Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Technology Consultant: Mgr. Pavel Ondrejček, Ph.D. Student: Tomáš Marcinek Title of Thesis: The influence of the tableting speed on the compaction process The main aim of this thesis was to determine the influence of tableting speed on the compaction process of four substances. The compaction process was evaluated by three- exponential equation. The parameters of this equation describe the individual phases of compression, the precompression phase, the phase of elastic deformation and the phase of plastic deformation. Furthermore, the effect of tableting speed on the compressibility of the material was studied using the force-displacement record. Finally, the influence of tableting speed on tensile strength of the prepared tablets was evaluated. Four materials were used for the evaluation. Microcrystalline cellulose Avicel PH-102 and dicalcium phosphate dihydrate DI-CAFOS were used as model fillers. Theophylline and paracetamol were used as model drugs. The course of the compaction process was evaluated at five compaction speeds. The results of this evaluation revealed different behavior of used materials. Furthermore different influence on the compaction process by changing compaction speed was...

Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Consultant: Mgr. Pavel Ondrejček, Ph.D. Student: Nikola Marcinková Title of Thesis: The influence of the die size on the compaction process This diploma thesis is focused on exploration the influence of the die size on the compaction process. That was evaluated by parameters of three-exponential equation. Compressibility was studied by using force-displacement record. In this work was also observed an effect of die size on the tensile strength. In processing the experimental part of this work were used four different model materials. Microcrystalline cellulose and dicalcium phosphate are used as model fillers and theophylline and paracetamol as model active substances. Compaction of these materials was carried out in dies of size 7 mm, 9 mm, 11 mm, 13 mm and 15 mm. The results of the work showed that the die size significantly affects all parameters force-displacement record. With the growing size of the die there was a reduction of energy parameters. Most of the compaction parameters were statistically influenced. Increasing die size caused reducing volume reduction and energy consumption and increased speed of volume reduction at the stage of pre- compression and elastic...

Project focusing on healthy lifestyles of preschool children According to the recent epidemiological examination has more than half the Czech population overweight. Overweight and obesity are associated with many serious health problems, higher mortality and significant are also high financial charges of their treatment. This thesis deals with a healthy life style and children's obesity issue. It's divided into theoretical and practical part. Theoretical chapters discuss about issues associated with health, nutrition, drinking regime, physical activity, relaxation, causes and consequences of children's obesity, food allergies and outline the principles of healthy nursery school. The practical part is about week project developing principles of a healthy life style. This inspiring instruction aims to take children and gently pull them to the topic and develop healthy living habits and attitudes. Due to the project realisation I was able to find out, that most pre-school children have acquired knowledge regarding healthy life style. However there are mainly parents, who are affecting food and leisure time their child, unfortunately not always in the right way.

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Mgr. Pavel Ondrejček, Ph.D. Student: Simona Berková Title of Thesis: The evaluation of compressibility of the mixtures pellets and microcrystalline cellulose This thesis is focused on the evaluation of powdered microcrystalline cellulose, pellets and mixtures thereof. Comprecel 102 was used as powdered microcrystalline cellulose. The used pellets were commercially available pellets Cellets 100 made of microcrystalline cellulose. The flow properties of used materials and their mixtures were evaluated by using the angle of repose, flow through orifice and Hausner ratio methods. Further the compressibility was evaluated using the force-displacement record. For the evaluation of compaction proces the three exponential compaction was used. Finally the radial tablet strength and tablet friability was tested. The results showed, that the flow properties improved with an increasing amount of pellets in mixture. I tis due to higher bulk and tapped density and also narrower particle size distribution, smoother surface and the regular shape of used pellets. The parameters of the force-displacement method showed different compressibility of used tabletting mixtures. The evaluation of...

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: Mgr. Petra Svačinová, Ph.D. Student: Michaela Přeučilová Title of Thesis: A comparison of viscoelastic properties of mixtures of lactose and different lubricants using the stress relaxation test This diploma thesis deals with viscoelastic properties of pharmaceutical excipients and tensile strength of tablets made of these excipients. Theoretical part is dedicated to description of lactose and lubricants, further the tablets compressibility and compression energy profile are described. The end of theoretical part deals with the stress relaxation test, with evaluation methods and the stress relaxation test influence on lactose tablets with different types of lubricants as well. The experimental part deals with the evaluation of the viscoelastic properties of two types of lactose and their mixtures with different types of lubricants at concentration of 1%. These characteristics were evaluated by stress relaxation test. All tablets were compressed by compression forces of 13 kN and 15 kN with dwell time 180 seconds. The study was about differences between two types of lactose, effect of lubricants and effect of two different compression forces on parameters of elasticity A1 -A3 and...

