La propuesta principal de este proyecto de tesis, es crear un equipamiento arquitectónico y urbano que, mediante la implementación de actividades culturales, recreativas y deportivas fomente en los niños y adolescentes valores educativos, culturales y deportivos, además de mostrarles mediante esta nueva propuesta arquitectónica y con novedosas técnicas de aprendizaje que culturizarse es importante para su desarrollo, además de que se implementaran educación para el trabajo. Dichos elementos mencionados anteriormente, son parte de los criterios principales para la creación de este nuevo polo recreativo y de esparcimiento que tiene como principal énfasis la creación de nuevos espacios públicos y la adaptación de estos con los ya existentes. Además, este nuevo modelo de Centro Cultural podría adaptarse en otros distritos de Lima, ya que existe carencia de equipamientos que fomenten en niños y jóvenes actividades recreativa, culturales, deportivas. / The main proposal of this thesis project is to create an equipment architectural and urban, through the implementation of cultural activities, recreational and sports fosters in children and adolescents, educational values, cultural and sporting, in addition to show you through this new architectural proposal and with new techniques of learning how important culture is to the development of our professional lives . In addition, the project will foster the education for the job. These elements mentioned above, are part of the major criteria for the creation of this new center for recreation and entertainment that have as main focus the creation of new public spaces and the adaptation of those already existing. In addition, this new model of a Cultural Centre could be adapted in other districts of Lima, as there is lack of facilities that encourage children and youth activities recreation, cultural, sports. / Tesis

Doctor of Philosophy(PhD) / Mid-ocean ridges are a fundamental but insufficiently understood component of the global plate tectonic system. Mid-ocean ridges control the landscape of the Earth's ocean basins through seafloor spreading and influence the evolution of overriding plate margins during midocean ridge subduction. The majority of new crust created at the surface of the Earth is formed at mid-ocean ridges and the accretion process strongly influences the morphology of the seafloor, which interacts with ocean currents and mixing to influence ocean circulation and regional and global climate. Seafloor spreading rates are well known to influence oceanic basement topography. However, I show that parameters such as mantle conditions and spreading obliquity also play significant roles in modulating seafloor topography. I find that high mantle temperatures are associated with smooth oceanic basement, while cold and/or depleted mantle is associated with rough basement topography. In addition spreading obliquities greater than > 45° lead to extreme seafloor roughness. These results provide a predictive framework for reconstructing the seafloor of ancient oceans, a fundamental input required for modelling ocean-mixing in palaeoclimate studies. The importance of being able to accurately predict the morphology of vanished ocean floor is demonstrated by a regional analysis of the Adare Trough, which shows through an analysis of seismic stratigraphy how a relatively rough bathymetric feature can strongly influence the flow of ocean bottom currents. As well as seafloor, mid-ocean ridges influence the composition and morphology of overriding plate margins as they are consumed by subduction, with implications for landscape and natural resources development. Mid-ocean ridge subduction also effects the morphology and composition of the overriding plate margin by influencing the tectonic regime experienced by the overriding plate margin and impacting on the volume, composition and timing of arc-volcanism. Investigation of the Wharton Ridge slab window that formed beneath Sundaland between 70 Ma and 43 Ma reveals that although the relative motion of an overriding plate margin is the dominant force effecting tectonic regime on the overriding plate margin, this can be overridden by extension caused by the underlying slab window. Mid-ocean ridge subduction can also affect the balance of global plate motions. A longstanding controversy in global tectonics concerns the ultimate driving forces that cause periodic plate reorganisations. I find strong evidence supporting the hypothesis that the plates themselves drive instabilities in the plate-mantle system rather than major mantle overturns being the driving mechanism. I find that rapid sub-parallel subduction of the Izanagi mid-ocean ridge and subsequent catastrophic slab break o_ likely precipitated a global plate reorganisation event that formed the Emperor-Hawaii bend, and the change in relative plate motion between Australia and Antarctica at approximately 50 Ma

