Mixing is a crucial process for many large scale and small scale applications from food industry to cosmetics, from drug industry to petrochemical processes, etc. Changes in parameters (temperature, viscosity, velocity distribution, etc.) during the mixing affect the production process and the end product quality and the cost. Thus, these parameters, mostly the hydrodynamic parameters, should be monitored closely during the process. In order to ensure good and efficient mixing in the solution, high degree of turbulence is maintained while dead zones in the tank should be avoided. In chemical industry, the mixing processes generally involve complex solutions that exhibit non-Newtonian flow behavior that merits a study on the agitation hydrodynamics and mixing time. Thus, in this study agitation of carboxymethyl cellulose (CMC) solution in a laboratory scale mixing tank is investigated. The effects of CMC concentration and agitation speed on the hydrodynamics of the solution and mixing time are studied in detail. CMC concentrations studied are 0.5 wt%, 1 wt% and 2 wt%. Impeller speeds, on the other hand, are set as 150 rpm, 300 rpm and 600 rpm. The hydrodynamics of mixing can be studied easily by Ultrasound Doppler Velocimetry (UDV) which is a fast, non-invasive measuring technique in fluid dynamics. Also, the mixing time measurements were carried out through electrical conductivity of the agitated solution. UDV results show that the flow field has a typical pattern produced by the Rushton turbine. The main characteristics of the flow are that, in the impeller region radial components of the flow dominate. Near the wall flow occurs mainly in the axial direction towards the top and bottom of the tank. Mixing time measurements reveal that mixing time increases with decreasing impeller speed and with increasing solution concentration (i.e. viscosity). Typical mixing time values are in the range of 250-2600 seconds for different impeller speeds and CMC concentrations.

The pattern of mucosal blood flow in normal human stomachs, and benign gastric ulcers was assesed with laser Doppler flowmetry and the relationship between a single determination of ulcer blood flow and the systemic level of growth factors was investigated. A significant ascending gradient in mucosal blood flow from the antrum to fundus was demonstrated. Different levels of cellular activity in the regions of the stomach may explain this gradient. In the gastric ulcers that healed on standard medical therapy mucosal blood flow was significantly increased in comparison to normal stomachs. In the ulcers that were refractory to standard medical therapy mucosal blood flow was significantly lower than in normal stomachs and healing ulcers. Higher systemic levels of the growth factor bFGF were demonstrated in healing ulcers compared to non-healing ulcers. Gastric mucosal blood flow can increase in response to the increased metabolic demands of healing, however impairment of this response may be an important factor preventing healing of benign gastric ulcers. It would appear that non-healing of gastric ulcers can be predicted at initial diagnosis by reduced peri-ulcer gastric mucosal blood flow and low blood levels of bFGF. / Thesis (M.Med.Sc.)-University of Natal, Durban, 1999.

