Respiratory assistance devices bypass essential host defenses and allow these pathogens direct access to the lower respiratory tract and hinder these defense systems to effectively clear respiratory pathogens (1). Mechanical ventilation in the presence of dental plaque with respiratory pathogens has the potential to lead to ventilator-associated pneumonia (VAP). Ventilator-associated pneumonia is the leading cause of morbidity and mortality in intensive care units. VAP influences increasing need for medical treatment and hospital length of stay (LOS) (2-4). Lower respiratory tract infections (LRTI) have been found to be the most expensive site per infection with 13% of all infections accounting for 29% of the total recorded cost (5). The purpose of this systematic review is to perform a comprehensive literature search to identify published randomized clinical trials relating to the efficacy of chlorhexidine gluconate (CHX) oral rinse in preventing VAP. CHX has been identified as the "gold standard" to reduce the number of microorganisms. This review also addresses the importance of oral health and the increased risk of respiratory infections from colonization by harmful pathogens within the oral mucosa. Clinical trials relating to the hypothesis in question were evaluated using Consolidated Standards of Reporting Trials (CONSORT) checklist for validity. Quality and strength of each randomized clinical trial were evaluated based on the requirements of the Agency for Healthcare Research and Quality (AHRQ). Nine bibliographic databases, from 1965-2012 were used to conduct the literature inquiry. Ten studies included populations greater than or equal to 18 years of age and admitted to the intensive care unit receiving mechanical ventilation. The patients were, ventilated due to either trauma, undergoing elective cardiothoracic surgery, or from some other form of surgery, at risk for VAP. In one study, CHX oral rinse decreased microbial colonization of the respiratory tract and hospital-acquired pneumonia (HAP) in patients who underwent open-heart surgery and were intubated less than 24 hours. Yet the difference was not significant in patients intubated more than 24 hours who had a higher amount of bacterial colonization (6). Modulation of oropharyngeal colonization by the use of oral chlorhexidine has reduced the number of ICU-acquired HAP in selected patient populations such as those undergoing coronary bypass grafting, but its routine use is not recommended until more data become available (7). Findings from several studies suggest a significant decrease in the incidence of total nosocomial respiratory infections and systemic antibiotic use in patients who underwent open heart and used a CHX oral rinse as compared with ventilator patients who did not use the rinse; there was also a 65% decrease (13% vs. 4%) in the overall nosocomial infection rate in the chlorhexidine group (7,8,9). Using 2% chlorhexidine solution presents the strongest evidence for decreasing VAP (10,11). From Scannapieco and colleagues' study we can conclude that twice daily is not necessarily better than once daily, but maybe a four times daily regimen with 2% instead of 0.12% CHX does make a difference in reducing the incidence of VAP (12).

This diploma thesis deals with the basic theoretical overview of air-conditioning noise, the description of individual devices used in ventilation and active ventilation during storage of cereals. It also describes the possibilities of application of silencers for these devices. In the practical part, it focuses on the noise measurement in the post-harvest line and the design of appropriate noise measures to meet the under-noise levels.

The aim of this thesis is to introduce the reader into theory, which is needed to make an aerodynamic calculation of flue gas part of steam boiler. On the back of the knowledge, project documentation and other entry parameters calculate sectional losses for each component and design a ventilator, that is suitable for our requirements.

