La complexification des systèmes et la réduction du nombre de capteurs nécessitent l’élaboration de méthodes de surveillance de plus en plus efficaces. Le travail de cette thèse s’inscrit dans ce contexte et porte sur le diagnostic et le pronostic des Systèmes à Événements Discrets (SED) temporisés. Les réseaux de Petri stochastiques partiellement mesurés sont utilisés pour modéliser le système. Le modèle représente à la fois le comportement nominal et le comportement dysfonctionnel du système. Il permet aussi de représenter ses capteurs à travers une mesure partielle des transitions et des places. Notre contribution porte sur l’exploitation de l’information temporelle pour le diagnostic et le pronostic des SED. À partir d’une suite de mesures datées, les comportements du système qui expliqueraient ces mesures sont d’abord déterminés. La probabilité de ces comportements est ensuite évaluée pour fournir un diagnostic du système en termes de probabilité d’occurrence d’un défaut. Dans le cas où une faute est diagnostiquée, une approche permettant d’estimer la distribution de sa date d’occurrence est proposée. L’objectif est de donner plus de détails sur cette faute afin de mieux la caractériser. Par ailleurs, la probabilité des comportements compatibles est exploitée pour estimer l’état actuel du système. Il s’agit de déterminer les marquages compatibles avec les mesures ainsi que leurs probabilités associées. À partir de cette estimation d’état, la prise en considération des évolutions possibles du système permet d’envisager la prédiction de la faute avant son occurrence. Une estimation de la probabilité d’occurrence de la faute sur un horizon de temps futur est ainsi obtenue. Celle-ci est ensuite étendue à l’évaluation de la durée de vie résiduelle du système. Enfin, une application des différentes approches développées sur un cas d’un système de tri est proposée. / Due to the increasing complexity of systems and to the limitation of sensors number, developing monitoring methods is a main issue. This PhD thesis deals with the fault diagnosis and prognosis of timed Discrete Event Systems (DES). For that purpose, partially observed stochastic Petri nets are used to model the system. The model represents both the nominal and faulty behaviors of the system and characterizes the uncertainty on the occurrence of events as random variables with exponential distributions. It also considers partial measurements of both markings and events to represent the sensors of the system. Our main contribution is to exploit the timed information, namely the dates of the measurements for the fault diagnosis and prognosis of DES. From the proposed model and collected measurements, the behaviors of the system that are consistent with those measurements are obtained. Based on the event dates, our approach consists in evaluating the probabilities of the consistent behaviors. The probability of faults occurrences is obtained as a consequence. When a fault is detected, a method to estimate its occurrence date is proposed. From the probability of the consistent trajectories, a state estimation is deduced. The future possible behaviors of the system, from the current state, are considered in order to achieve fault prediction. This prognosis result is extended to estimate the remaining useful life as a time interval. Finally, a case study representing a sorting system is proposed to show the applicability of the developed methods.

My dissertation critiques Western culture’s vertical command of “growing up” to adult completion (rational, heterosexual, married, wealthy, professionally successful) as a reductionist itinerary of human movement leading to subjective sedimentations. Rather, my project proposes ways of “moving rhizomatically” by which it advances a notion of a machinic identity that moves continuously, contingently, and waywardly along less vertical, less excruciating and more horizontal, life-affirmative trails. To this end, my thesis proposes a “rhizomatic semiosis” as extrapolated from the philosophy of Gilles Deleuze and Félix Guattari to put forward a notion of language and, by implication, subjectivity, as dynamic and metamorphic. Rather than trying to figure out who the child is or what it experiences consciously, my project wishes to embrace an elusiveness at the heart of subjectivity to argue for continued identity creation beyond the apparently confining parameters of adulthood. This dissertation, then, is about the need to re-examine our ways of growing beyond the lines of teleological progression. By turning to Deleuze’s child, an intangible one that “makes desperate attempts to carry out a performance that the psychoanalyst totally misconstrues” (A Thousand Plateaus 13), I wish to shift focus away from the hierarchical, binary, and ideal model of “growing up” and toward a notion of movement that makes way for plural identities in their becoming. This endeavour reveals itself in particular in the work of John Wray, Todd Field, Peter Cameron, Sara Prichard, Michael Cunningham, and Cormac McCarthy, whose work has received little or no attention at all—a lacuna in research that exists perhaps due to these artists’ innovative approach to a minor literature that promotes the notion of a machinic self and questions the dominant modes of Western culture’s literature for, around, and of children.

