Indiana University-Purdue University Indianapolis (IUPUI) / With bombings in the United States on the rise for the first time since 2016, the detection and identification of explosives remains of pertinent interest to law enforcement agencies. This work presents two soon-to-be published research articles that focus on the detection and identification of explosives by both chemical instrumentation and canines. The first article, Quantitative Analysis of Smokeless Powder Particles in Post-Blast Debris via Gas Chromatography/Vacuum Ultraviolet Spectroscopy (GC/VUV), utilizes gas chromatography/vacuum ultraviolet spectroscopy (GC/VUV) to determine the difference in chemical composition of two smokeless powders in both pre- and post-blast conditions. The compounds of interest in this study were nitroglycerin, 2,4- dinitrotoluene, diphenylamine, ethyl centralite, and di-n-butyl phthalate. Concentration changes between pre- and post-blast smokeless powder particles were determined as well as microscopic differences between pre- and post-blast debris for both smokeless powders in all devices. To our knowledge, this is the first use of GC/VUV for the quantification of explosives. The second article, An Odor-Permeable Membrane Device for the Storage of Canine Training Aids, proposes the use of an odor-permeable membrane device (OPMD) as a standardized storage method for canine training aids. It is hypothesized that the OPMD would minimize cross-contamination between training aids, and that the OPMD could be used for canine training as well as storage. The goal of this research is to use flux and evaporation rate to quantify the explosive odor that escapes from the OPMD compared to unconfined explosives. Preliminary data suggests that there is an exponential relationship between relative boiling point and evaporation rate. It has been determined that compounds with higher boiling points have lower evaporation rates than compounds that have lower boiling points. The materials studied thus far are known odor compounds produced by explosive formulations. These include nitromethane, nitroethane, 1- nitropropane, r-limonene, and toluene.

The diagnostic technique, polarization and depolarization current (PDC) is useful for insulation testing. It requires applying a DC step voltage to the test sample and measuring the current. To measure fast PDC phenomena a fast step is needed. One way of applying a fast high voltage step is to use power electronic switches. Series connection can be used to increase the voltage limit, but this result in unequal voltage sharing unless equipped with voltage balancing. In this work a high voltage vacuum reed switch is investigated as a simple and low-cost alternative to power electronic switches, handling up to 10 kV with a single device. The switch turn on and off behavior was studied. It was found that the initial turn-on is good, in the range of nanoseconds, but there is a problem with the vacuum recovering its insulating properties at low currents before the contacts fully close. The required output voltage level is therefore obtained only after a further settling time that increases with increased input voltage and is much longer than the initial breakdown, e.g. 20 µs for the case of 4.5 kV input voltage. Other limitations of the fast high voltage PDC were also studied. The output voltage was measured across the test sample without adding an intentional resistor in the circuit. There were large oscillations for 1 µs but these oscillations are damped due to inherent resistance of the connecting leads, series resistance of the capacitors and resistance of the reed switch. A comparison is made between the measured and the simulated results using MATLAB to see the effect of parasitic inductance. A damping resistor was added in the circuit and the output results were again compared. With the addition of the damping resistor, the number of oscillations were reduced and their time scale was limited to 0.1 µs . An analysis is made at the end which describes the limitation occurring in determining the high frequency component of PDC. The current during the step is many orders of magnitude higher than the polarization current even at 1 µs , so measurement of the current and protection of the apparatus is not trivial.

