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The aim of the work was to measure and evaluate the strength of deep stabilizing system (DSS) in connection with correct body posture and, subsequently, to asses the efficiency of the existing known exercise of the lumbar spine area as well as drawing comparison to the exercise recently introduced by doc. PaedDr. Pavel Kolář. The research was carried out on two sample groups of sixth form boys attending elementary school. It was necessary in the first place to detect, test and document correct body posture and, above all, the functionality of the DSS in members of the respected groups. This was followed by six weeks of active exercise according to exercise programme focusing primarily on the lumber spine area. The control group of ten boys carried out exercises based mainly on general principles of correct exercise whereas the experimental group totalling the same number of boys did exercises of DSS and lumbar spine area according to doc. PaedDr. Pavel Kolář. A muscle dynamometer was used to objectify and check the DSM in lumbar spine area. The measuring was than documented, processed and evaluated by means of charts and graphs. The work also comprises an overview of basic principles of lumbar spine stability as well as a questionnaire designed to assess health and lifestyle.\\

An investigation of the interaction of stable opioid/ligands and unstable opioid peptides with opioid receptors in guinea pig brain, guinea pig myenteric plexus and mouse vas deferens has been carried out. The initial aim of the study was to further characterise K opioid receptors, using binding assays and isolated tissue bioassays. The second aim was to determine the true affinity and potency of small dynorphin peptides for the K opioid receptor and to determine if metabolism of the peptides to non K opioid receptor-preferring products contributes to their observed in vitro pharmacology.

A presente pesquisa foi desenvolvida com o objetivo de analisar qual a maneira mais adequada de evidenciar na Demonstração do Valor Adicionado, as receitas das entidades do terceiro setor diante das diversas fontes disponíveis para captá-las. Subsidiariamente e com base na conclusão da tese de doutorado de Fregonesi (2009) de que os investimentos socioambientais feitos pelas empresas às entidades sem fins lucrativos são, em determinadas situações, distribuição do valor adicionado, o presente estudo objetivou analisar o impacto da referida conclusão na DVA das entidades sem fins lucrativos, mais especificamente, das fundações e institutos empresariais e suas eventuais implicações na utilidade da DVA como instrumento auxiliar para o cálculo da participação deste setor no produto nacional. As entidades utilizadas como exemplos são as associadas ao Grupo de Institutos, Fundações e Empresas (GIFE) sendo descartadas as que não possuíam a expressão \"Instituto\" ou \"Fundação\" em suas denominações sociais e entidades que não publicaram suas demonstrações contábeis de 2010 com notas explicativas em suas páginas eletrônicas ou no Diário Oficial Empresarial de São Paulo entre o período de janeiro a abril de 2011. Foram incluídas na análise a Fundação Instituto de Pesquisas Contábeis, Atuariais e Financeiras (FIPECAFI) e a Fundação Salvador Arena em função de sua notoriedade e para enriquecer a compreensão do modus operandi dessas entidades no processo de captação de recursos. Os resultados sugerem que nem todas as entidades do terceiro setor geram valor adicionado, assumindo, em alguns casos, o papel de meras gestoras de recursos advindos de suas mantenedoras, que buscam dar forma à sua responsabilidade social. Neste caso, por haver redistribuição secundária de renda, o produto nacional não computaria a participação dessas entidades. / This research was developed in order to analyze what the most appropriate way to highlight the Value Added Statement, revenues from the third sector entities on the various sources available to capture them. Secondly and based on the conclusion of the doctoral thesis of Fregonesi (2009) that social and environmental investments made by companies to nonprofits are, in certain situations, the distribution of value added, this study aimed to analyze the impact of this conclusion at VAS of nonprofits, more specifically, enterprise foundations and institutes and its possible implications on the usefulness of the VAS as an aid for calculating the contribution of this sector in the national gross product. The entities used as examples are associated with the Group of Institutes, Foundations and Enterprises (GIFE) being discarded those that did not have the term \"Institute\" or \"Foundation\" in their names or entities that did not publish its financial statements with notes, 2010 explanatory in its pages in the Official Gazette or Electronic Business São Paulo between January and April 2011. Were included in the analysis the Research Institute of Accounting, Actuarial and Financial (FIPECAFI) and Salvador Arena Foundation because of its reputation and to enrich the understanding of the modus operandi of these entities in the process of fundraising. The results suggest that not all third sector entities generate added value, assuming in some cases, the role of mere management of resources from their keepers, who seek to shape their social responsibility. In this case, because there is secondary redistribution of income, national gross product does not compute the participation of these entities.

