published_or_final_version / Medicine / Master / Doctor of Medicine

Enabled by advanced communication and information technologies, the smart grid represents a major transformation for the electricity sector. Vast quantities of data and two-way communications abilities create the potential for a flexible, data-driven, multi-directional supply and consumption network well equipped to meet the challenges of the next century. For electricity service providers (“utilities”), the smart grid provides opportunities for improved business practices and new business models; however, a transformation of such magnitude is not without risks. Three related studies are conducted to explore the implications of the smart grid on utilities’ demand-side activities. An initial conceptual framework, based on organizational information processing theory, suggests that utilities’ performance depends on the fit between the information processing requirements and capacities associated with a given demand-side activity. Using secondary data and multiple regression analyses, the first study finds, consistent with OIPT, a positive relationship between utilities’ advanced meter deployments and demand-side management performance. However, it also finds that meters with only data collection capacities are associated with lower performance, suggesting the presence of information waste causing operational inefficiencies. In the second study, interviews with industry participants provide partial support for the initial conceptual model, new insights are gained with respect to information processing fit and information waste, and “big data” is identified as a central theme of the smart grid. To derive richer theoretical insights, the third study employs a grounded theory approach examining the experience of one successful utility in detail. Based on interviews and documentary data, the paradox of dynamic stability emerges as an essential enabler of utilities’ performance in the smart grid environment. Within this context, the frames of opportunity, control, and data limitation interact to support dynamic stability and contribute to innovation within tradition. The main contributions of this thesis include theoretical extensions to OIPT and the development of an emergent model of dynamic stability in relation to big data. The thesis also adds to the green IS literature and identifies important practical implications for utilities as they endeavour to bring the smart grid to reality. / Thesis (Ph.D, Management) -- Queen's University, 2013-01-21 12:04:43.652

This thesis deals with the Shannon-theoretic fundamental limits of channel coding for single-user channels with memory and feedback and for multi-user channels with side information. We first consider the feedback capacity of a class of symmetric channels with memory modelled as nite-state Markov channels. The symmetry yields the existence of a hidden Markov noise process that facilitates the channel description as a function of input and noise, where the function satisfies a desirable invertibility property. We show that feedback does not increase capacity for such class of finite-state channels and that both their non-feedback and feedback capacities are achieved by an independent and uniformly distributed input. As a result, the capacity is given as a difference of output and noise entropy rates, where the output is also a hidden Markov process; hence, capacity can be approximated via well known algorithms. We then consider the memoryless state-dependent multiple-access channel (MAC) where the encoders and the decoder are provided with various degrees of asymmetric noisy channel state information (CSI). For the case where the encoders observe causal, asymmetric noisy CSI and the decoder observes complete CSI, inner and outer bounds to the capacity region, which are tight for the sum-rate capacity, are provided. Next, single-letter characterizations for the channel capacity regions under each of the following settings are established: (a) the CSI at the encoders are non-causal and asymmetric deterministic functions of the CSI at the decoder (b) the encoders observe asymmetric noisy CSI with asymmetric delays and the decoder observes complete CSI; (c) a degraded message set scenario with asymmetric noisy CSI at the encoders and complete and/or noisy CSI at the decoder. Finally, we consider the above state-dependent MAC model and identify what is required to be provided to the receiver in order to get a tight converse for the sum-rate capacity. Inspired by the coding schemes of the lossless CEO problem as well as of a recently proposed achievable region, we provide an inner bound which demonstrates the rate required to transmit this information to the receiver. / Thesis (Ph.D, Mathematics & Statistics) -- Queen's University, 2013-07-12 13:48:59.849

Growing demand for electricity forces suppliers to expand their generation capacity. Financing these expansion programmes results in electricity cost increases above inflation rates. By reducing electricity consumption, additional supply capacity is created at lower costs than the building of conventional power stations. Therefore, there is strong justification to reduce electricity consumption on the supplier and consumer side. The mining and industrial sectors of South Africa consumed approximately 43% of the total electricity supplied by Eskom during 2012. Approximately 10% of this electricity was used to produce compressed air. By reducing the electricity consumption of compressed air systems, operating costs are reduced. In turn this reduces the strain on the South African electricity network. Previous energy saving projects on mine compressed air systems realised savings that were not always sustainable. Savings deteriorated due to, amongst others, rapid employee turnover, improper training, lack of maintenance and system changes. There is therefore a need to improve projects that have already been implemented on mine compressed air systems. The continuous improvement of equipment (such as improved control valves) and the availability of newer technologies can be used to improve existing energy saving strategies. This study provides a solution to reduce the electricity consumption and operating costs of a deep level mine compressed air system. This was achieved by modernising and improving an existing underground compressed air saving strategy. This improvement resulted in a power saving of 1.15 MW; a saving equivalent to an annual cost saving of R4.16 million. It was found that the improved underground compressed air DSM project realised significant additional electrical energy savings. This resulted in ample cost savings to justify the implementation of the project improvements. It is recommended that opportunities to improve existing electrical energy saving projects on surface compressed air systems are investigated. / MIng (Mechanical Engineering), North-West University, Potchefstroom Campus, 2014

