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Structural and Biochemical Studies of Protein-Ligand Interactions: Insights for Drug DevelopmentMishra, Vidhi January 2013 (has links)
No description available.
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NMR structural studies on the periplasmic domain of CitA and DcuS. / Strukturuntersuchungen an der periplasmatischen Domäne von CitA und DcuS mit NMR-SpektroskopieVijayan, Vinesh 03 May 2007 (has links)
No description available.
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Synthèse et étude de ligands hydroxamates cycliques dérivés des sidérophores naturels pour la complexation sélective des actinides / Synthesis and investigation of cyclic hydroxamate ligands derived from natural siderophores for selective complexation of actinidesJewula, Pawel 25 September 2013 (has links)
Pas de résumé en français / The goal of this research was the synthesis and spectroscopic, structural andphysical-chemical characterization of cyclic 6- and 7-membered hydroxamicacids, a tetrahydroxamic calix[4]arene-based tetrapodal receptor, and their metalcomplexes with trivalent and tetravalent metal cations. They were characterizedby several techniques such as 1H and 13C NMR, IR, and mass spectroscopies,single crystal X-ray analysis, and potentiometry. Cyclic hydroxamic acids arefound in a few mix siderophores but their coordination properties were stillunknown. The structural features of metal complexes formed with Fe(III),Ga(III), Ce(IV), Zr(IV), Hf(IV), U(IV) and U(VI) have been investigated both inthe solid state and in solution. The synthesis and complexation studies of anoriginal calix[4]arene-based tetrapodal receptor is described. Reactionparameters for all key steps in the synthetic route have been optimized. Thesingle X-ray crystal analysis of benzyl-protected receptor was obtained.Complexation studies with zirconium(IV) and hafnium(IV) evidenced theformation of two metal two ligand complexes rather than 1:1 species, whichwere shown to interact in solution with a third alkali cation
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LHCb Upstream Tracker box : Thermal studies and conceptual designMårtensson, Oskar January 2016 (has links)
The LHC (Large Hadron Collider) will have a long shut down in the years of 2019 and 2020, referred to as LS2. During this stop the LHC injector complex will be upgraded to increase the luminosities, which will be the first step of the high luminosity LHC program (which will be realized during LS3 that takes place in 2024-2026). The LHCb experiment, whose main purpose is to study the CP-violation, will during this long stop be upgraded in order to withstand a higher radiation dose, and to be able to read out the detector at a rate of 40MHz,compared to 1MHz at present. This change will improve the trigger efficiency significantly. One of the LHCb sub-detectors the Trigger Tracker (TT), will be replaced by a new sub-detector called UT. This report presents the early stage design (preparation for mock-up building) of the box that will be isolating the new UT detector from the surroundings and to ensure optimal detector operation. Methods to fulfill requirements such as light and gas tightness, Faraday-cage behavior and condensation free temperatures, without breaking the fragile beryllium beam pipe, are established. / LHC (Large Hadron Collider) kommer under åren 2019-2020 att ha ett längre driftstopp. Under detta driftstopp så kommer LHC's injektionsanordningar att uppgraderas för att kunna sätta fler protoner i circulation i LHC, och därmed öka antalet partikelkollisioner per tidsenhet. Denna uppgradering kommer att vara första steget i "High Luminocity LHC"-programmet som kommer att realiseras år 2024-2026. LHCb-experimentet, vars främsta syfte är att studera CP-brott, kommer också att uppgraderas under stoppet 2019-2020. Framför allt så ska avläsningsfrekvensen ökas från dagens 1MHz till 40MHz, och experimentet ska förberedas för de högre strålningsdoser som kommer att bli aktuella efter stoppet 2024-2026. En av LHCb's deldetektorer, TT detektorn, kommer att bytas ut mot en ny deldetektor som kallas UT. Den här rapporten presenterar den förberedande designen av den låda som ska isolera UT från dess omgivning och försäkra optimala förhållanden för detektorn. Kraven på den isolerande lådan och tillvägagångssätt för att uppfylla dessa krav presenteras. / LHCb, LS2 and LS3 Upgrade
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