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Orientador: Anibal Faundes / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-08T03:02:55Z (GMT). No. of bitstreams: 1 FerreiraNeto_PedroPires_D.pdf: 756822 bytes, checksum: 391b94a37ae61d1eb12c2c4f4b8aeacb (MD5) Previous issue date: 2006 / Resumo: Objetivo: Avaliar a capacidade dos índices de pulsatilidade das artérias umbilical e cerebral média e a relação do índice de pulsatilidade umbilico-cerebral em fetos de gestantes hipertensas de predizer risco de resultados perinatais adversos de acordo com a idade gestacional. Métodos: No período de janeiro de 2000 a agosto de 2004 foi realizada a avaliação dopplervelocimétrica dos índices de pulsatilidade da artéria umbilical (IPAU), da artéria cerebral média (IPACM) e da relação do índice de pulsatilidade umbilical/cerebral (IPAU/IPACM) de 289 gestantes com hipertensão artérial, com idade gestacional entre 24 a 41 semanas de gestação. Os resultados doplervelocimétricos que apresentaram IPAU acima do percentil 95 ou fluxo diastólico ausente ou reverso, IPACM abaixo do percentil 5 e relação IPAU/IPACM acima do percentil 95, foram avaliados quanto à capacidade de prever resultados perinatais adversos (Apgar do 5º minuto < 7, recém-nascido pequeno para a idade gestacional (RN PIG), ocorrência da doença da síndrome do desconforto respiratório (SDR), ocorrência da síndrome hipóxico-isquêmica (SHI) e óbito perinatal. Estes resultados foram comparados entre si sem ajuste e com ajuste pela idade gestacional no parto. Resultados: Os resultados alterados da dopplervelocimetria não estiveram associados ao risco de Apgar do 5º minuto < 7, antes de ajustar por idade gestacional. Com o ajuste, o risco aumentou. Entretanto, apenas a associação com alteração do IPAU alcançou significação estatística. O risco de ocorrência de recém-nascido PIG aumentou entre cinco e sete vezes na análise sem ajuste e em torno de três vezes na análise ajustada, e foi estatisticamente significativa para todos os parâmetros da dopplervelocimetria estudados. O risco de SHI aumentou entre duas e cinco vezes antes do ajuste. O aumento do risco ajustado foi significativo apenas para IPAU e relação IPAU/IPACM. Quanto ao risco da SDR houve aumento de duas a seis vezes na análise sem ajuste, mas na análise ajustada não houve aumento. Na análise da mortalidade perinatal o risco não ajustado foi entre três e dez vezes maior, nos casos com alteração do IPAU, IPACM e na relação IPAU/IPACM. Na análise ajustada apenas o IPAU alterado apresentou associação com risco quase três vezes maior e foi estatisticamente significativo. Conclusão: Neste grupo selecionado de gestantes hipertensas, a análise isolada do IPAU apresentou melhor correlação com os resultados perinatais do que a análise do IPACM ou da relação IPAU/IPACM, particularmente quando a análise foi feita com o ajuste da idade gestacional / Abstract: Objetive: To evaluate the capacity of the pulsatility Index of the umbilical artery and of the median cerebral artery and of the umbilical/cerebral ratio to predict adverse perinatla outcomes. Métodos: Dopplervelocimetric evaluation of the pulsatility Index of the umbilical artery (IPAU) and of the Median cerebral artery (IPACM) and of the umbilical/cerebral ratio (IPAU/IPACM) was carried out 289 pregnant women with hypertension at 24 through 41 weeks of gestation. Abscent or reverse diastolic flux and, IPAU above the 95 percentil, IPACM below percentil 10 and IPAU/IPACM ratio over the 95 percentil were evaluated in relation to its associasaion with adverse perinatal outcomes (5 minutes Apgar score < 7, small for gestational age (PIG), hialine membrane disease (DMH), hipoxic ischemic syndrome (SHI) and perinatal death. These results were compare before and after adjustment by gestational age at birth. Results: Abnormal Doppler results were not associated with the risk of 5 minutes Apgar score < 7 before adjustment by gestational age. After adjustment the risk increased, but only adnormal IPAU was significantly associated with. 5 minutes Apgar score < 7. The risk of PIG was 5 to 7 times higher before adjustment and arround 3 times and significantly higher after adjustment in cases with alterations in any of the three Doppler indicators studied. The risk of SHI was increased between 2 and 5 times before adjustment, but after adjustment the risk was significantly higher when the IPAU and the IPAU/IPACM ratio were adnormal. The risk DMH appeared to be between 2 and 6 times higher before adjustment, but became insignificant for the three indicators after adjustment. The risk of perinatal death before adjustment was between 3 and 10 times higher in cases with alteration in the IPAU, IPACM and the IPAU/IPACM ratio. After adjustment, only adnormal IPAU was associated with a three folds increase risk, that was statistiocally significant. Conclusion: In this selected group of preganat women with hypertension the isolated analysys of IPAU showed the best correlation with adverse perinatal outcomes, particularly after adjustment by gestational age / Doutorado / Tocoginecologia / Doutor em Tocoginecologia

A set of laboratory experiments was carried out to distinguish flow characteristics(bed origin, shear velocity, turbulence intensity, turbulent kinetic energy) between beds of differing gravel angularity. Ten vertical profiles of velocity measurements were taken from angular and rounded fixed gravel beds with a 16 MHz micro acoustic Doppler velocimeter (ADV) sampling at 50 Hz. Both gravel beds had a bottom slope of 0.2% and were in the intermediate - roughness scale. Shear velocities were calculated using three common methods: St Venant, Reynolds stress, and Clauser. The Reynolds stress method resulted in the closest visual match to turbulence distributions proposed by others. The bed origin was found to be on average 0.24D50 and 0.21D50 for the angular and rounded gravel beds respectively. These differences, however, were not statistically significant. Turbulence intensity within 20% of the bed showed considerable scatter. The difficult measuring conditions likely prevented the ADV to detect significant differences of turbulence intensity in the longitudinal and transverse directions between the two gravel beds. But the ADV measurements in the vertical direction may well resolve turbulence even in difficult flow conditions (determined by acoustic Doppler performance curve formulation). For the vertical direction, the angular gravel bed showed an increase in TImax that extended throughout the profile. The increased turbulence intensity had a concomitant effect of increasing the turbulent kinetic energy for the angular bed.

Thesis. 1975. Ph.D.--Massachusetts Institute of Technology. Dept. of Nuclear Engineering. / Vita. / Includes bibliographical references. / Ph.D.