Indiana University-Purdue University Indianapolis (IUPUI) / In the area of forensic chemistry, improved or new analysis methods are continually being investigated. One common and powerful technique used in forensic chemistry is wall-coated open-tubular column (WCOT) gas chromatography with electron ionization single quadrupole mass spectrometry (GC-MS). Improvements to and effectiveness of alternatives to this instrumental platform were explored in an array of parallel inquiries. The areas studied included the column for the chromatographic separation, the universal detection method employed, and the fragmentation method used to enhance molecular identification. Superfine-micropacked capillary (SFµPC) columns may provide an alternative to commercial packed GC columns and WCOT GC columns that combines the benefits of the larger sample capacity of packed columns and the benefits of the excellent separation capabilities and mass spectrometry (MS) flow rate compatibility of WCOT columns. SFµPC columns suffer from high inlet pressure requirements and prior reported work has required specialized instrumentation for their use. Fabrication of and chromatography with SFµPC GC columns was successfully achieved with typical GC-MS instrumentation and within the flow rate limit of a MS. Additionally, the use of higher viscosity carrier gasses was demonstrated to reduce the required inlet pressure for SFµPC GC columns. Recently, a new vacuum ultraviolet spectrometer (VUV) universal detector has been commercialized for GC. The ability of VUV detectors to acquire absorbance spectra from 125 nm to 430 nm poses a potential alternative to MS. As such, GC-VUV provides an exciting potential alternative approach to achieving excellent quantitative and qualitative analysis across a wide range of analytes. The performance of VUV and MS detectors for forensic analysis in terms of quantitative and qualitative analysis was compared. Analysis of alkylbenzenes in ignitable liquids was explored, which can be important evidence from suspected arson fires and are difficult to differentiate with MS. The VUV detector was found to have superior specificity and comparable sensitivity to the MS detector in scan mode. Addition of thermolysis (Th) as an orthogonal fragmentation pathway provides the opportunity to increase the differences between MS fragmentation patterns. Fragmentation has been widely established to aid in identification of molecules with MS by providing characteristic fragments at characteristic relative abundances. However, molecules with very similar structures do not result in sizable spectral differences in all cases with typical MS fragmentation techniques. A series of Th units were fabricated and integrated into GC-Th-MS instruments. Th-MS was conducted with the thermally labile nitrate esters across a range of instrumentation and thermal conditions.

Haemolysis and other biochemical evaluations of vacuum-assisted venous drainage in cardiac surgery Aims of the study: Vacuum-assisted venous drainage (VAVD) improves the quality of venous return in procedures using extracorporeal circulation systems (ECC). Nevertheless, there is not an evidence that such high negative pressure applied to ECC in combination with selective bicaval cannulation due to open heart surgery cause a trauma to blood elements and deteriorates organ function. A prospective randomised study was designed to demonstrate that negative pressure of -20 mm Hg to -80 mm Hg does not cause a significant haemolysis and organ deterioration in such procedures. Materials and methods: 85 consecutive patients undergoing combined cardiac surgery procedure with two separate venous cannulas were randomised in three groups A, B and C. VAVD with negative pressure of -20 to -45 mm Hg was applied to 28 patients in group A and negative pressure of -45 mm Hg to -80 mmHg was applied to 28 patients in group B. There was zero negative pressure applied to 29 patients in group C. Six blood samples were taken from each patient and examinated for haemolysis and other indicators of organ deterioration such as hemoblobin, platelet count, free hemoglobin, aptoglobin, lactate-dehydrogenase, aspartate-amino-transferase,...

The optimisation of the specular reflectance of solar collectors is a key parameter to increase the global yield of concentrated solar power (CSP) plants. In this work, the influence of filtered cathodic vacuum arc deposition parameters, particularly working pressure and deposition time, on the specular and diffuse reflectance of aluminium thin films, was studied. Changes in specular reflectance, measured by ultraviolet–visible and near-infrared spectroscopy (UV-vis-NIR) spectrophotometry, were directly correlated with thin film elemental concentration depth profiles, obtained by Rutherford backscattering spectrometry (RBS), and surface and cross-sectional morphologies as measured by scanning electron microscopy (SEM) and profilometry. Finally, atomic force microscopy (AFM) provided information on the roughness and growth mechanism of the films. The two contributions to the total reflectance of the films, namely diffuse and specular reflectance, were found to be deeply influenced by deposition conditions. It was proven that working pressure and deposition time directly determine the predominant factor. Specular reflectance varied from 12 to 99.8% of the total reflectance for films grown at the same working pressure of 0.1 Pa and with different deposition times. This transformation could not be attributed to an oxidation of the films as stated by RBS, but was correlated with a progressive modification of the roughness, surface, and bulk morphology of the samples over the deposition time. Hence, the evolution in the final optical properties of the films is driven by different growth mechanisms and the resulting microstructures. In addition to the originally addressed CSP applications the potential of the developed aluminium films for other application rather than CSP, such as, for example, reference material for spectroscopic diffuse reflectance measurements, is also discussed.