La construction de modèles de pronostic nécessite la compréhension du processus de dégradation des composants critiques surveillés afin d’estimer correctement leurs durées de fonctionnement avant défaillance. Un processus de d´dégradation peut être modélisé en utilisant des modèles de Connaissance issus des lois de la physique. Cependant, cette approche n´nécessite des compétences Pluridisciplinaires et des moyens expérimentaux importants pour la validation des modèles générés, ce qui n’est pas toujours facile à mettre en place en pratique. Une des alternatives consiste à apprendre le modèle de dégradation à partir de données issues de capteurs installés sur le système. On parle alors d’approche guidée par des données. Dans cette thèse, nous proposons une approche de pronostic guidée par des données. Elle vise à estimer à tout instant l’état de santé du composant physique et prédire sa durée de fonctionnement avant défaillance. Cette approche repose sur deux phases, une phase hors ligne et une phase en ligne. Dans la phase hors ligne, on cherche à sélectionner, parmi l’ensemble des signaux fournis par les capteurs, ceux qui contiennent le plus d’information sur la dégradation. Cela est réalisé en utilisant un algorithme de sélection non supervisé développé dans la thèse. Ensuite, les signaux sélectionnés sont utilisés pour construire différents indicateurs de santé représentant les différents historiques de données (un historique par composant). Dans la phase en ligne, l’approche développée permet d’estimer l’état de santé du composant test en faisant appel au filtre Bayésien discret. Elle permet également de calculer la durée de fonctionnement avant défaillance du composant en utilisant le classifieur k-plus proches voisins (k-NN) et le processus de Gauss pour la régression. La durée de fonctionnement avant défaillance est alors obtenue en comparant l’indicateur de santé courant aux indicateurs de santé appris hors ligne. L’approche développée à été vérifiée sur des données expérimentales issues de la plateforme PRO-NOSTIA sur les roulements ainsi que sur des données fournies par le Prognostic Center of Excellence de la NASA sur les batteries et les turboréacteurs. / Constructing prognostics models rely upon understanding the degradation process of the monitoredcritical components to correctly estimate the remaining useful life (RUL). Traditionally, a degradationprocess is represented in the form of physical or experts models. Such models require extensiveexperimentation and verification that are not always feasible in practice. Another approach that buildsup knowledge about the system degradation over time from component sensor data is known as datadriven. Data driven models require that sufficient historical data have been collected.In this work, a two phases data driven method for RUL prediction is presented. In the offline phase, theproposed method builds on finding variables that contain information about the degradation behaviorusing unsupervised variable selection method. Different health indicators (HI) are constructed fromthe selected variables, which represent the degradation as a function of time, and saved in the offlinedatabase as reference models. In the online phase, the method estimates the degradation state usingdiscrete Bayesian filter. The method finally finds the most similar offline health indicator, to the onlineone, using k-nearest neighbors (k-NN) classifier and Gaussian process regression (GPR) to use it asa RUL estimator. The method is verified using PRONOSTIA bearing as well as battery and turbofanengine degradation data acquired from NASA data repository. The results show the effectiveness ofthe method in predicting the RUL.

In my diploma thesis called Everyday Politics I deal with the insufficiently solved topic of economic relations and structural inequalities of actors in contemporary art. I focus on the issue of economic situation of art students and their position within the university of technical direction with high demands on results and future use of measurable prestige and lucrative work position.

