Thesis--Freiburg im Breisgau. / Includes bibliographical references (p. 247-254).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1953. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves [178]-180).

This thesis considers the relationship between adaptive behaviour and metabolism, using theoretical arguments supported by computational models to demonstrate mechanisms of adaptation that are uniquely available to systems based upon the metabolic organisation of self-production. It is argued how, by being sensitive to their metabolic viability, an organism can respond to the quality of its environment with respect to its metabolic well-being. This makes possible simple but powerful ‘self-sensitive' adaptive behaviours such as “If I am healthy now, keep doing the same as I have been doing – otherwise do something else.” This strategy provides several adaptive benefits, including the ability to respond appropriately to phenomena never previously experienced by the organism nor by any of its ancestors; the ability to integrate different environmental influences to produce an appropriate response; and sensitivity to the organism's present context and history of experience. Computational models are used to demonstrate these capabilities, as well as the possibility that self-sensitive adaptive behaviour can facilitate the adaptive evolution of populations of self-sensitive organisms through (i) processes similar to the Baldwin effect, (ii) increasing the likelihood of speciation events, and (iii) automatic behavioural adaptation to changes in the organism itself (such as genetic changes). In addition to these theoretical contributions, a computational model of self-sensitive behaviour is presented that recreates chemotaxis patterns observed in bacteria such as Azospirillum brasilense and Campylobacter jejuni. The models also suggest new explanations for previously unexplained asymmetric distributions of bacteria performing aerotaxis. More broadly, the work advocates further research into the relationship between behaviour and the metabolic organisation of self-production, an organisational property shared by all life. It also acts as an example of how abstract models that target theoretical concepts rather than natural phenomena can play a valuable role in the scientific endeavour.

Revideret udgave af disputats 1999. / Originally presented as the author's thesis (doctoral)--Universität Hamburg, 1999.

Recent effort to teach Western science in the Tibetan Buddhist monasteries has drawn interest both within and outside the quarters of these monasteries. This novel and historic move of bringing Western science in a traditional monastic community began around year 2000 at the behest of His Holiness the Dalai Lama, the spiritual head of Tibetan Buddhism. Despite the novelty of this effort, the literature in science education about learners from non-Western communities suggests various "cognitive conflicts" experienced by these non-Western learners due to fundamental difference in the worldview of the two knowledge traditions. Hence, in this research focuses on how six Tibetan Buddhist monks were situating/reconciling the scientific concepts like the theory of evolution into their traditional Buddhist worldview. The monks who participated in this study were engaged in a further study science at a university in the U.S. for two years. Using case study approach, the participants were interviewed individually and in groups over the two-year period. The findings revealed that although the monks scored highly on their acceptance of evolution on the Measurement of Acceptance of Theory of Evolution (MATE) survey, however in the follow-up individual and focus group interviews, certain conflicts as well as agreement between the theory of evolution and their Buddhist beliefs were revealed. The monks experienced conflicts over concepts within evolution such as common ancestry, human evolution, and origin of life, and in reconciling the Buddhist and scientific notion of life. The conflicts were analyzed using the theory of collateral learning and was found that the monks engaged in different kinds of collateral learning, which is the degree of interaction and resolution of conflicting schemas. The different collateral learning of the monks was correlated to the concepts within evolution and has no correlation to the monks’ years in secular school, science learning or their proficiency of English language. This study has indicted that the Tibetan Buddhist monks also experience certain cognitive conflict when situating Western scientific concepts into their Buddhist worldview as suggested by research of science learners from other non-Western societies. By explicating how the monks make sense of scientific theories like the theory of evolution as an exemplar, I hope to inform the current effort to establish science education in the monastery to develop curricula that would result in meaningful science teaching and learning, and also sensitive to needs and the cultural survival of the monastics.

No description available.

Bei der Replikation monotoner DNA - Sequenzen tritt theoretisch ein Vorgang auf, den wir als „Basenkonkurrenz“ bezeichnen: Da sich an jeder Replikations-Stelle mehrere Basenbausteine bewerben, aber immer nur einer benötigt wird, bewerben sich die übrig gebliebenen Bausteine an den jeweils nächsten Replikations - Positionen und erlangen wegen der fortwährenden Beschleunigung durch elektrostatische Anziehung immer größere kinetische Energien. Das führt dazu, dass an einer bestimmten Stelle der replizierenden monotonen Sequenz der eine Partner der Wasserstoffbrückenbindung ein hohes Energieniveau erreicht. Es wird berechnet, dass sich dadurch kurzzeitig eine sehr hohe Bindungsenergie zwischen den beiden Partnern der Wasserstoffbrückenbindung einstellt, wodurch der in dieser kurzen Zeitspanne wirkende DNA-Reparaturmechanismus unterdrückt wird. Die Auswirkungen der hohen Basenkonkurrenz – Energien werden berechnet (hohe Bindungsenergien der Wasserstoffbrückenbindungen, Tunnelvorgänge, irreparable Mutationen). Die Folgen dieser Erscheinung sind Tumorbildung, Alterung, Veränderung der DNA – Struktur, Beeinflussung der Evolution, worauf im Einzelnen eingegangen wird. Es zeigt sich, dass die negativen Auswirkungen der Basenkonkurrenz vorwiegend bei zu niedriger Viskosität des Zellplasmas auftreten.

