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Cardiovascular disease is the leading cause of mortality in diabetic patients, and diabetes is one of the main causes of cardiovascular disease. Risk factors for cardiovascular disease result in structural and functional changes in the vascular wall. Arterial stiffness is a prominent structural change observed in the arterial wall that can be measured in clinical settings. The purpose of this thesis was to create a static model of the changes in arterial stiffness seen in diabetes. Elastic tubes with varying wall thicknesses were used to create artificial arteries for this purpose. Compliance (inverse of stiffness) of the arteries was determined using a pressurevolume model and a mathematical model. The compliance curves generated using the pressurevolume model exhibited trends predicted by the mathematical model. These trends were comparable to arterial stiffness changes seen in diabetes. Compliance obtained from pressurevolume measurements of elastic tubes with varying wall thickness can therefore be used to model the general trends of arterial stiffness in diabetes.

京都大学 / 新制・課程博士 / 博士(理学) / 甲第23726号 / 理博第4816号 / 新制||理||1689(附属図書館) / 京都大学大学院理学研究科化学専攻 / (主査)教授 杉山 弘, 教授 深井 周也, 教授 秋山 芳展 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

Measurements and predictions of railway-induced vibrations are becoming a necessity in today’s society where land scarcity causes buildings to be put close to railway traffic. The short distances mean an increased risk of the indoor vibration and noise disturbances experienced by residents. In short, the scope of the project is to investigate the transmission loss and vibration level decrease across various junction geometries. The junctions are modelled in both the Finite Element Method (FEM) and the Dynamic Stiffness Method (DSM). Resonances are avoided when possible by using semi-infinite building components. A two-dimensional model that included Timoshenko beams was set up by Wijkmark [1] and solved using the variational formulation of the DSM by Finnveden [2]. The model is efficient and user-friendly but there is no easy way to adjust the junction geometry since the depths of the walls and the floor slabs are the same. From that study, the current topic was formulated. The results presented in this paper indicate that both the Euler-Bernoulli DS model and the three-dimensional FE model have good potential in describing the vibration transmission across the different junction geometries. The two modelling types show more similar results in the analyses of the bending wave attenuation than in the analyses of the quasilongitudinal wave attenuation. One of the probable causes is that the set length of the Perfectly Matched Layers (PML) is not sufficient at such low frequencies. Larger PMLs require bigger geometries that lead to an increase of the computational time. The other proposed reason is the fact that bending waves are created above the asymmetrical junction when the lower beam is excited by a vertical harmonic force. The flexural displacements are neglected in those cases. The results however, were good enough to be satisfactory. Three junction models were investigated and the attenuation is the highest for both wave types in the case with a beam pair attached to the “middle” of an infinite plate. The attenuation is the second highest across the edge of a semi-infinite plate and the lowest across a junction corner of a semi-infinite plate. As part of the suggested future work, the wave transmission between beam and plate needs to be investigated when Timoshenko beams are included in the DS model. In the Euler-Bernoulli beam theory the cross-section remains perpendicular to the beam axis, which is different to the behaviour of solid elements in FEM.

