Made available in DSpace on 2014-10-09T12:34:20Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:10:41Z (GMT). No. of bitstreams: 0 / A principal finalidade deste estudo foi avaliar a dose efetiva recebida pelos profissionais de saúde no setor de hemodinâmica de um hospital universitário, na cidade de São Paulo. Para delinear o perfil dos profissionais de saúde foi utilizado um questionário auto-aplicável considerando as variáveis sociodemográficas e variáveis relacionadas ao trabalho em presença de radiação ionizante. A avaliação das doses ocupacionais foi realizada por meio de consulta aos históricos de dose individual do banco de dados da instituição, durante os anos de 2000 a 2009. Um total de 240 registros foi avaliado, envolvendo 38 profissionais ativos (2009), de diferentes categorias profissionais, entre elas, médicos, enfermeiros, tecnólogos em radiologia e auxiliares de enfermagem. As doses efetivas anuais foram comparadas com os limites estabelecidos pelas autoridades regulatórias nacionais. Com base nas doses recebidas e registradas durante o período estudado, foram selecionados cinco médicos para usar mais um dosímetro termoluminescente (em caráter experimental) na mão esquerda, durante a realização dos procedimentos de hemodinâmica. Além disso, foram averiguados os procedimentos de radioproteção adotados pelos profissionais de saúde da instituição estudada. Este estudo permitiu traçar o perfil da equipe médica que integra o serviço de hemodinâmica assim como conhecer a distribuição de suas doses em relação aos limites ao longo dos anos. / Dissertação (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

More than hundred years after the discovery of X-rays different kinds of ionizing radiation are ubiquitous in medicine, applied to clinical diagnostics and cancer treatment as well. Irrespective of their nature, the widespread application of radiation implies its precise dosimetric characterization and detailed knowledge of the radiobiological effects induced in cancerous and normal tissue. Starting with in vitro cell irradiation experiments, which define basic parameters for the subsequent tissue and animal studies, the whole multi-stage process is completed by clinical trials that translate the results of fundamental research into clinical application. In this context, the present dissertation focuses on the establishment of radiobiological in vitro cell experiments at unconventional, but clinical relevant radiation qualities. In the first part of the present work the energy dependent biological effectiveness of photons was studied examining low-energy X-rays (≤ 50 keV), as used for mammography, and high-energy photons (≥ 20 MeV) as proposed for future radiotherapy. Cell irradiation experiments have been performed at conventional X-ray tubes providing low-energy photons and 200 kV reference radiation as well. In parallel, unconventional quasi-monochromatic channeling X-rays and high-energy bremsstrahlung available at the radiation source ELBE of the Forschungszentrum Dresden-Rossendorf were considered for radiobiological experimentation. For their precise dosimetric characterization dosimeters based on the thermally stimulated emission of exoelectrons and on radiochromic films were evaluated, whereas just the latter was found to be suitable for the determination of absolute doses and spatial dose distributions at cell position. Standard ionization chambers were deployed for the online control of cell irradiation experiments. Radiobiological effects were analyzed in human mammary epithelial cells on different subcellular levels revealing an increasing amount of damage for decreasing photon energy. For this reason, the assumed photon energy dependence was reconfirmed for a cell line other than human lymphocytes, an important finding that was discussed on the 2007 Retreat of the German Commission on Radiological Protection. After successful finalization of the photon experiments the focus of the present dissertation was directed to the realization of in vitro cell irradiation experiments with laser-accelerated electrons. This research was carried out in the frame of the project onCOOPtics that aims on the development of laser-based particle accelerators, which promise accelerators of potentially compact size and more cost-effectiveness suitable for a widespread medical application, especially for high precision hadron therapy. The unique properties, i.e., the ultrashort bunch length and resultant ultrahigh pulse dose rate, of these unconventional particle accelerators demand for extensive investigations with respect to potential effects on the dosimetric and radiobiological characterization. Based on the experiences gained at ELBE first experiments on the radiobiological characterization of laser-accelerated electrons have been performed at the Jena Titanium:Sapphire laser system. After beam optimization, a sophisticated dosimetry system was established that allow for the online control of the beam parameters and for the controlled delivery of dose to the cell sample. Finally, worldwide first systematic in vitro cell irradiation experiments were carried out resulting in a reduced biological effectiveness for laser-accelerated electrons relative to the 200 kV X-ray reference, irrespectively on the biological effect and cell lines examined. These successful results are the basis for future in vivo studies and experiments with laser-accelerated protons.

