Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.

Diss. Linköping : Linköpings universitet, 2008.

Master's thesis. / Format: PDF. Bibl.

Thesis (M.A.)--Kutztown University of Pennsylvania, 1995. / Source: Masters Abstracts International, Volume: 45-06, page: 3309. Typescript. Abstract precedes thesis as 1 preliminary leaf. Includes bibliographical references (leaves 46-51).

Introduction: Mucosal human papillomavirus (HPV) infection is the most common sexually transmitted infection (STI) and is associated with genitals warts, anogenital cancers, and oropharyngeal cancers. Most sexually active persons will become infected with HPV at some point in their lives, however few will develop HPV-related diseases such as warts, lesions, or cancer as a result of the infection. It is unclear why a minority of individuals fail to clear HPV infection and develop clinical disease. Due to initial associations with cervical lesions, much research has focused on women. Th1 type immune responses have been associated with successful response to HPV infection. Factors such as psychological stress and sleep have been associated with immune function. Stress has been associated with cervical lesions, however no study has evaluated effects of stress or sleep on HPV infection. This research sought to examine the associations between perceived stress and sleep problems with HPV prevalence, incidence, and clearance among men. Methods: Men were tested for 37 individual HPV genotypes every 6 months as part of a large natural history study. A total of 426 men were followed over 1 to 4 visits. Perceived stress was measured with a modified 4-item Perceived Stress Scale (PSS-4) assessing stress in the past six months and was dichotomized into high (scores in the 4th quartile) and low perceived stress. Self-reported sleep problems were measured by seven likert-scale items and categorized as high (4th quartile of sleep problems scores), moderate (second and third quartiles; reference group), and low (first quartile). Three HPV classifications were examined; men were categorized as positive for 'Any HPV' if they tested positive for any of the 37 HPV genotypes in the study protocol, men were categorized as positive for 'Oncogenic HPV' if they tested positive for any oncogenic HPV type, and men were categorized as positive for 'Non-oncogenic HPV' if they tested positive for any non-oncogenic HPV genotype. In the prevalence analysis, men who had no detectable HPV infection with any of the 37 types were the reference group in all analyses. Prevalence ratios and 95% confidence intervals (95% CI) were calculated using Poisson regression with robust variance. For HPV clearance and incidence, Cox regression with the robust sandwich estimator was used to calculated hazard ratios and 95% confidence intervals. Results: A total of 424 men had genotyping results available for the prevalence analysis. High perceived stress was significantly associated with higher prevalence of any HPV infection [PR =1.33 (95% CI: 1.06-1.68)] and oncogenic HPV infection [PR=1.53 (95% CI: 1.06-2.20)], adjusting for demographics, sexual behavior, and sleep problems. High self-reported sleep problems was significantly associated with higher prevalence of oncogenic HPV infection [PR=1.50 (95% CI:1.01-2.13)], adjusting for demographics, sexual behavior, and perceived stress. Perceived stress and self-reported sleep problems were not associated with incidence of HPV infection. Perceived stress was not significantly associated with clearance of HPV infection overall. Among men 50 and older however, men with high stress were significantly less likely to clear any HPV infection than those with low stress adjusting for demographics, HR=0.09 (95% CI: 0.02-0.49). Compared to men with moderate sleep problems, those with high sleep problems were significantly less likely to clear an infection with any HPV type, HR=0.68 (95% CI: 0.49-0.94), or an oncogenic HPV type, HR=0.51 (95% CI: 0.28-0.94), after adjustment for demographics and perceived stress. Discussion: This is the first study to examine associations between HPV infection with perceived stress and self-reported sleep problems. It is also the largest study to examine associations between these exposures and an infection outcome. Results suggest that perceived stress and self-reported sleep problems have independent effects on HPV. Evaluation of perceived stress, biological indicators of stress, objective measures of sleep, and measurement of immune parameters may aid in further elucidating how stress and sleep disturbance are related to HPV infection. Determination of modifiable factors that can influence HPV infection may aid in the prevention of adverse disease outcomes related to infection with this virus. Examining the impact of factors such as perceived stress and sleep problems on HPV infection may aid in risk stratification of patients and allow more targeted interventions among those most at risk for developing disease.

