Bakgrund: Undernäring är ett vanligt förekommande tillstånd inom hälso- och sjukvården. Undernäring har samband med ökad sjuklighet och dödlighet. Det leder till ökade kostnader för samhället då vårdtiderna blir längre. Patienterna blir utsatta för ett ökat lidande. Enligt nutritionsvårdsprocessen kan undernäring upptäckas om en screening av nutritionsstatusen  utförs. För att sedan utreda vad som orsakar undernäringen kan ät- och måltidsobservationsinstrument utnyttjas. Syfte: Syftet med föreliggande litteraturstudie var att identifiera vilka faktorer som observeras i samband med screening för nutritionsstatus och ät -och måltidsobservationer och vilka instrument som finns utvecklade för att identifiera dessa faktorer hos multisjuka äldre. Metod: Litteraturöversikten baserad på vetenskapliga artiklar utifrån studiens syfte. De vetenskapliga artiklarna fanns tillgängliga på Uppsala universitets elektroniska prenumerationer. Analysarbetet gjordes genom granskning och bearbetning av insamlat material. Resultat: Resultatet av granskningen visade att viktminskning, BMI, diagnos, aptit och funktionsförmåga var faktorer som de flesta nutritionsstatus screeninginstrument observerade. Faktorer som observerades i störst utsträckning i ätobservationsinstrument var tugg och sväljsvårigheter, transport av mat till munnen, sittposition och energitillförsel. De flesta av instrumenten som granskades visade sig vara reliabla och validerade. Det fanns inget instrument som observerade endast måltidsmiljön. Det finns även andra faktorer som visat sig ha inverkan på nutritionsstatusen som inte observeras i något instrument. Dessa faktorer var av psykosociala och ekonomisk karaktär.  Slutsats: Det finns nutritionsstatus screening instrument av god kvalité däremot finns det inte lika omfattande ät – och måltidsobservationsinstrument. / Background: Malnutrition is a common condition in health care. Malnutrition is associated with increased morbidity and mortality. It leads to increased charges imposed on society when the length at hospital becomes longer. Patients becomes vulnerable to increased suffering. According to the nutrition care process, malnutrition can be detected when a nutritional status screening is performed. Then, to investigate the causes of malnutrition eating and meal instruments can be utilized. Aim: The aim of the present study was to identify the factors that are observed in connection with the nutritional status screening and eat -and meal observations. Which instruments are developed to identify these factors in multi-ill elderly. Methods: The review was based on scientific papers on the basis of the study's purpose. The data were available at Uppsala University's electronic subscriptions. The analysis was done by examination and processing of the collected material. Result: The result showed that the weight loss, body mass index, diagnosis, appetite and functional capacity were factors that most nutritional screening instruments observed. Factors that were observed to the greatest extent in eat observation instrument was chewing and swallowing difficulties, transportation of food to the mouth, sit position and energy intake. There was no instrument that observed only meal environment. Most of the instruments examined proved to have reliability and validity. There are also other factors shown to influence the nutritional status that is not observed in any instrument. These factors were of the psychosocial and economic character. Conclusion:There are nutritional status screening instruments of good quality, however, there are not as extensive eat -and meal instruments.

- cz Tato práce se zabývá analýzou antimonopolní politiky se zaměřením na kartelové dohody v Evropské unii. Cox·v model proporcionálních rizik je v rámci této práce použit pro predikci proměnných, které ovlivňují trvání a stabilitu kartel·. Tyto proměnné jsou rozděleny do následujících skupin. Velikost a vnitřní struk- tura kartelu, charakteristika účastník· kartelové dohody, ukazatele vnějšího prostředí na trhu, vnitřní kontrolní mechanismy a proměnné, určující účin- nost antimonopolní politiky. Pro účely této práce byl sestaven data set, který zahrnuje kartely soudně stíhané Evropskou komisí v období mezi lety 1990 a 2004. Tato práce navíc obsahuje přehled detekčních metod. Zahrnuje jak metody, které jsou v současnosti aktivně využívány Evropskou komisí za účelem detekce kartel·, tak i nové metody, tzv. screeningové metody trh·, které mohou do budoucna přispět k efektivnějšímu procesu detekce. Screeningové metody se zabývají zkoumáním reálných tržních proces· a hledají znaky koluzního chování. Součásti této práce je mimo jiné i analýza politiky shovívavosti a její dopad na životnost kartel· a na délku administrativních proces·. Očekávaným přínosem této práce je poskytnutí uceleného přehledu detekčních metod a proměnných, které ovlivňují životnost a stabilitu kartel·. 1

