• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 77
  • 25
  • 13
  • 7
  • 6
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • Tagged with
  • 159
  • 14
  • 12
  • 12
  • 11
  • 10
  • 9
  • 9
  • 9
  • 8
  • 8
  • 8
  • 7
  • 7
  • 7
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Dream and reality in Oliver Twist.

Benoit, Marie Antonia. January 1970 (has links)
No description available.
22

Dream and reality in Oliver Twist.

Benoit, Marie Antonia. January 1970 (has links)
No description available.
23

Avaliação da expressão das proteínas Twist, Caderina-E, e p-Akt nos eventos que regem a progressão do carcinoma epidermóide oral / Analysis of Twist, E-cadherin and p-Akt expression in oral squamous cell carcinomaprogression

Silva, Brunno Santos de Freitas 05 August 2011 (has links)
A carcinogênese oral é um processo multifásico, onde componentes genéticos levam a desregulação de vias de sinalização celular que controlam funções celulares básicas, como divisão, diferenciação e morte celular. Uma das maneiras de compreender a natureza biológica dos cânceres, além do curso clínico, é através do entendimento do processo de progressão e metástase destas neoplasias. Este estudo teve como objetivo avaliar a participação da proteína Twist no desenvolvimento e progressão dos carcinomas epidermóides orais. Com tal proposta, também foi avaliada a participação das proteínas caderina-E e p-Akt, e sua possível interação com Twist no processo de carcinogênese oral. O trabalho em questão analisou a expressão imuno-histoquímica destas proteínas em 30 espécimes de displasia oral, 20 de carcinoma epidermóide oral e 10 de mucosa oral normal, e avaliou também a possível inter-relação dessas proteínas em linhagens derivadas de carcinoma epidermóide de cabeça e pescoço por meio dos ensaios de Western Blotting e imunofluorescência. Os resultados deste estudo demonstraram uma relação inversamente proporcional entre Twist e caderina-E desde os estágios mais precoces da carcinogênese oral. Tal afirmação baseou-se na presença de diferenças significantes entre a expressão imuno-histoquímica de Twist e Caderina-E na amostras de epitélio oral, epitélio displásico e nos espécimes de carcinoma epidermóide oral. Adicionalmente, foi observada a relação inversa entre Twist e a Caderina-E nas linhagens de carcinoma epidermóide de cabeça e pescoço, sendo este evento constatado pelo decréscimo nos níveis protéicos da Caderina-E frente a uma elevação de Twist. Estes resultados sugerem um importante papel de Twist na progressão do carcinoma epidermóide oral, e juntamente com a Caderina-E, pode representar um relevante marcador biológico do câncer oral. / The oral carcinogenesis is a multi-stage process, where genetic components leads to deregulation of cell signaling pathways that control basic cellular functions such as division, differentiation and cell death. One way to understand the biological nature of cancers, besides the clinical course, is through understanding the process of progression and metastasis of these neoplasms. This study aimed to evaluate the role of Twist protein in the development and progression of oral squamous cell carcinomas. With this proposal, was also evaluated the involvement of E-cadherin and p-Akt proteins, and its possible interaction with Twist in the process of oral carcinogenesis. The work in question examined the immunohistochemical expression of these proteins in 30 specimens of oral dysplasia, 20 oral squamous cell carcinoma and 10 normal oral mucosa, and also evaluated the possible interrelationship of these proteins in lines derived from squamous cell carcinoma of head and neck by means of Western blotting assays and immunofluorescence. The results of this study showed an inverse relationship between Twist and E-cadherin since the earliest stages of oral carcinogenesis. These results were based on the presence of significant differences between the immunohistochemical expression of Twist and ECadherin in samples of oral epithelium, dysplastic epithelium and in specimens of oral squamous cell carcinoma. In addition, we observed the inverse relationship between Twist and E-Cadherin in the lines of squamous cell carcinoma of head and neck; this event was evidenced by the decrease in protein levels of E-Cadherin forward to a high of Twist. These results suggest an important role of Twist in the progression of oral squamous cell carcinoma, and along with E-cadherin may represent a relevant biomarker of oral cancer.
24