Phenotypic differences between the sexes evolve largely because selection favours a different complement of traits in either sex. Theory suggests that, despite its frequency, sexual dimorphism should be generally constrained from evolving because the sexes share much of their genome. While selection can lead to adaptation in one sex, correlated responses to selection can be maladaptive in the other. In this thesis I use Drosophila to examine the extent to which the shared genome constrains the evolution of sexual dimorphism and whether the sex chromosomes might play a special role in resolving intralocus sexual conflict. Gene expression data shows that intersexual genetic correlations are generally high, suggesting that genes often affect both sexes. The intersexual genetic correlation is negatively associated with sex-bias in expression in D. melanogaster, and the rate of change in sex-bias between D. melanogaster and six closely related species, showing that a sex-specific genetic architecture is a prerequisite for the evolution of sex difference. In further studies I find that genetic variance affecting lifespan is found in the male-limited Y chromosome within a population, which could offer a route to the evolution of further sexual dimorphism in lifespan, though the amount of variance was small suggesting adaptive potential from standing genetic variance is limited. Genetic variance on the X chromosome is also expected to be depleted once the sex chromosomes evolve, but here I find no evidence of depletion in either sex. Dosage compensation does not appear to double the male X-linked genetic variance, but this effect may be complex to detect. Finally, the X chromosome appears to be enriched for sex-specific genetic variance, and the consequences of this are explored using a variety of analytical methods to test biologically meaningful aspects of G-matrix structure. In summary, this thesis suggests that the evolution of sexual dimorphism is generally constrained by the shared genome, but intralocus sexual conflict could be resolved by novel mutations on the Y chromosomes, and by standing sex-specific genetic variance on the X chromosome. It highlights a special role for the X chromosome in the evolution of sexual dimorphism.

The impact of self awareness during sexual activity has been widely discussed. However, research has been largely focused on the effects of performance anxiety in male erectile functioning. Based on research linking sexual difficulties to lower levels of body image, it has been suggested that physical appearance concerns may have a similar influence on sexual functioning in women as does men's self-awareness about erectile functioning. On the other hand, research has also shown that in some cases self awareness can improve sexual functioning among women. The role that physical appearance or awareness of one's body specifically may play in female sexual response has received little empirical attention. The aim of the current study was to examine the impact of body image on sexual arousal response to erotica among 48 women with Female Sexual Arousal Disorder (FSAD). Women were randomized to one of two Body Image conditions: Positive Body Image or Negative Body Image. Each woman participated in two sessions: Experimental and Control. In the experimental sessions, participants were asked to adopt and attend to their positive or negative body parts, and a full-length mirror was placed in front of them. Self-reported mental arousal, perceptions of physical arousal, body awareness, body image, anxiety, and cognitive distraction were assessed. Results showed that in the negative and positive experimental sessions, women experienced increased mental and perceptions of physical sexual arousal compared to the control session. Findings were mainly accounted for by levels of body image and body awareness. There were no differences in anxiety or cognitive distraction. Findings suggest that body image and body awareness, whether positive or negative, can result in increased subjective sexual arousal response. / text

