Thesis (MScSportSc)--Stellenbosch University, 2014. / ENGLISH ABSTRACT: Autism Spectrum Disorder (ASD) has been described as a neuro-developmental disorder influencing the social interaction and communication skills of individuals. Those with ASD have been observed to experience sensory input challenges, which could result in motor delays. Descriptive research was conducted with two case studies, who were boys aged 6- and 8-years, diagnosed with ASD. The purpose of the study was to design and implement a Sensory-Motor Integration (SMI) programme for each boy and to assess the effect it had on the sensory motor skills of the boys over time. At the start of the intervention, the boys were assessed with three neuro-developmental and diagnostic evaluations (Social Communication Questionnaire, Autism Diagnostic Interview Revised and Autism Diagnostic Observation Schedule-2nd Edition) conducted by a psychiatrist to re-affirm their previous ASD diagnoses. The two boys (Subject A and Subject G) participated in individualised sessions of 30 minutes each, twice a week for seven months. The SMI programme focused on vestibular and somato-sensory (proprioceptor) variables. The Quick Neurological Screening Test-3 (QNST III) and the Sensory Input Systems Screening Test (SISST) were used to evaluate the latter at baseline. These were repeated regularly, every 4 to 5 weeks, over the 7-month period and included a retention test of 5 weeks. Based on the results from the subtests of the motor skill tests, a self-designed SMI programme was integrated into the planning of the intervention programme for each boy according to their sensory-motor needs. Subject A showed improvement in the following vestibular subtests in the QNST-III: Stand on one leg (67%) and Tandem walk (83%) and retaining his standard from the Post-test to the Retention test. For muscle tone ability and proprioception, the Arm and leg extension subtest also demonstrated improvement (67%) from the Pre-to the Post-test. The results of the subtest were not retained over the retention period and increased only slightly being 33% from the baseline score. The proprioceptive function of Subject A showed great improvement in the following QNSTIII subtests: Finger to nose (67%), Rapidly reversing repetitive hand movements (88%) and Left and right discrimination (67%). The results of vestibular-related subtests for Subject G showed improvement in the following: Stand on one leg (33%) and the Arm and leg extension task (33%). Some of the scores of Subject G started in the functional category of “severe discrepancy”; however there was improvement in the following proprioceptionrelated subtests: Finger to nose (43%), Thumb and finger circles (20%), and Reversing repetitive hand movements (86%). Although Subject G showed gradual improvement over time, his two sensory systems struggled to integrate with the more complex tasks. The outcome of the individualised SMI programmes showed that the sensory-motor skills improved by enhancing the stimulation of their vestibular and somato-sensory (proprioception) function. Regarding the SISST, Subject A progressed from a ‘fail’ to ‘pass’, in the following test items: the Tonic Labyrinthine Supine (TLS), Tonic Labyrinthine Prone (TLP), Positive Support Reflex (PSR) and the Ocular Alignment test items. Results from the Vestibular test for both Subject A and Subject G appeared to be ‘hypo-vestibular’ (under-stimulated) according to the Post- Rotary Nystagmus test (PRN) score at baseline. These scores were inconsistent during the intervention. The only test item to show positive improvement for Subject G was the Equilibrium Reactions. Lastly, both Subject A and Subject G remained in the ‘fail’ category for Kinaesthesis, which may indicate their ongoing poor proprioception and spatial orientation. There is a need for further research in the area of sensory-motor individualised programmes for children with ASD. Suggestions for future research interventions are to conduct the individualised programmes either over a longer period of time and more frequently at three times a week. / AFRIKAANSE OPSOMMING: Outisme Spektrum Versteuring (OSV) word beskryf as 'n neuro-ontwikkelingsversteuring wat die