The aim of this thesis is to provide a SWOT analysis of the Via Foundation through which is detected potential opportunities and threats for the organization and its current strengths and weaknesses. The theoretical part explains the basic concepts, theoretical knowledge and the process itself concerning the creation of a SWOT analysis. The described methods are then used in the practical part on the example of the Via Foundation. To identify potential opportunities and threats from the external environment is used PEST analysis supported by time series analysis. For discovering potential of the organization in terms of strengths and weaknesses is used the evaluation of selected parameters of the organization as compared to the analogous organizations. In conclusion, the thesis summarizes important information obtained by this analysis and there are proposed recommendations for the organization.

The thesis focuses on the issue of spatial neglect and its neuropsychological diagnostics. The theoretical part of the thesis first summarizes recent knowledge about the neglect and offers its classification, which maps the heterogeneous nature of the disorder. Furthermore, two areas of diagnostic methods aimed at neglect detection are discussed, which are the classic "paper-pencil" tests and functional tests. Finally, these methodological areas are put into relationship, the work discusses their possible complementarity and also their use in clinical practice. In the empirical part we focus on selected classic methods and their ability to diagnose mild neglect in the Czech population. For 64 patients, we compared the sensitivity of the Bells test, the line bisection test, and the scene copying test using different criteria. We also examined double dissociations and relationships between tests, and then the relationships between the ability of instruments to detect neglect and the characteristics of probands. The results mostly confirmed the findings of the theoretical part of the thesis. The sensitivity of the methods was low and variable, there were double dissociations between the line bisection test and the other tests, and there were practically no statistically significant correlations...

Text in Afrikaans / Aquinas's five point argument for God's existence views creation as a holistic entity in which synthesis and creative influences are initiated through the interaction between minimal and maximal acts of being. These acts are represented by the per accidens and the per se respectively. Both these acts are fundamental acts which are crucial to the outcome of the argument for the existence of God. The creature who, because of his per accidens dependency, possesses minimal status, is elevated to a place of honour by participation in creation. Both the essence and esse of creatures have their origin in the pure esse of the maximal act of being (God). Maximal being, the efficient cause, grounds the similarity between itself and minimal acts of being. Both the per accidens and the per se have crucial roles to play in the verification of tbe argument. Should any one of these two elements be lacking, the argument would be invalid. / Aquinas se Quinque Via as 'n Holistiese Beredenering is 'n vyfpunt-argument vir die bestaan van God wat die skepping as 'n eenheid beskou waarin sintese en skeppende invloede bewerkstellig word deur interaksie tussen minimale en maksimale bestaansaktes. Die bestaansaktes word deur die per accidens en die per se (wat die fundamentele boustene in die argument vorm) verteenwoordig. Die skepsel wat vanwee sy per accidens- afhanklikheid beperkte status beklee, word deur bemiddeling van die per se of maksimale bestaansakte (God) tot deelgenoot verhef en beklee ·n ereplek in die skepping. Beide die esse en essensie van menslike wesens het hul oorsprong in die suiwer esse van die maksimale bestaansakte. Maksimale bestaan, die effektiewe oorsaak, begrond die ooreenkoms tussen sigself en die minimale bestaansaktes. Die per accidens sowel as die per se vervul 'n onontbeerlike rol in die bewysvoering van die argument. Sou een van die twee fundamentele elemente ontbreek, sou die argument in geheel ongeldig wees. / Philosophy, Practical & Systematic Theology / M.A. (Wysbegeerte)

Text in Afrikaans / Aquinas's five point argument for God's existence views creation as a holistic entity in which synthesis and creative influences are initiated through the interaction between minimal and maximal acts of being. These acts are represented by the per accidens and the per se respectively. Both these acts are fundamental acts which are crucial to the outcome of the argument for the existence of God. The creature who, because of his per accidens dependency, possesses minimal status, is elevated to a place of honour by participation in creation. Both the essence and esse of creatures have their origin in the pure esse of the maximal act of being (God). Maximal being, the efficient cause, grounds the similarity between itself and minimal acts of being. Both the per accidens and the per se have crucial roles to play in the verification of tbe argument. Should any one of these two elements be lacking, the argument would be invalid. / Aquinas se Quinque Via as 'n Holistiese Beredenering is 'n vyfpunt-argument vir die bestaan van God wat die skepping as 'n eenheid beskou waarin sintese en skeppende invloede bewerkstellig word deur interaksie tussen minimale en maksimale bestaansaktes. Die bestaansaktes word deur die per accidens en die per se (wat die fundamentele boustene in die argument vorm) verteenwoordig. Die skepsel wat vanwee sy per accidens- afhanklikheid beperkte status beklee, word deur bemiddeling van die per se of maksimale bestaansakte (God) tot deelgenoot verhef en beklee ·n ereplek in die skepping. Beide die esse en essensie van menslike wesens het hul oorsprong in die suiwer esse van die maksimale bestaansakte. Maksimale bestaan, die effektiewe oorsaak, begrond die ooreenkoms tussen sigself en die minimale bestaansaktes. Die per accidens sowel as die per se vervul 'n onontbeerlike rol in die bewysvoering van die argument. Sou een van die twee fundamentele elemente ontbreek, sou die argument in geheel ongeldig wees. / Philosophy, Practical and Systematic Theology / M.A. (Wysbegeerte)