Transporte e simetria em sistemas Hamiltonianos não twist

Mugnaine, Michele 21 February 2019 (has links)
Submitted by Angela Maria de Oliveira (amolivei@uepg.br) on 2019-03-15T17:47:02Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Michele_Mugnaine.pdf: 11968218 bytes, checksum: 5ba2af6a329e543934e520e416683d5c (MD5) / Made available in DSpace on 2019-03-15T17:47:02Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) Michele_Mugnaine.pdf: 11968218 bytes, checksum: 5ba2af6a329e543934e520e416683d5c (MD5) Previous issue date: 2019-02-21 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / O mapa padrão não twist é um exemplo simples e geral de sistemas Hamiltonianos que violam a condição twist. Sua aplicação abrange fenômenos associados a plasmas, dinâmica celeste, guias de onda, aceleradores de partículas, entre outros. A presença de cadeias gêmeas e da curva shearless, neste mapa, tem uma grande influência sobre as barreiras presentes no espaço de fase e sobre o transporte observado através dele. Neste trabalho, fornecemos uma conexão entre os mecanismos de turnstiles e o cenário de intersecção entre variedades das cadeias gêmeas com o transporte no espaço de fase, uma situação ainda não completamente entendida em sistemas Hamiltonianos não twist. O alto transporte está relacionado com o cenário de intercrossing, com a proximidade dos pontos homoclínicos e heteroclínicos das duas cadeias e com os turnstiles agindo como um mecanismo de transporte, como uma passagem da trajetória de uma região a outra no espaço de fase. Já o transporte baixo é representado pelo cenário oposto, temos um cenário de intracrossing com uma distância maior entre os pontos de interseção e os turnstiles agindo como mecanismo de barreira de trajetórias. O mapa não twist é um mapa simétrico, sendo assim, não há uma direção preferencial para o transporte. Entretanto, a adição de uma nova perturbação na forma c sen(2πmx) é capaz de quebrar a simetria, para m par, e assim o transporte direcionado é um fenômeno possível. O mapa com esta nova perturbação é denominado mapa padrão não twist estendido e ele apresenta fenômenos interessantes como a quebra de simetria, transporte direcionado e a recuperação do cenário monotônico, cenário não observado no mapa não twist original. / The standard nontwist map is a simple and general example of Hamiltonian systems that does not satisfy the twist condition. The map applications cover phenomenons related to plasmas, celestial mechanics, wave guides, particle accelerators and other examples. The presence of twin islands chains and the shearless curve has a big influence over barriers in the phase space and, consequently, over the transport through the space. In this work, we provide a connection between turnstiles, the manifolds intersection scenario and the transport in the phase space. This connection is still not completely understood in non twist Hamiltonian systems. The high transport is associated to the intercrossing scenario and how the homoclinic and heteroclinic points from different islands chains are close to each other and how the turnstiles act like a transport mechanism. The turnstile is the gate or the barrier to the trajectories from one region of the phase space to another. The low transport is represented by the opposite scenario, the intracrossing scenario has a larger distance between the intersection points. In this case, the turnstiles act as a trapping mechanism. The standard nontwist map is a symmetric map, i.e, there is not a preferential direction for the trajectories to follow. However, the addition of a new perturbation with a shape as csin(2πmx) is able to break the symmetry, if m is even, and the directed transport is a possible phenomenon to exist in the phase space. The map with the new perturbation is called extended standard nontwist map and it features interested phenomenon as the symmetry breaking, directed transport and the recovery of the monotonic scenario, which is not present in the original nontwist map.
25

Avaliação da expressão das proteínas Twist, Caderina-E, e p-Akt nos eventos que regem a progressão do carcinoma epidermóide oral / Analysis of Twist, E-cadherin and p-Akt expression in oral squamous cell carcinomaprogression