Ventilator associerad pneumoni är idag en av de vanligaste vårdrelaterade infektionerna som drabbar 8- 28 procent av respiratorvårdade patienter. Denna vårdrelaterade infektion är svårast att förebygga och har högst dödlighet. Ventilator associerad pneumoni ökar patientens lidande och kostnader för samhället genom att förlänga vårdtiden och användning av antibiotika. Uppsatsens syfte var att belysa munvårdens betydelse hos intuberade patienter för att förebygga uppkomsten av VAP. Som metod att besvara studiens syfte valdes litteratutöversikt. Arton vetenskapliga artiklar inkluderades utifrån författarens syfte och frågeställningen. Samtliga publicerades mellan år 2005 och 2015. Sökning efter artiklar gjordes i databaserna Cinahl och PubMed. Sammanställning över de inkluderde studierna återfinns i matrisöversikt. Resultatet handlar om olika former av munvårdåtgärder som utförs av sjuksköterskan hos den intuberade patienten. Författaren fokuserade på munvård med Klorhexidin, munvård med tandborste, sugning ovanför trakealtubens kuff, munvård med munsköljningsmedel, oral hälsostatus i samband med förekomsten av VAP och användning av munvårdprotokoll. Slutsatsen författaren kom fram till var att oral hälsa och förekomsten av VAP står i ett tydligt samband. Risken att lungorna koloniseras genom mikroaspiration av patogena mikrober som utvecklas i munhålan hos den intuberade patienten och förorenar orofaryngeal sekret var en av de betydande mekanismer som kunde leda till VAP. Att hålla munhålan så frisk och ren som möjligt samt minimera risken för mikroaspiration av förorenad saliv var viktiga åtgärden som minimera denna mekanism. Vårdprogram som innehåller evidensbaserad munvård i kombination med andra omvårdnadsåtgärder som minimerade risken för aspiration och patogen kolonisering av munhålan gav stor effekt på förekomsten av VAP. För att kunskapen om den uppdaterade forskning inom munvården skulle nå sjukvården var det viktig att skapa skriftliga riktlinjer som introducerades hos alla personalgrupper som arbetar runt den intuberade patienten.

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Base teórica: Muitos pacientes internados em Unidade de Terapia Intensiva (UTI) necessitam da instituição da ventilação mecânica invasiva (VM). Porém esta pode trazer efeitos deletérios como: alteração na higiene brônquica e pneumonia associada à ventilação mecânica (PAV). Devido a isso, faz-se necessária avaliação de técnicas de higiene brônquicas eficazes e o menos deletérias possíveis. Objetivos: Comparar a eficácia das técnicas em estudo: vibrocompressão (VB) (G1), hiperinsuflação com o ventilador mecânico (HMV) (G2) VB + HMV (G3) na quantidade de secreção aspirada (SEC), no tempo de VM, na incidência de PAV, na reintubação orotraqueal (Re-IoT) e na mortalidade de pacientes em VM. Método: Ensaio clínico randomizado, realizado no Centro de Terapia Intensiva do Hospital de Clínicas de Porto Alegre (HCPA). Foram incluídos no estudo 93 pacientes (29 G1, 32 G2 e 32 G3) em VM por mais de 24 horas. Foram aplicadas as seguintes técnicas: aspiração isolada (ASP), VB, HMV e VB + HMV. Foram medidas as seguintes variáveis: frequência cardíaca (FC), frequência respiratória (FR), pressão arterial média (PAM), saturação arterial periférica de oxigênio (SpO2), pressão inspiratória de pico (PIP), volume corrente (VC), complacência dinâmica (Cdyn), peso da SEC; tempo de VM, Re-IoT, incidência de PAV e mortalidade na VM. Conclusão: O grupo 3 foi o único que apresentou aumento significativo da SEC, quando comparado à ASP (0,7 g (0,1-2,5) vs 0,2 g (0,0-0,6) – p = 0,006). Em comparação com os demais grupos, o grupo 2 apresentou aumento significativo na incidência de PAV (22% - p = 0,003) e Re-IoT (21,9% - p = 0,048), demonstrando assim, na amostra estudada, que VB + HMV é mais eficaz quanto à quantidade de SEC e exerce efeito protetor, juntamente com a VB, na incidência de PAV e Re-IoT. / Background: Many patients admitted to the Intensive Care Unit (ICU) require the institution of invasive Mechanical Ventilation (MV). However, this can bring harmful effects such as changes in mucociliary transport and cough capacity, leading to bronchial obstruction and Ventilator Associated-Pneumonia (VAP). Objective: To compare the efficacy of the techniques: Vibrocompression (G1), Hyperinflation with Mechanical Ventilation (G2) Vibrocompression + Hyperinflation with Mechanical Ventilation (G3) in the amount of Aspirated Secretions (AS), MV time, the incidence of VAP, Re-intubation tracheal (Re-IoT) and mortality of patients on MV. Method: Randomized clinical trial, conducted at the Intensive Care Unit, of the Hospital de Clinicas de Porto Alegre (HCPA). 93 patients were included in the study (29 G1, 32 G2 and 32 G3) in mechanical ventilation for more than 24 hours. The following techniques were applied: Isolated Aspiration (ASP), Vibrocompression (VB), Hyperinflation with Mechanical Ventilation (HMV) Vibrocompression + Hyperinflation with Mechanical Ventilation (HMV + VB). The following variables were measured: Heart Rate (HR), Respiratory Rate (RR), Mean Arterial Pressure (MAP), Peripheral Arterial Oxygen Saturation (SpO2); Peak Inspiratory Pressure (PIP), Tidal Volume (TV); Dynamic Compliance (Cdyn); weight of the AS; VM time; Re-IoT; VAP incidence and mortality in the VM. Conclusion: The HMV + VB (G3) was the only group that showed significant increase in the AS (0.7 g (0.1-2.5) vs 0.2 g (0.0-0.6) – p = 0.006) when compared to ASP. Compared with the other groups G2 showed a significant increase in the incidence of VAP (22% - p = 0.003) and Re-IoT (21.9% - p = 0.048). Thus demonstrating in the sample, which HMV + VB is more effective as the amount of secretion aspirated and has a protective effect, along with the VB, the incidence of VAP and Re-IoT.

