No description available.

No description available.

Activation of the unfolded protein response follows induction of endoplasmic reticulum (ER) stress, resulting in widespread inhibition of protein expression. FLIP protein is particularly sensitive to stresses that perturb protein translation; as such, a reduction in FLIP is likely an early outcome of ER stress. Due to the anti-apoptotic role of FLIP, it is anticipated that potential decreases in FLIP would bring about an increase in sensitivity to death receptor stimuli and anoikis, a form of anchorage-dependent cell death. It was hypothesized that induction of ER stress results in downregulation of FLIP expression, resulting in sensitization of resistant tumour cells to death receptor stimuli and anoikis. From this hypothesis, it was determined that induction of ER stress through treatment of cells with brefeldin sensitized tumour cells to Fas-mediated cell death and anoikis. Moreover, over-expression of FLIP appeared to protect against ER stress-induced sensitization to cell death.

The objective of this thesis is to investigate well-defined cross-linked particles synthesized via the reversible addition fragmentation chain transfer (RAFT) process that can be used for drug delivery. To achieve this aim, a wide range of cross-linked micelle systems have been synthesized and intensively investigated. Various biocompatible monomers were employed, including poly (ethylene glycol) methyl ether methacrylate, 2-hydroxyl ethyl acrylate, functionalized glucosamine and nucleotides containing monomers. Different cross-linked structures were used, for example, core-cross-linked, nexus-cross-linked and shell-cross-linked micelles. Diverse stimuli-responsive particles were used, such as pH-sensitive, thermo-sensitive and thiol-sensitive cross-linked systems. Evidences of the successful synthesis of all the resulting cross-linked products are given. They displayed better properties, as drug carriers, than non-cross-linked micelles. A thermo-responsive seven-arm star glycopolymer, synthesized via the RAFT process, was also investigated.

Thesis (B.A. (Hons.))-- University of Adelaide, Dept. of Psychology, 1972.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1963. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves [32-33]).

Thesis (M.Sc.) -- Memorial University of Newfoundland. 1973. / Typescript. Bibliography : leaves 58-69. Also available online.

Thesis (Ph.D) - University of Queensland, 2006. / Includes bibliography.

<p>Ur den holistiska synen på människan kommer variationen av varje individs upplevelse av hälsa att se olika ut. Med ålderdomen anländer förändringar av hälsan inom de olika hälsodimensionerna, psykologisk/emotionell, fysisk, social och spirituell. Författarna till föreliggande litteraturstudie anser att hälsopromotiva åtgärder bör vara grundade från denna teoretiska bas. Syftet med denna litteraturstudie, var att belysa hälsopromotion för äldre (65+) ur detta mångdimensionella hälsoperspektiv. Sju kvantitativa och två kvalitativa studier kvalitetsgranskades och analyserades. En teoretisk ram utvecklades av hälsodimensionerna och gav ett raster inom vilket studiernas resultat sorterades. Resultatet visade att stimuli inom de olika hälsoperspektiven ger äldre en ökad eller bibehållen upplevd hälsa. Den ökade upplevda hälsan inom en hälsodimension påverkade ofta andra dimensioner på ett positivt sätt. Att ingå i ett sammanhang, känna sig accepterad och bekräftad och känna mening i livet manifesterade äldre människors syn på den upplevda hälsan. För att ytterligare öka kunskapen och förstå vikten av det centrala i äldres upplevelse av hälsa och på vilket sätt sjuksköterskan kan implementera det i den kliniska verksamheten krävs vidare forskning.</p>

The following study aims to understand the effects Acceptance and Commitment Therapy, or ACT, has on individuals who have experienced discomfort through exposure to aversive stimuli. Experiencing discomfort is a natural part of human life. Each person has their own class of responses to respond to discomfort. A typical response may include avoiding an object, person, or situation that had made the person uncomfortable in the past. Batten, Follette, and Aban (2001) found that women who experienced childhood sexual abuse and scored high in experiential avoidance where more likely to engage in high risk sexual behaviors. Avoiding discomfort can have serious repercussions. ACT has been a proven therapy to treat anxiety, gambling, PTSD, eating disorders among other disorders. Previous studies show the effectiveness of ACT on treating discomfort (Cohrane, Barnes-Holmes, & Barnes-Holmes, 2008; Hayes, Bissett, Korn, Zettle, Rosenfarb, Cooper, & Grundt, 1999; Luciano, et al., 2010). This study extends the findings and further supports the utility of ACT to treat discomfort through a laboratory study. This study exposes participants to “disgusting” stimuli to evoke disgust and discomfort. A brief ACT session is administered to half the participants which is compared to a control task which includes a distraction/avoidance task. Findings from this study suggest the utility of ACT to increase tolerance to discomfort.