Brunno Santos de Freitas Silva 05 August 2011 (has links)
A carcinogênese oral é um processo multifásico, onde componentes genéticos levam a desregulação de vias de sinalização celular que controlam funções celulares básicas, como divisão, diferenciação e morte celular. Uma das maneiras de compreender a natureza biológica dos cânceres, além do curso clínico, é através do entendimento do processo de progressão e metástase destas neoplasias. Este estudo teve como objetivo avaliar a participação da proteína Twist no desenvolvimento e progressão dos carcinomas epidermóides orais. Com tal proposta, também foi avaliada a participação das proteínas caderina-E e p-Akt, e sua possível interação com Twist no processo de carcinogênese oral. O trabalho em questão analisou a expressão imuno-histoquímica destas proteínas em 30 espécimes de displasia oral, 20 de carcinoma epidermóide oral e 10 de mucosa oral normal, e avaliou também a possível inter-relação dessas proteínas em linhagens derivadas de carcinoma epidermóide de cabeça e pescoço por meio dos ensaios de Western Blotting e imunofluorescência. Os resultados deste estudo demonstraram uma relação inversamente proporcional entre Twist e caderina-E desde os estágios mais precoces da carcinogênese oral. Tal afirmação baseou-se na presença de diferenças significantes entre a expressão imuno-histoquímica de Twist e Caderina-E na amostras de epitélio oral, epitélio displásico e nos espécimes de carcinoma epidermóide oral. Adicionalmente, foi observada a relação inversa entre Twist e a Caderina-E nas linhagens de carcinoma epidermóide de cabeça e pescoço, sendo este evento constatado pelo decréscimo nos níveis protéicos da Caderina-E frente a uma elevação de Twist. Estes resultados sugerem um importante papel de Twist na progressão do carcinoma epidermóide oral, e juntamente com a Caderina-E, pode representar um relevante marcador biológico do câncer oral. / The oral carcinogenesis is a multi-stage process, where genetic components leads to deregulation of cell signaling pathways that control basic cellular functions such as division, differentiation and cell death. One way to understand the biological nature of cancers, besides the clinical course, is through understanding the process of progression and metastasis of these neoplasms. This study aimed to evaluate the role of Twist protein in the development and progression of oral squamous cell carcinomas. With this proposal, was also evaluated the involvement of E-cadherin and p-Akt proteins, and its possible interaction with Twist in the process of oral carcinogenesis. The work in question examined the immunohistochemical expression of these proteins in 30 specimens of oral dysplasia, 20 oral squamous cell carcinoma and 10 normal oral mucosa, and also evaluated the possible interrelationship of these proteins in lines derived from squamous cell carcinoma of head and neck by means of Western blotting assays and immunofluorescence. The results of this study showed an inverse relationship between Twist and E-cadherin since the earliest stages of oral carcinogenesis. These results were based on the presence of significant differences between the immunohistochemical expression of Twist and ECadherin in samples of oral epithelium, dysplastic epithelium and in specimens of oral squamous cell carcinoma. In addition, we observed the inverse relationship between Twist and E-Cadherin in the lines of squamous cell carcinoma of head and neck; this event was evidenced by the decrease in protein levels of E-Cadherin forward to a high of Twist. These results suggest an important role of Twist in the progression of oral squamous cell carcinoma, and along with E-cadherin may represent a relevant biomarker of oral cancer.
26

Existência e destruição de toros invariantes, para uma certa família de sistemas Hamiltonianos no R4 / Existence and destruction of invariant torus, for a certain family of Hamiltonian systems in R4

Andrade, Julio Cezar de Oliveira 07 June 2019 (has links)
Estudaremos uma fam lia de sistemas hamiltonianos no R 4 , H : R 4 R, satisfazendo certas condi c oes, dependendo de um parametro . Iremos ca- racterizar algumas condi c oes sobre n veis de energia desse sistema, que nos permitem concluir existencia e destrui c ao de toros invariantes, em tais n veis de energia. Al em disso, podemos concluir que o fluxo hamiltoniano, restrito a esses n veis de energia, possui entropia topol ogica positiva. / We will study a family of Hamiltonian Systems in R 4 , satisfying certain conditions, H : R 4 R, depending of a parameter . We will characterize some conditions about the energy levels of this system, which allow us to conclude existence and destruction of invariant torus, at such energy levels. Moreover, we can conclude that the hamiltonian flow, restricted to these energy level, has positive topological entropy.
27

Hygrothermally stable laminated composites with optimal coupling

Haynes, Robert Andrew 25 June 2010 (has links)
This work begins by establishing the necessary and sufficient conditions for hygrothermal stability of composite laminates. An investigation is performed into the range of coupling achievable from within all hygrothermally stable families. The minimum number of plies required to create an asymmetric hygrothermally stable stacking sequence is found to be five. Next, a rigorous and general approach for determining designs corresponding to optimal levels of coupling is established through the use of a constrained optimization procedure. Couplings investigated include extension-twist, bend-twist, extension-bend, shear-twist, and anticlastic. For extension-twist and bend-twist coupling, specimens from five- through ten-ply laminates are manufactured and tested to demonstrate hygrothermal stability and achievable levels of coupling. Nonlinear models and finite element analysis are developed, and predictions are verified through comparison with test results. Sensitivity analyses are performed to demonstrate the robustness of the hygrothermal stability and couplings to deviations in ply angle, typical of manufacturing tolerances. Comparisons are made with current state-of-the-art suboptimal layups, and significant increases in coupling over previously known levels are demonstrated.
28