Occupant thoracic injury incurred during side impact automotive crashes constitutes a significant portion of all fatal and non-fatal automotive injuries. The limited space between the impacting vehicle and occupant can result in significant loads and corresponding injury prior to deceleration of the impacting vehicle. Within the struck vehicle, impact occurs between the occupant and various interior components. Injury is sustained to human structural components such as the thoracic cage or shoulder, and to the internal visceral components such as the heart, lungs, or aorta. Understanding the mechanism behind these injuries is an important step in improving the side impact crash safety of vehicles. This study is focused on the development of a human body numerical model for the purpose of predicting thoracic response and trauma in side impact automotive crash. <br /><br /> The human body model has been created using a previously developed thoracic numerical model, originally used for predicting thoracic trauma under simple impact conditions. The original version of the thorax model incorporated three-dimensional finite element representations of the spine, ribs, heart, lungs, major blood vessels, rib cage surface muscles and upper limbs. The present study began with improvements to the original thorax model and furthered with the development of remaining body components such that the model could be assessed in side impact conditions. <br /><br /> The improvements to the thoracic model included improved geometry and constitutive response of the surface muscles, shoulder and costal cartilage. This detailed thoracic model was complimented with a pelvis, lower limbs, an abdomen and a head to produce the full body model. These components were implemented in a simplified fashion to provide representative response without significant computational costs. The model was developed and evaluated in a stepwise fashion using experimental data from the literature including side abdominal and pelvic pendulum impact tests. <br /><br /> The accuracy of the model response was investigated using experimental testing performed on post mortem human subjects (PMHS) during side and front thoracic pendulum impacts. The model produced good agreement for the side thoracic and side shoulder pendulum impact tests and reasonable correlation during the frontal thoracic pendulum impact test. Complex loading via side sled impact tests was then investigated where the body was loaded unbelted in a NHTSA-type and WSU-type side sled test system. The thorax response was excellent when considering force, compression and injury (viscous criterion) versus time. Compression in the thorax was influenced by the arm position, which when aligned with the coronal plane produced the most aggressive form of compressive loading possible. The simplified components provided good response, falling slightly outside experimental response corridors defined as one standard deviation from the average of the experimental PMHS data. Overall, the predicted model response showed reasonable agreement with the experimental data, while at the same time highlighting areas for future developments. The results from this study suggested that the numerical finite element model developed herein could be used as a powerful tool for improving side impact automotive safety.

The anticonvulsant drug, Dilantin, in many cases must be taken by epileptic mothers to control seizures during pregnancy, but unfortunately, it has been characterized as a human teratogen. It has also been demonstrated that many of the teratogenic effects of Dilantin occur during postimplantation, but some studies implicate a detrimental role for Dilantin during the preimplantation stages of development. Some of the postimplantation effects include congenital malformations and the potential'loss of the fetus. Our lab has proposed that in preimplantation mouse embryos the drug may be altering the timing of expression of cell cycle regulatory proteins and therefore, we have begun to examine the expression of these proteins. Thus, it was the goal of this study to characterize and localize various cell cycle proteins at specific time points in normal in vivo preimplantation mouse embryos, as this will provide important baseline information for studies on how anticonvulsant drugs may alter cell cycle regulation in embryos.Western blotting has confirmed the presence of cyclin BI in G1 of the first cell cycle. Both cyclin E and CDK2 were not detected in GI or G2/M of the first cell cycle or GI of the second cell cycle.From the immunogold TEM experiments, the density of cyclin B1 staining was observed to be the highest at G1 of the first cell cycle and declined at S and G2/M. Cyclin B 1 was detected in all regions of the embryo including the microvilli, cortical cytoplasm, interior cytoplasm, and was observed to be associated with vesicles and some filaments. The gold particles at GI, S, and G2/N4 of the first cell cycle and G1 of the second cell cycle appear to be associated with filamentous and membraneous structures and not free in the cytoplasmic spaces. Cyclin B 1 expression was more concentrated around vesicles at G1 of the first cell cycle and in general, was more concentrated around vesicles than in microvilli and cortical cytoplasm, interior cytoplasm, or around filaments at each cell cycle stage tested. / Department of Biology

