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BACKGROUND: One of the most recurrent complaints after total joint replacement is difficulty sleeping. Sleep disturbance after major surgery is common. The “stress response” to surgery, personal factors and environmental factors can affect quality and quantity of sleep in the hospital setting. Occupational therapy intervention for individuals that have problems with function as a result of sleep insufficiency is an emerging practice area. However, there are few occupational therapy practitioners who have addressed the important occupation of sleep in acute care settings. There is a need to develop science-driven research and establish evidence to support acute care occupational therapy interventions that address sleep hygiene, a set of behavioral and environmental practices designed to improve both quality and quantity of sleep. In response to this need, the author designed and carried out a non- randomized controlled study to evaluate the effectiveness of a non-pharmacological occupational therapy intervention to improve quality and quantity of clients’ sleep in a fast track joint replacement center. OBJECTIVE: In the author’s study, the aim was to compare sleep quality, sleep quantity, and activities of daily living (ADL) performance before and after fast track total joint replacement surgery for clients who received an occupational therapy intervention targeted at improving sleep hygiene, in addition to conventional acute care occupational therapy, compared to those that received only conventional acute care occupational therapy. The project focused on 1) identifying evidence-based literature to support the benefit of non-pharmacological interventions for joint replacement surgery clients, 2) designing a program that represented best practice while incorporating the holistic and occupation-based theoretical base of occupational therapy, 3) implementing the program, 4) conducting summative program evaluation, and 5) developing a dissemination plan and implementation budget. RESULTS: There were no initial significant differences between the control and experimental groups. The quality of sleep in the experimental group at discharge was significantly better than in the controls and this group reported significantly improved quality of sleep at discharge compared to 2 weeks before surgery. At discharge the experimental group reported significantly longer sleep duration compared to the control group and the increase in duration from 2 weeks before surgery to discharge was significant. CONCLUSION: The results of this study demonstrated that improvement in sleep quality and quantity can be achieved in clients undergoing fast track joint replacement surgery who receive an occupation-based intervention that incorporates implementation of sleep hygiene practices. Moreover the change appears to persist after the client returns home. More research examining the effectiveness of this intervention with other surgical populations and the persistence of learned sleep hygiene practices over time after hospital discharge are warranted. / 2018-11-07T00:00:00Z

BACKGROUND: There has been an enormous rise in total joint arthroplasties (TJA) in the United States over the past several years. Researchers have documented the increase in healthcare costs associated with unplanned hospital readmissions among patients post-TJA, specifically total hip and total knee arthroplasties. Additionally, researchers have reported the burden that these costs place on the healthcare system, private payers and on patients and their caregivers. Social routines, quality of life and occupational functioning are often interrupted because of a patient’s unplanned hospital readmission after receiving a total hip or total knee arthroplasty. Investigators have identified the major causes of costly unexpected hospital readmissions among patients with a TJA; they include surgical site infections, blood clots, joint dislocations and periprosthetic fractures. The Occupational Therapy Practice Framework: Domain and Process describes the practice of occupational therapy as promoting health, well-being, and engagement in meaningful occupation. Nonetheless, there is limited literature in the occupational therapy field directed towards reducing hospital readmissions among patients with a total hip or knee arthroplasty, thus suggesting an area that is well-positioned for intervention development and testing. PURPOSE: This Occupational Therapy Doctoral Project entitled Teaching Intervention to Reduce Readmissions-Post Surgery (TIRR-PS) is a proposed program for an acute care hospital setting which: (a) described the problem of hospital readmissions among patients with a total hip or total knee arthroplasty, (b) investigated evidence and best practices for imparting knowledge and/or teaching skills to hospital administrators, healthcare professionals, occupational therapy staff, patients, and caregivers, (c) proposed an intervention based on empirically supported strategies and theoretical frameworks, (d) recommended activities to include as part of the program evaluation, the funding plan and the dissemination plan to promote this multi-level, multi-component pilot program. TIRR-PS will aim to reduce unplanned 30-day hospital readmissions and their associated healthcare costs. Unplanned readmissions are in part caused by inadequate education of hospital administrators, occupational therapy staff, patients, and caregivers. The TIRR-PS program will raise awareness about how to address common medical complication risks and promote the support of hospital administration for the education and skill building activities directed towards healthcare professionals with an emphasis on occupational therapy. CONCLUSION: TIRR-PS was designed for an acute care setting to reduce hospital readmission rates, to reduce healthcare costs, to improve patient quality of life, and to reduce the societal burden of unplanned hospital care. TIRR-PS is an innovative program designed to be comprehensive and to impart knowledge and skills to all relevant professionals in an acute care setting with a particular emphasis on the contribution of the OT profession. TIRR-PS, once evaluated, will provide a standardized, systematic approach to reducing unexpected hospitalizations post-TJA and shows promise for contributing to routine orthopaedic rehabilitative practice in acute care hospitals. This in turn will not only reduce healthcare costs, but will improve the post-surgery quality of life for patients with a recent total hip or total knee arthroplasty.

