To better manage deteriorating infrastructure, quantitative data about the performance of infrastructure assets is required. Rayleigh based distributed fibre optic strain sensing (FOS) is a technology that has the potential to offer this type of data and unlike traditional strain sensors it can measure the strain along the full length of the structure. A series of experiments were undertaken to develop installation techniques and evaluate sensor accuracy for typical civil engineering materials: steel, concrete and reinforced concrete. The results of these experiments showed that the choice of sensing fibre and adhesive was dependent on the material being monitored. When the sensing fibre and adhesive are chosen correctly, the Rayleigh system can provide the same accuracy as a strain gauge for steel and concrete, and useful measurements can be obtained even in areas of concrete cracking. The FOS technique was utilized to determine whether distributed strain measurements could be used to detect and quantify localized deterioration of the steel reinforcement (localized area reductions of 0-30%) at service loads. A series of specimens was tested, the sensing system was able to detect the presence of localized deterioration with embedded nylon and polyimide fibres, but the nylon fibre cannot quantify large strain gradients due to slip within the sensing fibre. The strain profiles gave insights to the failure mechanism occurring in the reinforced concrete specimens. The strain profiles for both test series indicated that the tension reinforcement was acting as a tension tie and the strain profiles suggested the presence of compressive struts indicative of an arching mechanism in the specimens. The Black River bridge in Madoc, Ontario was instrumented with fibre optics sensors to determine whether the use of FOS is both practical and beneficial for reinforced concrete bridge assessment when compared to conventional instrumentation. The FOS showed reasonably good agreement with conventional sensors. The fibre optic strain results are used to calculate curvature, slope and displacement but careful consideration of the boundary conditions is required. The results from the fibre optic sensors can be used to show the bridge load distribution and give insights into the support conditions of the beams. / Thesis (Master, Civil Engineering) -- Queen's University, 2013-08-21 11:56:53.276

Vibratory driven sheet piles are a cost-effective retaining wall structure, and in coming decades the continued use of this method will be crucial for minimising costs within the construction sector. However, vibratory driven sheet piles are a source of ground vibrations, which may harm structures or induce disturbance. Most urban construction projects face strict limits on permissible vibration level. Being able to reliably predict the expected vibration level prior to construction is therefore highly important. Reliable prediction demands a profound knowledge of the vibration transfer process, from source to point of interest. This thesis focuses on clarifying the vibration transfer process and will serve as a platform for the future development of a reliable prediction model. The vibration transfer process is divided into two main parts: vibration source and vibrations in soil. The different parts in the vibration transfer process are studied and investigated with the help of a literature review, field tests and numerical modelling. Within the scope of this thesis, three field tests have been conducted and a new instrumentation system has been developed. The new instrumentation system enables recording of both sheet pile vibrations and ground vibrations at depth during the entire driving. The field tests aimed to study the vibration transfer from sheet pile to soil and the vibration transfer within a sheet pile wall, as well as the wave pattern in soil. To study sheet pile behaviour during driving a numerical model was developed, which is also meant to serve as a basis for further studies. The main scientific contribution of this thesis is the identification of the sheet pile behaviour during driving. For practical application, the main contribution is the development of an increased knowledge of the vibration transfer process from source to soil, together with the new instrumentation system and the development of the numerical model. / Vibrodriven spont är en kostnadseffektiv stödkonstruktion och i framtiden kommer den fortsatta användningen av denna metod att vara nödvändig för att minimera kostnader för byggprojekt. Vibrodriven spont är dock en källa till markvibrationer, som kan skada byggnader eller orsaka störningar. De flesta byggprojekt måste förhålla sig till strikta krav gällande vibrationsnivåer. Möjligheten att på ett tillförlitligt sätt förutsäga vibrationsnivåerna innan bygget startar är därför av största vikt. Tillförlitlig prognos av vibrationsnivåer i samband med vibrodrivning av spont kräver god kännedom om vibrationsöverföringsprocessen, från källan till det potentiella skadeobjektet. Denna avhandling fokuserar på att förtydliga vibrationsöverföringsprocessen och fungera som en plattform för framtida utveckling av en tillförlitlig prognosmodell. Vibrationsöverföringsprocessen delas in i två huvuddelar; vibrationskällan och vibrationer i jord. De olika delarna av vibrationsöverföringsprocessen studeras och undersöks med hjälp av litteraturstudie, fältförsök och numerisk modellering. Inom ramarna för denna avhandling har tre fältförsök utförts och ett nytt instrumenteringssystem har utvecklats. Det nya instrumenteringssystemet möjliggör mätning av både spontvibrationer och vibrationer på djup i jorden, under hela neddrivningsfasen. Fältförsöken syftade till att studera vibrationsöverföringen mellan spont och jord, vibrationsöverföringen inom en spontvägg samt vågmönstret i jorden under drivning. För att studera spontens beteende under neddrivning utvecklades en numerisk modell, som också kan fungera som en bas för framtida studier. Avhandlingens huvudsakliga vetenskapliga bidrag är identifieringen av spontens beteende under neddrivning. För praktisk tillämpning är det huvudsakliga bidraget förklaringen av vibrationsöverföringsprocessen från källa till jord, det nya instrumenteringssystemet samt utvecklingen av den numeriska modellen.