Darwinian Evolutionary system - a system satisfying the abstract conditions: reproduction with heritable variation, in a finite world, giving rise to Natural Selection encompasses a complex and subtle system of interrelated theories, whose substantive transplantation to any artificial medium let it be mathematical model or computational model - will be very far from easy. There are two motives in bringing Darwinian evolution into computational frameworks: one to understand the Darwinian evolution, and the other is to view Darwinian evolution - that carries out controlled adaptive-stochastic search in the space of all possible DNA-sequences for emergence and improvement of the living beings on our planet - as an optimization process, which can be simulated in appropriate frameworks to solve some intractable problems. The first motive led to emerging field of study commonly referred to as Artificial Life, and other gave way to emergence of Evolutionary Computation, which is speculated to be the only practical path to the development of ontogenetic machine intelligence. In this thesis we touch upon all the above aspects. Natural selection is the central concept of Darwinian evolution and hence capturing natural selection in computational frameworks which maintains the spirit of Darwinian evolution in the sense of conventional, terrestrial and biological perspectives is essential. Naive models of evolution define natural selection as a process which brings in differential reproductive capabilities in organisms of a population, and hence, most of the evolutionary simulations in Artificial Life and Evolutionary Computation implement selection by differential reproduction: the Attest members of the population are reproduced preferentially at the expense of the less fit members of the population. Formal models in evolutionary biology often subdivide selection into components called 'episodes of selection' to capture the different complex mechanisms of nature by which Darwinian evolution can occur. In this thesis we introduce the concept of 'episodes of selection' into computational frameworks of Darwinian evolution by means of A Conceptual Evolutionary model (ACE-model). ACE-model is proposed to be simple and yet it captures the essential features of modern evolutionary perspectives in evolutionary computation framework. ACE-model is rich enough to offer abstract and structural framework for evolutionary computation and can serve as a basic model for evolutionary algorithms. It captures selection in two episodes in two phases of evolutionary cycle and it offers various parameters by which evolutionary algorithms can control selection mechanisms. In this thesis we propose two evolutionary algorithms namely Malthus evolutionary algorithms and Malthus Spencer evolutionary algorithms based on the ACE-model and we discuss the relevance of parameters offered by ACE-model by simulation studies. As an application of ACE-model to artificial life we study misconceptions involved in defining fitness in evolutionary biology, and we also discuss the importance of introducing fitness landscape in the theories of Darwinian evolution. Another important and independent contribution of this thesis is: A Mathematical Abstraction of Evolutionary process. Evolutionary process is characterized by Evolutionary Criteria and Evolutionary Mechanism which are formalized by classical mathematical tools. Even though the model is in its premature stage to develop any theory based on it, we develop convergence criteria of evolutionary process based on this model.

Recent anti-evolution legislation, in the form of Academic Freedom bills, has been introduced in many state legislatures over the last three years. The language in the proposed Academic Freedom bills may allow different interpretations of what can be taught in the science classrooms, and possibly spur parents to take advantage of their perceived parental rights to request their child be opted-out of class when the scientific theory of evolution is taught. Five research questions guided the analysis of participant responses to questions and perception statements focusing on secondary school administrators' actions, perceptions, and awareness as they relate to their decision to allow or not allow a student to opt out of academics, specifically evolution, through the collection of data using a web-based survey. Opt out policies are typically invoked to excuse students from activities to which they or their parents may have religious objections (Scott & Branch, 2008). Florida statutes allow parents to opt out their child from human sexuality and animal dissection. The population consisted of 281 Florida public secondary school administrators, who were divided into two subgroups based on whether they have allowed or would allow a student to opt out of evolution, or have not allowed or would not allow a student to opt out of class when the scientific theory of evolution is taught. Results found that over 70% of the administrators who completed the survey have allowed or would allow parents to opt out their child from learning about the scientific theory of evolution. There was a significant relationship between the decision to allow opt out and the following variables: (a) Free and Reduced Lunch population, (b) grade level served, (c) support for teaching evolution and alternative theories, and (d) the perception that parent rights supersede state statute requiring students to learn evolution. In Florida, any scientific concept that is based on empirical evidence is included in the state-mandated curriculum. If administrators are influenced to believe teachers have the academic freedom to teach alternative ideas that are not scientifically valid, they may be intentionally or unintentionaly allowing subject matter relevant to a student's academic success t to be suppressed or distorted, which is also a violation of state statute. The implications from this study indicated that many participants would allow a student to opt out of class when evolution is taught, including assigning an alternative assignment. Since the scientific theory of evolution is infused into the biological sciences, and therefore, the Florida State Standards for science, evolution concepts are assessed on the Florida Comprehensive Assessment Test (FCAT) and the Biology End-of-Course exam. Allowing students to opt out of class when evolution is taught may have a negative impact on student success on state mandated assessments, which can directly impact school grades and state and federal funding that is tied to Adequate Yearly Progress.

It is the contention of this thesis that the field of adaptation studies is struggling to emerge from a restrictive, outdated and static paradigmatic framework. It proposes that the field would benefit from widening its current frame of reference to include more input and perspectives from the evolutionary biological sciences. This thesis considers the implications for the study of culture of the Darwinian theory of evolution – how it might become a more integral part of how we understand culture generally, and of how we read specific texts. It attempts to re-contextualise adaptation studies within an ongoing, conceptual paradigm shift in Western culture, initiated by Darwin’s publication of his theory of evolution by natural selection. It contends that the Darwinian Revolution is far from complete within the humanities and that the time is ripe for greater consilience and exchange between the bio-sciences and humanities disciplines. This thesis explores the current state of adaptation studies as a discipline, referring in particular to recent work by adaptation theorists such as Robert Stam, Linda Hutcheon, Thomas Leitch and Julie Sanders and their efforts to reinvigorate and redirect adaptation studies. It considers how deeply ingrained, evaluative modes of thought could be holding back these efforts, and if an updated, mutable Darwinian paradigm could aid them. This thesis also speculates on the viability of an evolutionary unit of culture, the meme, and its possible relevance to adaptation studies and the wider study of culture. Finally, it applies a Darwinian perspective, on various levels, to an extensive, detailed textual analysis of the non-fiction book The Orchid Thief and the film Adaptation.