Made available in DSpace on 2017-07-10T16:32:27Z (GMT). No. of bitstreams: 1 Osmarina_ Garcia.pdf: 2444640 bytes, checksum: bb0fc20ecfd6367dce2985afacf8a24d (MD5) Previous issue date: 2015-03-03 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Lately, much has been studied and discussed in the academic and business worlds for Knowledge Management and the interaction between tacit and explicit knowledge. In the quest to find out the trapping of people in organizations, this study aimed mainly to investigate which factor(s) of knowledge management by tacit route and/or explicit are crucial in retaining professionals in a company of furniture industry. In the methodology, it was used exploratory research to conduct a survey with quali-quantitative approach. The data were collected between June to August 2014, in a furniture industry located in Francisco Beltrão - PR. Data collection was conducted through a questionnaire administered to 224 employees of administrative, industrial and commercial, distributed according to their positions in: 11 managers, 44 sectors chargers and 169 operational workers. The Likert scale was the mean of detecting the frequency of the opinions of the employees that answered the research. To provide greater consistency to the conclusions, the data were analyzed statistically, using the Multivariate Analysis. It was applied the techniques of Principal Component Analysis and Factor Analysis, separately for the tacit and explicit way to identify the relationship between the factors of both pathways through indexes. Subsequently, it was used the techniques Correspondence Analysis and Canonical Correlation Analysis to measure the association between tacit via versus service time and explicit via versus service time (present company and position). It was also elaborated a contingency table for variables: group 1 - age, gender, education level, area and position with the group 2 - length of service in the current position and length of service in the company, through the Chi-square test. Statistical analyzes have been made in the free software R. It was found that among these hypotheses, the confirmed one was: knowledge management is a determining factor in retaining professionals to the organization by the tacit and explicit way. In seeking the association between groups formed by similar questionnaire answers with the group 1 (social factors) and group 2 (service time), found that the explicit route has more influence on employee retention by the factors: selection policies, remuneration policies, benefits policies, training systems, performance evaluation, promotion systems in career and job title. Only the recruitment policies factor exerts no influence on employee retention. For tacit way, the greatest influence is on the factors: management leadership and interpersonal skills. Therefore, it is concluded that both pathways influence the retention of employees of the company searched. / Ultimamente muito se tem pesquisado e discutido nos meios acadêmicos e empresarial em relação a Gestão do Conhecimento e a interação entre o conhecimento tácito e explícito. Na busca para descobrir o que determina a retenção das pessoas nas organizações, este trabalho teve como objetivo central, investigar qual(is) fator(es) da gestão do conhecimento pela via tácita e/ou explícita são determinantes na retenção dos profissionais em uma empresa do ramo moveleiro. Na metodologia, utilizou-se de pesquisa exploratória para realizar um levantamento com abordagem quali-quantitativa. Os dados foram coletados no período de junho a agosto de 2014, em uma indústria de móveis localizada na cidade de Francisco Beltrão - PR. A coleta foi realizada por meio de um questionário aplicado a 224 funcionários das áreas administrativa, industrial e comercial, distribuídos conforme seus cargos em: 11 gerentes, 44 encarregados de setores e 169 trabalhadores operacionais. A escala de Likert foi o meio de detectar a frequência das opiniões dos funcionários respondentes da pesquisa. Para proporcionar maior consistência às conclusões, os dados foram submetidos a tratamento estatístico, utilizando-se da Análise Multivariada. Foram aplicadas as técnicas de Análise de Componentes Principais e Análise Fatorial, separadamente para a via tácita e explícita para identificar a relação existente entre os fatores de ambas as vias por meio de índices. Posteriormente, utilizou-se das técnicas Análise de Correspondência e Análise de Correlação Canônica para medir a associação entre via tácita versus tempo de serviço e via explícita versus tempo de serviço (cargo atual e empresa). Elaborou-se também uma tabela de contingência para relacionar as variáveis: grupo 1 idade, gênero, grau de escolaridade, área e cargo com o grupo 2 tempo de serviço no cargo atual e tempo de serviço na empresa, por meio do Teste Qui-Quadrado. As análises estatísticas foram elaboradas no software livre R. Constatou-se que dentre as hipóteses levantadas, a confirmada foi: a gestão do conhecimento é fator determinante na retenção de profissionais para a organização pelas vias tácita e explícita. Ao buscar a associação entre grupos formados pelas respostas similares do questionário com o grupo 1 (fatores sociais) e grupo 2 (tempo de serviço), verificou que a via explícita exerce maior influência na retenção do funcionário pelos fatores: políticas de seleção, políticas de remuneração, políticas de benefícios, sistemas de treinamento, avaliação de desempenho, sistemas de promoção na carreira e cargo. Apenas o fator políticas de recrutamento não exerce influência na retenção dos funcionários. Para a via tácita, a maior influência está nos fatores: gestão de líderes e relacionamento interpessoal. Portanto, conclui-se que ambas as vias exercem influência na retenção dos funcionários da empresa pesquisada.