sosiale interaksie en kommunikasie van individue beïnvloed. Daar is waargeneem dat diegene met OSV, uitdagings met betrekking tot sensoriese insette ervaar, wat kan lei tot motoriese agterstande. Beskrywende navorsing is toegepas met twee gevalle-studies. Die ouderdom van die twee seuns wat met outisme gediagnoseer was, was 6- en 8-jaar oud. Die doel van die studie was om ʼn Sensories-Motoriese Integrasie (SMI) program te ontwikkel en te implementeer as intervensie wat op elk van die seuns spesifiek toegespits is. Die intervensie-program het voorsiening gemaak om aan die uitvoering van bepaalde motoriese vaardighede aandag te skenk en om die uitwerking daarvan oor die 7-maande tydperk te assesseer. Die twee seuns (Geval A en Geval G) het individuele sessies van 30 minute elk twee keer per week bygewoon. Die SMI program het op die vestibulêre en somato-sensoriese (proprioseptor) sisteme gefokus om hul vermoë en vordering waar te neem. Aan die begin van die studie is drie neuro-ontwikkelings- en diagnostiese meetinstrumente (SCQ, ADIR-R en ADOS) deur 'n psigiater gelei om die vorige OSV diagnose van die seuns te bevestig. Die “Quick Neurological Screening Test” (QNST III) en die “Sensory Input Systems Screening Test“ (SISST) is benut om hul aanvangsvermoë as basislyn te bepaal. Hierdie toetse was gereeld herhaal, elke 4 tot 5 weke oor ʼn tydperk van 7 maande en het ʼn retensie toets van 5 weke ingesluit. Op grond van die resultate van die sub-toetse van die vermelde motoriese vaardigheidstoetse, is die self-ontwerpte SMI intervensie-program vir elke seun, volgens sy persoonlike sensoriese-motoriese behoeftes, beplan. Geval A het verbetering getoon in die volgende QNST-III sub-toets: Staan op een been (67%) en Tandemloop (83%), en handhaaf sy standaard vanaf die na-toets tot en met die retensie toets. Vir spiertonus en propriosepsie, het die Arm- en been-ekstensie sub-toets ook ʼn verbetering (67%) van die voor-toets tot die na-toets getoon. Die resultaat van hierdie subtoets is nie oor die hele tydperk gehandhaaf nie, en het net effens verhoog (33%) van die basislyn telling. Die proprioseptiewe funksie van Geval A het 'n groot verbetering in die volgende QNST-III sub-toetse getoon: Vinger na neus (67%), Vinnige omkeer, herhalende hand bewegings (88%) en Links en regs diskriminasie (67%). Geval G se resultate vir die vestibulêre-verwante sub-toetse het verbetering in die volgende getoon: Een been staan (33%) en Arm- en Been-ekstensie (33%). Sommige van die resultate van Geval G het op 'n ernstige diskripansie begin, maar daar was verbetering in die volgende proprioseptiewe verwante sub-toetse: Vinger na neus (43%), Duim en vinger sirkels (20%) en Vinnige omkeer, herhalende hand bewegings (86%). Ten spyte daarvan dat Geval G ʼn geleidelike verbetering oor tyd getoon het, het sy twee sensoriese stelsels gesukkel om met die meer komplekse take met mekaar te integreer. Die uitkoms van die geïndividualiseerde SMI programme het getoon dat die sensoriesemotoriese vaardighede by beide seuns verbeter as gevolg van die verbeterde stimulering van hul vestibulêre en somato-sensoriese (proprioseptiewe) funksie. Die SSIST resultate toon dat Geval A van ‘druip’ na ‘slaag’ in die volgende toetsitems gevorder het: Tonic Labyrinthine Supine (TLS), Tonic Labyrinthine Prone (TLP), Positive Support Reflex (PSR) en die Ocular Alignment toetsitems. Resultate van die vestibulêre toets, blyk dit dat sowel Geval A as Geval G ‘hipo-vestibulêr’ (onder-gestimuleer) was volgens die “Post-Rotary Nystagmus toets” (PRN) meting wat by die basislyn toetsing behaal is. Hierdie tellings was veranderlik tydens die intervensie. Die enigste toetsitem wat ʼn positiewe verbetering by Geval G getoon het, was die Ekwilibriumsreaksie. Laastens, beide Geval A en Geval G het in die ‘druip’ kategorie vir Kinestese gebly wat daarop dui dat hul swak propriosepsie en ruimtelike oriëntasie steeds teenwoordig was. Daar is 'n behoefte aan verdere navorsing op die gebied van sensoriese-motoriese individuele programme vir kinders met OSV. Toekomstige navorsing wat individuele programme benut, moet oorweeg om die intervensie oor ʼn langer tydperk (bv. een jaar) te laat geskied met meer sessies per week (bv. drie sessies).