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: Mgr. Petra Svačinová, Ph.D. Student: Straková Markéta Title of Thesis: The influence of dwell time on the parameters of the stress relaxation test for lactose and calcium hydrogen phosphate The aim of this thesis is to find out viscoelastic properties of pharmaceutical excipients and to evaluate the tensile strength of tablets made of them. The theoretical part describes used materials, these are lactose, calcium hydrogen phosphate and magnesium stearate. The thesis also deals with the stress relaxation test, its evaluation and usage. Tensile strength, calculation and various factors that affect tensile strength are described in the text. The experimental part deals with viscoelastic properties of used materials and their mixtures with lubricant using the stress relaxation test. Different dwell times (60 s, 120 s, 180 s, 240 s, 300 s, 360 s, 420 s, 480 s, 540 s, 600 s) were used for individual measurements. The relation between elasticity parameters (A1, A2, A3) and plasticity parameters (P1, P2, P3) depending on the dwell time was investigated. As for calcium hydrogen phosphate, the dwell time 180 - 240 seconds was found as the most appropriate. As for lactose, the optimum dwell...

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Mgr. Pavel Ondrejček, Ph.D. Student: Žofie Trpělková Title: A study of a compaction process of microcrystalline cellulose pellets This work is aimed at the comparison of two types of microcrystalline cellulose (Comprecel 102 a Avicel PH-200) with two types of pellets made of microcrystalline cellulose (Cellets 100 a Cellets 200). Important properties for the compaction into tablets were analyzed in these materials. The particle size distribution, the content of moisture, the bulk and tapped density, the flowability, the angle of repose and the Hausner ratio were evaluated. Furthermore, the compaction process was described by using the force displacement method and the three-exponential equation. Finally, the radial strength and the friability of tablets prepared by using two different compaction forces were evaluated. The results proved that both types of pellets have much better flow properties than powdered microcrystalline celluloses. This is primarily caused by the narrow particle size distribution, higher bulk and tapped density and the significantly smoother surface of pellets. Better flow properties of the pellets also influenced the parameters of the force-displacement...

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: Mgr. Svačinová Petra, Ph.D. Student: Hamplová Kateřina Title of Thesis: The influence of the dwell time on the parameters of the stress relaxation test for microcrystalline cellulose and starch. This thesis is focused on the viscoelastic properties of pharmaceutical excipients and the tensile strength of tablets. The theoretical part describes used materials. Microcrystalline cellulose and starch were used as fillers and magnesium stearate at concentration of 1% was used as lubricant. The stress relaxation test and its evaluation and utilization not only in pharmacy is described as well as the tensile strength of tablets. The experimental part deals with the viscoelastic properties of used materials and their mixtures with lubricant. These properties were evaluated using the stress relaxation test. At maximum compression force of 10 kN the length of dwell time was changed (60 s, 120 s, 180 s, 240 s, 300 s, 360 s, 420 s, 480 s, 540 s, 600 s). For derived parameters of elasticity A1-3 and plasticity P1-3 the dependence on the length of dwell time was evaluated. Parameter A1 increases with increasing dwell time for all substances. For parameters A2, A3, the dependence on the dwell...

This dissertation thesis is concerned with developing a mesoscopic model for sin- gle crystalline shape-memory alloys including thermo-dynamically consistent thermo- mechanical coupling - here the term "mesoscopic" refers to the ability of the model to capture fine spatial oscillations of the deformation gradient by means of gradient Young measures. Existence of solutions to the devised model is proved in a "phase-field-like approach" by a scale transition from a microscopic model that features a term related to the interfacial energy; this scale transition from a physically relevant model justifies the mesoscopic relaxation. Further, existence of solutions is also proved by backward- Euler time discretization which forms a conceptual numerical algorithm. Based on this conceptual algorithm a computer implementation of the model has been developed and further optimized in the rate-independent isothermal setting; some calculations using this implementation are also presented. Finally, refinements s of the analysis in the convex case as well as a limit of the phase-field-like approach in this case are exposed, too.

The thesis presents the results of theoretical and empirical study. The thesis deals with primary monitoring of lifestyle of students with special educational needs, the creation of an educational program designed for dormitory of secondary vocational school and the program's impact on quality of life. The work consists of several parts. The theoretical part describes the principles of a healthy lifestyle (healthy eating, physical activity, mental activity), special educational needs, the age period of 15-18 years, secondary vocational school and quality of life. The practical part analyzes the lifestyle of students at secondary vocational school in Soběslav. This part highlights the different attitudes of commuter students and students living in dormitories. The analysis is based on questionnaire my own creation. The results are shown in the graphs. For dormitory of secondary vocational school an educational program "A year in a dorm" was created. The program is aimed at a comprehensive understanding of health and healthy lifestyle. The influence of the educational process on the quality of life we investigated using a standardized questionnaire PedsQl. Data are evaluated by ANOVA and Tukey statistical method. In conclusion we disprove the hypothesis that commuter students have a healthier lifestyle than students staying at the dorms. We confirm the positive effect of educational program on quality of life for boarding students statistically significant in the group of girls. We also confirm that the effect of the program lasted three months