Made available in DSpace on 2014-06-11T19:26:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-25Bitstream added on 2014-06-13T20:53:57Z : No. of bitstreams: 1 gamba_bf_me_botib.pdf: 1144074 bytes, checksum: 38b7854a72a3108b08ac952129465214 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / A síndrome de Smith-Magenis (SMS) é uma complexa anomalia caracterizada por atraso no desenvolvimento neuro-psico-motor (ADNPM), anomalias craniofaciais, esqueléticas e comportamentais. Dentre as anomalias destacamos braquicefalia, baixa estatura, distúrbio do sono, comportamentos de auto-injúria e movimentos estereotipados. SMS é causada por uma deleção intersticial do cromossomo 17(p11.2) ou mutação no gene RAI1, presente nesta região cromossômica. Sua prevalência é estimada em 1:25.000 nascidos vivos podendo chegar até 1:15.000. O diagnóstico clínico para SMS é confirmado pela técnica de citogenética molecular FISH. Neste trabalho realizamos estudo citogenético por bandamento GTG, GTG em alta resolução e FISH no total de 17 casos com suspeita clínica para SMS. Para realização de FISH foram utilizadas duas sondas comerciais da CYTOCELL ®, uma contendo o gene FU1 e outra o gene RAI1. Os resultados clínicos desta casuística comparados com a literatura internacional mostrou que embora fizemos algumas considerações, demonstramos a similaridade do diagnóstico clínico de SMS nos subgrupos SMS-del e SMS-like tanto brasileiros quanto da literatura. Os resultados citogenéticos do bandamento GTG revelaram que sete casos (7/17) apresentam deleção 17(p11.2) e o FISH confirmou a deleção tanto do gene FU1 como do gene RAI1 nos sete casos identificados. Este trabalho é de grande importância por tratar de uma afecção rara, pouco conhecida, e subdiagnosticada no Brasil. Assim destacamos que o uso de ficha clínica específica para SMS é importante para a definição da hipótese diagnóstica, 7/17 casos avaliados apresentaram deleção 17p11.2, e deleção dos genes... / Smith-Magenis syndrome (SMS) is a complex anomaly characterized by developmental delay (ADNPM), craniofacial anomalies, and behavioral disorders. Among the anomalies highlight brachycephaly, short stature, sleep disturbance, behavior of self-injury and stereotyped movements. SMS is caused by an interstitial deletion of chromosome 17 (p11.2) or mutation in the retinoic acid-induced 1 (RAI1) gene, present in this chromosomal region. Its prevalence is estimated at 1:25.000 live births and may reach up to 1:15.000. The c1inical diagnosis for SMS is confirmed by molecular cytogenetic technique of FISH. In this work we performed a cytogenetic study by GTG, GTG high resolution and FISH total of 17 cases with c1inical suspicion for SMS.To perform FISH probes were used two commercial CYTOCELL ®, one containing the FLl1 gene and another gene RAI1. The c1inical results in this series compared to the literature showed that although we made some considerations, we demonstrate the similarity of the clinical diagnosis of SMS in both sub-del SMS and SMS-like Brazilians and literature. The cytogenetic results of GTG banding revealed that seven cases (7 1 17) have deletion 17(p11.2) and FISH confirmed the deletion of both the FLl1 gene and the gene RAI1 the seven cases identified. This work is of great importance for treating arare, little known and under-diagnosed in Brazil. Thus we emphasize that the use of medical records specific to SMS is important to define the diagnosis, 7 117 cases showed stable 17p11.2 deletion, and deletion of genes FUI and RAI, no significant differences between the c1inicalfeatures of this sample group comparing it with the literature and this is about the largest sample of Brazilian SMS already described

abstract: This final research paper provides both a performer's perspective and a recording of double clarinet literature by William O. Smith (b. 1926), Eric Mandat (b. 1957), and Jody Rockmaker (b. 1961). The document includes musical examples, references to the recording, and interviews with the composers. The first chapter contains a brief literature review of sources on world double clarinets, biographies of the above-mentioned composers, and other pertinent information. Chapters 2-4 include the performer's perspective on the following works: Epitaphs for Double Clarinet by William O. Smith, Double Life for Solo Clarinet by Eric Mandat, and two compositions by Jody Rockmaker, Half and Half for demi-clarinet in A, and Double Dip. The final chapter examines how double clarinet music has evolved, the challenges and limitations of the repertoire, and the future of the double clarinet genre. / Dissertation/Thesis / D.M.A. Music 2013

Adam Smith is often thought to be an unequivocal advocate of capitalism based on unfettered self-interest. Against this caricature, I argue that his attitudes towards commercial society are, in fact, more ambivalent. To ground this claim, I outline Smith’s account of ambition, a passion responsible for the dynamism of commercial economies but deleterious to individual happiness, and focus on the rhetoric Smith deploys in his portraits of three ambitious characters: the poor man’s son, the ambitious man, and the prudent man. Next, I challenge alternative interpretations. In particular, I contest Samuel Fleischacker’s view that Smith no longer sees ambition, motivated by vanity, as the driving force behind economic growth in commercial society by the time he writes the Wealth of Nations and, thus, is not meaningfully ambivalent. In the last section, I draw on recent work by Amelie Rorty to argue that Smith’s ambivalence towards commercial society is both appropriate and constructive.