MACHADO DE ASSIS E A (RE)ESCRITA DE OLIVER TWIST / MACHADO DE ASSIS AND THE (RE)WRITING OF OLIVER TWIST

Camelo, Franciano 05 March 2013 (has links)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / In early 1870, Machado de Assis translated part of Oliver Twist, a novel by Charles Dickens (LÍSIAS, 2002). Although unfinished, since the Brazilian writer stopped his contribution at chapter twenty-eight, this translation presents particularities, which are worth being analysed. It is especially noticeable the French mediation in the translation of the Dickensian novel into Portuguese as well as the manipulation of the narrative, which remodelled the novel (MASSA, 1965). Recent studies approached the issue to a limited extent, mainly for not regarding the implications of both major and minor adjustments promoted by Machado. Hence, this study has a two-fold purpose: a) to investigate the route of Oliver Twist to Brazil, through the analysis of the relation between the English editions of this novel, the French translation made by Alfred Gérardin and the Brazilian translation by Machado de Assis; b) to analyse in detail the procedures adopted by the Brazilian writer while translating Dickens novel and discuss their implications for the narrative structure. The (re)writing of Oliver Twist seems to have encompassed, so as to say, a process of selection of repertoire and formal reorganisation of the narrative, which appears to respond to the specificity of nineteenth-century Brazilian context of reception. / No início de 1870, Machado de Assis traduziu parte do romance Oliver Twist, de Charles Dickens (LÍSIAS, 2002). Mesmo inconclusa, dado que o escritor brasileiro encerrou sua contribuição no capítulo vinte e oito, essa tradução apresenta particularidades de grande interesse analítico. É especialmente notável a mediação francesa no processo tradutório do romance dickensiano para o português, bem como a manipulação da narrativa, que remodelou o romance (MASSA, 1965). Estudos recentes abordaram a questão de modo limitado, principalmente por não considerarem as implicações dos ajustes, sejam eles grandes ou pequenos, promovidos por Machado. Em vista disso, este estudo tem o duplo objetivo de: a) investigar o percurso de Oliver Twist até o Brasil, analisando a relação entre as edições inglesas desse romance, a tradução francesa de Alfred Gérardin e a brasileira de Machado de Assis; b) analisar em detalhe os procedimentos adotados pelo escritor brasileiro ao traduzir o romance de Dickens, bem como discutir suas implicações na estrutura narrativa. A (re)escrita de Oliver Twist teria implicado, por assim dizer, um processo de seleção de repertório e reorganização formal da narrativa, que responderia à especificidade do contexto de recepção do Brasil oitocentista.
29

Twist proteins as oxidative and hypoxic stress regulators / Etude des facteurs oncogéniques Twist dans la régulation du stress oxydatif et hypoxique