Utgångspunkten för denna litteraturstudie är att ventilatorassocierad pneumoni (VAP) går att förebygga. Syftet med detta arbete var att kartlägga olika evidensbaserade munvårdsmetoder som används av intensivvårdssjuksköterskor för att förebygga VAP hos ventilatorbehandlade patienter. Syftet var också att belysa vilka faktorer som påverkar intensivvårdssjuksköterskans utförande av evidensbaserad munvård till ventilatorbehandlade patienter. Studien utfördes som en systematisk litteraturstudie. Till resultatet användes 16 vetenskapliga artiklar. För att kunna bedöma artiklarnas vetenskapliga kvalitet granskades artiklarna utifrån en modifierad granskningsmall. Samtliga artiklar fick höga kvalitetspoäng, vilket innebär hög vetenskaplig relevans. Resultatet av litteraturstudien visar att i flera av de evidensbaserade munvårdsprotokoll som publicerats den senaste tiden finns några återkommande punkter. Dessa punkter är; bedömning av munhålans status, tandborstning med barntandborste, munsköljmedel och att munnen fuktas med ett intervall av två till sex timmar. Flera faktorer påverkar intensivvårdssjuksköterskans utförande av evidensbaserad munvård. Genom att införa ett evidensbaserat munvårdsprotokoll för ventilatorbehandlade intensivvårdspatienter och ge personalen utbildning i munvård kan incidensen av VAP minska. Resultatet visar också att generellt sett är kunskapsnivån låg hos intensivvårdssjuksköterskor gällande förebyggande åtgärder för att förhindra VAP. Om sjuksköterskan anser att hon/han har tid att utföra munvård blir resultatet av högre kvalitet och hon/han upplever också åtgärden som mindre obehaglig. Detta innebär att försök att förbättra omvårdnaden och därmed minska antalet vårdrelaterade infektioner även är en organisatorisk fråga.

Patienter som vårdas på en intensivvårdsavdelning (IVA) är allvarligt sjuka och behöver specialiserad vård. En del av den vården är ofta ventilatorbehandlingen som kan uppfattas som en mycket mentalt påfrestande upplevelse. Syftet med denna litteraturbaserade studie var att beskriva patienters upplevelser av att vårdas i ventilator på en intensivvårdsavdelning. Datamaterialet har utgjorts av kvalitativa studier med ett patientperspektiv, vilka har analyserats kvalitativt. I resultatet framkom två huvudteman; Verkliga upplevelser och Overkliga upplevelser. Subteman som framkom till Verkliga upplevelser var upplevelser av Kommunikation, Självbestämmande och kontroll samt Miljön. Overkliga upplevelser fick subteman om IVA-syndrom och upplevelser av Sedering. Patienterna upplevde ofta en brist på kontroll där den mest dominanta orsaken var svårigheten att kunna kommunicera vilket bidrog till mental ohälsa. Denna mentala ohälsa manifesterades ofta i IVA–syndrom eller liknande tillstånd där en bidragande orsak var en orolig och förvirrande miljö samt påverkan av sedering. Positiva upplevelser beskrevs och då gärna i samband med fysisk kontakt och anhörigas närvaro. Författarna diskuterar om de olika temans faktorer och sätter dessa i samband med hälsa enligt det salutogena synsättet. / Patients in need of intensive care treatment are seriously ill and require specialized care. This includes ventilator support, which can potentially be perceived as a mentally stressful experience. The aim of this literature-based study is to describe patients' experiences of ventilatory care in an intensive care setting. The collected data contains qualitative studies from a patient perspective, which have undergone qualitative analysis. The result revealed two main themes; actual experiences and perceived experiences. Subthemes for actual experiences were; Experiences of communication, Experiences of autonomy and control as well as Experiences of the environment. Subthemes for Perceived experiences were; Experiences of ICU-syndrome and Experiences of sedation. Patients frequently perceived loss of control, which was primarily associated with difficulty to communicate. This contributed to mental ill health, and often manifested as the ICU-syndrome or a similar condition. Contributing factors included the stressful and confusing environment, as well as the effects of sedation. Conversely, the positive experiences described included physical contact and the presence of relatives. The authors discuss the aforementioned categories and their contributors whilst associating these with health according to the salutogenic model.