MSc (Microbiology) / Department of Microbiology / BACKGROUND: Medicinal plants form an important part of the Southern African cultural heritage. Indigenous populations, for example the Vha-Venda people, tend to use medicinal plants in formulations rather than western medicines for health and survival. In order to certify and give scientific credibility to the use of medicinal plants formulations used by Vha-Venda people for the treatment of diseases, several assays were carried out. The present study was aimed at assessing phytochemical content, antimicrobial, antioxidant and cytotoxic activities of four indigenous Venda medicinal plants in a formulation and compare their activity with each plant used individually. METHODS: Peltophorum africanum (roots), Pterocarpus angolensis (bark), Terminalia sericea (roots) and Ximenia caffra (roots) were collected from the Thohoyandou area. The collected plant parts were extracted with methanol and water respectively. Individual plant extracts and Five designed formulations were tested for their antimicrobial activity against Staphylococcus aureus ATCC 25923 (Methicillin Resistant), Staphylococcus aureus ATCC 33591(Methicillin Susceptible), beta lactamase producing Klebsiella pneumonia (ATCC 700603) and extended spectrum beta lactamase producing E. coli (ATCC 35218), four clinical isolates of Candida spp and Cryptococcus neoformans using the Broth dilution method. Minimum bactericidal concentration (MBC) of the extracts was determined by culturing the contents of minimum inhibitory concentration (MIC) on nutrient agar. Similarly, minimum fungicidal concentration (MFC) was also determined by culturing contents of MIC in sabouraud dextrose agar (SDA). Extracts were further assessed for their total phenolic content, total flavonoid content and Qualitative phytochemical analysis. The antioxidant ability of the plants extracts and formulations to scavenge free radical DPPH was also determined. The plant formulations were assessed for their anti-HIV activity using the reverse transcriptase colorimetric assay kit. Cytotoxicity against human lymphatic endothelial cells (HLEC) was determined using MTT assay. RESULTS: Methanolic and aqueous extracts of T. sericea exhibited the best antifungal and antibacterial activities whilst P. angolensis and X. caffra showed poor activities. Methanolic plant formulations showed good activities compared to aqueous formulations. However, Fractional Inhibition Concentration Index showed that there was 1 synergistic interaction, 25 additive interactions and 14 antagonistic interactions between the plant extracts. The methanolic formulation 3 showed the best overall phenolic content at 11.85±0.109 mgGAE/g whilst aqueous X. caffra extract showed the least content at 4.546±0.104 mgGAE/g. Higher total flavonoid contents were seen in methanolic formulation 4 at 2.75±0.02 mgQE/g. Qualitative phytochemical analysis revealed the presence of flavonoids, phenolics, terpenoids, tannins, saponins and steroids in 80% of the tested plant extracts and formulations. All plant extracts and formulations exhibited good antioxidant activity against DPPH. The methanolic formulation showed the best antioxidant activity with IC50 of 0.094 ± 0.33μg/ml. For anti- HIV inhibition, all formulations at 200μg/ml exhibited higher percentage of HIV-1 reverse transcriptase inhibition with methanolic mixture 3 being the best overall at 97.5% activity whilst aqueous mixture5 was the least active with 63.03% inhibition activity. Moreover, the best anti-HIV activity at 100μg/ml was exhibited by methanolic mixture 3 at 71% inhibition. Furthermore, aqueous X. caffra, mixture 2 inhibited 26% and 51% at 12.5mg/ml and 3.125mg/ml respectively. Peltophorum africanum and mixture 5 inhibited 34%, 54% and 43% at 3.125mg/ml, 6.25mg/ml and 12.5 mg/ml respectively of Human Lymphatic Endothelial cells growth. CONCLUSIONS: The results from the study indicated that most of the commonly used traditional medicinal Plants in the Venda region when mixed together have merit for use in traditional medical practice as they have shown good antimicrobial activities, good antioxidant xviii activities, good phytochemical activities and good cell proliferation activity. However some formulations showed antagonistic interaction against bacteria. Some Individual medicinal plants showed toxicity at higher concentrations against immune cells. Whereas formulations promoted cell proliferation, therefore, the use of such individual plants in the treatment of infections should be highly monitored as they may pose a health threat to normal immune cells. Generally, plants are potential pharmacological agents which needs to be preserved and harvested with care. / NRF