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / Avaliou-se a atividade de Bothrops marajoensis (Bmj) e suas fraÃÃes no sistema cardiorrenal. A resposta pressora do veneno bruto demonstrou uma diminuiÃÃo da pressÃo arterial mÃdia e da freqÃÃncia cardÃaca, sem alteraÃÃes significativas na freqÃÃncia respiratÃria. Em ratos atropinizados demonstrou a permanÃncia dos efeitos. Na perfusÃo de coraÃÃo isolado de ratos observou-se uma diminuiÃÃo na forÃa de contraÃÃo miocÃrdica acompanhada de um aumento da pressÃo de perfusÃo, sem alteraÃÃes no fluxo coronariano. A anÃlise eletrocardiogrÃfica em ratos apÃs injeÃÃo de Bmj provocou um bloqueio Ãtrio ventricular gradual atà um bloqueio completo indicando arritmia e dificuldade de conduÃÃo atrial. Em leito vascular mesentÃrio prÃ-contraÃdo com fenilefrina nÃo houve alteraÃÃes significativas. No sistema de perfusÃo renal em ratos apresentou decrÃscimo significativo na pressÃo de perfusÃo, resistÃncia vascular, fluxo urinÃrio, ritmo de filtraÃÃo e transportes de sÃdio e de cloreto. Fosfolipase miotÃxica (tipo 1) demonstrou alteraÃÃes somente no transporte de Ãons. A atividade de Bmj em doses crescentes em nervo FrÃnico Diafragma de rato mostrou um bloqueio na forÃa de contraÃÃo dose dependente, com efeito significante nas maiores doses. Em canal deferente de camundongos induziu a uma inibiÃÃo dose dependente da contraÃÃo estimulada por campo elÃtrico. Este feito nÃo foi revertido pela Ioimbina nem por naloxone. Em outro estudo a adiÃÃo do veneno bruto de Bmj inibiu a contraÃÃo neurogÃnica,quando comparado com nenhuma queda significante pela contraÃÃo com Cch, NA ou ATP (em Krebs normal ou enriquecido com guanetidina e fentolamina. A ausÃncia de efeito do veneno bruto de Bothrops marajoensis sobre a contraÃÃo induzida pelos principais agonistas purinÃrgicos demonstra provÃvel atividade a nÃvel prÃ-sinÃptico. FraÃÃes de fosfolipases miotÃxicas (tipo 1 e tipo 2) demonstraram uma inibiÃÃo da contraÃÃo dose dependente. / In this article we evaluated the activity of Bothrops marajoensis (Bmj) and its fractions in the cardio-renal system. The results of the total venom in blood pressure experiments showed a decrease in the mean arterial pressure and heart rate without significant changes in respiratory rate. The same experiments performed in rats atropinized showed the permanence of falling blood pressure and heart rate. After administration of Bmj used in infusion of isolated rats heart of there was a decrease in myocardial force of contraction accompanied by an increase in perfusion pressure, without changes in coronary flow. The electrocardiographic analysis after injection of Bmj in rats causes a progressive atrioventricular block until a complete blockage and difficulty in atrial conduction. The assessment in the mesenteric vascular bed Bmj did not produce significant changes. The system renal perfusion in rats caused significant decrease in perfusion pressure, renal vascular resistance, urinary flow, filtration rate, transport of sodium and chloride. The phospholipase (PLA2) type 1 showed only an alteration in the transport of electrolytes. The Bmj fractions neurotoxicity in rat phrenic nerve diaphragm increasing showed a blockage dose-dependent in the strength of contraction. In mice vas deferens we observed an induced of a dose-dependent inhibition of contraction stimulated by electric field. This fact was not reversed by yohimbine or by naloxone. In another study the addition of the total venom of Bmj inhibited the neurogenic contraction, compared with no significant decrease in contraction by Cch, NA or ATP (in normal Krebs solution or with enriched with guanethidine and phentolamine). The fractions, PLA2 (type 1 and type 2) showed a dose-dependent inhibition of contraction.