Teckning är för mig ett koncentrerat, metodiskt och poetiskt sätt att nå ogripbara fenomen och visuellt fascinerande eller tankeeggande återgivningar. Ofta utgår jag från naturvetenska- pens bildmaterial och insprieras av dess metodiska och till synes sakliga sätt att beskriva och redogöra för hur verkligheten tycks hänga samman. I korthet kan mitt arbete beskrivas som ett tankemässigt och bildmässigt utforskande där urval och sammanförande genererar symboliska närmanden på flera skalor och nivåer samtidigt.

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Modeling approaches are developed to optimize emerging on-chip and off-chip electrical interconnect technologies and benchmark them against conventional technologies. While transistor scaling results in an improvement in power and performance, interconnect scaling results in a degradation in performance and electromigration reliability. Although graphene potentially has superior transport properties compared to copper, it is shown that several technology improvements like smooth edges, edge doping, good contacts, and good substrates are essential for graphene to outperform copper in high performance on-chip interconnect applications. However, for low power applications, the low capacitance of graphene results in 31\% energy savings compared to copper interconnects, for a fixed performance. Further, for characterization of the circuit parameters of multi-layer graphene, multi-conductor transmission line models that account for an alignment margin and finite width of the contact are developed. Although it is essential to push for an improvement in chip performance by improving on-chip interconnects, devices, and architectures, the system level performance can get severely limited by the bandwidth of off-chip interconnects. As a result, three dimensional integration and airgap interconnects are studied as potential replacements for conventional off-chip interconnects. The key parameters that limit the performance of a 3D IC are identified as the Through Silicon Via (TSV) capacitance, driver resistance, and on-chip wire resistance on the driver side. Further, the impact of on-chip wires on the performance of 3D ICs is shown to be more pronounced at advanced technology nodes and when the TSV diameter is scaled down. Airgap interconnects are shown to improve aggregate bandwidth by 3x to 5x for backplane and Printed Circuit Board (PCB) links, and by 2x for silicon interposer links, at comparable energy consumption.

Em estudos anteriores desenvolvidos por este grupo de pesquisa uma expressão mais elevada de alvos transcricionais e componentes da via NF-kB, bem como altos níveis de NOTCH1, foi identificada em células-tronco hematopoéticas (CTH) CD34+ de sangue de cordão umbilical (SCU) quando comparadas às CTH CD34+ de medula óssea (MO). Este grupo verificou ainda, por comparação das células CD34+ com as CD133+ (mais primitivas) que diversos fatores de transcrição (FT) envolvidos com o potencial de hemangioblasto, com a autorenovação das CTH, e com a diferenciação linfóide; como: RUNX1/AML1, GATA3, USF1, TAL1/SCL, HOXA9 e HOXB4 apresentaram-se mais expressos em células mais primitivas. A potencial participação das vias Notch e NF-kB na regulação destes FT tem importância conceitual e prática no entendimento da biologia das CTH, e dos processos envolvidos na diferenciação destas células. Com isto em vista, este projeto teve como objetivo, estudar o papel da via NF-kB e da via Notch na regulação destes FT. Para isso, um modelo experimental in vitro, de diferenciação de CTH CD34+ em linfócitos T, foi utilizado e a influência de fatores agonistas e inibidores farmacológicos destas vias, foram avaliados por citometria de fluxo e PCR em tempo real. Nossos resultados evidenciam o papel da via Notch na regulação