published_or_final_version / abstract / Education / Master / Master of Education

The practice of yoga is an increasingly popularized movement within the West that incorporates the desire for physical fitness, spiritual consciousness, and environmentalism. Emanating from the New Age movement, the popularity of yoga has proliferated as a subculture that seeks to encourage mind–body wellbeing while representing an ethos that assumes environmental responsibility. This thesis examines the techniques of modern yoga and the influence that asana (posture) and meditational relaxation have on the senses and subsequently on environmental awareness and activism. / Includes bibliography. / Thesis (M.A.)--Florida Atlantic University, 2015. / FAU Electronic Theses and Dissertations Collection

The thesis presents a new paradigm for studying the importance of interactions between an organism and its environment using a combination of biology and technology: embodying cultured cortical neurons via robotics. From this platform, explanations of the emergent neural network properties leading to cognition are sought through detailed electrical observation of neural activity. By growing the networks of neurons and glia over multi-electrode arrays (MEA), which can be used to both stimulate and record the activity of multiple neurons in parallel over months, a long-term real-time 2-way communication with the neural network becomes possible. A better understanding of the processes leading to biological cognition can, in turn, facilitate progress in understanding neural pathologies, designing neural prosthetics, and creating fundamentally different types of artificial cognition. Here, methods were first developed to reliably induce and detect neural plasticity using MEAs. This knowledge was then applied to construct sensory-motor mappings and training algorithms that produced adaptive goal-directed behavior. To paraphrase the results, most any stimulation could induce neural plasticity, while the inclusion of temporal and/or spatial information about neural activity was needed to identify plasticity. Interestingly, the plasticity of action potential propagation in axons was observed. This is a notion counter to the dominant theories of neural plasticity that focus on synaptic efficacies and is suggestive of a vast and novel computational mechanism for learning and memory in the brain. Adaptive goal-directed behavior was achieved by using patterned training stimuli, contingent on behavioral performance, to sculpt the network into behaviorally appropriate functional states: network plasticity was not only induced, but could be customized. Clinically, understanding the relationships between electrical stimulation, neural activity, and the functional expression of neural plasticity could assist neuro-rehabilitation and the design of neuroprosthetics. In a broader context, the networks were also embodied with a robotic drawing machine exhibited in galleries throughout the world. This provided a forum to educate the public and critically discuss neuroscience, robotics, neural interfaces, cybernetics, bio-art, and the ethics of biotechnology.

Children who have sensory integration disorders face many physical, social and emotional challenges. Unusual emotional and behavioural reactions to sensory stimuli are often displayed. These children are referred to professionals including Gestalt play therapists, although formal training in sensory integration is limited to the scope of occupational therapy. Gestalt play therapists routinely utilize sensory rich activities during therapy. This study sought to explore and describe how Gestalt play therapists establish sensory contact with children who have sensory integration disorders. A combined qualitative and quantitative approach was utilized. A questionnaire and semi-structured interviews were used to gain rich descriptive data. Participants felt that the therapeutic process with these children was markedly different than with other children. Participants who were aware of their own sensory difficulties demonstrated an increased ability to accommodate these children in therapy. A need for increased knowledge and/ or training in sensory integration was strongly expressed. / Social Work / M. Diac. (Play Therapy)

La perception visuelle de l’espace est largement déterminée par les capacités visuelles des individus. Cependant, la recherche sur l’influence de variables dites non visuelles semble indiquer une importance déterminante des dimensions corporelle et émotionnelle sur la perception visuelle. Dans cette thèse, nous nous sommes intéressés à la perception des distances et avons tenté de comprendre en quoi nos perceptions pouvaient refléter la nature de nos interactions sensorimotrices avec notre environnement. Dans une première étude nous avons montré que des contraintes d’actions, tel que le coût énergétique, générées par les dispositions de l’environnement, pouvaient avoir une influence sur la perception de distances allocentriques. Dans une seconde étude, nous avons tenté de mettre en évidence le rôle du processus d’intégration sensorimotrice dans des tâches d’évaluation de distances, ainsi que de comprendre l’influence des modalités non visuelles, telles que l’audition et la motricité, dans ce même type de tâche. Enfin, dans une troisième étude, nous nous sommes intéressés au concept de fluence – i.e., information métacognitive renseignant le système sur la qualité de ses interactions dans son environnement – et proposons l’idée selon laquelle ce signal contenu dans le flux perceptif permettrait d’expliquer différentes variations perceptives liées aux contraintes de nos actions. Finalement, cette thèse défend une approche unifiée de la perception, selon laquelle la limite entre les concepts d’action et de perception devrait être repensée afin de rendre compte de la nature sensorimotrice de nos connaissances. / Visual perception of space is mainly known as depending upon one’s vision capacity. However, research about the influence of non-visual variables seems to indicate that the body also plays an important role in visual perception. In this Ph.D. thesis, we support the idea that distance perception has to be studied as a function of the sensorimotor interactions between the individuals and their environment. In the first study, we showed that action constraints in the environment such as energetic cost could influence allocentric distance perception. In the second study, we focused on the role of the sensorimotor integration process in distance perception tasks, as well as the influence of non-visual variables such as audition and motor activity. In the third study, we investigated the phenomenology of perception, and more precisely in the relative fluency of motor activity. In other words, we focused here on the metacognitive feedback that emerges from the quality of the interactions with the environment. We highlighted that such a metacognitive signal could explain the influence of action constraints on distance perception. Finally, this work provides strong supports to the idea of an integrative approach of perception according to which the theoretical boundary between perception and action is questioned by the sensorimotor nature of our knowledge.