The purpose of this study was to examine the clinical outcomes of negative pressure wound therapy (NPWT) using reticulated open-cell foam (ROCF) in the adjunctive management of abdominal wounds with exposed and known infected synthetic mesh. A non randomised, retrospective review of medical records for 21 consecutive patients with infected abdominal wounds treated with NPWT was conducted. All abdominal wounds contained exposed synthetic mesh [composite, polypropylene (PP), or knitted polyglactin 910 (PG) mesh]. Demographic and bacteriological data, wound history, pre-NPWT and comparative post-NPWT, operative procedures and complications, hospital length of stay (LOS) and wound healing outcomes were all analysed. Primary endpoints measured were (1) hospital LOS prior to initiation of NPWT, (2) total time on NPWT, (3) hospital LOS from NPWT initiation to discharge and (4) wound closure status at discharge. A total of 21 patients with abdominal wounds with exposed, infected mesh were treated with NPWT. Aetiology of the wounds was ventral hernia repair (n = 11) and acute abdominal wall defect (n = 10). Prior to NPWT initiation, the mean hospital LOS for the composite, PP and PG meshes were 76 days (range: 21-171 days), 51 days (range: 32-62 days) and 19 days (range: 12-39 days), respectively. The mean hospital LOS following initiation of NPWT for wounds with exposed composite, PP and PG mesh were 28, 31 and 32 days, respectively. Eighteen of the 21 wounds (86%) reached full closure after a mean time of 26 days of NPWT and a mean hospital LOS of 30 days postinitiation of NPWT. Three wounds, all with composite mesh left in situ, did not reach full closure, although all exhibited decreased wound dimensions, granulating beds and decreased surface area exposure of mesh. During NPWT/ROCF, one hypoalbuminemic patient with exposed PP mesh developed an enterocutaneous fistula over a prior enterotomy site. This patient subsequently underwent total mesh extraction, takedown of the fistula and PP mesh replacement followed by reinstitution of NPWT and flap closure. In addition to appropriate systemic antibiotics and nutritional optimisation, the adjunctive use of NPWT resulted in successful closure of 86% of infected abdominal wounds with exposed prosthetic mesh. Patient hospital LOS (except those with PG mesh), operative procedures and readmissions were decreased during NPWT compared with treatment prior to NPWT. Future multi-site prospective, controlled studies would provide a strong evidence base from which treatment decisions could be made in the management of these challenging and costly cases.

Gabriel A, Shores J, Bernstein B, de Leon J, Kamepalli R, Wolvos T, Baharestani MM, Gupta S. A Clinical Review of Infected Wound Treatment with Vacuum Assisted Closure ® (V.A.C. ®) Therapy: Experience and Case Series. ABSTRACT Over the last decade Vacuum Assisted Closure ® (KCI Licensing, Inc., San Antonio, TX) has been established as an effective wound care modality for managing complex acute and chronic wounds. The therapy has been widely adopted by many institutions to treat a variety of wound types. Increasingly, the therapy is being used to manage infected and critically colonized, difficult-to-treat wounds. This growing interest coupled with practitioner uncertainty in using the therapy in the presence of infection prompted the convening of an interprofessional expert advisory panel to determine appropriate use of the different modalities of negative pressure wound therapy (NPWT) as delivered by V.A.C. ® Therapy and V.A.C. Instill ® with either GranuFoam ™ or GranuFoam Silver ™ Dressings. The panel reviewed infected wound treatment methods within the context of evidence-based medicine coupled with experiential insight using V.A.C. ® Therapy Systems to manage a variety of infected wounds. The primary objectives of the panel were 1) to exchange state-of-practice evidence, 2) to review and evaluate the strength of existing data, and 3) to develop practice recommendations based on published evidence and clinical experience regarding use of the V.A.C. ® Therapy Systems in infected wounds. These recommendations are meant to identify which infected wounds will benefit from the most appropriate V.A.C. ® Therapy System modality and provide an infected wound treatment algorithm that may lead to a better understanding of optimal treatment strategies.