transcricional de HOXB4 e GATA3 em células-tronco hematopoéticas CD34+ humanas, o que foi confirmado com base na expressão dos alvos diretos de Notch (HEY1 e HES1). Notamos ainda, que a expressão dos transcritos HES1, GATA3 e HOXB4 é prejudicada pela síntese protéica das CTH, uma vez que quando empregamos o prétratamento com a droga CHX há aumento da transcrição dos mesmos. Também podemos inferir que a ação do TNF- é positiva sobre esses transcritos, já que quando o utilizamos há elevação do nível de expressão desses transcritos, com exceção a HES1. Em relação ao cocultivo das CTH com as células estromais de camundongos, verificamos que apenas a linhagem OP9-DL1 detém a capacidade de promover a diferenciação celular T, e isso foi comprovado pelo surgimento de células comprometidas com a linhagem linfocítica T, através da presença dos marcadores de superfície específico CD7+ e CD1a+. Esses resultados auxiliarão na compreensão dos mecanismos moleculares de regulação transcricional envolvidos não apenas na diferenciação de linfócitos T, mas também na manutenção de um estado mais primitivo das CTH. Este conhecimento pode vir a contribuir com o desenvolvimento ou otimização de protocolos laboratoriais visando à expansão de CTH ou geração de células T para usos terapêuticos. / In previous studies by this research group a higher expression of transcriptional targets and components via NF-kB, as well as high levels of NOTCH1, was identified in hematopoietic stem cells (HSC) CD34 + cells from umbilical cord blood (UCB) compared to CD34 + hematopoietic stem cells from bone marrow (BM). This group also found, by comparing the CD34 + cells with CD133 + (more primitive) that several transcription factors (TF) involved in the potential of hemangioblast, with self-renewal of hematopoietic stem cells and to differentiated lymphocytic; as Runx1 / AML1, GATA3, USF1, TAL1/SCL, HOXB4 and HOXA9 were more expressed in more primitive cells. The potential involvement of Notch signaling pathways and NF-kB in the regulation of FT has conceptual and practical importance in understanding the biology of HSC, and the processes involved in differentiation of these cells. With this in mind, this project aimed to study the role of NF-kB pathway and Notch signaling in the regulation of FT. For this, an experimental model in vitro differentiation of CD34 + hematopoietic stem cells into T lymphocytes, was used and the influence of pharmacological agonists and inhibitors of these pathways were evaluated by flow cytometry and real-time PCR. Our results highlight the role of Notch signaling in the transcriptional regulation of GATA3 and HOXB4 in hematopoietic stem cells CD34 + human, which was confirmed based on the expression of direct targets of Notch (HES1 and HEY1). We also note that the expression of transcripts HES1, GATA3 and HOXB4 protein synthesis is hampered by the HSC, since when we use the pre-treatment with the drug there CHX increased transcription thereof. We can also infer that the action of TNF- is positive about these transcripts, since when we use it for raising the level of expression of these transcripts, except the HES1. In relation to the HSC coculture with stromal cells of mice, we found that only the line-DL1 Op9 has the ability to promote T cell differentiation, and this was evidenced by the appearance of cells committed to the T lymphocyte lineage, through the presence of specific surface markers CD7 + and CD1a +. These results will help understand the molecular mechanisms of transcriptional regulation involved not only in the differentiation of T lymphocytes, but also in maintaining a more primitive state of HSC. This knowledge may contribute to the development or optimization of laboratory protocols aimed at the expansion of HSC or generation of T cells for therapeutic use.