Integrins are a family of conserved cell surface receptors found throughout the animal kingdom. They comprise 24 dimers in mammals, and regulate a number of processes including cell survival, differentiation, and migration. These complex cellular responses involve processes such as cell attachment, spreading, and various signaling pathways, which in turn depend on the composition of the extracellular environment, on its mechanical properties, and involved integrin types. This thesis focuses on identifying molecules that signal downstream of integrins and how integrin-induced signals may differ dependent on the type of mechanical stimulus that is given. In Paper I, we show that cell spreading and the activation of AKT is regulated by the catalytic PI3K isoform p110α. An intact β1 integrin cytoplasmic tail and actin polymerization was needed for spreading, whereas the presence of FAK or SRC, or the interaction between p110α and RAS was dispensable. Paper II reports that the RICTOR-mTOR complex (TORC2) acts as the kinase downstream of β1 integrins in order to phosphorylate AKT on Ser473, which was functionally linked to cell survival. β1 integrins activated both AKT1 and AKT2, but seemed to prefer AKT2. The investigation of several receptor types with regard to their requirement of TORC2, PAK, and ILK for AKT Ser473 phosphorylation revealed that different kinds of receptors engage specific enzyme combinations depending on cell type and context. In the third paper, we demonstrate that adhesion- and mechanical stretch-induced integrin signaling lead to divergent protein phosphorylation patterns, and that most signals from cell adhesion were not dependent on intracellular contractility. This indicates that integrin ligand binding and mechanical stretch induce signaling via distinct mechanisms. Reactive oxygen species (ROS) derived from different cellular sources modulated these responses. Stretching primarily induced phosphorylation of ERK1/2, and this signal was markedly increased by a derivative of the antioxidant ascorbate and extracellularly administered catalase. The robust AKT phosphorylation in response to adhesion was almost completely abolished with an inhibitor targeting mitochondrial ROS, whereas phosphorylation levels were only marginally affected in stretch assays. Similar results were obtained with siRNA knock-down of a critical subunit of ROS-producing NADPH oxidases.

Owing to the insufficient varieties of the financial products or the offer of identical financial services or merchandise by banks, Taiwan¡¦s financial environment has resulted in over-banking predicaments. In addition, the financial company managing directors are bewilderedly on the concept of economies of scale so as to consider that the more physical banking chains they construct, the more business deals will be done. Owing to the said reasons, the banks have involved in large scale and intense competition such as applying low margin strategy over the years. In the early days, the banks have established branches, ATM, as well as telephone speech banking to better service their customers. Nowadays, electronic banking, the newest banking service, is undoubtedly included by each bank to provide even better and quick service to answer to customers¡¦ instant demands. By providing 24 hours a day, all yearlong prompt services and convenient access, the electronic banking have considerably increased the banking transactions, largely reduced the operating cost, brought more earnings and created preferable competitive advantage so that it is unquestionably considered as the 21st century¡¦s revolutionary financial service innovation. In theory, owing to its traits of no boundary to territory and time, the electronic banking could ideally contribute to more revenues than that of the physical banking chains. The phenomenon, moreover, stands for that the original electronic banking has reformed from its affiliated role to the banks to the fact that it could successfully compete with the physical banking chains. In retrospect to the early stage of the electronic banking, bank companies have purposely established the electronic banking in attempt to lower the operating cost such as bank account checking service that has obviously consumed a great deal of the manpower and in the hope of transferring those activities from the bank counters or telephone speech banking to electronic or virtual banking. By doing that, the customers could personally check through their accounts from the electronic banking system banks provide. Along with the rapid growth and use of the internet, more and more banks have realized that the electronic banking could contribute more and more innovative banking services and good margin. Through the study, we have found that the major obstacles to the development of the electronic banking are resulted from that the users have very little trust on the internet transaction mechanism. In addition to that, 1) alternatives such as physical banking chains and ATM are easy to access 2) users¡¦ not being able to access to the electronic banking unless certain application is submitted to banks beforehand 3) the interference on banking by government¡¦s regulation 4) banks¡¦ failure to lessen users¡¦ concern of the internet transaction safety through advertisement or propaganda have all dragged the development of domestic electronic banking. By interviewing professionals, here we conclude the following suggestions to solve the issue that very few people using the electronic banking. 1) It is suggested that IC card and card reader to be applied for the verification of users¡¦ identity instead of solely inserting users¡¦ name and password on the internet as a way to lessen users¡¦ perceived risk. 2) It is suggested that the electronic banks should include the tax paying platform. Considering that the low cost electronic bank will substantially surpass the physical banking chains owing to its effortless access, electronic banking executives should come up with revolutionary solutions to enhance the efficiency as well as added value of electronic banking.