Schizophrenia is a debilitating psychiatric condition affecting almost one percent of the US population. Typical antipsychotics (e.g., haloperidol) have been in use for several decades and are generally very effective in treating the emotional and cognitive effects of schizophrenia, but are used as the last line of treatment due to their severe extrapyramidal motor side effects under chronic exposure. The present study was conducted to investigate the role of sex in determining the oromotor side effects of typical antipsychotics via measuring different behavioral dimensions of male and female Sprague-Dawley rats licking sucrose after haloperidol treatment. The results showed a stronger sensitivity in female rats than male rats within total licking responses and inter-lick intervals. The present results suggest closer attention needs to be paid to the role that sexual hormones play in the motor slowing and behavior-reducing effects of antipsychotics.

Research questions 1. What kind of risks in the supply side of HUAWEI supply chain can be identified? 2. How can supply side risks of HUAWEI supply chain be assessed? 3. How can supply side risks of HUAWEI supply chain be mitigated? Purpose This paper describes supply side risks in HUAWEI in China, the types of risks identified, provides guidelines for assessment of these risks and suggestions for mitigation. Methodology In order to answer above research questions empirical data have been collected through observations, interviews at with logistics managers of HUAWEI in China, and from the official documents, annual reports and authentic web pages of the HUAWEI. Theoretical framework has been built through scientific articles, peer reviewed journals, authentic web based documents, and textbooks. The information is then assessed and analyzed, which result in conclusion and recommendations for the company. Conclusion There can be four major risks identified on the supply side. Manufacturing risk, logistics risk, information risk and inventory risk. The manufacturing risk include risks related to production, skill, and quality. The logistics risk further include delivery risk, lead time risk, and transportation risk. Production risk and skill risk are critical and they can be avoided by enhancing risk awareness, evaluating production feasibility, strengthen staff training, investing in high skills, strengthening R&amp;D, and analysis of the external environment. The quality and inbound delivery risks can be reduced through supplier inspection and establishing good supplier relations. Lead time risk and inventory risk can be reduced by vendor based managed inventory system and mass customization. Meanwhile, transportation risk can adopt risk transfer strategy. The information risk can be reduced by increasing information sharing levels and adopting modern communication technologies.