PhD (Chemistry) / Department of Chemistry / Terminalia sericea Burch. ex. DC (Combretaceae) is one of the 50 most popular medicinal plants in Africa. The fruit, leaves, stems and roots are commonly used for the treatment of cough, skin infections, diabetes, diarrhoea, venereal diseases and tuberculosis. However, the roots are most commonly used in the preparation of traditional medicines. Pharmacological studies have revealed that the crude root extracts display antibacterial activity against several Gram-positive and Gram-negative bacteria. Anolignan b, termilignan b and arjunic acid are reported to be the major antibacterial constituents present in the roots. Other compounds isolated from the roots include resveratrol-3-rutinoside, sericic acid, sericoside and arjunglucoside I. Authorities worldwide, including the Medicines Control Council of South Africa, have begun to regulate herbal drugs sold in the form of commercial formulations. Quality control of herbal drugs is challenging, since the chemical profiles of the raw materials may vary, depending on the origin of the plant material and the way that it was handled and processed. The chemistry, in turn, impacts on the safety and efficacy of the plant material. To date, there are no available data on parameters that can be used to standardise the quality of T. sericea raw materials. The aim of this study was therefore to provide information on the variation of the chemical constituents that contribute to the biological effects of the roots of T. sericea and also establish its safety. Since the compounds previously isolated from the roots were not commercially available, isolation of the major constituents of the roots was undertaken to obtain analytical standards. A crude dichloromethane:methanol (1:1) extract was initially fractionated using silica gel column chromatography, where after, some of the fractions were further purified using silica gel and Sephadex LH-20 column chromatography. Final purification of the enriched fractions was achieved using preparative high performance liquid chromatography coupled with mass spectrometry (prep-HPLC-MS). The structures of these compounds were subsequently elucidated using one- and two- dimensional nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry and identified as sericic acid (340 g), sericoside (500 g), resveratrol-3-rutinoside (240 mg) and arjunglucoside I (74 mg). The chemical variation within the crude root extracts of samples (n = 42) from ten populations in the Limpopo Province of South Africa, was determined using ultra performance liquid chromatography-mass spectrometry (UPLC-MS). A method was developed for the simultaneous determination of sericic acid, resveratrol-3-rutinoside, sericoside and arjungluicoside I in the extracts using UPLC with photodiode array detection (PDA). The method was validated according to the guidelines of the International Council for Harmonisation (ICH). A regression coefficient (R2) of 0.998 was obtained for sericic acid, resveratrol-3- rutinoside and arjunglucoside I, while the R2 value for sericoside was 0.999, indicating a linear relationship between the concentration and the detector response. Satisfactory limits of detection for sericic acid (25.2 ng/mL), sericoside (11.6 ng/mL), resveratrol-3-rutinoside (23.3 ng/mL) and arjunglucoside I (8.81 ng/mL) were determined. Recoveries of 98 % and 80% were obtained for samples spiked with 12.5 μg/mL and 25 μg/mL of resveratrol-3-rutinoside, respectively, indicating that the method is accurate. The intra- and inter-day variation in resveratrol-3-rutinoside concentration, measured over three days, indicated excellent analytical precision, since all the relative standard deviations were below 0.70 %. The quantitative data revealed that sericic acid (1.59 to 8.45 mg/g), sericoside (2.07 to 20.17 mg/g), resveratrol-3-rutinoside (0.65 to 29.82 mg/g) and arjunglucoside I (0.86 to 8.44 mg/g dry weight) were the major constituents of the root samples, but their concentrations were highly variable. Chemometric analysis of the aligned UPLC-MS data was used to investigate similarities and differences in the chemical profiles of the samples using an untargeted approach. A principal component analysis (PCA) model was constructed and subsequently hierarchical cluster analysis (HCA) indicated the presence of two main groups, which were found to be independent of the populations to which the samples