The use of a counter-balance weight system of a Smith machine affects measures of bench press throw performance. Twenty-four men performed bench press throws at 30% of their one-repetition maximum under four different conditions: 1) counter-balance and rebound movement (RC), 2) no counter-balance and rebound movement (RNC), 3) counter-balance and concentric only movement (CC), and 4) no counter-balance and concentric only movement (CNC). Peak power, force, and concentric and eccentric velocities were measured using a linear accelerometer; and peak ground reaction force (GRF) was measured using a forceplate. Peak measures for concentric and eccentric velocities showed that NCB> CB and RBT > CBT. Peak GRF measures showed CB > NCB and RBT > CBT. The lower performance measures for CB were likely due to an increase in the net external load when the barbell accelerates faster than the gravitational constant causing the counter-balance weight becomes ineffective.

"Often there is interest in living authors for whom information about their lives and writings has not been gathered together in any one place. In seeking material about Miss Lillian Smith, the writer of this paper found no complete bibliography of her writings; no complete biography. The purpose of the paper, therefore, is to set forth, in the form of a bio-bibliography, the life and works of Miss Smith"--Introduction. / Typescript. / "August, 1956." / "Submitted to the Graduate Council of Florida State University in partial fulfillment of the requirements for the degree of Master of Arts." / Advisor: Sarah Rebecca Reed, Professor Directing Paper. / Includes bibliographical references (leaves 67-70).

<p> intrusive Ultramafic sill of the Cape Smith-Wakeham Bay Fold Belt, located in the Ungava Peninsula P.Q., was studied. Measurements of olivine crystals were made on enlarged images of thin sections to determine the average olivine grain size and volume across the intrusion. </p> <p> The Bravo ultramafic sills exhibit a peculiar petrographic and chemical zoning, the rocks becoming increasingly rich in olivine as one moves toward the centre of the intrusion. Rock Compositions range from gabbro at the margin to olivine rich peridotite near the centre. The olivine grain size distribution exhibits n similar zoning, the grain size increasing toward the centre. However, the maximum value is skewed somewhat to the south along the edge of the central olivine rich zone, coinciding with the maximum value of Ns (Nickel in sulfides). </p> <p> The zoning is a consequence of flowage differentiation. Along the margins of the intrusion grain dispersive pressure (the pressure due to mechanical interaction between phenocrysts is dominant and grains are forced toward the centre. Within the centre of the intrusion, where the increased crystal concentration results in plug flow, the force of gravity is dominant and the largest grains make their way to the base of the plug. </p> <p> The Bravo Ultramafic Sills are pre-tectonic in origin being intruded into a group of eugeosynclinal strata in a sub-horizontal attitude. </p> / Thesis / Bachelor of Science (BSc)

This paper reflects and explores the grand narrative on work set by Adam Smith and Karl Marx during the early and later modernity. It tires to push forward the idea that Marx and Smith are one of the major influencers to the contemporary notion on work. It also tries to show the major differences and similarities between these two authors. Moreover, this paper seeks to point out the failures of idealism on work and tries to put forward critics of contemporary society. Maybe in this conduct idealism could be overcome in future and the world could be built on material, actual, needs, not on ideology.

