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Previous issue date: 2010-05-07 / Introduction: Mouth cancer is classified as having one of the ten highest cancer incidences in the world. In Brazil, the incidence and mortality rates of oral cancer are among the highest in the world. Intraoral cancer (tongue, gum, floor of the mouth, and other non-specified parts of the mouth), the accumulated survival rate after five years is less than 50%. Objectives: Estimate the accumulated survival probability after five years and adjust the Cox regression model for mouth and oropharyngeal cancers, according to age range, sex, morphology, and location, for the city of Natal. Describe the mortality and incidence coefficients of oral and oropharyngeal cancer and their tendencies in the city of Natal, between 1980 and 2001 and between 1997 and 2001, respectively. Methods: Survival data of patients registered between 1997 and 2001 was obtained from the Population-based Cancer Record of Natal. Differences between the survival curves were tested using the log-rank test. The Cox proportional risk model was used to estimate risk ratios. The simple linear regression model was used for tendency analyses of the mortality and incidence coefficients. Results: The probability after five years was 22.9%. The patients with undifferentiated malignant neoplasia were 4.7 times more at risk of dying than those with epidermoid carcinoma, whereas the patients with oropharyngeal cancer had 2.0 times more at risk of dying than those with mouth cancer. The mouth cancer mortality and incidence coefficients for Natal were 4.3 and 2.9 per 100 000 inhabitants, respectively. The oropharyngeal cancer mortality and incidence coefficients were, respectively, 1.1 and 0.7 per 100 000 87 inhabitants. Conclusions: A low survival rate after five years was identified. Patients with oropharyngeal cancer had a greater risk of dying, independent of the factors considered in this study. Also independent of other factors, undifferentiated malignant neoplasia posed a greater risk of death. The magnitudes of the incidence coefficients found are not considered elevated, whereas the magnitudes of the mortality coefficients are high / Introdu??o: O c?ncer de boca ? classificado como uma das dez maiores incid?ncias de c?ncer no mundo. No Brasil, as taxas de incid?ncia e de mortalidade por esse c?ncer encontram-se entre as mais elevadas do mundo. Para o c?ncer intraoral (l?ngua, gengiva, base da boca e outras e n?o especificadas partes da boca), a taxa acumulada de sobrevida ap?s 5 anos ? menor que 50%. Objetivo: Estimar a probabilidade acumulada de sobrevida ap?s 5 anos, ajustar o modelo de regress?o de Cox para os c?nceres de boca e de orofaringe, segundo faixa et?ria, sexo, morfologia e localiza??o, para a cidade de Natal, Brasil. Descrever os coeficientes de mortalidade e de incid?ncia dos c?nceres de boca e de orofaringe e as tend?ncias desses coeficientes para a cidade de Natal, nos per?odos de 1980 a 2001 e de 1997 a 2001, respectivamente. Metodologia: Foi obtida a sobrevida de pacientes registrados entre 1997 e 2001 no Registro de C?ncer de Base populacional de Natal. Foram testadas as diferen?as entre as curvas de sobrevida atrav?s do teste log-rank. O modelo de riscos proporcionais de Cox foi utilizado para estimativas das raz?es de riscos. O modelo de regress?o linear simples foi utilizado para as an?lises de tend?ncia dos coeficientes de incid?ncia e de mortalidade. Resultados: A probabilidade acumulada ap?s 5 anos para todos os casos foi de 22,9%. Os pacientes com neoplasia maligna indiferenciada t?m 4,7 vezes mais risco de morrer do que aqueles com carcinoma epiderm?ide, enquanto que os pacientes com c?ncer de orofaringe t?m 2,0 vezes mais risco de morrer do que aqueles com c?ncer de boca. Os coeficientes padronizados de mortalidade e de incid?ncia do c?ncer de boca em Natal foram, respectivamente, 2,9 e 4,3 por 100 mil habitantes. Para o c?ncer de orofaringe 10 os coeficientes obtidos de mortalidade e de incid?ncia foram, respectivamente, 1,1 e 0,7 por 100 mil habitantes. Conclus?o: Identifica-se uma baixa taxa de sobrevida ap?s 5 anos. Pacientes com c?ncer de boca apresentam menos risco de morte, independentemente dos fatores considerados neste estudo. Tamb?m de forma independente dos demais fatores, a neoplasia maligna indiferenciada apresenta um maior risco de morte. As magnitudes dos coeficientes de incid?ncia encontradas n?o s?o consideradas elevadas, enquanto que de forma contr?ria est?o as magnitudes dos coeficientes de mortalidade
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/13182 |
| Date | 07 May 2010 |
| Creators | Azevedo, Paulo Roberto Medeiros de |
| Contributors | CPF:32381611487, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4786083Z7&dataRevisao=null, Galv?o, H?bel Cavalcanti, CPF:41291824472, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4794937Z9, Ferreira, Maria ?ngela Fernandes, CPF:39817270459, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4767285D3, Oliveira, M?rcio Campos, CPF:67676146534, http://lattes.cnpq.br/5703051980918880, Maciel, Shirley Suely Soares Veras, CPF:42637910453, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4773895T8, Costa, Ant?nio de Lisboa Lopes |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Ci?ncias da Sa?de, UFRN, BR, Ci?ncias da Sa?de |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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