CD45 is a protein tyrosine phosphatase that is expressed on all nucleated hematopoietic cells. The major substrates of CD45 in thymocytes and T cells are the Src family kinases Lck and Fyn. The role of CD45 in thymocyte development and T cell activation via its regulation of Src family kinases in T cell receptor signaling has been studied extensively. However, the role of CD45 in processes that affect thymocyte development prior to the expression of the T cell receptor has not been explored. The overall hypothesis of this study was that CD45 is a regulator of spreading, migration, proliferation, and differentiation of early thymocytes during development in the thymus and the absence of CD45 would alter the outcome of thymocyte development. The first aim was to determine how CD45 regulates CD44-mediated signaling leading to cell spreading. The interaction between CD44 and Lck was first examined. CD44 associated with Lck in a zinc-dependent and a zinc-independent manner. Mutation analysis localized the zinc-dependent interaction to the membrane proximal region of CD44, but did not involve individual cysteine residues on CD44. CD44 and Lck co-localized in microclusters upon CD44-mediated cell spreading. CD45 co-localized with Lck and CD44 in microclusters and with F-actin in ring structures. The recruitment of CD45 to microclusters may be a mechanism of how CD45 negatively regulates CD44-mediated spreading. The second specific aim was to determine the role of CD45 in migration, proliferation, and progression and differentiation of early thymocytes. CD45 negatively regulated CXCL12-mediated migration, and positively regulated the proliferation and progression of CD117- DN1 thymocytes. Absence of CD45 led to an altered composition of thymic subsets. The CD45-/- thymus contained decreased numbers of ETPs and an aberrant CD117- DN1 population that lacked CD24, TCRbeta, and CCR7 expression. There were also increased thymic NK and gamma/delta T cells, but decreased NKT cells. In addition, a novel intermediate between DN1 and DN2 that required Notch for progression was identified. Overall, this study identified new roles for CD45 in early thymocytes and provided a better picture of how the development of T cells, a central component of the immune system, is regulated.

No description available.

Supersaturated water injection (SWI) is a novel remediation technology which is able to remove entrapped residual NAPLs from saturated porous media by both volatilization (partitioning of volatile contaminants into the gas phase) and mobilization (displacement of isolated NAPL residuals by gas clusters). The character of gas saturation evolution in-situ in saturated porous media during SWI results in high sweep efficiency. This work focuses on studying the recovery of entrapped residual NAPL by the mobilization mechanism during SWI, thus low-volatility NAPL residuals, kerosene and a kerosene-hexadecane mixture, are used as contaminants. A series of SWI recovery experiments are conducted to investigate the influence of grain size, low-permeability layering, and physical properties of the contaminants on the recovery behavior. For columns contaminated with kerosene, the residual saturation can be reduced to around 4% from an initial value of 16%, and over 70% of the residual kerosene is recovered by a combination of mobilization and volatilization in homogeneous sand packs. For columns contaminated with a kerosene-hexadecane mixture, the final residual saturation is 7.4% and the final NAPL recovery is lower than that in kerosene columns. Grain size has little influence on NAPL recovery, but low permeability layering has a significantly negative influence. Experiments designed to compare SWI to sparging, and water-gas co-injection showed that water-gas co-injection was able to effectively recovery residual NAPLs albeit not as efficiently as SWI, while steady gas sparging is completely ineffective at recovering residual NAPL by mobilization. Based on these experimental observations, a conceptual model, involving double displacements and NAPL bank formation, is purposed to explain the experimental observations.