With the emerging hybrid multi-core and many-core compute platforms delivering unprecedented high performance within a single chip, and making rapid strides toward the commodity processor market, they are widely expected to replace the multi-core processors in the existing High-Performance Computing (HPC) infrastructures, such as large scale clusters, grids and supercomputers. On the other hand in the realm of bioinformatics, the size of genomic databases is doubling every 12 months, and hence the need for novel approaches to parallelize sequence search algorithms has become increasingly important. This thesis puts a significant step forward in bridging the gap between software and hardware by presenting an efficient and scalable model to accelerate one of the popular sequence alignment algorithms by exploiting multigrain parallelism that is exposed by the emerging multiprocessor architectures. Specifically, we parallelize a dynamic programming algorithm called Smith-Waterman both within and across multiple Cell Broadband Engines and within an nVIDIA GeForce General Purpose Graphics Processing Unit (GPGPU). Cell Broadband Engine: We parallelize the Smith-Waterman algorithm within a Cell node by performing a blocked data decomposition of the dynamic programming matrix followed by pipelined execution of the blocks across the synergistic processing elements (SPEs) of the Cell. We also introduce novel optimization methods that completely utilize the vector processing power of the SPE. As a result, we achieve near-linear scalability or near-constant efficiency for up to 16 SPEs on the dual-Cell QS20 blades, and our design is highly scalable to more cores, if available. We further extend this design to accelerate the Smith-Waterman algorithm across nodes on both the IBM QS20 and the PlayStation3 Cell cluster platforms and achieve a maximum speedup of 44, when compared to the execution times on a single Cell node. We then introduce an analytical model to accurately estimate the execution times of parallel sequence alignments and wavefront algorithms in general on the Cell cluster platforms. Lastly, we contribute and evaluate TOSS -- a Throughput-Oriented Sequence Scheduler, which leverages the performance prediction model and dynamically partitions the available processing elements to simultaneously align multiple sequences. This scheme succeeds in aligning more sequences per unit time with an improvement of 33.5% over the naive first-come, first-serve (FCFS) scheduler. nVIDIA GPGPU: We parallelize the Smith-Waterman algorithm on the GPGPU by optimizing the code in stages, which include optimal data layout strategies, coalesced memory accesses and blocked data decomposition techniques. Results show that our methods provide a maximum speedup of 3.6 on the nVIDIA GPGPU when compared to the performance of the naive implementation of Smith-Waterman. / Master of Science

A obra de Adam Smith é expressão de uma nova concepção de progresso elaborada principalmente durante a segunda metade do século XVIII. O desenvolvimento da sociedade passa a ser compreendido enquanto resultado da interação entre os indivíduos e expressão das faculdades e disposições humanas. Examinamos como essa nova perspectiva aparece nos estudos de Smith sobre as mais diversas áreas, como produção de riquezas, linguagem e ciência, mostrando como a relação entre essas esferas da sociedade é de interdependência dentro de um sistema. Ao analisar como Smith aborda diferentes temas, destacamos um aspecto comum importante entre os diferentes textos do autor: a noção de ordem. A procura desta aparece enquanto estímulo para as transformações da sociedade. Ela também conforma o método de investigação utilizado por Smith: a criação de sistemas explicativos com base nas regularidades entre as mais diferentes sociedades. Esse modelo possibilita, por exemplo, a formulação da teoria de desenvolvimento baseada em quatro estágios. Também acaba por conformar uma nova forma de se produzir história: em vez de narrar os acontecimentos de certos grupos particulares, procuram-se as regularidades entre estes para construir a história da espécie. Em suma, esta dissertação interpreta como as ideias de progresso e ordem na obra de Adam Smith estão fortemente interconectadas. / The work of Adam Smith is an expression of a new conception of progress elaborated mainly during the second half of the eighteenth century. Society\'s development comes to be understood as an effect of the interaction between individuals and of the expression of human faculties and dispositions. We examine how this new perspective appears in Smith\'s studies on different topics, such as the production of wealth, language and science, showing how the relationship between those spheres of society is characterized by an interdependence within a system. In analyzing how Smith addresses distinctive themes, we highlight an important common aspect among the author\'s different texts: the notion of order. The demand for it appears as a stimulus for the transformations of society. It also corresponds to the method of investigation used by Smith: the creation of explanatory systems based on the regularities among the most different societies. This model enables, for example, the formulation of the four-stage theory of development. It also ends up in a new way of producing history: instead of narrating the events of particular groups, one searches for the regularities between them to construct the history of the species. In short, this dissertation interprets how the ideas of progress and order in Adam Smith\'s work are strongly interconnected.

by Wong Chun Wing, Eddy. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1990. / Bibliography: leaves 70-71. / Abbreviations --- p.ii / Chapter Chapter 0 --- Introduction --- p.1 / Chapter Chapter 1 --- George Stigler on the Political Economy of Adam Smith --- p.4 / Chapter Chapter 2 --- E. G. West in Defense of Adam Smith --- p.16 / Chapter Chapter 3 --- A Supplement to West's Arguments --- p.25 / Chapter Chapter 4 --- The Spectator Principle and the Theory of Justice --- p.34 / Chapter Chapter 5 --- Justice Is the Foundation of Law --- p.42 / Chapter Chapter 6 --- Justice Ought to Be the Foundation of Law --- p.55 / Chapter Chapter 7 --- Conclusion --- p.63 / References --- p.70