Background: Ventilator associated pneumonia (VAP) is a major cause of morbidity, longer intensive care unit (ICU) stay, increased duration of mechanical ventilation, and increased healthcare cost in critically ill patients. Critically ill patients are at increased risk for malnutrition, which is associated with impaired immune function, impaired ventilator drive and weakened respiratory muscles. Malnutrition has been thought to increase the risk of VAP due to bacterial translocation from the gastrointestinal tract to the lungs. Previous research that has evaluated the effect of enteral nutrition on malnutrition associated with VAP has been inconsistent in part because of the subjectivity of the old definition of VAP. In 2013, the Center for Disease Control and Prevention (CDC) developed a new definition for the diagnosis of VAP, which includes three tiers of a ventilator associated event (VAE); ventilator associated condition, infection-related ventilator-associated complication, or possible or probable VAP). The purpose of this study is to retrospectively examine the relationship between enteral formula, tube-feeding placement site, time of tube feeding initiation and the incidence of VAE using this new CDC definition. Objective: The aim of the study was to retrospectively examine the relationship between enteral formula, tube-feeding placement site, time of tube feeding initiation and the incidence of VAE using this new CDC definition. Participants/setting: The medical records of 162 adult patients admitted to one of the ICUs (Medical ICU, Surgical ICU, Neurological ICU, Burn ICU) at Grady Memorial Hospital (GMH) in Atlanta, GA in 2013 Main outcome measures: Demographic and baseline medical characteristics including the type of enteral formula used (standard, immune-modulating, hydrolyzed, immune-modulating and hydrolyzed, or mixed), enteral tube feeding placement (gastric or small bowel), and timing of enteral nutrition (never fed, fed48 hours after admission) were collected. Statistical analysis: Demographic and baseline medical characteristics were described using frequency statistics and compared by VAE status using the Mann-Whitney U and Kruskal-Wallis tests. The relationship between tube placement, enteral formula, timing of feeding and the diagnosis of a VAE was evaluated using the Chi-square test. Results: In 2013, 81 patients admitted to the ICU at GMH were diagnosed with a VAE. The median age of the study population (n=162) was 50 years (range, 19 to 88 years) and the median BMI was 27.6 kg/m2 (range, 13.2 to 83.2 kg/m2). The majority of the population was African American (53.1%) and male (64.2%). Most patients were fed through a gastric tube (86.4%), were given an immune-modulating enteral formula (32.1%) and were fed after 48 hours of admission (44.4%). After subdividing by ICU location, 12 of 14 patients (86%) in the Medical ICU who were diagnosed with a VAE were either never fed or fed >48 hours after admission vs. 7 of 13 (54%) of patients in the Medical ICU who were not diagnosed with a VAE (p=0.031). No other relationships between the type of feeding initiation, tube placement, and enteral formula were found by VAE status for the population or by ICU location. Conclusion: Adults admitted to the Medical ICU may have a reduced risk of developing a VAE if fed within 48 hours of admission. The type of enteral formula provided and the route of administration was not associated with the diagnosis of VAE. Future prospective studies should include all critical care patients to further evaluate the effect of nutrition on VAE outcome.