OBJETIVO: Avaliar a capacidade do potencial visual evocado multifocal (PEV-mf) em diferenciar pacientes portadores de hemianopsia temporal de controles normais e avaliar a correlação entre o PEV-mf, o campo visual (CV) realizado com a perimetria automatizada e a tomografia de coerência óptica de domínio fourier (TCO-dF). MÉTODOS: Vinte sete olhos de 21 pacientes com defeito de campo visual temporal secundário a compressão quiasmática e 43 olhos de 23 controles normais foram submetidos aos exames PEV-mf, CV e TCO-dF (3D OCT-1000®, Topcon) da mácula e da camada de fibras nervosas da retina (CFNR). Foi calculada a média das respostas do PEV-mf global, do PEV-mf central e a média de espessura do TCO-dF da mácula para cada quadrante e para cada hemicampo, enquanto a espessura da CFNR foi dividida em 12 setores ao redor do nervo óptico. A perda de CV foi calculada para os quatro quadrantes e para os hemicampos temporal e nasal no CV 24-2 e CV 10-2. Os dois grupos foram comparados utilizando equações de estimativas generalizadas (GEE) e as correlações entre o PEV-mf, CV e o TCO-dF foram calculadas. RESULTADOS: As médias das amplitude P1 e N2 do PEV-mf global e central para os hemicampos e os quadrantes temporais foram significativamente menores nos pacientes que nos controles (p < 0.004). Não houve diferença estatística entre os grupos para os parâmetros de amplitudes do PEV-mf nos setores nasais. Não houve diferença estatística nas médias das latências do PEV-mf global e central entre os pacientes e os controles normais. Foi encontrada correlação moderada, estatisticamente significativa, entre os parâmetros de amplitudes temporais do PEV-mf - global e central com a perda de CV 24-2 e 10-2 temporal, assim como com as medidas de espessura macular e da espessura CFNR na TCO-dF. CONCLUSÕES: As médias das amplitudes do PEV-mf foram capazes de diferenciar olhos de pacientes com hemianopsia dos controles normais e apresentaram correlação significativa com os dados obtidos pela perimetria automatizada e pelo TCO-dF. Estes dados sugerem que o PEV-mf global e central podem ser utilizados na detecção de anormalidades do campo visual em pacientes portadores de compressão quiasmática / PURPOSE: To evaluate the ability of multifocal visual evoked potential (mfVEP) to differentiate patients with temporal hemianopia due to chiasmal compression from normal controls. To assess the relationship between mfVEP, standard automated perimetry (SAP) and fourier domain-optical coherence tomography (fd-OCT). METHODS: Twenty-seven eyes of 21 patients with permanent temporal visual field (VF) defects from chiasmal compression and 43 eyes of 23 healthy controls underwent mfVEP, SAP and fd-OCT (3D OCT-1000®, Topcon) macular and peripapillary retinal nerve fiber layer (RNFL) measurements. It was averaged the responses for global mfVEP, central mfVEP and fd-OCT macular measurements were averaged in quadrants and halves, while peripapillary RNFL thickness was averaged in 12 sectors around the disc. VF loss was estimated in four quadrants and each half of 24-2 and 10-2 strategy test points. The two groups were compared using generalized estimated equations (GEE). Correlations between mfVEP, VF and fd-OCT findings were verified. RESULTS: Global and central mfVEP P1 and N2 amplitude parameters of temporal measurements were significantly smaller in patients than controls (p < 0.004). No significant differences were observed between the groups with respect to mfVEP amplitude parameters from the nasal measurements. No significant differences were observed in global and central mfVEP latency parameters for all averaged measurements between patients and healthy controls. A significant moderate correlation was found between global and central mfVEP amplitude parameters of temporal measurements and temporal VF 24-2 and 10-2 loss as well as with corresponding fd-OCT macular and RNFL thickness measurements. CONCLUSIONS: mfVEP amplitude parameters were able to differentiate eyes with temporal hemianopia from controls and were significant correlated with VF and fd-OCT findings. These data suggest that it is a useful technology for detecting visual abnormalities in patients with chiasmal compression