This dissertation examines those attributes of full-color display systems (particularly color matrix displays) which degrade image quality. Based on this analysis, it is suggested that a comprehensive metric should measure image quality in terms of transmitted signal and noise modulation, both achromatic and chromatic. Moreover, it is suggested that these signal and noise measurements be weighted in terms of human spatial-chromatic visual characteristics. A review of extant image quality metrics reveals several limitations of these metrics which make them unsuitable for the evaluation of color matrix displays. These limitations include the inability to account for chromatic modulation transfer and chromatic noise as well as the general inability to account for spatial and grey-scale sampling. This work describes a new methodology for assessing image quality that can be applied to full-color as well as monochromatic, and sampled as well as continuous, display systems. Unlike most display quality metrics, the proposed methodology is not based on the tools of linear systems analysis. Rather, it is based on more veridical models of the human visual system (HVS), including multi-channel models of spatial vision, the zone theory of color vision, physiological models of retinal processes, and models of the optics of the eye. A display evaluation system consisting of the HVS model used in conjunction with a display simulator is described. The HVS model employs nine image processing stages to account for nonlinear retinal processes, opponent color encoding, and multiple spatial frequency channels. A detailed procedure for using the HVS model to evaluate display systems is provided. The validity of the HVS model was tested by conducting contrast detection, discrimination, and magnitude estimation experiments on the model. The results of these experiments correspond closely with published human performance data The utility of the display evaluation system was assessed by making image quality predictions for the display systems used in three image quality studies. Image quality predictions using the proposed system correlate strongly with ratings of image quality provided by human subjects. Results of these validation studies indicate that the proposed method of display evaluation is viable and warrants further development. / Ph. D.

Current interest in three-dimensional (3-D) information displays has focused on the use of field-sequential CRT techniques to present binocular stereoscopic images. Although it is widely believed that stereopsis provides a potent depth information cue, numerous monocular cues exist which may augment, detract from, or even supplant stereopsis. Unfortunately, few guidelines or well-controlled analyses on the use of depth cues are available to direct engineering implementations of stereoscopic display systems. This dissertation describes three experiments using 3-D images presented on a Tektronix SGS 620 field-sequential stereoscopic CRT (19-inch diagonal, 120-Hz field rate, passive glasses). In the first experiment, 10 participants with normal vision judged the relative apparent depth ordering of three simple geometric figures (planar circle, square, and triangle). Four sources of depth information (cue types) were factorially combined to construct exemplary images of planar figures in apparent depth: Relative Size (angular subtense decreased with increasing apparent depth); Disparity (binocular disparity varied from crossed to uncrossed with increasing apparent depth); Interposition (closer figures partially occluded ones farther away in apparent depth); and Luminance (luminance decreased with increasing apparent depth). The three monocular cues (Interposition, Size, and Luminance) produced significantly faster depth judgments when used alone; however, when used in combination, Interposition dominated the response time data trends. Although the Disparity cue received moderately high "perceived effectiveness" ratings, response time measures indicated that it played a minor role in the relative depth judgment task. The second experiment was conducted to investigate further the subjective value of the various depth cues. Participants rated subjective image quality (quality of depth) rather than making rapid relative depth judgements. As anticipated, the most satisfactory ratings of depth were made for display images which included stereoscopic depth (Disparity), with the very highest ratings given to display images which included all four depth cues. The results of these first two experiments illustrated a task-demand (objective vs. subjective) discrepancy in the utility of stereoscopic depth cues. The third experiment extended the initial work to include more geometrically complex stimuli in visual search and cursor positioning tasks. In these task environments, stereoscopic disparity and monocular depth cues had an interactive effect on improving visual search times and reducing cursor positioning errors on the depth axis, with the best performance associated with the presence of all depth cues. The complementary nature of these effects was attenuated when depth cue salience was elevated to suprathreshold levels. Based on the results of this research, recommendations are presented for the display of depth information with the stereoscopic CRT. The importance of this research is underscored by the fact that while technological advances have been made in the field of stereoscopic display, very few usability data exist either from laboratory testing or from the implementation of such displays in operational systems. This research provides information to complete cost/performance benefit analyses for 3-D display designs which could in turn significantly impact industry acceptance of the field-sequential stereoscopic CRT. / Ph. D.