belong. Classes, based on the HCA class identifiers, were subsequently assigned to the samples, and an orthogonal projection to latent structures-discriminant analysis (OPLS-DA) model was then constructed, (R2 cum = 0.996 and Q2 cum = 0.967). The corresponding loadings plot allowed sericic acid, sericoside and resveratrol-3-rutinoside to be identified as biomarkers associated with the first group. Quantitative, rather than qualitative differences were responsible for the observed clustering pattern. Techniques that could be applied in quality control protocols for T. sericea root were investigated. High performance thin layer chromatography (HPTLC) analysis of the root extracts was optimised by testing different developing solvents and visualization reagents. The presence of the sericic acid (Rf = 0.80), sericoside (Rf = 0.49) and resveratrol-3-rutinoside (Rf = 0.36) were clearly visible on the plates. There were visible variations in the concentrations of resveratrol-3-rutinoside in representative samples from the 10 populations, corresponding to the UPLC results. The powdered samples were then analysed by mid-(MIR) infrared spectroscopy. Chemometric analysis of the data revealed no definitive clustering pattern. Partial least squares-discriminant analysis (PLS-DA) calibration models were established from the MIR spectral data combined with the accurate UPLC-values, for the prediction of the sericoside (R2Y = 0.848, Q2 = 0.757, RMSEP = 2.70 mg/g) and resveratrol-3-rutinoside (R2Y = 0.794, Q2 = 0.695, RMSEP = 4.37 mg/g) concentrations in powdered root samples. The antibacterial activities of the root extracts, column fractions and isolated compounds were determined using three Gram-positive and five Gram-negative bacteria, all selected due to their ability to cause intestinal and skin disorders. Extracts and fractions containing high concentrations of sericic acid exhibited the highest activities against Klebsiella pneumoniae (ATCC 13883), Pseudomonas aeruginosa (ATCC 27858), Salmonella typhimurium (ATCC 14028), Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12223) and Shigella sonnei (ATCC 9292). The pure compound (sericic acid) was highly active against S. sonnei (MIC 0.078 μg/mL), a Gram- negative bacterium. There were no variations in the activity of the crude extracts against B. cereus and P. aeruginosa, while the MIC values obtained against S. typhi were variable and ranged from 0.25 to 1.0 mg/mL. Sericoside and resveratrol-3-rutinoside did not display any activity. The anti-oxidant activities were evaluated using DPPH (2,2-diphenyl-1-picrylhydrazyl) and reducing power assays. The anti-oxidant assays revealed that resveratrol-3- rutinoside exhibited lower activity (DPPH = 186 μg/mL; RP = 184 μg/mL) compared to the crude extract (DPPH = 22.3 μg/mL; RP = 24.4 μg/mL) and ascorbic acid (DPPH = 11.3 μg/mL, RP = 145 μg/mL). Sericic acid and sericoside did not display any anti- oxidant activities. The variation in the anti-oxidant activities (4.58 to 26.0 μg/mL) of the samples from different populations was an indication of chemical variability. A toxicity study of the raw powdered plant material was conducted using vervet monkeys (Chlorocebus pygerythrus). Biochemical analysis (liver function tests, kidney function tests and hematology), physical and physiological examinations were conducted. The subjects were fed a normal diet supplemented with T. sericea root powder (2.14 g/kg per day) for 120 days, where after the diet was returned to normal (washout) for another 30 days. The treatment groups presented with elevated serum enzymes at Week 4, followed by the reduction of the elevated serum enzymes levels at Week 12. These results indicate short-term hepatotoxic effects, followed by hepatoprotective activity. Reduction of the serum glucose at Week 4 suggests hypoglycemic potential. However, elevated serum creatinine levels indicated possible nephrotoxicity. In conclusion, this study has indicated the variability in the chemical constituents of the roots of T. sericea, which affects the antibacterial and anti-oxidant activities. Sericic acid, resveratrol-3-rutinoside, and sericoside were, for the first time, identified as biomarkers that can be used for the quality control of raw root material to be used in herbal products. Sericic acid was also found to be the main antibacterial constituent of the roots. The hepatoprotective, nephrotoxic and hematotoxic effects observed in monkeys to which the root powder had been administered is cause for concern. / NRF

