Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hippocampal pyramidal neurons. The pattern of inhibition mirrored the binding kinetics of insulin in the hippocampus. Two related peptides, proinsulin and desoctapeptide insulin, had neuronal effects consistent with their binding to insulin receptors in the brain. Proinsulin was effective in doses 30-fold greater than insulin, whereas desoctapeptide insulin had little or no effect. These observations indicate that the inhibitory effect of insulin in this tissue may be insulin receptor-mediated and support a previously suggested functional role of insulin in the central nervous system.

<p> A new dating method has been developed which uses fission product xenon in a manner similar to radiogenic argon in the 40Ar - 39Ar method. Measurable quantities of spontaneous fission xenon accumulate with time in rocks and minerals containing approximately 1 ppm or more of uranium as a result of the spontaneous fission of 238u. In the past, attempts have been made to date this type of sample by measuring the absolute amount of fission product xenon and the uranium content. In the new method a sample is irradiated in a thermal neutron flux to implant xenon from the neutron induced fission of 235u in amounts proportional to the uranium content. After a short cooling period (before radioactive 133xe has decayed) the sample is placed in a high vacuum system and the xenon is released by heating in a series of temperature steps. For each step the isotopic composition of the xenon is measured using a high sensitivity mass spectrameter and the ratio of spontaneous fission xenon to neutron fission xenon is calculated. Fission xenon ages for all steps are then calculated from the spontaneous to neutron fission xenon ratios and the measured integrated neutron flux. </p> <p> The method has several advantages over the conventional U - Xe technique. {a) The measurement of isotope ratios is inherently more precise than the measurement of absolute quantities. (b) Whereas the conventional U - Xe technique measures the sample date only once, the method described in this thesis measures the sample date several times. (c) If a geological disturbance has caused loss of fission xenon a valid date can still be obtained using the low mobility xenon released at high temperatures. (d) In some samples disturbed dates as well as initial formation dates can be measured. </p> <p> The method was developed and evaluated by a series of experiments which dated four zircon samples, one sphene sample, and a carbonatite sample. The zircon and sphene samples had been dated in other laboratories by the conventional u - Th - Pb and Rb - Sr methods. Fission xenon dating of these samples provided valuable new geochronological information. The experiments also showed that in addition to the advantages mentioned, the new method appears to be better able to see past metamorphic events than other methods. </p> / Thesis / Candidate in Philosophy

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The absolute abundances of fission-product xenon and krypton isotopes in six uranium minerals were determined mass spectrometrically using the isotope dilution technique. The fission products were resolved into a U spontaneous fission component, a U 235 neutron-induced fission component, and a U 238 neutron-induced fission component. The presence of U 238 of neutron-induced fission indicated that t he neutron energies in uranium minerals were higher than had been suspected. Internal consistency in the analysis was achieved only when the I 29 yield in u235 thermal neutron fission reported by Purkayastha and Martin was lowered by 20%. The number of U 238 spontaneous fissions was calculated from the lead age, U 238 content, and the U 238 pontaneous fission half life. A comparison of the number of fission products from U 238 spontaneous fission and the number of spontaneous fissions in each of the six minerals showed that five of the six minerals had lost large portions of their noble gases. A fractionation of krypton relative to xenon accompanied this loss. The results obtained for the sixth mineral indicated little or no loss of xenon and krypton. Absolute yields for U 238 spontaneous fission were therefore determined from an analysis of this mineral. / Thesis / Doctor of Philosophy (PhD)

no / This research explores the possibility that a person's (perceiver's) prospects of making a correct inference of another person's (target's) inner states depends on the personal characteristics of the target, potentially relating to how readable they are. Twenty-seven targets completed the Empathy Quotient (EQ) and were classified as having low, average or high EQ. They were unobtrusively videoed while thinking of an event of happiness, gratitude, anger and sadness. After observing targets thinking of such a past event, fifty-two perceivers (participants) in Study 1 were asked to infer what the target was thinking, and fifty perceivers in Study 2 were asked to rate the target's expression – positive or negative. Results suggested that (1) perceivers' accuracy in detecting targets' thoughts depended on which EQ group the target belonged to, and (2) target readability is not a proxy measure for level of target expressiveness. In other words, something about EQ status renders targets more or less easy to read in a way that is not simply explained by expressive people being more readable. We conclude with discussion of the importance of the target's trait as well as situation they experience in determining how accurately a perceiver might infer their inner states.