Master of Public Health - MPH / Background: In South Africa, tuberculosis (TB) detection remains a major problem, as notified cases are estimated to account for only 68% of all incident cases. Health services have relied on passive case finding and this leads to missed or delayed diagnosis. In Cape Town, City Health has embarked on an active surveillance programme to systematically screen all adults seeking health care at PHC facilities for active TB, in order to identify undiagnosed incident TB cases and avert missed opportunities for treating TB. Aim: The aim of this study was to evaluate the effects of an intensified TB screening strategy on changes in facility level TB case finding in City Health PHC facilities in Cape Town.

O Mal de Alzheimer é a causa mais importante de demência em idosos. A progressão dos sintomas da doença está associada com modificações estruturais nas sinapses colinérgicas em determinadas regiões cerebrais e, consequentemente, à diminuição do potencial de neurotransmissão colinérgica. Desta forma, o aumento da capacidade de neurotransmissão colinérgica constitui o mecanismo fundamental dos fármacos utilizados para o tratamento do Mal de Alzheimer. Atualmente, o único tratamento clínico eficaz para o Mal de Alzheimer (MA) é a utilização de inibidores da acetilcolinesterase (AChE). Os anticolinesterásicos são os fármacos mais promissores desenvolvidos até hoje, pois é a única classe terapêutica que mostrou melhora nos sintomas cognitivos do MA. Para esse projeto, foram utilizadas diferentes técnicas de modelagem molecular como estratégia de planejamento racional de fármacos, tendo como base os inibidores de Acetilcolinesterase (AChE) descritos na literatura além dos que possuem estruturas depositadas no PDB, incluindo alguns que já vêm sendo utilizados no tratamento do Mal de Alzheimer. O objetivo foi planejar e testar novos potenciais inibidores desse alvo terapêutico, na tentativa de obter e futuramente otimizar novos protótipos como futuros candidatos a fármacos em Mal de Alzheimer. Os objetivos estendem-se a propostas de novos potenciais protótipos, selecionados de bases de dados de compostos comerciais contendo propriedades de fármacos. Os screenings virtuais foram tendenciados às estruturas dos inibidores já reportados da literatura bem como ao padrão farmacofórico comum a eles, a ser modelado. / Alzheimer\'s disease is the leading cause of dementia in the elderly. The progression of symptoms is associated with structural changes in cholinergic synapses in specific brain regions and consequentely to decrease the potential of cholinergic neurotransmission. Thus, the increased capacity of cholinergic neurotransmission is the fundamental mechanism of the drugs used to treat Alzheimer\'s disease. Currently, the only effective clinical treatment for Alzheimer\'s (MA) is the use of inhibitors of acetylcholinesterase (AChE). Cholinesterase inhibitors are the most promising drugs developed so far, it is the only therapeutic class that showed improvement in cognitive symptoms of MA. For this project, we used different techniques of molecular modeling as a strategy for rational design of drugs based on inhibitors of acetylcholinesterase (AChE) in the literature than those which have structures deposited in the PDB, including some that have already been used in the treatment Alzheimer\'s disease.The objective was to design and test new potential inhibitors of therapeutic target in attempts to obtain and optimize future new prototypes as future drug candidates in Alzheimer\'s disease. The goals extend to proposals from potential new prototypes, selected from databases of commercial compounds containing properties of drugs. The virtual screenings were trends to structures of the inhibitors already reported in the literature as well as the pharmacophoric pattern common to them, to be modeled.