In many studies of the side-chain liquid crystalline polymers (SCLCPs) bearing azobenzene mesogens as pendant groups, obtaining the orientation of azobenzene mesogens at a macroscopic scale as well as its control is important, because it impacts many properties related to the cooperative motion characteristic of liquid crystals and the trans-cis photoisomerization of the azobenzene molecules. Various means can be used to align the mesogens in the polymers, including rubbed surface, mechanical stretching or shearing, and electric or magnetic field. In the case of azobenzene-containing SCLCPs, another method consists in using linearly polarized light (LPL) to induce orientation of azobenzene mesogens perpendicular to the polarization direction of the excitation light, and such photoinduced orientation has been the subject of numerous studies. In the first study realized in this thesis (Chapter 1), we carried out the first systematic investigation on the interplay of the mechanically and optically induced orientation of azobenzene mesogens as well as the effect of thermal annealing in a SCLCP and a diblock copolymer comprising two SCLCPs bearing azobenzene and biphenyl mesogens, respectively. Using a supporting-film approach previously developed by our group, a given polymer film can be first stretched in either the nematic or smectic phase to yield orientation of azobenzene mesogens either parallel or perpendicular to the strain direction, then exposed to unpolarized UV light to erase the mechanically induced orientation upon the trans–cis isomerization, followed by linearly polarized visible light for photoinduced reorientation as a result of the cis–trans backisomerization, and finally heated to different LC phases for thermal annealing. Using infrared dichroism to monitor the change in orientation degree, the results of this study have unveiled complex and different orientational behavior and coupling effects for the homopolymer of poly{6-[4-(4-methoxyphenylazo)phenoxy]hexyl methacrylate} (PAzMA) and the diblock copolymer of PAzMA-block- poly{6-[4-(4-cyanophenyl) phenoxy]hexyl methacrylate} (PAzMA-PBiPh). Most notably for the homopolymer, the stretching-induced orientation exerts no memory effect on the photoinduced reorientation, the direction of which is determined by the polarization of the visible light regardless of the mechanically induced orientation direction in the stretched film. Moreover, subsequent thermal annealing in the nematic phase leads to parallel orientation independently of the initial mechanically or photoinduced orientation direction. By contrast, the diblock copolymer displays a strong orientation memory effect. Regardless of the condition used, either for photoinduced reorientation or thermal annealing in the liquid crystalline phase, only the initial stretching-induced perpendicular orientation of azobenzene mesogens can be recovered. The reported findings provide new insight into the different orientation mechanisms, and help understand the important issue of orientation induction and control in azobenzene-containing SCLCPs. The second study presented in this thesis (Chapter 2) deals with supramolecular side-chain liquid crystalline polymers (S-SCLCPs), in which side-group mesogens are linked to the chain backbone through non-covalent interactions such as hydrogen bonding. Little is known about the mechanically induced orientation of mesogens in S-SCLCPs. In contrast to covalent SCLCPs, free-standing, solution-cast thin films of a S-SCLCP, built up with 4-(4’-heptylphenyl) azophenol (7PAP) H-bonded to poly(4-vinyl pyridine) (P4VP), display excellent stretchability. Taking advantage of this finding, we investigated the stretching-induced orientation and the viscoelastic behavior of this S-SCLCP, and the results revealed major differences between supramolecular and covalent SCLCPs. For covalent SCLCPs, the strong coupling between chain backbone and side-group mesogens means that the two constituents can mutually influence each other; the lack of chain entanglements is a manifestation of this coupling effect, which accounts for the difficulty in obtaining freestanding and mechanically stretchable films. Upon elongation of a covalent SCLCP film cast on a supporting film, the mechanical force acts on the coupled polymer backbone and mesogenic side groups, and the latter orients cooperatively and efficiently (high orientation degree), which, in turn, imposes an anisotropic conformation of the chain backbone (low orientation degree). In the case of the S-SCLCP of P4VP-7PAP, the coupling between the side-group mesogens and the chain backbone is much weakened owing to the dynamic dissociation/association of the H-bonds linking the two constituents. The consequence of this decoupling is readily observable from the viscoelastic behavior. The average molecular weight between entanglements is basically unchanged in both the smectic and isotropic phase, and is similar to non-liquid crystalline samples. As a result, the S-SCLCP can easily form freestanding and stretchable films. Furthermore, the stretching induced orientation behavior of P4VP-7PAP is totally different. Stretching in the smectic phase results in a very low degree of orientation of the side-group mesogens even at a large strain (500%), while the orientation of the main chain backbone develops steadily with increasing the strain, much the same way as amorphous polymers. The results imply that upon stretching, the mechanical force is mostly coupled to the polymer backbone and leads to its orientation, while the main chain orientation exerts little effect on orienting the H-bonded mesogenic side groups. This surprising finding is explained by the likelihood that during stretching in the smectic phase (at relatively higher temperatures) the dynamic dissociation of the H-bonds allow the side-group mesogens to be decoupled from the chain backbone and relax quickly. In the third project (Chapter 3), we investigated the shape memory properties of a S-SCLCP prepared by tethering two azobenzene mesogens, namely, 7PAP and 4-(4'-ethoxyphenyl) azophenol (2OPAP), to P4VP through H-bonding. The results revealed that, despite the dynamic nature of the linking H-bonds, the supramolecular SCLCP behaves similarly to covalent SCLCP by exhibiting a two-stage thermally triggered shape recovery process governed by both the glass transition and the LC-isotropic phase transition. The ability for the supramolecular SCLCP to store part of the strain energy above T[subscript g] in the LC phase enables the triple-shape memory property. Moreover, thanks to the azobenzene mesogens used, which can undergo trans-cis photoisomerization, exposure the supramolecular SCLCP to UV light can also trigger the shape recovery process, thus enabling the remote activation and the spatiotemporal control of the shape memory. By measuring the generated contractile force and its removal upon turning on and off the UV light, respectively, on an elongated film under constant strain, it seems that the optically triggered shape recovery stems from a combination of a photothermal effect and an effect of photoplasticization or of an order-disorder phase transition resulting from the trans-cis photoisomerization of azobenzene mesogens.

This study determined attitudes held by television reporters nationwide toward PR practitioners' demonstrated knowledge of the technical side of television news. Findings. that emerged from the study were: 1. Television reporters were undecided whether practitioners needed an educational background in PR, and believed they needed an educational but not a professional background in television reporting. 2. They believed practitioners knew too little and should improve their knowledge, and that practitioners' employers would benefit therefrom. 3. They valued the assistance of practitioners. 4. There were moderate degrees of off-the-job contact and interest therein. 5. They divided evenly on the question concerning practitioners' specific demonstrated knowledge of the technical side of television news.