain relatively little studied. This thesis investigates surviving warren architecture within south-west England, incorporating archaeological data into a GIS in order to identify the locational, morphological and typological trends of the region’s warrens. It also assesses associations between warrens and other classes of archaeology, notably elite residences and parks, large ecclesiastical institutions and prehistoric earthworks. Doing so allows for a better understanding of warrens’ roles within their immediate environs and of their relationships with other aspects of the human landscape. This study also addresses natural geographical aspects of the landscape in order to determine the principal factors that influenced where warrens were installed. This study investigates documentary reference to warrens as many have not survived within the landscape. Medieval chancery rolls in particular allow for the creation of a national framework of warrening so that the South West can be compared and contrasted to other regions of medieval England. Documentary references, both medieval and post-medieval, to the South West’s warrens allow for the creation of a discrete regional history that defines the context for the establishment of the region’s warren architecture. This study assesses how rabbits were interpreted by medieval society and discusses symbolism, particularly the visual role played by warrens in advertising their owners’ wealth and any possible religious concepts associated with rabbits.

It has been proven that white lupine seeds (WLS) is a suitable crude protein (CP) source for growing-fattening rabbits, as well as for the lactating rabbit does. There are no reports, however, in the literature regarding the effect of blue lupine seeds (BLS) on rabbit doe milk production and composition as well as the growth of their litters. Therefore, the aim of this diploma thesis was to evaluate the effect of lactation and weaning diets based on BLS (Lupinus angustifolius cv Probor) on milk yield and milk composition of the rabbit does, as well as on growth performance and carcass quality of their progeny. Two lactation diets (LLB and LLU, having identical DP/DE ratio) and two weaning diets (VLB and VLU, having identical DP/DE ratio) were formulated. The LLB diet (control) contained WLS (25.0%) as the main CP sources, whereas the LLU diet was based on BLS (28.5%). As a result, the LLB diet had slightly greater ether extract content than did the LLU diet. The VLB diet (control) included WLS (12.0%) as the main CP source, whereas the VLU diet was based on BLS (15.0%). No additional fat was added to any of the diets. A total of 32 Hyplus rabbit does (16 animals per treatment; at the 3rd parturition) were fed 1 of the 2 lactation diets during the entire lactation (35 days). Does were housed in modified cages which allowed controlled suckling (once a day at 7 am) and separate access of does and their litters to feed. Feed intake and milk yield were measured daily during the entire lactation period, whereas litter weight was measured every 7 d. Milk yield was measured by weighing the rabbit does immediately before and after suckling. Five does of each group were used to evaluate milk composition. Milk was collected manually at d 21 of lactation. The litters were standardized to 9 kits on the day of birth. Litters were offered weaning diets with the same CP source as in the lactation diet of their mothers from d 17 to 80 of age. At d 37 of age (weaning), 99 rabbits on each weaning diet were used to evaluate growth performance and health. Feed intake, feed efficiency and milk production of does (on average 263 g/d) were not affected by dietary treatments, as well as milk efficiency (on average 0.59) and the growth of their litters (on average 30.4 g/d per rabbit). Live weight at weaning (P=0.005), milk dry matter (P=0.028) and fat contents (P=0.016), as well as fat output per kg of metabolic weight (P<0.001) were higher in does fed the WLS diet. After weaning, final live weight (by 168 g; P=0.061), average daily weight gain (by 3 g/d; P=0,024) and carcass weights were lower in rabbits fed the diet based on BLS than in those fed with the WLS diet. The number of ill + dead rabbits caused by digestive disease was lower (23 rabbits vs. 38 rabbits; P=0.042) in rabbits fed the diet based on WLS. The results of the diploma thesis confirmed that WLS is a suitable CP source for the rabbit diets. Negative findings such as a higher mobilisation of body reserves of does in the later phase of lactation, as well as the lower final live weight and the higher sanitary risk index of rabbits fed the diets based on blue lupine seeds suggest difference between lupine species in terms of feed efficiency. These findings should be elucidated and confirmed by the comparing with other blue lupine varieties.

A diálise peritoneal (DP) é uma técnica de reposição renal utilizada mundialmente tanto na medicina como na medicina veterinária. Na medicina veterinária, a pesquisa por técnicas minimamente invasivas para a implantação de cateteres de DP se mostra de grande valia, visto que a indicação de diálise em animais é, principalmente, para casos de injúria renal aguda e agudização da doença renal crônica, e, muitas vezes, o paciente não tem condições de aguardar a cicatrização da ferida cirúrgica para iniciar o procedimento de diálise. O objetivo desta pesquisa foi descrever a técnica de omentectomia e de implantação do cateter de Tenckhoff pelo acesso videolaparoscópico com três portais em coelhos, além de avaliar a funcionalidade do cateter. Foram utilizados oito coelhos adultos, fêmeas, da raça Nova Zelândia para a realização de implantação de cateter de Tenckhoff e omentectomia por videolaparoscopia. As medianas do Tempo Cirúrgico Total (TCT), Tempo para Omentectomia (TOm) e Tempo para implantação do Cateter de Tenckhoff (TICT) foram 65,5, 30, e 5 minutos, respectivamente. As principais complicações apresentadas pela técnica foram hemorragia e herniação pela ferida cirúrgica. Foram realizados oito procedimentos de DP em cada animal, sendo o primeiro iniciado três horas após a implantação do cateter. A principal complicação observada foi o vazamento do dialisato para o espaço subcutâneo, ocorrido em todos os animais. Com base na metodologia utilizada e nos resultados obtidos neste estudo, pode-se concluir que a técnica de omentectomia videolaparoscópica é factível em coelhos, permitindo que o procedimento seja realizado de forma segura e sem intercorrências significativas, além de permitir adequado posicionamento do cateter. / Peritoneal dialysis (PD) is a renal replacement technique used worldwide in both medicine and veterinary medicine. In veterinary medicine, the search for minimally invasive techniques for PD catheters implantation is of great value. The indication of dialysis in animals is mainly for cases of acute renal injury and exacerbation of chronic kidney disease and, the patient is often unable to wait for wound healing to begin the dialysis procedure. The objective of this research was to describe the technique of Tenckhoff catheter implantation and omentectomy by videolaparoscopic access with three portals in rabbits. In addition, to evaluating the catheter functionality. Eight female New Zealand rabbits were used to perform omentectomy and videolaparoscopic Tenckhoff catheter implantation. Median Total Surgical Time (TCT), Time for Omentectomy (TOm) and Time for Tenckhoff Catheter Implantation (TCTI) were 65.5, 30, and 5 minutes, respectively. The main complications presented by the technique were hemorrhage and herniation in the surgical wound. Eight procedures of PD were performed in each animal, the first one being started three hours after catheter implantation. The main complication observed was the leakage of the dialysate into the subcutaneous space, which occurred in all animals. Based on the methodology used and the results obtained in this study, it can be concluded that the videolaparoscopic omentectomy technique is feasible in rabbits, allowing the procedure to be performed safely and without significant intercurrences, besides allowing the adequate catheter positioning.