É comum, em problemas de inferência bayesiana, deparar-se com uma distribuição a priori para o parâmetro de interesse, theta, que seja intratável analítica ou computacionalmente. Como a priori é uma escolha do pesquisador, tal situação ocorre por conta da intratabilidade da função de verossimilhança. Por meio de algoritmos ABC, é possível simular-se uma amostra da distribuição a posteriori, sem a utilização da verossimilhança. Neste trabalho, aplica-se o ABC no contexto de Environmental Stress Screening - ESS. ESS é um procedimento de estresse, em um processo de produção industrial, que visa evitar que peças de qualidade inferior sejam utilizadas no produto final. A partir de uma abordagem bayesiana do ESS, depara-se com uma verossimilhança (e, consequentemente, uma posteriori) intratável para o vetor de parâmetros de interesse. Utiliza-se, então, o ABC para obtenção de uma amostra da posteriori e calcula-se o tempo ótimo de duração de um futuro procedimento de estresse a partir da simulação feita. É também proposta uma generalização do problema de ESS para a situação em que existem k tipos de peças no processo de produção. Quantifica-se o problema e, novamente, aplica-se um algoritmo ABC para a obtenção de uma simulação da posteriori, bem como calcula-se o tempo ótimo de duração de um futuro teste de estresse. / In Bayesian inference problems, it is common to obtain a posterior distribution for the parameter of interest, theta, which is analytically or computationally intractable. Since the priori is chosen by the researcher, this situation arises from the intractability of the likelihood function. Through ABC algorithms it is possible to simulate a sample from the posterior distribution, without the analytical use of the likelihood function. In this work ABC is applied in the context of Environmental Stress Screening - ESS. ESS is a stress procedure, in an industrial production process, which aims to avoid low quality parts to be used in the final product. Under a Bayesian approach to ESS, an intractable likelihood (consequently, a posterior) is obtained for the paramater of interest. ABC is used to simulate a sample from the posterior and the optimal duration for a next stress procedure is calculated afterwards. A generalization of the ESS is also proposed considering that there are k types of parts in the production process. Again, ABC is used to simulate a sample from the posterior, and it is calculated the optimal duration for a next stress procedure.

Thesis advisor: James Lubben / In 2011, an estimated 12,710 women suffered from cervical cancer and 4,290 died from it in the U.S. HPV vaccination (HPV-V) and PAP screening (PAP-S) could reduce this burden. Using 2010 National Health Interview Survey data, current disparities in the use of PAP-S and HPV-V in U.S. women aged 18-30 years were investigated. An adapted Behavioral Model of Health Care Utilization guided the study. Main outcomes were PAP-S in prior year and ever-HPV-V, both initiation and completion. Adjusted predictor estimates were obtained through multivariate logistic regressions with appropriate statistical procedures and weights for complex survey design. A sub-analysis focused on unvaccinated women. The sample had 3,129 women aged 18-30 years, representing about 27 million women of similar age in the U.S. PAP-S, HPV-V initiation and completion rates were 53.5%, 17.9%, and 10.3%, respectively. Hispanics were 33% less likely than Non-Hispanic-Whites to initiate HPV-V. Non-Hispanic-Blacks were 55% more likely and 57% less likely than Non-Hispanic-Whites to receive PAP-S and complete HPV-V, respectively. Non-Hispanic Asians were 36% less likely than Non-Hispanic-Whites to receive PAP-S, but this result was borderline significant. Younger age and being unmarried were predictors of lower PAP-S but higher HPV-V. Ever gave birth was a predictor of higher PAP-S but lower HPV-V. Preventative behaviors (PAP-S and flu vaccination) were predictors of higher HPV-V. STI-history was a predictor of higher HPV-V and PAP-S. Not having health insurance for over one year or recent health provider visit were predictors of lower PAP-S and HPV-V. Living in the South was a predictor of lower HPV-V. Household income was not a predictor of any outcomes. Most common reported reason for no HPV-V was "no need." Study findings indicate interventions to mitigate disparities in cervical cancer prevention are needed. Tailored education interventions for both women and health care providers along with opportunities associated with the 2010 Affordable Care Act, such as broader access to health care, emphasis on health information technology, and initiatives with PAP screening and adult vaccination as potential quality indicators for performance/payment, can reduce these disparities. Future research should focus on the feasibility of alternative venues for receiving HPV-V and PAP-S. / Thesis (PhD) — Boston College, 2013. / Submitted to: Boston College. Graduate School of Social Work. / Discipline: Social Work.