[Truncated abstract] Broadly, research literature on the physiological aspects of water polo game play is limited, but particularly so in the women's game. Moreover, significant changes to game rules in recent years are likely to have had an impact on the game demands. Therefore, this research project sought to investigate the physiological characteristics of contemporary elite female water polo players and the demands of match play. Overall, the five studies comprising this thesis aimed to improve the practical knowledge of coaches and sport scientists concerning the training and monitoring of players. Study one (Chapter 3) compared two water polo-specific field tests of aerobic and/or match fitness (MSST, multistage shuttle swim test; and WIST, water polo intermittent shuttle test) with a traditional incremental swimming test to exhaustion (IST, 5 x 200 m). Prior to this study, the physiological responses to the MSST and WIST were not well understood. Additionally, the degree of association between these two tests was unknown. Therefore, 14 Australian National Women's Water Polo Squad players performed the MSST and WIST, and 13 players from a National Water Polo League club performed the MSST, WIST and IST, on separate occasions. Peak heart rate, blood lactate and ratings of perceived exertion were obtained for all tests. Expired air was collected post test for the National League players. The results showed that the National Squad players performed significantly better in the MSST (636 ± 114 vs. 437 ± 118 m, p < 0.001) and WIST (270 ± 117 vs. 115 ± 57 m, p < 0.001) than the National League players. ... Absolute decrement yielded TE of 0.55 s (-0.42-0.81), CV of 26.0% (19.3-41.0) and ICC of -0.002 (-0.44-0.44). Relative (%) decrement yielded TE of 1.6% (1.2-2.3), CV of 27.2% (20.1-42.9) and ICC of -0.02 (-0.46-0.42). Results indicate that total time was a reliable measure, whilst decrement was not. Similar to land-based RSA tests, total time should be the criterion measure of performance in the RST. The RST can form part of a specific battery of field tests for water polo, and can also be used as a conditioning tool. The final study (Chapter 7) was a nutritional-intervention study. Based on the time-motion data from study three, a 59-min match simulation test (MST) was designed to mimic the activity profiles and physical demands of water polo match play. Using a randomized cross-over double-blind design, 12 Australian National Women's Water Polo Squad players ingested 0.3 g·kg-1 of NaHCO3 or placebo, 90 min before performing the MST, which included 56 x 10-m maximal-sprint swims as the performance measure. Although pre-exercise ingestion of NaHCO3 was effective in enhancing extracellular pH and bicarbonate levels, the percentage difference in mean sprint times between trials showed no substantial effects of NaHCO3 (0.4; ±0.9%, effect size = 0.09; ±0.23, p = 0.51). The results suggest that elite water polo players should not expect enhancement in intermittent-sprint performance from NaHCO3 supplementation. These findings are contrary to previous NaHCO3 studies on simulated team-sport performance, but this investigation is unique in that it examined highly-trained athletes performing sport-specific tasks. In conclusion, the findings of this thesis add to the existing literature on the applied physiology of women's water polo. It is hoped that the knowledge gained from these findings will lead to more appropriate conditioning, testing and selection outcomes.