Yes / Less than optimal particle isolation techniques have impeded analysis of orthopaedic wear debris in vivo. The purpose of this research was to develop and test an improved method for particle isolation from tissue. A volume of 0.018 mm3 of clinically relevant CoCrMo, Ti-6Al-4V or Si3N4 particles was injected into rat stifle joints for seven days of in vivo exposure. Following sacrifice, particles were located within tissues using histology. The particles were recovered by enzymatic digestion of periarticular tissue with papain and proteinase K, followed by ultracentrifugation using a sodium polytungstate density gradient. Particles were recovered from all samples, observed using SEM and the particle composition was verified using EDX, which demonstrated that all isolated particles were free from contamination. Particle size, aspect ratio and circularity were measured using image analysis software. There were no significant changes to the measured parameters of CoCrMo or Si3N4 particles before and after the recovery process (KS tests, p > 0.05). Titanium particles were too few before and after isolation to analyse statistically, though size and morphologies were similar. Overall the method demonstrated a significant improvement to current particle isolation methods from tissue in terms of sensitivity and efficacy at removal of protein, and has the potential to be used for the isolation of ultra-low wearing total joint replacement materials from periprosthetic tissues.

Osteoarthritis is a degenerative disease of joints, which can be solved with implantation of total joints prosthesis. A high-quality proprioception of knee joint protects the joint against possible bending injury, it is also participating in stabilizing the knee in static position and it is important in the process of coordination of the motion system and precise flexibility of the knee joint. In this thesis are summed up the knowledge of osteoarthritis, total joints prosthesis and proprioception, all is taken in context of connection. The research includes comparison of proprioception of knee joint with arthrosis and total joints prosthesis. Also, the research compared mentioned knee joints with the healthy verification group. All monitored individuals absolved a medical examination of the quality of proprioception in the form of move sensitivity in position of 30ř, 50ř and 80ř. Amongst the knees with arthrosis and knees with total joints prosthesis there were not found a differences with static importance in each of the angle test. In the total comparison there was significantly better proprioception of the knees with the total joints prosthesis. The knee joints of the verification group unlike the joints with arthrosis and total prosthesis showed significantly better flexibility in position of...

Title: Effect of physiotherapy to reduce the length of hospital stay in patients with total hip arthroplasty: a literature review Objective: The purpose of this thesis is to research and compare available studies investigating the effect of extra physiotherapy in reducing the length of stay for patients with total hip arthroplasty. In addition, to make a compilation of available sources about issue of the hip, total hip arthroplasty in terms of anatomy, kinesiology and biomechanics and length of hospital stay. Methods: This diploma thesis has descriptively-analytical character and is structured in the form of literary review. Results: Physiotherapy decreases length of stay in patients with total hip arthroplasty. Future research could address a specific group of subjects and the issue of cost-effectiveness in reducing the length of hospital stay by physiotherapy. Key words: Hip joint, total joint replacement, THA, physiotherapy, length of stay

Objective: The purpose of this study was to examine social cognitive constructs as predictors of preoperative exercise (PE) in a sample of individuals waiting for total joint replacement (TJR) surgery using the framework of Bandura’s Social Cognitive Theory (SCT). Methods: Participants (N = 78) were individuals waiting for TJR at the two major urban centres on Vancouver Island, Canada who completed measures of the SCT (barrier self-efficacy, outcome expectancy, self regulation, task efficacy & sociocultural factors of pain, physical function and neighbourhood walking environment) framed for (PE). Results: Independent t-tests suggested no differences between type of surgery (hip versus knee), gender or age for PE (p<.05). Over half of the sample was considered inactive (55%) using a definition of physical activity as accumulating at least 30 minutes of exercise at a moderate or vigorous intensity at least 3 days per week in bouts of 10 minutes or more. Bivariate correlations relating to PE were significant (p<.05) between self regulation (SR) (.25), task efficacy for exercise (TEE) (.27) and pain (-.28). Hierarchical regression analysis revealed that SR (β=.17) and TEE (β=.20) explained 10% of the variance in PE behaviour, but were not significant predictors of PE independently. The addition of pain to the regression analysis added 4% of the explained variance, and remained the only significant predictor (p<.05) of Pe behaviour. Conclusions: SCT showed modest capability in predicting PE in this sample, suggesting further testing of theoretical models is warranted in this area. These findings highlight the influence of pain on exercise before TJR surgery, and support the importance of considering individual factors such as pain when designing targeted interventions to increase activity in this population.