Background HIV/AIDS has always been a concern since it first came up in 1981 in the field of medicine and public health. The trend of overall HIV epidemic has slow down through over 30 years fighting against the disease. Yet, being the largest population nowadays, young people still face high risk of HIV/AID. Sexual transmitted diseases, similar with HIV infection, are also a serious concern in young people. Peer education is widely used in the sexual education in young people. No review focused on the school-based peer education while most young people received their sexual education in schools. This systematic review aims to evaluate the effectiveness of school-based peer education on HIV/STD prevention and evaluate the factors that are likely to influence the effect of school-based peer education. Method Searching through PubMed and Cochrane Library, a literature review was carried out on the relevant articles about the evaluation of school-based peer education in developing and developed countries around the world from 2000-01-01 to 2014-05-31. Findings 10 experimental studies were chosen in this review, including 3 randomized controlled trials. Among 10 studies, 8 found significant improved about the general knowledge of HIV/STD and all studies showed positive change in attitude and risk perception in the peer-led education. However, no studies found significant effect of peer education on the behavioral change regarding condom use, postponing sexual intercourses and the reduction of sexual partners, etc. The interaction of peer education and the quality of peer-educators plus other demographical factors such as socioeconomic status and religions may influence the effect of school-based peer-led education. Conclusion School-based peer education was demonstrated to be effective on the prevention of HIV/STD in knowledge and attitude improvement, similar with other kinds of peer education. Peer educators and interactions between educators and educatees play important roles in the peer education. Yet, the effect of school-based education still requires long-term assessment. / published_or_final_version / Public Health / Master / Master of Public Health

This paper explores some of the factors that influence whether African American female college students implement safe sex knowledge. High rates of HIV/AIDS and other sexually-transmitted infections (STIs) in the black community and the overrepresentation of individuals under the age of 25 in sexually-transmitted infection (STI) reports indicate the need for research that investigates the physical, social, and cultural aspects of high-risk sexual behaviors and the factors that influence them for this group. African American female college students present a unique challenge to sexual health educators; a challenge that has been relatively under acknowledged and under addressed in research and scholarly literature. This omission from research is likely the result of assumptions that suggest that the structural barriers that greatly impact the use of sexual health knowledge in low-income African American women do not exist for female college students from the same racial/ethnic background. However, focus group and survey data, collected during this study, suggest that this group may in-fact share some structural barriers with low-income African American women since financial and cultural barriers that may have existed in their communities do not necessarily become obsolete upon entering college.

Theoretical and epidemiological studies indicate that women with a history of child sexual abuse (CSA) experience more sexual problems during adulthood compared to non-abused women. Despite the abundance of research conducted on prevalence and incidence of sexual difficulties associated with a history of CSA, very little is known on the psychophysiological sexual response of CSA survivors. A study was conducted to examine whether women with and without a history of CSA differed in their physiological and subjective sexual responses when exposed to erotic videos. A second study was conducted to explore potential predictors of the physiological and subjective sexual responses of women with a history of CSA. Overall, the physiological sexual arousal of CSA survivors was not significantly weaker than the response of women with no history of CSA. However, when controlling for levels of sexual distress and sexual function those CSA survivors with higher levels of sexual distress showed lower physiological sexual arousal compared to CSA survivors with less sexual distress. In agreement with prior studies, for women with no history of CSA the relationship between levels of distress and physiological sexual arousal was not significant. Similarly, levels of subjective sexual arousal reported in the laboratory were associated with sexual distress in CSA survivors but not in women with no history of CSA. Women who reported more re-experiencing symptoms and more negative affect before the erotic video showed a significantly lower increase in subjective sexual arousal in the presence of an increase in physiological sexual arousal. Cortisol levels measured before and after exposure to the erotic video indicated that higher dissociation experienced during the sexual interaction with a partner is associated with a cortisol secretion during exposure to sexual stimuli. This finding suggests a potentially learned stress response to erotic stimuli which may negatively affect the physiological sexual arousal for a subgroup of CSA survivors. Findings from the two studies suggest that the psychophysiological assessment of the sexual response of CSA survivors captures some important aspects of the sexual difficulties experienced by these women. A number of potential predictors of the physiological and the subjective sexual responses of CSA survivors were identified. Future studies will need to examine whether interventions that target these predictors can help CSA survivors to increase their physiological and subjective sexual arousal to sexual cues and whether this provides some relief to their sexual distress.