Made available in DSpace on 2014-07-29T15:18:23Z (GMT). No. of bitstreams: 1 Dissertacao part1 Nelson Luis da Cunha.pdf: 8015945 bytes, checksum: 4d6119f1259b4290890438622c5cd008 (MD5) Previous issue date: 2011-03-29 / The city of Aparecida de Goiania-GO has a current estimate of 16,782,313 m² of urban roads, and there are still 51.5% to be paved. However, the technical staff of the mayor is facing a challenge related to the purchase of lateritic gravel for paving of these streets. Taking into account that most roads in the city has a low volume of traffic (N &#8804; 5.105), it becomes necessary to find an alternative solution to this adversity to show technical and economic viability. Through a partnership between the Federal University of Goiás (UFG) and the city hall of Aparecida de Goiânia-GO, it was started a study to propose the use of nonconventional materials in paving. This way, initially a study was developed through laboratory tests of characterization, compactation, swelling, California Bearing Ratio and dynamic triaxial with the following materials: soil typical abundant in the area, crushed rock, quarry waste and hydrated lime type III and lateritic gravel. The results of these tests presented better performances for the mixtures soil (50%)-crushed rock(50%), soil(50%)- quarry waste(50%) and soil(91%)-lime(9%) which were the samples chosen for use in experimental pavement. To evaluate the behavior of these mixtures and lateritic gravel at layer pavement were used tests of Dynamic Cone Penetrometer (DCP), loading plate and beam Benkelman during construction of subgrade, on base and at coating pre-mixed cold (PMF) and also six and twelve months after opening to traffic. At the end was made a cost estimate of materials used in each subarea for assessment of the economical viability and the possible replacement of lateritic gravel by these materials. It is possible to conclude that the mixtures studied in this research present technical, economical and environmental viability and can be used to replace the lateritic gravel traditionally used in paving in the region. / O município de Aparecida de Goiânia-GO tem uma estimativa atual de 16.782.313 m² de vias urbanas, sendo que deste total ainda faltam 51,5% para serem pavimentados. No entanto, a equipe técnica da prefeitura enfrenta um desafio relacionado à aquisição de cascalho para pavimentação dessas ruas. Tendo em vista que a maioria das vias do município apresenta baixo volume de tráfego (N&#8804; 5.105), torna-se necessário encontrar uma solução alternativa a essa adversidade que apresente viabilidade técnica e econômica. Uma parceria realizada entre a Universidade Federal de Goiás (UFG) e a Prefeitura de Aparecida de Goiânia-GO, iniciou um estudo para utilização de materiais não convencionais nas obras de pavimentação. Inicialmente foi desenvolvido um estudo laboratorial com ensaios de caracterização, compactação, expansão, Índice de Suporte Califórnia e triaxial dinâmico com os seguintes materiais: solo fino típico abundante na região, brita 1, expurgo de pedreira, cal hidratada do tipo CH-III e cascalho. Os resultados desses ensaios indicaram melhor desempenho para as misturas solo(50%)-brita1(50%), solo(50%)-expurgo(50%) e solo(91%)-cal(9%) que foram as amostras escolhidas para utilização em um trecho experimental. Para avaliar o comportamento dessas misturas e do cascalho laterítico na camada de base do pavimento foram realizados ensaios de penetrômetro dinâmico de cone (DCP), prova de carga sobre placa e viga Benkelman durante a construção no subleito, sobre a base e no revestimento de pré misturado a frio (PMF) e também seis e doze meses após abertura ao tráfego. Ao final realizou-se estimativa de custo dos materiais utilizados em cada subtrecho para avaliação da viabilidade econômica e a possível substituição do cascalho por esses materiais. Conclui-se que as misturas estudadas nesta pesquisa apresentam viabilidade técnica, econômica e ambiental e podem ser utilizados em substituição ao cascalho laterítico tradicionalmente usado nas obras de pavimentação da região. OBS: Está sobrescrito o 5 em 5.105. O programa não copia algumas formatações.