MSc (Chemistry) / Department of Chemistry / Rauvolfia caffra Sond, a species of evergreen trees and shrubs in the dogbane family, (Apocynaceae), is used as a medicinal plant among traditional communities in many countries for the treatment of malaria, diabetes, coughs, gastrointestinal disturbances, skin infections, impotence, insomnia, diarrhoea, dysentery, scabies, worm infections, and both parasitic and microbial infections. Phytochemical studies have revealed that indole alkaloids are the major constituents of the stem bark. However, there are limited studies linking the compounds with the ethnomedicinal uses. The aim of this study is to isolate and characterize bioactive compounds from Rauvolfia caffra Sond. The highest phenolic content found in a fraction was 16.06±0.125 mg GAE/g, while the highest flavonoid content measured was 9.453±0.081 mg QE/g. In the DPPH free radical scavenging activity and reducing power tests, a lowest IC50 value of 0.022±0.003 μg/mL and IC0.5 value 0.518±0.044 μg/mL, respectively, was found. Six compounds were isolated from the stem bark, including lupeol, a pentacyclic tri-terpenoid isolated for the first time from the genus Rauvolfia; raucaffricine, a rare glycoalkaloid of the monoterpenoid indole class; N-methylsarpagine, an indole alkaloid isolated for the time from R. caffra and spegatrine, an indole alkaloid isolated for the first time from R. caffra, respectively. Concerning antimicrobial activity, the highest activity of a fraction was against B. cereus with MIC values as low as 12.5 mg/mL. One fraction at the tested concentration (250 μg/mL) decreased the viability of Plasmodium falciparum (4.149±6.979 %) with an IC50 value of 6.533 μg/mL. The crude extract and some fractions affected the viability of the Trypanosomes at the tested concentration (250 μg/mL), giving -0.133 ± 0.206 %, 11.334 ± 2.692 %, 1.026 ± 0.143 % and 20.769 ± 9.054 % with IC50 values of 18.50 μg/mL, 14.15 μg/mL, 15.58 μg/mL and 34.71 μg/mL, respectively. Furthermore, the fractions did not show significant cytotoxic effects at a concentration of 50 μg/mL. / NRF

Atea är ett företag som ger sina anställda friheten att arbeta på valfri plats och detta kan leda till att ett kontor inte kanske används tillfullo. Denna studie kommer därför lägga fokus på att ta fram en lösning som kommer räkna antalet personer som är på Ateas kontor i realtid och även spara data för tidigare dagar för att ge statistik över en längre tid. Syftet med denna typ av lösning är att se hur ett kontor används, samt om detta är en lösning som kommer vara användbar och för vem. En prototyplösning har tagits fram för att testa denna typ av lösning på ett kontor. Lösningen kommer bestå av olika delar som innehåller IoT, API, Next.js och hostas på Azure. I resultatet så kan man konstaterat en rad brister och svagheter existerar i denna lösning. Mätningar visar olika data ifrån vad man personligen uppskattar gentemot vad lösningen visar. Detta beror på flera faktorer, varav den största är att lösningen endast hade tillgång till en kamera och kontoret har två in- och utgångar. Vid sammanställning av användartester så kan man se en trend av att många anser att denna typ av lösning kan vara bra i en personlig synvinkel men också ur en professionell synvinkel, och det finns ett uttryckt intresse för denna typ av lösning. / Atea is a company that gives its employees the opportunity to work from where ever they want and this can lead to the office not being used to its full potential. This study will therefore explore the option to develop a solution that can count the amount of people coming and going to an Atea office in real-time, and also save the data for previous days in order to give statistic over a longer period of time. The purpose with this type of solution is to evaluate how well an office is being used, and also to determine if the solution is useful and for who. A prototype has been created in order to test the solution at an office. The solution consists of different parts made up of IoT, API, Next.js and is hosted on Azure. The results show a lot of weaknesses and flaws in this solution. The measurements show different numbers from the ones that was estimated by personal headcount versus what the solution produced. This has to do with a couple of factors but the main one being that the solution only had access to one smart camera and the office has two entrances. When compiling the user tests, we can see a trend that most people like the solution and this type of solution would be good in a personal perspective but also in a professional one. There is also an expressed interest in a solution like this.