Hästar producerar gödsel som är en   blandning av avföring, urin och det strömaterial som hästarna står på.   Hippologum är en ridanläggning i Umeå (Västerbotten, Sverige) som producerar   20-25 ton gödsel per vecka och när denna rapport skrevs hade anläggningen   ingenstans att lagra gödseln. Detta var våren 2016. Målet med denna studie var att   undersöka ett möjligt förvaltning- och komposteringssystem för hästgödsel   mellan Hippologum och deponi- och avfallscentret Dåva DAC (som också är   beläget i Västerbotten, Sverige) och var systemets största klimatpåverkan   finns. En liten marknads-undersökning baserad på personintervjuer och ett   kort kapitel om lagaspekter finns också med i rapporten. Enligt den screening livscykelanalys som genomfördes   inom ramen för denna C-uppsats är den största klimatförändrande effekten för   23 ton hästgödsel från Hippologum till Dåva DAC odlingen av fodret.   Marknadsundersökningen som utfördes kan inte direkt säga att det finns en   marknad i Umeå kommun för komposterad hästgödsel. Gällande den lagliga biten   så kan sägas att EU har mycket att säga till om gällande animaliska   biprodukter och att den lagliga aspekten tyckts vara väl utvecklad. / Horses   produce feces and urine and this mixed with a bedding material such as   sawdust or cutterdust gives you horse manure. Hippologum is an equestrian   facility in Umeå (county of Västerbotten, Sweden) which produces 20-25 tons   of manure per week and when this report was written the facility had some   trouble to get rid off the manure. This was in Spring 2016. The aim of this study is to look into the possible soil   improver production as a management strategy for the horse manure produced at   Hippologum and the report also looks   into which part of this proposed system which has the greatest climate   impact. The landfill- and waste   center Dåva DAC (also located in the county of Västerbotten, Sweden) is the   assumed receiver of the manure, and this is were the manure would be refined   (composted). Research based on personal interviews about the manure market in   Umeå municipality as well as a short chapter about legal aspects of manure   are also included in the report. According to the screening LCA conducted during this   thesis work the greatest impact for 23 tons of horse manure from Hippologum   to Dåva DAC is the cultivation of the   fodder. The report cannot conclude if there is a manure market in Umeå   municipality. Concerning the legal aspects it can be said that the European   Union has well developed legislation concerning animal by-products and   regulates many aspects of handling and treating of horse manure. / <p>2019-01-08</p>