The population over 65 years of age is increasing and health in elderly has been a subject of research for decades but voice function and vocal health has not been prioritized. The purpose of this study is to obtain reference value for the Swedish version of Voice Handicap Index (RHI) and the Throat Scale among people over 65 years of age and assess voice function and vocal health for this age group. The questions were as followed: 1) What is the reference value of RHI for people over 65 years of age? 2) What is the reference value of the Throat Scale for people over 65 years of age? 3) Is there a correlation between a self-rated VA-scale on the perceived degree of voice problems, and the self-rated RHI-/Throat Scale result? 4) Does age, gender or previous profession matter for the self-perceived voice? In total 100 individuals participated in the study, 50 women and 50 men, between 65 and 92 years old. The reference value of RHI for people over 65 years of age was 13,4 points and the reference value for the Throat Scale was 7,7 points. Both reference values are higher than reference values for younger people. The reference value of RHI is mainly described from the high points of the participants over 85 years of age. There was a correlation between the results of the RHI/the Throat Scale and the VA-scale concerning the perceived degree of voice problems, p < .01. Age is a significant factor for self-perceived voice problems. The older the subject, the higher points scored, both on the RHI, p < .05 and the Throat Scale. The results of the Throat Scale, however, were not significant. Even though most of the participants were active the reference value of RHI and the Throat Scale was higher than the reference value for younger people. The conclusion is that the voice changes in elderly affect voice experience. / Befolkningsgruppen över 65 år ökar i storlek och äldre personer är allt friskare. Äldre människors hälsa har sedan länge varit föremål för forskning men röstfunktion och rösthälsa hos de äldre har inte varit prioriterade områden. Syftet med föreliggande studie är att fastställa normalvärden för Rösthandikappindex och Halsskalan hos personer över 65 år samt kartlägga röstfunktion och rösthälsa i denna åldersgrupp. Frågeställningarna var följande: 1) Hur ser normalvärdet av RHI ut för personer över 65 år? 2) Hur ser normalvärdet av Halsskalan ut för personer över 65 år? 3) Finns det något samband mellan en självskattad VAS-skala för upplevd grad av röstproblem och det självskattade RHI-/Halsskaleresultatet? 4) Har ålder, kön eller tidigare yrke betydelse för den subjektiva röstupplevelsen? 100 personer, 50 kvinnor och 50 män, mellan 65 och 92 år, deltog i föreliggande studie. Normalvärdet av RHI för personer över 65 år är 13,4 poäng och normalvärdet av Halsskalan är 7,7 poäng. Båda dessa normalvärden är högre än normalvärden för yngre personer. Normalvärdet av RHI förklaras främst av höga värden för deltagarna över 85 år. Det fanns ett samband mellan resultaten på RHI/Halsskalan och VAS-skalan för grad av röstproblem, p < .01. Ålder har betydelse för den subjektiva röstupplevelsen. Ju äldre deltagarna var, desto högre poäng fick de på både RHI, p < .05 och Halsskalan. Åldersskillnaderna på Halsskalan var dock inte signifikanta. Trots att det i föreliggande studie till största del var aktiva äldre som deltog blev normalvärdet av RHI och Halsskalan högre än för yngre personer. Slutsasten är att de röstförändringar som sker med åren faktiskt har betydelse för röstupplevelsen.