Serial articulated industrial manipulators are increasingly used in machining applications due to their flexibility in application and their cost-effectiveness compared to conventional machinery. However, the use of industrial manipulators in machining processes that subject the robot to high loads such as in drilling is limited. The relatively low mechanical stiffness leads to position offsets from the anticipated position. Efforts have been made in the past to create manipulator calibration methods to compensate for their low stiffness and to increase their pose accuracy. The Department of Production Engineering at KTH Royal Institute of Technology defined a static and quasi-static compliance calibration procedure for industrial manipulators. Contrary to the hypothesis, the two methods produce different results in terms of the measured magnitude of Cartesian deflections. This study compares static and quasi-static compliance measurement procedures on an ABB IRB 6700-300/2.70 and aims at finding causes for the difference in the measured deflection of the manipulator between the two methods. Therefore, a literature review is performed and based on the review a novel quasi-static measurement procedure is presented. Deflections during the application of static and quasi-static loads with a frequency of less than 0.5 Hz on the manipulator are measured and compared. Differences in deflection are seen and potential causes are analyzed in several experiments. Namely, by changing parameters the resulting effects on the manipulator due to kinematic errors and dynamic effects are investigated. The results stress that unlike the expectation based on the theory of mechanics the system shows a dynamic behavior if a periodic loading with a frequency of less than 0.5Hz is applied during the quasi-static experiments. The difference in deflection is thus explained through load dissipation by damping and inertial forces during the quasi-static measurements of the novel method. This does not apply to the quasi-static measurement procedure defined by the Production Engineering department. Moreover, differences in deflection were identified due to friction and backlash acting in the transmissions system of the motors when static loads are applied in certain regions of the task space. Future work in the analysis of differences in compliance measurement procedures is encouraged to find causes for the quasi-static measurement results of the department. / Serieartikulerade industriella manipulatorer används allt mer i bearbetande operationer tack vare dess flexibilitet i användande och dess kostnadseffektivitet jämfört med konventionella maskiner. Dock är användandet av industriella manipulatorer i bearbetningsprocesser som utsätter roboten för höga laster så som borrande begränsat. Den relativt höga mekaniska stelheten leder till positionsförskjutningar från den förväntade positionen. Ansträngningar har tidigare gjorts för att skapa kalibreringsmetoder för manipulatorer som ska kompensera för dess låga stelhet och öka dess position och orienterings-exakthet. Institutionen för industriell produktion vid Kungliga Tekniska Högskolan har definerat en statisk och kvasistatisk efterlevnads-kalibrerings-procedur för industriella manipulatorer. I motsats till hypotesen producerade de två metoderna olika resultat i avseende till den uppmätta magnituden för Kartesiska böjningar. Denna studie jämför statiska och kvasistatiska efterlevnads-mätnings-procedurer hos en ABB IRB 6700-300/2.70 och siktar på att hitta orsaker för skillnaden i den uppmätta böjningen av manipulatorn mellan de två metoderna. Därmed genomförs en litteraturstudie och baserat på en översikt presenteras en ny kvasistatisk mätningsprocedur. Böjningar under påverkan av statiska och kvasistatiska laster på under 0.5 Hz på manipulatorn uppmäts och jämförs. Skillnader i böjningar kan ses och potentiella orsaker analyseras i flera experiment. Genom byte av parametrar kan effekter på den industriella manipulatorn som orsakas av kinematiska fel och dynamiska effekter undersökas. Resultatet understryker att olikt förväntningarna som baserats på teorier från mekaniken uppvisar systemet ett dymaniskt beteende om en periodisk last på mindre än 0.5 Hz appliceras under de kvasistatiska experimenten. Skillnaden i böjningen förklaras därmed genom ett lastminskande som beror på dämpande och tröga krafter under de kvasistatiska mätningarna av den nya metoden. Detta gäller inte den kvasistatiska mätningsproceduren som definerats av Institutionen för industriell produktion. Utöver detta identifieras skillnader i böjningar med avseende på friktion och glapp i överföringssystemet i motorerna när statiska laster appliceras på specifika regioner i arbetsområdet. Framtida arbete i analys av skillnader i efterlevnadsmätnings-procedurerna uppmuntras för att hitta orsaker till institutionens kvasistatiska mätningsresultat.

In this thesis project, the possibility to make use of a mechanical spring to achieve stiffness adjustability in a shock absorber for mountain bikes is evaluated. A mechanical spring increases the shock absorber’s sensitivity compared to a fully adjustable air spring. Today, there are no mechanical springs available on the market that offer enough stiffness adjustment to suit different riders with large variation in weight. Therefore, a mechanical spring with a wide stiffness adjustment range could be ground-breaking if it is possible to implement in mountain bike shock absorbers. The work has been carried out in accordance with a product- and concept development approach where the final concept design has been optimised analytically and verified numerically. The developed spring has been integrated in a new damper design and the complete damper and spring system has been dimensioned to fit current mountain bike frames. The result is a prototype shock absorber with a spring to suit riders between 70-88kg. An alternative spring for cyclists between 59-75kg has also been proposed. Since these springs have been made to fit current mountain bikes, it was possible to conclude that a mechanical spring witha wide range of adjustable stiffness is feasible for mountain bike application. With available spring steels, it is not possible to accommodate every rider with only one spring. It is however possible to achieve adjustment that is suitable for a rider weight range of roughly 15-16kg. This is between 70-110% more than similar products available on the market can offer. / I detta examensarbete utvärderas möjligheten att använda en mekanisk fjäder för att uppnå justerbar fjäderstyvhet hos en stötdämpare avsedd för terrängcykling. En mekanisk fjäder ökar stötdämparens känslighet jämfört med en fullt justerbar luftfjäder. I dagsläget finns på marknadeningen mekanisk fjäder vilken kan erbjuda tillräcklig justeringsmån för att passa cyklister med stor viktvariation. Därför kan en mekanisk fjäder med ett brett styvhetsspann vara banbrytande om en sådan kan tillämpas på dagens terrängcyklar. Arbetet har utförts som ett produkt- och konceptutvecklingsprojekt där den slutliga konceptdesignen har optimerats analytiskt och verifierats numeriskt. Den fjäder som tagits fram har integrerats i en ny dämparkonstruktion och stötdämparsystemet har dimensionerats för att passa dagens terrängcyklar. Resultatet är en prototyp av en stötdämpare med en fjäder som passar cyklister mellan 70-88kg. En alternativ fjäder passande cyklister mellan 59-75kg har också tagits fram. Eftersom en justerbar fjäder vars design möjliggör användning i en stötdämpare för dagens terrängcyklar har slutsatsen dragits att en justerbar mekanisk fjäder kan fungera inom detta tillämpningsområde. Det är inte möjligt med dagens material att utforma en mekanisk fjäder med tillräckligt justerbar styvhet föratt passa alla åkare. Det är däremot möjligt att använda en fjäder som passar cyklister inom ett viktspann på omkring 15-17kg. Detta är mellan 70–110% mer än vad liknande produkter tillgängliga på marknaden idag kan erbjuda.