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The bluehead chub (Nocomis leptocephalus) is a keystone species, an ecosystem engi- neer that constructs mounded gravel nests for spawning. Chubs provide benefits for other spawning fishes, predators, and benthic organisms through their nest construction. This study seeks to apply sediment transport models to find incipient motion criteria and erosion susceptibility of chubs nests. Field water flow velocities were measured with an acoustic Doppler velocimeter (ADV) in Tom's Creek, Blacksburg, Virginia, USA. ADVs are often used to collect in-situ turbulent velocity data. In almost all applications of ADVs, erroneous spikes are recorded during collection, which can significantly distort turbulence statistics de- rived from velocity fluctuations. In this study, a bivariate kernel density estimation despiking algorithm is compared to a novel univariate simplification developed as part of this work. Despiking methods are evaluated using field ADV and direct numerical simulation (DNS) data of a turbulent boundary layer. Visual assessment of despiked velocity time series and power spectra and corresponding changes in statistical moments, as well as response to arti- ficial spiking of DNS data, yield valid performance of the univariate method. After despiking chub nest data, multiple methods of finding bed shear stress from velocity vertical profiles are evaluated. Bed shear stress is found over the profile of 26 field nests. The ambient to peak flow stress amplification due to a nest's bed protrusion is found to be a proportion of τ = 1.66τ to determine a critical ambient Shields parameter of approximately τ∗ = 0.03 pa c,a for nests. / Master of Science / The bluehead chub is a keystone species, an ecosystem engineer that constructs mounded gravel nests for spawning. These nests benefit numerous other species within their habitat. The possibility of nest erosion is characterized in this study using existing sediment transport principles. Nest flow characteristics are measured using an acoustic Doppler velocimeter (ADV). ADVs are often the instrument of choice in measuring water velocity. The high resolution of these devices can capture turbulent flows well, however data collection often results in inclusion of erroneous spikes in velocity. These spikes represent points deemed impossible due to their sudden change in velocity magnitude. Spikes do not have a large effect on average velocities of ADV data, but can influence turbulence statistics that describe the turbulent fluctuations in flow velocities. To remove spikes, multiple methods incorporate different outlier detection principles. This study evaluates a popular method that employs a two-dimensional kernel density estimation (KDE) algorithm. A recent study suggested the possible simplification of this method to use a one-dimensional kernel density estimation instead. Both the 1D and 2D methods are evaluated in this study in how they filter ADV data and whether it results in a clean, improved velocity time series that would be expected in turbulent flows. A novel 1D KDE method was also developed as part of this study. The new method is found to produce the most reliable filtering. Despiked ADV data is used to characterize the hydraulics over bluehead chub nests sampled in Tom's Creek, Blacksburg, Virginia, USA. Hydraulics are evaluated to see if ambient flow upstream of a nest can characterize the flow characteristics over the peak of the nest. Shear stress amplification over the nest is used to find a critical threshold for nest erosion based on ambient flows. Stress amplification in the ambient flow to the peak over the nest is found to be a simple proportion, and amplification factor of 1.66. This means we expect shear stress over the peak of a chub nest to be 1.66 times greater than the ambient bed shear stress upstream of the nest. This amplification factor can be used with existing methods to calculate critical non- dimensional shear stress values, also known as the critical Shields stress. After accounting for the amplification factor of 1.66, a critical Shields of approximately 0.03 is found.

Turbulent swirling flows are important in many applications including gas turbines, furnaces and cyclone dust separators among others. Although the mean flow fields have been relatively well studied, a complete understanding of the flow field including its dynamics has not been achieved. The work contained in this dissertation attempts to shed further light on the behavior of turbulent swirling flows, especially focused on the dynamic behavior of a turbulent swirling flow encountering a sudden expansion. Experiments were performed in a new isothermal turbulent swirling flow test facility. Two geometrical nozzle configurations were studied. The \cb\ nozzle configuration exhibits a cylindrical \cb\ in the center of the nozzle. The free vortex nozzle configuration is obtained when the cylindrical \cb\ is removed. Detailed laser velocimeter measurements were performed to map out the flow field near the sudden expansion of the 2.9" (ID) nozzle leading to the 7.4" (ID) downstream section. In addition to presenting detailed flow profiles for both nozzle and downstream flow fields, representative frequency spectra of the flow dynamics are presented. Along with the flow time histories and histograms, the wide variety of dynamic behavior was thus described in great detail. The dynamics observed in the experiment can be classified into three main categories: coherent and large scale motion, intermittent motion and coherent periodic motion. Free vortex geometry flows, in the parameter space of the experiments (Swirl number = 0 - 0.21), exhibited mostly coherent and large scale motion. The spectra in these cases were broadband with very light concentration of spectral energy observed in some specific cases. Center--body geometry flows exhibited all three categories of flows as swirl strength was increased from zero. Flows with little or no swirl exhibited broad--band spectra similar to those for the free vortex geometry. Intermediate swirl levels resulted in a large amount of low frequency energy which, with the aid of the time histories, was identified as a large scale intermittence associated with radial movement of the annular jet as it enters the sudden expansion. Large swirl levels resulted in high magnitude coherent oscillations concentrated largely just downstream of the sudden expansion. Linear stability analysis was used to help in the interpretation of the observed dynamics. Although, as implemented here (using the parallel flow assumption), the analysis was not successful in quantitatively matching the experimentally observed dynamics, significant insight into the physical mechanisms of the observed dynamics was obtained from the analysis. Specifically, the coherent oscillations observed for larger swirl levels were able to be described in terms of the interaction between the inner and outer shear layers of the flow field. / Ph. D.