Submitted by Viviane Lima da Cunha (viviane@biblioteca.ufpb.br) on 2016-01-26T14:21:45Z No. of bitstreams: 1 arquivototal.pdf: 1043037 bytes, checksum: 92788ad999f4b08f8e2b154fa22c70b0 (MD5) / Made available in DSpace on 2016-01-26T14:21:45Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1043037 bytes, checksum: 92788ad999f4b08f8e2b154fa22c70b0 (MD5) Previous issue date: 2015-04-28 / Tinnitus is the perception of sound in the absence of a sound source. Occurring between 10-15% of the world population still needs better understanding of its pathophysiology, clinical comorbidities and more effective treatments. To this end, a better standardization of the use of evaluation methods in researches is required. This study aims the choice of most appropriate and easier use and interpretation methods. Initially an article in the form of a systematic review was performed in order to establish which evaluation methods of tinnitus are currently being used by scientific works. The aim of their uses was also identified. The THI, the EVA and the acuphenometry were the most used methods in 24 articles reviewed. The evaluation of therapy for tinnitus was the most frequent verified goal. A second article was performed to carry out a comparative analysis of these three methods. It was the THI, EVA (bother) and acuphenometry (loudness and pitch) in 44 patients with chronic tinnitus. A positive correlation of moderate intensity between them was found, being stronger between THI and VAS. It is concluded that the three evaluated tests keep moderate relation to each other. this should be taken into account when comparing with each other the results of different studies. The results of THI and EVA are be more strongly compared. Other future studies with more patients and more homogeneous sample can bring more contribution to the topic. / O zumbido é a percepção de um som na ausência de uma fonte sonora. Ocorre entre 10-15% da população mundial. Há a necessidade de melhor padronização do uso dos métodos avaliativos nas pesquisas, permitindo assim melhores comparações dos seus resultados. Este estudo visa contribuir na escolha dos métodos mais adequados e de mais fácil uso e interpretação. Inicialmente realizou-se um artigo de revisão sistemática, a fim de observar os métodos avaliativos do zumbido mais utilizados e o objetivo dos mesmos. Nos 24 artigos de revista analisados, o THI, a EVA e a acufenometria foram os métodos mais utilizados. A avaliação de terapia para o zumbido foi o mais frequente objetivo verificado. Um segundo artigo foi elaborado para analisar comparativamente estes 3 métodos. Aplicou-se o THI, EVA (incômodo) e acufenometria (loudness e pitch), em 44 pacientes com zumbido crônico. Encontrou-se uma correlação positiva de moderada intensidade entre eles, sendo mais forte entre o THI e a EVA. Concluiu-se que os 3 métodos avaliados guardam relação moderada entre si, devendo isso ser levado em consideração quando se comparam seus resultados entre si. Os escores do THI e da EVA podem mais fortemente serem comparados.

A presente pesquisa foi desenvolvida com o objetivo de analisar qual a maneira mais adequada de evidenciar na Demonstração do Valor Adicionado, as receitas das entidades do terceiro setor diante das diversas fontes disponíveis para captá-las. Subsidiariamente e com base na conclusão da tese de doutorado de Fregonesi (2009) de que os investimentos socioambientais feitos pelas empresas às entidades sem fins lucrativos são, em determinadas situações, distribuição do valor adicionado, o presente estudo objetivou analisar o impacto da referida conclusão na DVA das entidades sem fins lucrativos, mais especificamente, das fundações e institutos empresariais e suas eventuais implicações na utilidade da DVA como instrumento auxiliar para o cálculo da participação deste setor no produto nacional. As entidades utilizadas como exemplos são as associadas ao Grupo de Institutos, Fundações e Empresas (GIFE) sendo descartadas as que não possuíam a expressão \"Instituto\" ou \"Fundação\" em suas denominações sociais e entidades que não publicaram suas demonstrações contábeis de 2010 com notas explicativas em suas páginas eletrônicas ou no Diário Oficial Empresarial de São Paulo entre o período de janeiro a abril de 2011. Foram incluídas na análise a Fundação Instituto de Pesquisas Contábeis, Atuariais e Financeiras (FIPECAFI) e a Fundação Salvador Arena em função de sua notoriedade e para enriquecer a compreensão do modus operandi dessas entidades no processo de captação de recursos. Os resultados sugerem que nem todas as entidades do terceiro setor geram valor adicionado, assumindo, em alguns casos, o papel de meras gestoras de recursos advindos de suas mantenedoras, que buscam dar forma à sua responsabilidade social. Neste caso, por haver redistribuição secundária de renda, o produto nacional não computaria a participação dessas entidades. / This research was developed in order to analyze what the most appropriate way to highlight the Value Added Statement, revenues from the third sector entities on the various sources available to capture them. Secondly and based on the conclusion of the doctoral thesis of Fregonesi (2009) that social and environmental investments made by companies to nonprofits are, in certain situations, the distribution of value added, this study aimed to analyze the impact of this conclusion at VAS of nonprofits, more specifically, enterprise foundations and institutes and its possible implications on the usefulness of the VAS as an aid for calculating the contribution of this sector in the national gross product. The entities used as examples are associated with the Group of Institutes, Foundations and Enterprises (GIFE) being discarded those that did not have the term \"Institute\" or \"Foundation\" in their names or entities that did not publish its financial statements with notes, 2010 explanatory in its pages in the Official Gazette or Electronic Business São Paulo between January and April 2011. Were included in the analysis the Research Institute of Accounting, Actuarial and Financial (FIPECAFI) and Salvador Arena Foundation because of its reputation and to enrich the understanding of the modus operandi of these entities in the process of fundraising. The results suggest that not all third sector entities generate added value, assuming in some cases, the role of mere management of resources from their keepers, who seek to shape their social responsibility. In this case, because there is secondary redistribution of income, national gross product does not compute the participation of these entities.