No description available.

La détection de molécules chimiques par l'odorat est importante pour guider le comportement des animaux. Chez la lamproie marine, Petromyzon marinus, l'olfaction est vitale pour plusieurs fonctions telles que l’alimentation, l’évitement des prédateurs et la reproduction. Les différents comportements olfactifs de la lamproie sont les mieux caractérisés parmi tous les vertébrés aquatiques et ils font l’objet du premier chapitre de l’introduction. Les circuits du cerveau responsables des mouvements produits lors de la détection de stimuli olfactifs ont été examinés chez la lamproie. Des études récentes révèlent qu’il existe deux organes olfactifs périphériques ayant des projections parallèles qui innervent des parties distinctes du bulbe olfactif (BO). Dans les deux cas, le signal olfactif atteint éventuellement les cellules réticulospinales (RS), qui activent les réseaux locomoteurs spinaux. La littérature portant sur ces circuits neuronaux est décrite dans le deuxième chapitre introductif. Le substrat neuronal par lequel le signal olfactif est transmis aux cellules RS n'est pas complètement caractérisé mais des données du laboratoire Dubuc suggèrent que le tubercule postérieur (TP) serait une cible importante des projections du BO. Puisque cette région contient des neurones dopaminergiques (DA) impliqués dans le contrôle moteur, l’objectif principal de cette thèse était de déterminer leur rôle dans le traitement du signal olfactif et la production de locomotion. Nos résultats ont permis de caractériser l'innervation DA du BO de la lamproie et d’observer que les neurones DA du TP projettent à la partie médiane du BO chez les animaux de stade larvaire et adulte. De plus, l’activation de récepteurs D2 dans cette région diminue la transmission du signal olfactif aux cellules RS. Dans le reste du BO, des neurones DA apparaissent au stade adulte. Ces observations sont rapportées dans le premier chapitre des résultats. Puisque les neurones DA du TP peuvent moduler la transmission olfactomotrice au niveau du BO, ils pourraient aussi jouer un rôle via leurs projections connues vers le tronc cérébral. Le deuxième chapitre des résultats se penche donc sur l’implication du TP dans le relai de l’information olfactive au système moteur. L’étude des projections du BO montre que les neurones DA sont ciblés, incluant ceux qui projettent à la région locomotrice mésencéphalique (RLM), responsable de l’initiation et du contrôle de la locomotion. Aussi, la stimulation olfactive active des neurones du TP qui projettent à la RLM. Dans une préparation dont la tête est fixée mais le corps peut se déplacer, la stimulation olfactive induit de la nage en recrutant simultanément le TP et les cellules RS. Nous montrons aussi que le TP est recruté durant la nage survenant spontanément, ce qui indique que cette région joue un rôle important dans le contrôle locomoteur. Cette thèse révèle que les neurones DA du TP peuvent 1) être activés par la détection d’odeurs et ensuite 2) moduler la transmission au niveau du BO ainsi que 3) recruter la RLM pour produire un épisode de nage. Ces données suggèrent qu’ils occupent une position-clé dans l’intégration sensorimotrice des stimuli olfactifs puisqu’ils encodent à la fois de l’information sensorielle et motrice. / The detection of chemical molecules by smell is important in guiding the behavior of animals. In the sea lamprey, Petromyzon marinus, olfaction is vital for several functions such as feeding, predator avoidance and reproduction. The various olfactory behaviors of the lamprey are the best characterized among all aquatic vertebrates and they were reviewed in the first chapter of the introduction. The brain circuitry responsible for producing movement upon sensing olfactory stimuli has been examined in lamprey. Recent studies revealed that there are two peripheral olfactory epithelia with parallel projections that reach distinct parts of the olfactory bulb (OB). In both cases, the olfactory signal eventually reaches reticulospinal (RS) cells, which activate the locomotor networks of the spinal cord. The literature describing these neural circuits is thoroughly reviewed in the second chapter of the introduction. The neuronal substrate by which the olfactory signal is transmitted to RS cells is not fully characterized, but data from the Dubuc laboratory suggest that the posterior tubercle (PT) may be an important target for OB projections. Since this region contains dopaminergic (DA) neurons involved in motor control, the main objective of this thesis was to determine their role in olfactory signal processing and the production of locomotion. Our results have allowed to characterize the DA innervation of the lamprey OB and show that DA neurons of the PT send projections to the medial part of the OB in larval and adult animals. In addition, the activation of D2 receptors in this region decreases the transmission of the olfactory signal to RS cells. In the rest of the OB, DA neurons appear in adult animals. These observations are reported in the first chapter of the Results. Since DA neurons of the PT can modulate olfactory-motor transmission at the level of the OB, they could also play a role through existing descending projections to the brainstem. Thus, in the second chapter of the Results, we studied the involvement of the PT in the relay of olfactory information to the motor system. The analysis of OB projections shows that DA neurons are targeted, including those that project to the mesencephalic locomotor region (MLR), which is responsible for initiating and controlling locomotion. Moreover, olfactory stimulation activates PT neurons that project to the MLR. In a head-fixed preparation in which the body moves, olfactory stimulation induces swimming simultaneously with PT and RS cell activity. We also show that the PT is recruited during spontaneously occurring swimming, which indicates that this region plays an important role in locomotor control. This thesis reveals that DA neurons in the PT can 1) be activated following odorant detection and then 2) modulate the transmission at the level of the OB as well as 3) recruit the MLR to produce a swimming episode. These data suggest that they occupy a key position in the sensorimotor integration of olfactory stimuli since they encode both sensory and motor information.