The effects of physical image quality on reading and on perceived image quality from CRT and hard copy were studied in this experiment. The results showed that as the image quality of a display increased, indicated by an increase in the value of the MTFA, the reading speed increased and subjective image quality V; ratings increased. This change in reading speed and perceived image quality occurred in the hard copy as well as in the soft copy condition. Image quality, therefore, is concluded to be the major determinant of subjects' performance with respect to displayed information. This implies that if the image quality the displayed text ls the same on the display techniques used, subjects will read from CRT displays as fast as from hard copy displays. / Master of Science

This dissertation examined the relationships between color contrast and legibility for digital raster video imagery. CIE colorimetric components were combined into three-dimensional color coordinate systems whose coordinates map one-to-one with the physical energy parameters of all colors. The distance between any two colors' coordinates in these 3-spaces is termed Color-Difference (ΔE). ΔE was hypothesized as a metric of the speed (RS) with which observers possessing normal vision could accurately read random numeral strings of one color displayed against backgrounds of another color. Two studies totaling 32064 practice and experimental trials were conducted. The first study determined that the CIE Uniform Color Spaces are inappropriate for the modeling of RS. Subsequently, a different 3-space geometry and colorimetric component scaling were empirically derived from the Study 1 data to produce a one-dimensional ΔE scale which ” approximates an interval scale of RS. This ΔE scale and others were then applied to the different stimulus conditions in Study 2 to determine the generalizability of such ΔE metrics. The pair of studies is conclusive: several ΔE scales exist which serve equally well to describe or prescribe RS with multicolor CRT raster imagery for a range of character luminances in both positive and negative presentation polarities. These are the Y,u',v', logY,u',v', L*,u',v', and L*,u*,v* rescaled color spaces. Because of its predictive accuracy and simplicity, a luminance—generalized, ΔE—standardized Y,u',v' metric, accounting for 71% and 75% of the RS variability in Studies 1 and 2, respectively, is recommended as the most appropriate metric of emissive display legibility to be tested in these studies. / Ph. D.

This study considers the effect, on plasma ion oscillations, of various lengths of discharge tubes as well as various cross sections of discharge tubes. Four different gases were used in generating the plasma. Gas pressure and discharge voltage and current were varied to obtain a large number of signals. A historical survey is given to familiarize the reader with the field. The experimental equipment and procedure used in obtaining data is given. An analysis of the data obtained is presented along with possible explanations for the observed phenomena. Suggestions for future study are made.

Investigating and mapping fundamental processes in nature is a driving force for breakthroughs in research and technology. Doing so, requires knowledge of the smallest scales of the world. One way of performing measurements on these scales is through intense x-ray sources, which have improved greatly over the last decades. By combing these sources with state of the art optics, even higher flux densities can be reached, allowing for faster measurements and ground-breaking discoveries.  This study aims to explore the performance of polycapillary optics, when aligned to one of the most intense x-ray micro sources in the world, the liquid-metal-jet D2+. Knife edge scans were performed together with a photon-counting medipix x-ray camera to quantify focus properties such as, flux, flux density, transmission, gain and beam width. Measurements were conducted with a 20 μm source spot that was compared to a simulated 200 μm source spot, both at 260 W electron beam power. The data from vertical and horizontal scans were combined to reconstruct the 2D functionality of the polycapillary optic. The flux density were almost four times higher with the 20 μm spot compared to the simulated 200 μm spot. This result correlated with the condition for total external reflection and the local divergence. The conclusion is that the small source spot of the liquid-metal-jet source improves the efficiency of the polycapillary optic.  The efficiency could still be improved, if the deviation in the pointing accuracy could be minimized. Furthermore, the combination of liquid-metal-jet x-ray source and the polycapillary optic, achieved extremely high flux densities. This was specially compared to an x-ray source used for confocal micro XRF, where the flux was almost nine times higher with the liquid-metal-jet x-ray source. This allows for faster measurements within confocal micro XRF and other techniques demanding very high flux densities, but with low demands on beam divergence and spectral purity.