O Mal de Alzheimer é a causa mais importante de demência em idosos. A progressão dos sintomas da doença está associada com modificações estruturais nas sinapses colinérgicas em determinadas regiões cerebrais e, consequentemente, à diminuição do potencial de neurotransmissão colinérgica. Desta forma, o aumento da capacidade de neurotransmissão colinérgica constitui o mecanismo fundamental dos fármacos utilizados para o tratamento do Mal de Alzheimer. Atualmente, o único tratamento clínico eficaz para o Mal de Alzheimer (MA) é a utilização de inibidores da acetilcolinesterase (AChE). Os anticolinesterásicos são os fármacos mais promissores desenvolvidos até hoje, pois é a única classe terapêutica que mostrou melhora nos sintomas cognitivos do MA. Para esse projeto, foram utilizadas diferentes técnicas de modelagem molecular como estratégia de planejamento racional de fármacos, tendo como base os inibidores de Acetilcolinesterase (AChE) descritos na literatura além dos que possuem estruturas depositadas no PDB, incluindo alguns que já vêm sendo utilizados no tratamento do Mal de Alzheimer. O objetivo foi planejar e testar novos potenciais inibidores desse alvo terapêutico, na tentativa de obter e futuramente otimizar novos protótipos como futuros candidatos a fármacos em Mal de Alzheimer. Os objetivos estendem-se a propostas de novos potenciais protótipos, selecionados de bases de dados de compostos comerciais contendo propriedades de fármacos. Os screenings virtuais foram tendenciados às estruturas dos inibidores já reportados da literatura bem como ao padrão farmacofórico comum a eles, a ser modelado. / Alzheimer\'s disease is the leading cause of dementia in the elderly. The progression of symptoms is associated with structural changes in cholinergic synapses in specific brain regions and consequentely to decrease the potential of cholinergic neurotransmission. Thus, the increased capacity of cholinergic neurotransmission is the fundamental mechanism of the drugs used to treat Alzheimer\'s disease. Currently, the only effective clinical treatment for Alzheimer\'s (MA) is the use of inhibitors of acetylcholinesterase (AChE). Cholinesterase inhibitors are the most promising drugs developed so far, it is the only therapeutic class that showed improvement in cognitive symptoms of MA. For this project, we used different techniques of molecular modeling as a strategy for rational design of drugs based on inhibitors of acetylcholinesterase (AChE) in the literature than those which have structures deposited in the PDB, including some that have already been used in the treatment Alzheimer\'s disease.The objective was to design and test new potential inhibitors of therapeutic target in attempts to obtain and optimize future new prototypes as future drug candidates in Alzheimer\'s disease. The goals extend to proposals from potential new prototypes, selected from databases of commercial compounds containing properties of drugs. The virtual screenings were trends to structures of the inhibitors already reported in the literature as well as the pharmacophoric pattern common to them, to be modeled.

G-quadruplexes are non-canonical nucleic acid secondary structures of increasing biological and medicinal interest due to their proposed physiological functions in transcription, replication, translation and telomere biology. Aberrant G4 formation and stabilisation have been linked to genome instability, cancer and other diseases. However, the specific genes and pathways involved are largely unknown, and the work within this thesis aims to investigate this. Stabilisation of G4s by small molecules can perturb G4-mediated processes and initial studies suggest that this approach has chemotherapeutic potential. I therefore also aimed to identify cell genotypes sensitive to G4-ligand treatment that may offer further therapeutic opportunities. To address these aims, I present the first unbiased genome-wide genetic screen in cells where genes were silenced via short-hairpin RNAs (shRNAs) whilst being treated with either PDS or PhenDC3, two independent G4-stabilising small molecules. I explored gene deficiencies that enhance cell death (sensitisation) or provide a growth advantage (resistance) in the presence of these G4-ligands. Additionally, I present a validation screen, comprising hits uncovered via genome-wide screening, and also the use of this in another cell line of different origin. Sensitivities were enriched in DNA replication, cell cycle, DNA damage repair, splicing and ubiquitin-mediated proteolysis proteins and pathways. Ultimately, I uncovered four synthetic lethalities BRCA1, TOP1, DDX42, GAR1, independent of cell line and ligand. These were validated with three G4-stabilising ligands (PDS, PhenDC3 and CX-5461) using an independent siRNA approach. The latter siRNA methodology was used to screen 12 PDS derivatives with improved medicinal chemistry properties and ultimately identified SA-100-128, as a lead compound. The mechanism behind synthetic lethality with G4-stabilising ligands was explored further for DDX42, which I show has in vitro affinity for both RNA- and DNA-G4s and may represent a previously unknown G4-helicase. Also within this thesis, gene deficiencies that provided a growth advantage to PDS and/or PhenDC3 as uncovered by genome-wide and focused screening were explored. These showed enrichment in transcription, chromatin and lysosome-associated genes. The resistance phenotype of three gene deficiencies, TAF1, DDX39A and ZNF217 was further supported by additional siRNA experiments. Overall, I satisfied the primary aims and established many novel synthetic lethal and resistance interactions that may represent new therapeutic possibilities. Additionally, the results expand our knowledge of G4-biology by identifying genes, functions and subcellular locations previously not known to involve or regulate G4s.

Thesis (MPH.) --University of Limpopo, 2009 / Please refer to the document