Supersaturated water injection (SWI) is a novel remediation technology which is able to remove entrapped residual NAPLs from saturated porous media by both volatilization (partitioning of volatile contaminants into the gas phase) and mobilization (displacement of isolated NAPL residuals by gas clusters). The character of gas saturation evolution in-situ in saturated porous media during SWI results in high sweep efficiency. This work focuses on studying the recovery of entrapped residual NAPL by the mobilization mechanism during SWI, thus low-volatility NAPL residuals, kerosene and a kerosene-hexadecane mixture, are used as contaminants. A series of SWI recovery experiments are conducted to investigate the influence of grain size, low-permeability layering, and physical properties of the contaminants on the recovery behavior. For columns contaminated with kerosene, the residual saturation can be reduced to around 4% from an initial value of 16%, and over 70% of the residual kerosene is recovered by a combination of mobilization and volatilization in homogeneous sand packs. For columns contaminated with a kerosene-hexadecane mixture, the final residual saturation is 7.4% and the final NAPL recovery is lower than that in kerosene columns. Grain size has little influence on NAPL recovery, but low permeability layering has a significantly negative influence. Experiments designed to compare SWI to sparging, and water-gas co-injection showed that water-gas co-injection was able to effectively recovery residual NAPLs albeit not as efficiently as SWI, while steady gas sparging is completely ineffective at recovering residual NAPL by mobilization. Based on these experimental observations, a conceptual model, involving double displacements and NAPL bank formation, is purposed to explain the experimental observations.

The emergence of the Internet has made the global information communications much easier than before. Users can navigate the desired information over the Internet by means of search engines. Even though search engine can help users search specified topic in a primary way, users usually cannot gain the overall idea of what the entire navigated results mean. In addition, information over the Internet keeps changing. Users cannot even keep track of the changes, let alone to comprehend the meanings of such changes. Consequently, this research proposes a two-stage incremental approach to figuring out the concept structure that represents the main concepts of the search results in the first stage, and keeping track of the concept changes with time based on spreading activation theory to assist users in the second stage. Experiments are conducted to examine the feasibility of our proposed approach. The first experiment is to evaluate the results from the first stage. It shows that the performance on recall and precision is quite satisfactory based on human experts¡¦ results. The second experiment is to examine the changing results from the entire proposed approach. It shows that high degree of agreement with our results is achieved from domain experts. Both experiments justify the feasibility of our proposed approach in real applications. That is, applying our proposed approach, users can easily focus on the topic they are interested in and learn its trend with great support. Keywords: Internet, Concepts Extraction, Concept Change Detection, Spreading Activation Theory.

Extensive oil drilling and transportation activities increase the possibility of oil spills and the consequent threat of oil pollution to the regional environment. Oil spills are hazards for marine and freshwater environments. Oil spill/slick detection, monitoring and management has received considerable attention over the past few years. It is a highly non-linear problem to predict oil slick movement and spreading, and it is a subject of complicated science. Oil spill behavior become more complicated while involving the effects of winds, surface currents, oil evaporation, shoreline deposition, land boundary, vertical dispersion and underwater current. Cellular Automata is a solution for problems of complicated science. A three-dimensional model for the prediction of oil slick movement and spreading using Cellular Automata is presented in this paper. The effects of winds, surface currents, oil evaporation, shoreline deposition, land boundary and vertical dispersion have been taken into account while processing the surface cells. At the same time, the effects of underwater currents and land boundary have been taken into account while processing the underwater cells. The algorithm has been used to simulate hypothetical oil slick movement and spreading in hypothetical geographic regions. The results of the simulation are qualitative agreed with real oil slick movement and spreading.