En dosimétrie, la distribution énergétique des photons émis par une source constitue un paramètre incontournable. Dans la gamme des basses et moyennes énergies (i.e. E<150 keV ici), le LNHB possède 5 tubes à rayons X ainsi que des grains de curiethérapie à l’iode 125, présentant des hauts débits de fluence. La détermination du spectre émis par calcul (déterministe ou Monte-Carlo) est limitée, dans la gamme d’énergie considérée, par les incertitudes élevées sur les bases de données ainsi que par les approximations du modèle. La mesure directe avec un détecteur au germanium ultra-pur a donc été retenue, bien que nécessitant de lourds moyens. De plus, le spectre mesuré est le produit de convolution du spectre émis recherché par la réponse du système. Une fois la réponse du détecteur modélisée, il est possible de « déconvoluer» la mesure, i.e. de remonter au spectre réellement émis en corrigeant (par stripping, model-fitting, inférence bayésienne…) les déformations spectrales induites par le processus de détection. Pour la curiethérapie, le modèle de grain-source a ainsi pu être ajusté. Pour les tubes à rayons X, les résultats obtenus avec différents codes Monte-Carlo et 4 logiciels déterministes ont été comparés à un spectre dit de référence obtenu par mesure et déconvolué. Ainsi l’impact sur certaines grandeurs dosimétriques de la méthode utilisée a pu être quantifié. / In the field of dosimetry, the knowledge of the whole photon fluence spectrum is an essential parameter. In the low-to-medium energy range (i.e. E<150 keV), the LNHB possess 5 X-ray tubes and iodine-125 brachytherapy seeds, both emitting high fluence rates. The performance of calculation (either Monte Carlo codes or deterministic software) is flawed by increasing uncertainties on fundamental parameters at low energies, and modelling issues. Therefore, direct measurement using a high purity germanium is preferred, even though it requires a time-consuming set-up and mathematical methods to infer impinging spectrum from measured ones (such as stripping, model-fitting or Bayesian inference…). Concerning brachytherapy, the knowledge of the seed’s parameters has been improved. Moreover, various calculated X-ray tube fluence spectra have been compared to measured ones, after unfolding. The results of all these methods have then be assessed, as well as their impact on dosimetric parameters.

To investigate near-eld contributions for installed antennas, an in-house code iswritten to incorporate near-eld terms in Shooting and Bouncing Rays (SBR). SBRis a method where rays are launched toward an object and scatter using GeometricalOptics (GO). These rays induce currents on the object, from which the totalscattered eld can be found.To gauge the eect of near-eld terms, the in-house code can be set to excludenear-eld terms. Due to this characteristic, the method is named SBR Includingor Excluding Near-eld Terms (SIENT). The SIENT implementation is thoroughlydescribed. To make SIENT more exible, the code works with triangulated meshesof objects. Antennas are represented as near-eld sources, allowing complex antennasto be represented by simple surface currents. Further, some implementedoptimizations of SIENT are shown.To test the implemented method, SIENT is compared to a reference solution andcomparable commercial SBR solvers. It is shown that SIENT compares well to thecommercial options. Further, it is shown that the inclusion of near-eld terms actsas a small correction to the far-eld of the installed antenna. / För att undersöka närfältsbidrag för installerade antenner, har en kod skrivits för‌att ta med närfältstermer i Shooting Bouncing Rays (SBR). SBR är en metod där strålar (”rays”) skjuts mot ett object och sprids via Geometrisk Optik (GO). Dessa strålar inducerar strömmar på objectet, från vilka det totala sprida fältet kan hittas. För att undersöka bidraget från närfältstermer, så kan koden exkludera dessa. På grund av denna karaktär, kallas koden SBR Including or Excluding Near-field Terms (SIENT). Implementationen av SIENT beskrivs utförligt. För att göra SIENT mer flexibel, arbetar SIENT med triangulerade nät av objekt. Antenner representeras av närfältskällor, vilket låter komplexa antenner representeras med enkla yt-strömmar.Implementerade optimeringar av SIENT visas också.För att testa den implementerade metoden, jämförs SIENT med en referenslösning och jämförbara kommerciella SBR-lösare. Det visas att SIENT överensstämmer bra med kommerciella alternativ. Det visas också att närfältstermer agerar som enmindre korrektion till fjärrfältet av den installerade antennen.