The need to minimize carbon dioxide (CO2) emissions is becoming increasingly important with the total number of vehicles throughout the world exceeding one billion. Carbon dioxide emissions can be reduced by improving vehicle fuel efficiency. While electric transportation is gaining popularity, most passenger vehicles are still powered by gasoline or diesel engines. The main objective of this work was to provide opportunities for studying and improving the fuel efficiency of internal combustion engines (ICE). This was achieved by 1) Designing, building and testing auxiliary systems necessary to run a Cummins 2.8 L engine in a an engine test cell; 2) Creating educational labs for the ICE class; and 3) Measuring the parasitic losses of the vacuum pump and water pump on the installed Cummins 2.8 L diesel engine. All auxiliary systems were completed at a hardware cost of $8100 and are rated to support an engine with the power output capacity of 233 kW (312 hp). The educational laboratories enable future engineers to measure and assess the efficiency of internal combustions engines. The parasitic losses of the vacuum pump and water pump were found to impact the relative brake fuel conversion efficiency by 1.3% and 1.5% respectively over the Federal Test Procedure (FTP) cycle.

This classic grounded theory study reflects companies work with corporate philanthropy (CP), and has a specific focus on companies with Swedish roots who are operating in South Africa. The theory illustrates how the companies perceive themselves to be forced to engage in CP, and their main solution to this problem is trying to optimise their CP work so it benefits both themselves and their beneficiaries. The companies are operating in a structural vacuum with regards to their CP work, and consequently, they make use of impressionistic tools in their attempt to optimise the work. There is arguably a need for companies to adopt a more strategic approach. The empirical data is collected from semi structured interviews with companies during 2012.

The objective of this research based on both the theory and experimentation was to prove that the total pressure difference is the primary driving force during the vacuum drying. The theoretical drying rates of diffusion, free water bulk flow and water vapor bulk flow were calculated and compared. The concept of equilibrium moisture content under the vacuum was developed. The theoretical maximum moisture content drop in one cycle was calculated using energy balance. The model was developed for the vacuum drying to understand the mechanism of the vacuum drying including the boiling front and its movement. To evaluate the effect of the sample size on the drying rate, four different thicknesses (1, 1.5, 2, 2.5 inches) and three different lengths (5, 10, 15 inches) were used. In the cyclic drying, the specimens were heated to the 60 C. The vacuum was pulled to about 18 mm Hg. The vacuum pump was kept running for 140 minutes. It was found that in cyclic vacuum drying, drying rate was not affected by the thickness. However, it was affected by the length. The cyclic drying curve consisted of two distinct parts. The fast drying period lasted about 10 to 20 minutes. The slow drying period occurred next when the pressure inside wood got close to the ambient pressure. In end grain vacuum drying, the specimens were coated with wax, wrapped in the plastic film and inserted into a rubber tube to prevent the moisture loss from the side surfaces during drying. The specimen size was 1×1×10 inches. Red oak and white oak were sealed and dried in both cyclic and continuous vacuum drying. The results showed that sealed specimens dried almost as fast as unsealed specimen. There was little moisture loss from the side surfaces. There was a moisture gradient along the length in both cyclic drying and continuous vacuum drying. Red oak specimens of 2.5×1.5×10 inches were used to study the boiling front in the vacuum drying. In order to detect the boiling phenomenon, the saturation pressures were calculated and were compared with the pressures at the same time and the same location. Boiling occurred during drying and the boiling front retreated to the center of wood as drying proceeded. The retreating speed depended on the heat supply and the permeability. Vacuum drying at room temperature was investigated. The specimens were dried at 20 C and pressure near 18 mm Hg. The results showed that wood can be vacuum dried at room temperature with little or no degrade at a reasonable drying rate. All experimental results support the objective of this study that the primary driving force is the total pressure difference. / Ph. D.