Biotribology, the study of lubrication, wear and friction within the body, has become a topic of high importance in recent times as we continue to encounter debilitating diseases and trauma that destroy function of the joints. A highly successful surgical procedure to replace the joint with an artificial equivalent alleviates dysfunction and pain. However, the wear of the bearing surfaces in prosthetic joints is a significant clinical problem and more patients are surviving longer than the life expectancy of the joint replacement. Revision surgery is associated with increased morbidity and mortality and has a far less successful outcome than primary joint replacement. As such, it is essential to ensure that everything possible is done to limit the rate of revision surgery. Past experience indicates that the survival rate of the implant will be influenced by many parameters, of primary importance, the material properties of the implant, the composition of the synovial fluid and the method of lubrication. In prosthetic joints, effective boundary lubrication is known to take place. The interaction of the boundary lubricant and the bearing material is of utmost importance. The identity of the vital active ingredient within synovial fluid (SF) to which we owe the near frictionless performance of our articulating joints has been the quest of researchers for many years. Once identified, tribo tests can determine what materials and more importantly what surfaces this fraction of SF can function most optimally with. Surface-Active Phospholipids (SAPL) have been implicated as the body’s natural load bearing lubricant. Studies in this thesis are the first to fully characterise the adsorbed SAPL detected on the surface of retrieved prostheses and the first to verify the presence of SAPL on knee prostheses. Rinsings from the bearing surfaces of both hip and knee prostheses removed from revision operations were analysed using High Performance Liquid Chromatography (HPLC) to determine the presence and profile of SAPL. Several common prosthetic materials along with a novel biomaterial were investigated to determine their tribological interaction with various SAPLs. A pin-on-flat tribometer was used to make comparative friction measurements between the various tribo-pairs. A novel material, Pyrolytic Carbon (PyC) was screened as a potential candidate as a load bearing prosthetic material. Friction measurements were also performed on explanted prostheses. SAPL was detected on all retrieved implant bearing surfaces. As a result of the study eight different species of phosphatidylcholines were identified. The relative concentrations of each species were also determined indicating that the unsaturated species are dominant. Initial tribo tests employed a saturated phosphatidylcholine (SPC) and the subsequent tests adopted the addition of the newly identified major constituents of SAPL, unsaturated phosphatidylcholine (USPC), as the test lubricant. All tribo tests showed a dramatic reduction in friction when synthetic SAPL was used as the lubricant under boundary lubrication conditions. Some tribopairs showed more of an affinity to SAPL than others. PyC performed superior to the other prosthetic materials. Friction measurements with explanted prostheses verified the presence and performance of SAPL. SAPL, in particular phosphatidylcholine, plays an essential role in the lubrication of prosthetic joints. Of particular interest was the ability of SAPLs to reduce friction and ultimately wear of the bearing materials. The identification and knowledge of the lubricating constituents of SF is invaluable for not only the future development of artificial joints but also in developing effective cures for several disease processes where lubrication may play a role. The tribological interaction of the various tribo-pairs and SAPL is extremely favourable in the context of reducing friction at the bearing interface. PyC is highly recommended as a future candidate material for use in load bearing prosthetic joints considering its impressive tribological performance.

