This thesis investigates the associations between crash outcomes, the existence and type of driver distraction as well as driver’s age. The crash outcomes considered in this thesis consist of the type of crash as well as the injury severity sustained by occupants involved in the crash. An ordered logit model was built to predict the likelihood of severe injuries and a multinomial model was developed to predict the likelihood that a driver will be involved in one of three common crash types: singular, angular, and rearend. In these models, various factors (e.g., weather, driver’s gender, and speeding) have been statistically controlled for, but the main focus was on the interaction of driver’s age and distraction type. The findings of this thesis have implications for policy making and prioritizing capabilities of distraction-related safety systems.

This thesis investigates the associations between crash outcomes, the existence and type of driver distraction as well as driver’s age. The crash outcomes considered in this thesis consist of the type of crash as well as the injury severity sustained by occupants involved in the crash. An ordered logit model was built to predict the likelihood of severe injuries and a multinomial model was developed to predict the likelihood that a driver will be involved in one of three common crash types: singular, angular, and rearend. In these models, various factors (e.g., weather, driver’s gender, and speeding) have been statistically controlled for, but the main focus was on the interaction of driver’s age and distraction type. The findings of this thesis have implications for policy making and prioritizing capabilities of distraction-related safety systems.

Hantaviruses can cause two severe human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). Hantaviruses are spread to humans mainly through inhalation of infectious virions, secreted from infected rodents. The human diseases are characterized by an increased capillary leakage syndrome. Hantaviruses are known to infect endothelial cells, but they are non-cytopathogenic. The mechanism behind human disease is not well understood, but an overactive immune response is implicated in the pathogenesis. The aim of my thesis has been to investigate parts of innate and adaptive immune responses in Puumala virus-infected patients. In paper I we found a sex difference in the cytokine profile during acute infection. Females had significantly higher plasma levels of IL-9, FGF-2, GM-CSF and lower levels of IL-8 and IP-10 compared to males. These differences may affect the activation and function of the immune response. In paper II we studied the phenotype and kinetics of NK cells. We observed that CD56dim NK cells were elevated during acute infection and that these, predominantly NKG2C+ NK cells, remained elevated for at least two months after symptom debut. Our novel finding of a prolonged NK cell response, implicates that NK cells may possess adaptive immunity features.  In paper III we observed a vigorous cytotoxic T cell (CTL) response during acute infection, which contracted in parallel with decrease in viral load. The CTL response was not balanced by an increase in regulatory T cells. The T cells expressed inhibitory immunoregulatory receptors, known to dampen intrinsic T cell activity.  In paper IV, we found that a low IgG response in patients was significantly associated with more severe disease, while the viral load did not affect the outcome. Our findings support the use of passive immunization as a treatment alternative for hantavirus-infected patients. In conclusion, my thesis contributes to an increased knowledge about the immune response in hantavirus-infected patients. The findings, combined with future studies, will hopefully lead to a better understanding of the pathogenesis and possible treatment alternatives.

Alcohol and drug abuse are strong predictors of suicide. While screening methods have proven effective at identifying and treating substance abuse in non-treatment-seeking users (e.g., screening and brief intervention [SBI]), less attention has been given to the co-occurrence of suicidality among this population, including its correlates and etiology. The current study addresses this gap by presenting data from early adult emergency department (ED) patients (mean age = 27; N = 505), screened for substance abuse and suicidal ideation. Prevalence of past year ideation was high (15%). Results demonstrated a significant and positive indirect effect of cocaine use severity on likelihood of suicidal ideation, mediated through family support. The implications for SBI practices in the ED and suicide etiology among non-treatment-seeking substance abusers are discussed.

This study investigated the association between the severity of Tourette Syndrome (TS) and comorbid tendencies (Attention Deficit Hyperactivity Disorder (ADHD), Obsessive-Compulsive Disorder (OCD), and rage), maternal differential treatment, fairness evaluation of maternal differential treatment, and communication with both sibling and family relationships. Fifty-five mothers and healthy siblings of individuals with Tourette Syndrome participated in the study. The parents provided information regarding family demographics and the severity of Tourette Syndrome and comorbid tendencies, and the healthy siblings completed the sibling and family relationship questionnaires. The questionnaires were posted on a secure website, where the parents and healthy siblings could complete the online measures via internet connections. <br /><br /> The study revealed several important findings. The results showed significant associations between the severity of Tourette Syndrome and comorbid OCD, ADHD and rage tendencies thus suggesting that studying Tourette Syndrome without considering comorbidity would be unrealistic. Additionally, communication regarding Tourette Syndrome between the healthy siblings and their parents played an important role with respect to sibling and family relationships. Communication between the healthy siblings and their parents predicted more warmth between the healthy siblings and their sibling with Tourette Syndrome as well as more family cohesion and adaptability as reported by the healthy siblings. Communication had a significant moderating effect on both severity of Tourette Syndrome and healthy siblings' fairness evaluation of maternal differential treatment in predicting family relationships. When the sibling had less severe Tourette Syndrome, the healthy siblings reported more family adaptability when they had more communication with their parents, and reported less family adaptability when they had less communication with their parents. The results also indicated that when healthy siblings perceived their maternal differential treatment to be unfair, they reported more family cohesion when they had more communication with their parents, and reported less family cohesion when they had less communication with their parents. The study did not support the negative impact of maternal differential treatment on sibling relationships; however, the results confirmed the previous findings regarding the moderating effect of fairness evaluation on maternal differential treatment in predicting sibling relationships. When the sibling with Tourette Syndrome was favored, the healthy siblings reported more sibling warmth when they perceived the favouritism (maternal differential treatment) to be fair. Furthermore, the results showed that healthy siblings' perceptions of maternal differential treatment could predict cohesion and adaptability in the family. The more the healthy siblings reported being treated differently by their mothers, the less cohesion and adaptability they reported in their families. <br /><br /> The present study supported previous studies in finding that sibling conflict decreased with age. The results also highlighted the role of age in moderating the effects of communication and maternal differential treatment in predicting sibling conflict. When healthy siblings had more communication with their parents they reported more conflict with their sibling with Tourette Syndrome when they were younger, and reported less sibling conflict with their sibling with Tourette Syndrome when they were older. Furthermore, when healthy siblings were favored by their mothers, they reported more conflict with their sibling with Tourette Syndrome when they were younger than when they were older, thereby emphasizing the importance of developmental differences in dynamics between the siblings. The significant contributions of the study include underlining the importance of communication, the relationship between Tourette Syndrome and comorbid conditions, and healthy siblings' perceptions of sibling and family relationships.