La question prioritaire de constitutionnalité (QPC), instaurée en 2008, permet au Conseil constitutionnel de se prononcer sur la conformité d’une disposition législative déjà entrée en vigueur, aux « droits et libertés que la Constitution garantit ». Les effets substantiels des décisions QPC, c'est-à-dire la suppression ou la modification d’une disposition législative par le prononcé d’une inconstitutionnalité ou d’une réserve d’interprétation, peuvent se révéler importants compte tenu de la portée erga omnes de ces décisions. C’est alors par la maîtrise de leur application temporelle que les effets substantiels vont être encadrés voire modérés. Certains effets temporels revêtent un caractère automatique : la décision QPC en tant qu’elle porte sur une norme (la disposition législative en cause), s’insère dans l’ordonnancement juridique et, à ce titre, génère des conflits de normes. Par ailleurs, les effets temporels peuvent également, et surtout, être choisis par le Conseil constitutionnel, par l’utilisation de son pouvoir de modulation. Ce pouvoir a été conçu de manière à laisser une grande liberté au Conseil constitutionnel. Dans une démarche d’efficacité, le juge constitutionnel s’est fixé l’objectif de faire bénéficier le justiciable d’un« effet utile » de ses décisions et a par conséquent valorisé l’usage de la rétroactivité. Cependant, la liberté seule n’assure pas une pleine maîtrise de ce pouvoir de modulation et ce même pouvoir est parfois insuffisant pour régir les effets substantiels des décisions QPC. La thèse contribue, sur la base d’une analyse exhaustive de l’ensemble des décisions QPC du Conseil et de trèsnombreuses décisions dites « retour de QPC » des juridictions ordinaires, à étudier ces insuffisances et notamment le manque de réflexion sur la compatibilité entre la technique de la modulation et l’office du juge constitutionnel et sur la nécessité d’une collaboration avec les juridictions ordinaires. / The priority question of constitutionality (QPC), created in 2008, allows the french Constitutional Council to operate a judicial review of an adopted law. The substantial effects of a QPC decision, ie the abolition or the modification of a legislation by pronouncing its unconstitutionality or by interpreting it in accordance with the Constitution, can be considerable given the erga omnes impact of these decisions. These substantial effects can however be controlled or moderated by the temporal effects. Some temporal effects are inevitable: the QPCdecision since it concerns a norm (the law), integrates with the legal order and generates norms’ conflicts. Otherwise the temporal effects can be chosen by the Constitutional Council thanks to the ability of modulating the temporal effects of its decisions. This jurisdictional technical lets total liberty to the Constitutional Council. The court, in an efficacy perspective, sets the objectiveof giving a « useful effect » to the litigant and thus accords value to retroactivity. Yet this liberty alone isn’t enough to provide a complete control of this modulating ability and this ability can’t regulate all the substantial effects. This thesis, based on an exhaustive jurisprudential analysis ofthe QPC decisions, aims to study these difficulties and especially the lack of reflection about the compatibility of the technical into the judicial office of the court and about the essential collaboration with the ordinary jurisdictions.