Submitted by Miriam Lucas (miriam.lucas@unioeste.br) on 2018-05-08T16:32:57Z No. of bitstreams: 2 Tiago_Luis_Brugnera_2018.pdf: 272902 bytes, checksum: 78f3c5235d2759b653f42ffb28d643b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2018-05-08T16:32:57Z (GMT). No. of bitstreams: 2 Tiago_Luis_Brugnera_2018.pdf: 272902 bytes, checksum: 78f3c5235d2759b653f42ffb28d643b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-03-20 / Financial performance indicators are the most sought-after diagnostic methods by enterprise’s stakeholders, such as profitability, payable capacity and capital management. However, a growing interest has been redirected to the social reflexes of business activities, beyond the economic result. One of the contemporary ways of evaluating social indicators is by analyzing quotients from the Value Added Statement (VAS), an accounting statement integrated to Brazilian accounting by Law 11,638 / 2007. After selecting economic and social performance variables, the present paper aimed to investigate the possible correlation between such constructs in the non-cyclical market segment of the Brazilian stock market. Data collected by analyzing the individual financial statements of the entities selected revealed a strong canonical correlation between social performance and economic performance, with highlights to the correlated power between profitability, indebtedness and the potential of the entity's net equity to generate added value. / Indicadores de desempenho financeiros são os métodos diagnósticos mais buscados por stakeholders em um empreendimento, tais como rentabilidade, capacidade de pagamento e administração do capital. Todavia, um crescente interesse tem sido redirecionado aos reflexos sociais das atividades empresariais, para além do resultado econômico. Uma das formas contemporâneas de avaliar indicadores sociais é por meio de análise de quocientes provenientes da Demonstração do Valor Adicionado – DVA, demonstração contábil integrada à contabilidade brasileira pela Lei nº 11.638/2007. Após seleção de variáveis de desempenhos econômicos e sociais, o presente estudo objetivou investigar eventual correlação entre tais constructos no mercado do segmento de consumo não cíclico na bolsa de valores do Brasil. Dados levantados mediante análise das demonstrações contábeis individuais das entidades selecionadas para a pesquisa revelaram forte correlação canônica entre desempenho social e desempenho econômico, com destaques para o poder correlacionado entre rentabilidade, endividamento e o potencial do patrimônio líquido da entidade em gerar valor adicionado

The current trend towards large-scale research projects with big quantities of data from multiple sources require robust and efficient data handling. This thesis explores techniques for automatizing research data pipelines. Specifically, two tasks related to automation within a long-term research project in cognitive neuroscience are addressed. The first task is to develop a tool for automatic transcribing of paper-based questionnaires using computer vision. Questionnaires containing continuous scales, so called visual analog scales (VASs), are used extensively in e.g. psychology. Despite this, there currently exists no tool for automatic decoding of these types of questionnaires. The resulting computer vision system for automatic questionnaire transcribing we present, called "VASReader", reliably detects VAS marks with an accuracy of 98%, and predicts their position with a mean absolute error of 0.3 mm when compared to manual measurements. The second task addressed in this thesis project is to investigate whether machine learning can be used to detect anomalies in Magnetic Resonance Imaging (MRI) data. An implementation of the unsupervised anomaly detection technique Isolation Forest shows promising results for the detection of anomalous data points. The model is trained on image quality metric (IQM) data extracted from MRI. However, it is concluded that the site of scanning and MRI machine model used affect the IQMs, and that the model is more prone to classify data points originating from machines and institutions that have less support in the database as anomalous. An important conclusion from both tasks is that automation is possible and can be a great asset to researchers, if an appropriate level and type of automation is selected.