The purpose of this study was to understand how social workers experienced working with Addiction Severity Index (ASI) in relation to the goal set by the National Board of Health and Welfare. The method is spread nationwide and therefore it is of great importance to examine how the social workers themselves experience the demands and the resources surrounding ASI. We choose to do a qualitative study interviewing eight social workers at six different occasions. The result was analyzed using Max Weber’s ideal type bureaucracy and Michael Lipsky’s thesis on street-level bureaucrats. We found that the social workers consider the method useful when used from without their own purposes. The standards set by the National Board of Health and Welfare was considered hard to achieve because of the complexity of the method. Among other things the valuation done by both social worker and client was regarded as tough and therefore the results of the interview are at risk of not becoming reliable. We found that the outcome of the interview depends on the performer.

In this thesis, security measures and vulnerability mitigation are mainly addressed. How to improve the system vulnerability is one of the main issues for power system operation and planning. Recent research revealed that Energy Storage Systems (ESSs) have a great potential to be used to improve system vulnerability. A vulnerability assessment is proposed in this thesis to identify the impact factors in the power systems due to generation outage and line outage. A Bus Impact Severity (BIS) analysis is then proposed and used to find the vulnerable buses in the system. The buses with the larger BIS value defined in this thesis are the better locations for ESSs placement. Formulations for optimal locations and capacities of ESSs placement are derived and then solved by Genetic Algorithm (GA). Test results show that the proposed method can be used to find the optimal locations and capacities for ESSs for system vulnerability improvement.

This study presents the results of an extraction of the 2nd-order nonlinear responses from model test data. Emphasis is given on the effects of assumptions made for the Gaussian and non-Gaussian input on the estimation of the 2nd-order response, employing the quadratic Volterra model. The effects of sea severity and data length on the estimation of response are also investigated at the same time. The data sets used in this study are surge forces on a fixed barge, a surge motion of a compliant mini TLP (Tension Leg Platform), and surge forces on a fixed and truncated column. Sea states are used from rough sea (Hs=3m) to high sea (Hs=9m) for a barge case, very rough sea (Hs=3.9m) for a mini TLP, and phenomenal sea (Hs=15m) for a truncated column. After the estimation of the response functions, the outputs are reconstructed and the 2nd order nonlinear responses are extracted with all the QTF distributed in the entire bifrequency domain. The reconstituted time series are compared with the experiment in both the time and frequency domains. For the effects of data length on the estimation of the response functions, 3, 15, and 40- hour data were investigated for a barge, but 3-hour data was used for a mini TLP and a fixed and truncated column due to lack of long data. The effects of sea severity on the estimation of the response functions are found in both methods. The non-Gaussian method for estimation is more affected by data length than the Gaussian method.

<p>The purpose of this study was to <em>understand</em> how social workers experienced working with Addiction Severity Index (ASI) in relation to the goal set by the National Board of Health and Welfare. The method is spread nationwide and therefore it is of great importance to examine how the social workers themselves experience the demands and the resources surrounding ASI. We choose to do a qualitative study interviewing eight social workers at six different occasions. The result was analyzed using Max Weber’s ideal type bureaucracy and Michael Lipsky’s thesis on street-level bureaucrats. We found that the social workers consider the method useful when used from without their own purposes. The standards set by the National Board of Health and Welfare was considered hard to achieve because of the complexity of the method. Among other things the valuation done by both social worker and client was regarded as tough and therefore the results of the interview are at risk of not becoming reliable. We found that the outcome of the interview depends on the performer.</p>

Source: Masters Abstracts International, Volume: 47-06, page: 3546. Advisers: Zhi-Dong Jiang; Linda B. Piller. Includes bibliographical references.