Tool actions are characterized by a transformation between movements and their resulting consequences in the environment. This transformation has to be taken into account when tool actions are planned and executed. We investigated how angular shift transformations between circling movements and their visual feedback affect the coordination of this feedback with visual events in the environment. We used a task that required participants to coordinate the visual feedback of a circular hand movement (presented on the right side of a screen) with a circling stimulus (presented on the left side of a screen). Four stimulus-visual feedback relations were instructed: same or different rotations of stimulus and visual feedback, either in same or different y-directions. Visual speed was varied in three levels (0.8, 1, and 1.2 Hz). The movement-visual feedback relation was manipulated using eight angular shifts: (-180, -135, -90, -45, 0, 45, 90, and 135°). Participants were not able to perform the different rotation/different y-direction pattern, but instead fell into the different rotation/same y-direction pattern. The different rotation/same y-direction pattern and the same rotation/same y-direction pattern were performed equally well, performance was worse in the same rotation/different y-direction pattern. Best performance was observed with angular shifts 0 and -45° and performance declined with larger angular shifts. Further, performance was better with negative angular shifts than with positive angular shifts. Participants did not fully take the angular shift transformation into account: when the angular shifts were negative the visual feedback was more in advance, and when angular shifts were positive the visual feedback was less in advance of the stimulus than in 0° angular shift. In conclusion, the presence and the magnitude of angular shift transformations affect performance. Internal models do not fully take the shift transformation into account.

<p dir="ltr">Localizing movements in the external space is crucial for animals to navigate safely, find food, avoid predators, and interact with their surroundings. Efficient localization during body movements requires the brain to distinguish between externally generated movements and self-generated ones. This involves integrating external stimulation with a continuous estimate of one's body position, to isolate external motion by suppressing sensations arising from self-motion.</p><p dir="ltr">To explore the neural mechanisms underlying object localization during active touch, we focused on the mouse superior colliculus (SC), which harbors multiple egocentric maps of sensorimotor space. Our studies revealed that SC neurons exhibit a rapidly adapting tactile response during externally generated touch. The response is significantly attenuated during self-generated touch, thus enhancing the ability to distinguish between external and self-induced tactile stimuli. Additionally, the direction of external motion is precisely encoded in the firing rates of these tactile-responsive neurons, indicating a specialized localization mechanism within the SC.</p><p dir="ltr">In scenarios devoid of external stimuli, SC neural activity accurately reflects the kinematics of self-motion, such as whisker position and locomotion speed, capturing past, present, and future body positions. Half of the neurons that encode self-motion also respond to external tactile stimuli. This dual functionality suggests that these neurons not only track self-motion but also engage in the processing of external tactile information. The magnitude of the external tactile response in these neurons is modulated by the state of self-motion upon touch. These results suggest that SC neurons integrate internal estimates of body movements with external tactile inputs to compute the egocentric distance of objects.</p>