Abstract Treatment-related late effects have increasingly become important, since the majority of children, adolescents and young adults with cancer become long-term survivors. Osteonecrosis (ON) is recognized as a potential debilitating sequel in patients with cancer. The aims of this work were to define the incidence of and clinical risk factors for ON identified with end-of-therapy magnetic resonance imaging (MRI) screening among patients with childhood cancer and to investigate the incidence of and risk factors for ON requiring total joint arthroplasty (TJA) in patients treated for cancer in childhood, adolescence or young adulthood in a register-based study. MRI of the lower extremities revealed ON in 23 (24%) of the 97 patients with acute lymphoblastic leukemia (ALL) at the end of treatment. High body mass index, female gender, older age at diagnosis, and higher cumulative dexamethasone dose were independent risk factors for ON. Six of the 32 patients (19%) treated for lymphoma or solid tumor had ON in MRI scans at the end of the treatment. All of these patients with ON had non-Hodgkin lymphoma or Hodgkin lymphoma. In a register-based study, patients diagnosed with cancer before 31 years of age were identified from the Finnish and Danish Cancer registries. These data were combined with data from the National Hospital Discharge and the Finnish Arthroplasty registers. The cohort consisted of 6,358 patients diagnosed with hematologic malignancy and 18,542 patients diagnosed with solid tumor from 1975 to 2000 in Finland and from 1975 to 2006 in Denmark. The estimated cumulative incidence of TJA was 4.5% at 20 years for patients treated for chronic myeloid leukemia, followed by 2.1% for patients treated for acute myeloid leukemia and 0.4% for patients treated for ALL. Allogeneic stem cell transplantation increased the risk of TJA. In conclusion, ON as determined with MRI is a common complication in children after treatment for ALL. High BMI was identified as a new significant risk factor for ON in patients with pediatric ALL. The incidence of ON requiring TJA was highest among children, adolescents and young adults treated for myeloid leukemias. / Tiivistelmä Syöpähoitojen aiheuttamien myöhäisvaikutusten merkitys on viime vuosina kasvanut, koska suuri osa lapsena tai nuorena aikuisena syöpään sairastuneista paranee. Syöpähoitojen seurauksena voi syntyä luukuolioita, jotka heikentävät merkittävästi elämänlaatua ja liikuntakykyä. Tämän väitöskirjatyön tarkoituksena oli selvittää magneettitutkimuksella luukuolioiden ilmaantuvuus ja riskitekijät syöpähoitojen lopetusvaiheessa lapsuusiän syövän sairastaneilla sekä selvittää rekisteritutkimuksella tekonivelleikkausta vaativan luukuolion ilmaantuvuus ja riskitekijät lapsena tai nuorena aikuisena hoidetuilla syöpäpotilailla. Akuutin lymfaattisen leukemian (ALL) sairastaneista 23/97:lla (24 %) todettiin alaraajojen magneettitutkimuksessa luukuolioita. Korkea painoindeksi, naissukupuoli, vanhempi ikä diagnoosihetkellä ja suurempi kumulatiivinen deksametasoniannos lisäsivät luukuolion todennäköisyyttä. Lymfooman tai kiinteän kasvaimen sairastaneista 6/32:lla (19 %) todettiin luukuolioita. Tutkimme tekonivelleikkausta vaativan luukuolion ilmaantuvuutta Suomen ja Tanskan väestöpohjaisten rekistereiden avulla. Tutkimuskohorttimme muodostui 6 358 leukemiaan ja lymfooman sekä 18 542 kiinteään kasvaimeen Suomessa ja Tanskassa alle 31-vuotiaana sairastuneesta potilaasta. Tekonivelleikkausta vaativan luukuolion kumulatiivinen ilmaantuvuus 20 vuoden seurannan aikana oli kroonisen myelooisen leukemian sairastaneilla 4,5 %, akuutin myelooisen leukemian sairastaneilla 2,1 % ja ALL:n sairastaneilla 0,4 %. Allogeeninen kantasolujen siirto lisäsi luukuolioiden todennäköisyyttä. Tässä väitöskirjatyössä osoitettiin, että ALL:n sairastaneilla lapsilla magneettitutkimuksella todetut luukuoliot ovat yleinen haittavaikutus. Korkea painoindeksi on luukuolioiden uusi merkittävä riskitekijä. Tutkimus antoi myös uutta tietoa tekonivelleikkausta vaativan luukuolion ilmaantuvuudesta ja riskitekijöistä lapsuusiällä tai nuorella aikuisiällä syövän sairastaneilla.

This thesis deals with stress analysis strain proximal end of tibia with total joint replacements. The analysis is done on the basis of deformation characteristics of voltage, through the finite element method (FEM). We have developed two-dimensional models of the proximal end of tibia with tibial components total endoprosthesis (TEP), without loss and bone loss. Geometry model is created based on data obtained from computerized tomography, which were further processed in the program, Rhinoceros 3.0 and SolidWorks 2009th Computational solution was carried out by finite element method in Ansys Workbench 12.0. The model without loss of bone tissue was tested the hypothesis that the deformation is very small and there is no violation of the shank prosthesis. Due to loss of bone tissue is lost support to the tibial pulse in the proximal tibia and by a progressive increase in stress, which can lead to a breach of the shank total joint replacement. The analysis results show that, if the loss of bone tissue, so that the tibial part of the TEP will lose support, there is a crack stem total hip replacement due to stress.