O Bairro Cambuí surge com o início do povoamento da cidade de Campinas, no século XVIII, pelas incursões dos bandeirantes pelo interior do Brasil, através de uma estrada rústica que passava pelo local, denominada caminho dos Goiazes; um dos descampados, campinhos ou campinas do qual a cidade originou-se corresponde às proximidades da atual Praça XV de Novembro. O nome do bairro se deve à presença abundante, na época, da espécie denominada cambuí, Myrciaria tenella (DC.) O.Berg., em sua área, que a população, originalmente, chamava de cambuizal. O bairro constituiu-se, inicialmente, em morada e habitação para prostitutas e negros escravos, fugidos e libertos, tendo relação direta com essa importante etnia; posteriormente, passou a ser residência da nova elite cafeeira em ascensão. O ajardinamento público, a arborização viária do bairro, e da cidade de Campinas foram realizados para, juntamente à outras melhorias urbanas, transformar suas péssimas condições sanitárias, resgatando a auto-estima do campineiro e a sua qualidade de vida, após várias epidemias, que dizimaram e expulsaram parcela significativa de sua população. O acúmulo de capital oriundo da cultura do café permitiu a criação do grande patrimônio arbóreo, tanto do bairro, atualmente, com 47.000 moradores, quanto de Campinas, referendando-a. Realizou-se o censo da arborização viária do bairro, totalizando 2.087 árvores vivas, distribuídas em 117 espécies, 94 gêneros e 42 famílias identificadas, 21 indivíduos arbóreos e 12 palmeiras não identificadas, além, de 74 mortas. Existem 25,2 árvores a cada Km de calçada evidenciando uma carência, de 74,8 árvores/Km, nos seus 82.880m de passeio, resultando num total de 6.199 indivíduos, segundo a Lei 11.571. A espécie predominante foi a sibipiruna, Caesalpinia pluviosa DC., com 261 indivíduos (12,51%). As nativas representaram 1.117 exemplares (53,5%), distribuídas em 46 espécies; as exóticas, 937 (44,9%). As 10 primeiras espécies concentram (54,2%), 1.131 árvores, destacando-se a presença de 5 nativas e 5 exóticas (2 delas arbustivas); a primeira colocada desta categoria, a pata de vaca, Bauhinia variegata L., com 129 indivíduos (6,18%). Os principais problemas foram: afloramentos de raiz (24,39%), árvores desequilibradas por poda (22,62%), pragas (6,09%) e doença (1,39%). As substituições recomendadas por risco, sub-aproveitamento do local de plantio (pela utilização de arbustos), senescência das árvores e morte totalizam 497 indivíduos (23,81%). A falta de fiscalização, planejamento, acompanhamento e manejo técnicos, práticas adequadas por parte das concessionárias de serviços públicos aéreos e subterrâneos, a especulação imobiliária, prestadores de serviços, comércio, a própria população, o tráfego intenso e a poluição de veículos, tornam crítico o estado atual dessa arborização, ameaçando a história do bairro. Este bem comum deve ser o foco de políticas públicas que garantam a sua efetiva proteção. Como um dos benefícios à municipalidade, destaca-se, a área ocupada pela copa das árvores (13,92ha), superior à de várias áreas verdes centrais municipais. / The Cambuí neighborhood first appears with the start of the colonization in the city of Campinas in the century XVIII, by the bandeirantes incursions crossing the interior of Brazil, utilizing a rustic road which was located in the region denominated Goiazes way. One of the open descampados, campinhos , or campinas which the city originated from is near the XV de novembro square. It was named after the common presence, at that time, of the species denominated cambuí, Myrciaria tenella (DC.) O.Berg., in its area which the population called cambuizal and subsequently, Cambuí. The neighborhood was, initially, residence of prostitutes and black slaves, escaped and free, having a close relation with this important ethnic group; later on it became residence of the coffees new elite. The public gardening, the street arborization in the neighborhood and in the city of Campinas were realized, with other urban improvements, to transform its bad sanitary conditions and to recover the self esteem of Campinas citizen and his quality of life, after many epidemies, that decimated and banned significant portion of its population. The accumulation of capital produced in the coffee culture, allowed the creation of the big patrimony of the neighborhood, currently with 47.000 inhabitants, and as of Campinas and which transformed the city, making it a reference. The cense of the neighborhoods street arborization was carried out, totalizing 2.087 of live trees, distributed in 117 species, 94 genus and 42 families identified, furthermore, 74 dead. There are 25,2 trees on each Km of sidewalk, resulting in a less of 6.199 individuals, according the law 11.571. The predominant species was the sibipiruna, Caesalpinia pluviosa DC., with 261 individuals (12,52%). The natives represented 1.117 exemplaries (53,5%), distributed in 46 species; the exotics 937 (44,9%). The 10 first species concentrated (54,2%), 1.131 trees, highlighting the presence of 5 natives an 5 exotic (2 of it shrubs); the first classified on this category, the pata de vaca, Bauhinia variegata L., with 123 individuals (5,9%). Its main problems were: raising of roots (24,39%), lost balanced trees by prune (22,62%) plagues (6,09%) and disease (1,39%). It was indicated 497 individuals (23,81%) to be substituted and 1.470 potential places to immediate planting. The lack of control, planning, technical handle, adequate practices of the concessionaries of aerial and underground public services, real state speculation, commerce, own population, intense traffic and pollution of vehicles, make the current state this arborization critical, menacing the history of the neighborhood. This common area must be the focus of public politics to guarantee its effective protection. As one of the benefits to the municipalities, it stands out the fact that the area occupied by trees tops (13,92ha) is higher than many municipally central green areas.