Kolodziejski, Jakub 11 January 2016 (has links)
Les facteurs de transcription Twist1 et Twist2 (famille Twist) jouent un rôle majeur dans le développement embryonnaire et dans la progression tumorale. Leur potentiel oncogénique dérive directement de la combinaison de leurs nombreuses activités développementales. Les gènes Twist peuvent notamment, en induisant la transition épithélio-mésenchymateuse (EMT), promouvoir l’invasion des cellules cancéreuses et participer de ce fait aux processus métastatique. De plus, en bloquant l’activité des voies de signalisation Rb et p53, ils peuvent inhiber les deux principaux programmes de sauvegarde cellulaire que sont l’apoptose et la senescence. Enfin, ils sont également impliqués dans la résistance des cellules cancéreuses aux agents chimio-thérapeutiques. En plus de ces nombreuses activités, nos données préliminaires nous ont amené à considérer un rôle de Twist dans la réponse au stress. Les cellules cancéreuses doivent croitre dans un environnement en perpétuel changement qui génère de nombreux types de stress. Seules les cellules capables de s’adapter, peuvent survivre et acquérir de nouvelles capacités les rendant plus agressives. La résistance au stress fait donc partie intégrante de la progression tumorale. Nos travaux révèlent que Twist en induisant une résistance au stress, plus particulièrement métabolique, est un acteur essentiel de l’acquisition d’u phénotype agressif des cellules cancéreuses. Dans une première étude, nous avons montré que Twist module le stress oxydatif, une condition très fréquemment retrouvée dans les tumeurs. Ainsi, nos résultats indiquent que l’expression de Twist provoque une réduction du taux d’espèces réactives de l’oxygène (ROS) intracellulaire. Cette activité a pour conséquence directe d’induire une résistance accrue à l’apoptose déclenchée par divers traitements. Nous avons par la suite caractérisé cette activité et mis en évidence un programme génétique contrôlé par Twist impliquant divers facteurs possédant des propriétés anti-oxydantes. Dans un second temps, nous nous sommes intéressés à un autre type de stress métabolique, l’hypoxie. L’hypoxie définie par un taux insuffisant d’oxygène, est retrouvée dans la plupart des tumeurs solides du fait de l’absence ou de l’anomalité de la vascularisation. L’hypoxie mène à la stabilisation d’un facteur de transcription, HIF1α. Cette protéine est essentielle à l’adaptation hypoxique et contrôle l’expression de nombreux gènes impliqués dans le métabolisme du glucose, le transport de l’oxygène, l’angiogenèse ou l’apoptose. Dans les premiers temps d’hypoxie, l’effet d’adaptation induit par HIF1α est bénéfique pour les cellules. Cependant, si l’absence d’oxygène se prolonge, HIF1α, peut pousser les cellules vers la mort. Nos travaux démontrent que Twist est capable de rendre les cellules résistantes à une hypoxie prolongée. De plus, cette activité de protection contre le stress hypoxique agit via un effet paracrine. Enfin, nos données suggèrent que cet effet est médié par une interaction directe entre les protéines Twist et HIF1α. Au final, cette étude indique que l’expression de Twist dans les cellules cancéreuses, en conférant une résistance accrue à l’environnement hypoxique, joue un rôle essentiel dans l’adaptation au stress et à l’acquisition de nouveaux phénotypes agressifs. En résumé, L’objectif principal de ma thèse était de mettre en évidence de nouvelles propriétés cellulaires des oncogènes de la famille Twist. Nos résultats démontrent que Twist par ses capacités à contrôler le stress métabolique, permet à la cellule cancéreuse de mieux s’adapter et donc survivre dans un environnement en constante évolution. Nos travaux renforcent donc la notion de l’importance de ces facteurs dans la progression tumorale. / Twist1 and Twist2 are related transcription factors that play major roles both during embryonic development and in several pathologies, including cancer. Twists' oncogenic potential arises from a combination of their multiple functions in development. Notably, both Twist induce epithelial-to mesenchymal transition, thus promoting tumour invasiveness and possibly conferring to cells self-renewal properties. Furthermore, through disruption of both Rb- and p53-driven pathways, Twist override two major oncogene-induced fail-safe programs, namely senescence and apoptosis, thereby promoting malignant conversion. Twist has also been reported to participate in acquisition of drug resistance and in promotion of neo-angiogenesis.Current knowledge of pleiotropic activities of Twist prompted us to postulate that these factors may be major regulators of stress response. Cancer cells survive and grow within a continuously changing environment that creates multiple stresses to which they must adapt in order to survive and strive. Such adaptations often give rise to the acquisition of an aggressive phenotype. Consistent with this hypothesis, we recently unveiled new activities of Twist proteins that are related to stress response. We have shown that Twist regulates response to oxidative stress, a condition exacerbated in cancer by stimuli such as inflammation, increased cellular metabolism and changes in tumour oxygenation. Our work has contributed to the understanding of molecular mechanisms through which Twist diminishes cellular ROS and thus participates in the escape from apoptosis and senescence. In the first part of my thesis, I worked on the antioxidant activity of Twist and described its molecular mechanisms.The second part of my work addressed the impact of Twist proteins on cellular response to hypoxia that is insufficient oxygen supply, frequently found in solid tumours. Cellular response to hypoxic stress relies on stabilization and activation of HIF1α, a key transcriptional mediator of the hypoxic response, regulating numerous genes involved in glucose metabolism, oxygen transport, angiogenesis, cell growth and apoptosis. HIF1α is beneficial for cancer cells in response to short hypoxic episodes, however its sustained activation in case of prolonged hypoxia may push cancer cells towards apoptosis. In this context, we have shown that Twist protects cancer cells from hypoxia-induced apoptosis. We have discovered HIF1α and Twist physically interact, suggesting a possible mechanistic basis for Twist's protective effect. These results led us to postulate that Twist plays a role in cellular response to hypoxia and thus participates in cancer cell adaptation and acquisition of aggressive phenotypes triggered by lack of oxygen.Our results reinforce the notion that Twist factors are major cellular stress modulators that might be important for adaptation of cancer cells to changing conditions in the process of tumour progression.
30

Evaluation of Image Quality of Pituitary Dynamic Contrast-Enhanced MRI Using Time-Resolved Angiography With Interleaved Stochastic Trajectories (TWIST) and Iterative Reconstruction TWIST (IT-TWIST) / TWIST法と繰り返し再構成併用TWIST法を用いた下垂体ダイナミック造影MRIの画質評価

Yokota, Yusuke 23 September 2020 (has links)
京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第22743号 / 医博第4661号 / 新制||医||1046(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 花川 隆, 教授 渡邉 大, 教授 黒田 知宏 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Page generated in 0.4231 seconds