Made available in DSpace on 2016-04-28T14:16:37Z (GMT). No. of bitstreams: 1 Edaival Mulatti.pdf: 1316493 bytes, checksum: 2ddebbfbb24364b182ea454f86c50397 (MD5) Previous issue date: 2008-10-23 / The Royal Institution, English organization founded at the end of the eighteenth century in London and existing in this day and age as an institution dedicated to research in the theory and dissemination of science, was born with the purposes of an institution of public character, depending on financial contributions. Within a conception of science, categorized by its founders as "useful science," the Royal Institution had as main goals, the diffusion of knowledge and application of science in the life of the population. For the present work, we studied up some of the social and political circumstances present in England at the end of the eighteenth century, and provided evidence to the understanding of the reasons that enabled the creation of that institution. Also, we tried to identify in the creation and consolidation of that institution, the role played by personalities of the time, as Joseph Banks, Benjamin Thompson, Thomas Young, Thomas Garnett and Humphry Davy. This work was based on the study of the following documents: "Proposals for forming by subscription, in the Metropolis of the British Empire, the Public Institution for diffusing the knowledge and facilitating the general introduction of useful mechanical inventions and improvements, and for teaching, by Philosophical Lectures and courses of Experiments, the application of science to the common purposes of life.", document-creation of the Royal Institution, authored by Benjamin Thompson and dated March 1799,"The discourse introductory to the Course of Lectures on Chemistry , Delivered in the Theatre of the Royal Institution, on the 21st of January, 1802," inaugural lecture of the Royal Institution Humphry Davy, and "The Bakerian Lecture, on some chemical Agencies of Electricity," lecture in which Davy presented the results of their research on electrolysis, made the Royal Institution and presented at the Royal Society on November 20 de1806. The focus of this work was in the study of the model for dissemination of knowledge established on the origins of the Royal Institution, as well as some of the changes that have made this model a strong point of support for the Royal Institution to be seen, at the beginning of the nineteenth century, as a major scientific institutions of England / The Royal Institution, organização inglesa fundada no final do século XVIII em Londres e existente nos dias de hoje como uma instituição voltada a pesquisas no campo teórico e divulgação da ciência, nasceu com os propósitos de uma instituição de caráter público, dependendo financeiramente de contribuições. Dentro de uma concepção de ciência, categorizada por seus fundadores como ciência útil , a Royal Institution tinha como principais objetivos, a difusão do conhecimento e aplicação da ciência na vida da população. Para o presente trabalho, estudou-se algumas das circunstâncias sociais e políticas presentes na Inglaterra no final do século dezoito, e que forneceram elementos para o entendimento dos motivos que propiciaram a criação de tal instituição. Procurou-se também identificar, na criação e consolidação dessa Instituição, o papel desempenhado por personalidades da época, como Joseph Banks, Benjamin Thompson, Thomas Young, Thomas Garnett e Humphry Davy. Esta dissertação baseou-se no estudo dos seguintes originais: Proposals for forming by subscription, in the Metropolis of the British Empire, a Public Institution for diffusing the knowledge and facilitating the general introduction of useful mechanical inventions and improvements, and for teaching, by courses of Philosophical Lectures and Experiments, the application of science to the common purposes of life , documento de criação da Royal Institution, de autoria de Benjamin Thompson e datado de março de 1799, A discourse introductory to a Course of Lectures on Chemistry, Delivered in the Theatre of the Royal Institution, on the 21st of January, 1802 , palestra inaugural de Humphry Davy na Royal Institution, e The Bakerian Lecture, on some chemical Agencies of Electricity , palestra na qual Davy apresentou os resultados de suas pesquisas sobre eletrólise, efetuadas na Royal Institution e apresentadas perante a Royal Society em 20 de novembro de1806. O ponto central desse trabalho situou-se no estudo do modelo de difusão do conhecimento formulado nas origens da Royal Institution, bem como em algumas de suas modificações que fizeram desse modelo um forte ponto de apoio para que a Royal Institution se projetasse, no início do século dezenove, como uma das principais instituições científicas da Inglaterra