Traumatic brain injury (TBI) is an injury of the brain most often caused by blunt force trauma to the head and typically characterized by an increase in reactive oxygen species (ROS), inflammation, and hemorrhaging. Heme oxygenase (HO) catalyzes the breakdown of heme into carbon monoxide (CO), biliverdin which is further reduced to bilirubin, and ferrous iron. There are two active isoforms: HO-1 which is inducible and found predominantly in liver and spleen tissue; and HO-2 which is constitutive and found predominantly in the brain and testis. The metabolites of heme possess cytoprotective properties that can limit damage resulting from TBI. Our laboratory has found a selective HO-2 activator known as menadione (MD) that has been found to increase HO-2 activity by 4-fold while not affecting HO-1 in vitro. Given the higher amounts of HO-2 found in the brain and the cytoprotective properties of heme metabolites, we postulate that activation of HO-2 using menadione would mitigate further damage after TBI. The rat controlled cortical impact (CCI) model was used to simulate TBI with spontaneous locomotor activity (SLA), spontaneous alternation behaviour (SAB), and beam balance (BB) as the behavioural tasks to assess cognitive and motor function. A dose-response study (25, 50, 100, 200 μmol/kg) was performed to ascertain the effect of MD treatment on injured animals comparing to uninjured controls and injured animals treated with the vehicle (saline). We found that BB performance improved to control levels after MD treatment at 25 μmol/kg and 50 μmol/kg whereas animals treated with saline did not improve. SLA and SAB performance did not improve after treatment with MD. The findings suggest that HO-2 activation may be a viable method in mitigating further injury after TBI. / Thesis (Master, Pharmacology & Toxicology) -- Queen's University, 2014-06-27 19:33:45.645

Children show large individual differences in numerical skills, even before they begin formal education. These early differences have significant and long-lasting effects, with numerical knowledge before school predicting mathematical achievement throughout the primary and secondary school years. Currently, little is known about the dispositional factors influencing children's numerical development. Why do some children engage with and succeed in mathematics from an early age, whilst others avoid mathematics and struggle to acquire even basic symbolic number skills? This thesis examines the role of two dispositional factors: First, spontaneous focusing on numerosity (SFON), a recently developed construct which refers to an individual's tendency to focus on the numerical aspects of their environment; and second, mathematics anxiety (MA), a phenomenon long recognised by educators and researchers but one which is relatively unexplored in young children. These factors are found to have independent effects on children's numerical skills, thus the empirical work is presented in two separate parts. The SFON studies start by addressing methodological issues. It is shown that the current measures used to assess children's SFON vary in their psychometric properties and subsequently a new and reliable picture-based task is introduced. Next, the studies turn to theoretical questions, investigating the causes, consequences and mechanisms of SFON. The findings give rise to three main conclusions. First, children's SFON shows little influence from parental SFON and home numeracy factors. Second, high SFON children show a symbolic number advantage. Third, the relationship between SFON and arithmetic can be explained, in part, by individual differences in children's ability to map between nonsymbolic and symbolic representations of number. The MA studies focus primarily on gender issues. The results reveal no significant differences between boys' and girls' overall levels of MA; however, there are gender differences in the correlates of MA. Specifically, boys' (but not girls') MA is related to parents' MA. Moreover, the relationship between MA and mathematical outcomes is stronger for boys than it is for girls. Possible causal explanations for these gender differences are explored in two ways: First, by examining the reliability of the scales used to assess MA in boys and girls. Second, by investigating the relationship between girls' (and boys') mathematics anxiety and their societal math-gender stereotypes. The findings from both sets of studies draw a link between children's emerging dispositions towards mathematics and their early numerical skills. Future research needs to examine how these dispositional factors interact with other (cognitive and non-cognitive) predictors of mathematics achievement.

A research report submitted to the School of Chemical and Metallurgical Engineering, Faculty of Engineering and the Built Environment, University of the Witwatersrand, Johannesburg, 2016. / The self-heating of coals is a complex problem which has been occurring for centuries. This problem has been fatal to coal miners, an economical challenge to coal mines and a health risk in a release of greenhouse gases to the public in general. Therefore, everyone is affected by the self-heating of coal, which leads to spontaneous combustion when the ignition temperature is reached. There are many test methods that have been used to test spontaneous combustion in coal, but all have one common factor or disadvantage of requiring long periods of time before a conclusion can be deduced. This then creates a need for a rapid and reliable method to test the liability of coal to self-heat in the coal industry and thus the motivation for this project. The thermogravimetry analysis (TGA) method was selected to test the liability of coal to self-heat due to its short analytical duration. The Smith-Glasser oxidation test was selected to validate the TGA results obtained. The main aim of this project is to investigate the reliability of the TGA method to predict the propensity of coal to self-heat. 29 samples from different regions of South Africa were used, prepared to 250 μm for all the analyses and self-heating tests. All samples were analysed for proximate, calorific value, sulphur and petrographic properties before the spontaneous combustion liability tests began. The TGA method followed two tests: 1) the O2 adsorption and 2) the ignition test. Five different heating rates (3, 5, 7, 10, and 20) °C/min were run in order to obtain five derivative slopes which would be used to obtain the TGspc index. The oxygen adsorption test studies the mass increase at low temperature under exposure of air between the temperature ranges of 100 – 300°C. The Smith-Glasser oxidation test method studies the reaction of coal with O2 and calculates the O2 absorbed per amount of coal tested. The Smith-Glasser test results collaborated with most of the other analytical results, and with the TGA results to a certain extent. The TGA spontaneous combustion liability test requires additional analytical work to back up its results because the results do not appear as accurate as the Smith-Glasser oxidation test. It also requires repeatability tests to ensure the integrity of the results. / EM2017