<p>Arterial stiffness is a natural and inevitable process for an ageing artery. In adults and school-aged children, increased stiffness of the central arteries is associated with cardiovascular disease (CVD) and CVD risk factors. Arterial stiffness, and its relationship with adiposity and physical activity (PA), has not been studied in preschool-aged children (3-5 years) despite the high prevalence of obesity and inactivity in this age group. Ninety-eight healthy preschoolers (4.4 ± 0.9 years; 50% boys) participated in this thesis, completing baseline and follow up assessments 12.5 ± 1.1 months apart. Whole-body PWV (carotid to dorsalis pedis; m/s) was used to assess arterial stiffness, body mass index percentile (BMI%ile) was a surrogate measure of adiposity, and PA levels (total, TPA; moderate-to-vigorous, MVPA) were quantified objectively with accelerometers and expressed as a percent of wear time. In our cohort, PWV increased significantly from baseline (4.3 m/s) to follow up (4.8 m/s; p< .001). PWV also tracked fair-to-moderately well (κ=0.25, r=0.37) with no sex differences (χ²=.485, p=.785). Girls had a higher BMI%ile than boys, and the prevalence of overweight/obese preschoolers increased from 18.8% to 21.3% over the 1-year period. Boys were more active than girls and engaged in more MVPA. 75% of preschoolers at baseline, and 70% at follow up, met the current PA guidelines (3-hrs of TPA/day). PWV was not related to BMI%ile or PA at baseline; however, it was weakly related to TPA (r=-0.28, p=.013) and MVPA (r=-0.25, p=.024) at follow up. Furthermore, longitudinal and cross-sectional regression models of sex, age, BMI%ile and TPA or MVPA could not predict PWV. Our findings indicate that adiposity and PA do not influence arterial stiffness in healthy 3 to 5 year old children. Nevertheless, maintaining a healthy body composition and engaging in regular PA has other health benefits and should be encouraged.</p> / Master of Science (MSc)

<p>A comprehensive understanding of the mechanisms regulating vascular structure and function may assist in designing effective strategies to decrease cardiovascular disease risk. The current studies were designed to investigate a) relationships between collagen markers and arterial stiffness and markers of vasoconstriction and inflammation and endothelial function in humans with a wide range of vascular health, including overweight women, elderly healthy men, individuals with coronary artery disease, individuals with spinal cord injury and young healthy men and b) changes in arterial structure and function and circulating serum markers of type I collagen synthesis and degradation, vasoconstriction and inflammation in overweight pre-menopausal women before and after a 16- week diet and exercise intervention. Resting brachial artery flow mediated dilation (FMD), upper limb and/or central pulse wave velocity (PWV_c-r and PWV_c-f) and carotid artery distensibility were assessed at baseline in all groups and, in the overweight population, after the 16-week intervention. Pro-collagen type I C-peptide (PIP), C-telopeptide of type I collagen (CTX), markers of collagen synthesis and degradation respectively, endothelin-1 (ET-1) a vasoconstrictor and interleukin-6 (IL-6) an inflammatory marker were measured. In the spectrum of vascular health, a negative relationship exists between collagen markers and central PWV (CTX–PWV_c-f: r = -0.41, p = 0.001 and PIP – PWV_c-f: r = -0.32, p = 0.01) and a positive relationship between markers and carotid distensibility (CTX: r = 0.59, pc-r increased over time in the overweight population (FMD pre: 4.1 ± 0.5 % vs. post: 6.9 ± 0.7 %, pc-r pre: 8.1 ± 0.3 m/s vs. post: 8.9 ± 0.3 m/s, p</p> / Doctor of Philosophy (PhD)