OBJETIVO: Avaliar a capacidade do potencial visual evocado multifocal (PEV-mf) em diferenciar pacientes portadores de hemianopsia temporal de controles normais e avaliar a correlação entre o PEV-mf, o campo visual (CV) realizado com a perimetria automatizada e a tomografia de coerência óptica de domínio fourier (TCO-dF). MÉTODOS: Vinte sete olhos de 21 pacientes com defeito de campo visual temporal secundário a compressão quiasmática e 43 olhos de 23 controles normais foram submetidos aos exames PEV-mf, CV e TCO-dF (3D OCT-1000®, Topcon) da mácula e da camada de fibras nervosas da retina (CFNR). Foi calculada a média das respostas do PEV-mf global, do PEV-mf central e a média de espessura do TCO-dF da mácula para cada quadrante e para cada hemicampo, enquanto a espessura da CFNR foi dividida em 12 setores ao redor do nervo óptico. A perda de CV foi calculada para os quatro quadrantes e para os hemicampos temporal e nasal no CV 24-2 e CV 10-2. Os dois grupos foram comparados utilizando equações de estimativas generalizadas (GEE) e as correlações entre o PEV-mf, CV e o TCO-dF foram calculadas. RESULTADOS: As médias das amplitude P1 e N2 do PEV-mf global e central para os hemicampos e os quadrantes temporais foram significativamente menores nos pacientes que nos controles (p < 0.004). Não houve diferença estatística entre os grupos para os parâmetros de amplitudes do PEV-mf nos setores nasais. Não houve diferença estatística nas médias das latências do PEV-mf global e central entre os pacientes e os controles normais. Foi encontrada correlação moderada, estatisticamente significativa, entre os parâmetros de amplitudes temporais do PEV-mf - global e central com a perda de CV 24-2 e 10-2 temporal, assim como com as medidas de espessura macular e da espessura CFNR na TCO-dF. CONCLUSÕES: As médias das amplitudes do PEV-mf foram capazes de diferenciar olhos de pacientes com hemianopsia dos controles normais e apresentaram correlação significativa com os dados obtidos pela perimetria automatizada e pelo TCO-dF. Estes dados sugerem que o PEV-mf global e central podem ser utilizados na detecção de anormalidades do campo visual em pacientes portadores de compressão quiasmática / PURPOSE: To evaluate the ability of multifocal visual evoked potential (mfVEP) to differentiate patients with temporal hemianopia due to chiasmal compression from normal controls. To assess the relationship between mfVEP, standard automated perimetry (SAP) and fourier domain-optical coherence tomography (fd-OCT). METHODS: Twenty-seven eyes of 21 patients with permanent temporal visual field (VF) defects from chiasmal compression and 43 eyes of 23 healthy controls underwent mfVEP, SAP and fd-OCT (3D OCT-1000®, Topcon) macular and peripapillary retinal nerve fiber layer (RNFL) measurements. It was averaged the responses for global mfVEP, central mfVEP and fd-OCT macular measurements were averaged in quadrants and halves, while peripapillary RNFL thickness was averaged in 12 sectors around the disc. VF loss was estimated in four quadrants and each half of 24-2 and 10-2 strategy test points. The two groups were compared using generalized estimated equations (GEE). Correlations between mfVEP, VF and fd-OCT findings were verified. RESULTS: Global and central mfVEP P1 and N2 amplitude parameters of temporal measurements were significantly smaller in patients than controls (p < 0.004). No significant differences were observed between the groups with respect to mfVEP amplitude parameters from the nasal measurements. No significant differences were observed in global and central mfVEP latency parameters for all averaged measurements between patients and healthy controls. A significant moderate correlation was found between global and central mfVEP amplitude parameters of temporal measurements and temporal VF 24-2 and 10-2 loss as well as with corresponding fd-OCT macular and RNFL thickness measurements. CONCLUSIONS: mfVEP amplitude parameters were able to differentiate eyes with temporal hemianopia from controls and were significant correlated with VF and fd-OCT findings. These data suggest that it is a useful technology for detecting visual abnormalities in patients with chiasmal compression

Made available in DSpace on 2016-03-15T19:38:11Z (GMT). No. of bitstreams: 1 Danillo Ono.pdf: 2562799 bytes, checksum: e44e38bb2e4a5c5eef6578aaa17eed58 (MD5) Previous issue date: 2008-06-16 / Fundo Mackenzie de Pesquisa / The main objective of this work is to study and evaluate the reception s conditions of a Digital TV signal, modulated in Brazilian standard and received with the use of an internal and external antenna, to analyze and to study the interferences that affect it. Comparing the conditions for receipt of the theoretical model of Okumura Hata with real data collected in field tests. Field tests are carried out at several points of Sao Paulo city, to collect data that will be analyzed later. It will use a process of RF capturing, where digital signals are stored on a hard-disk and through the use of laboratory equipments, and through the help of softwares such as Matlab and EDX, data are analyzed taking up account of their impulsive response, the amount of multipaths present in the signal and sensibility to the doppler effect. It was chosen Sao Paulo city because it presents very adverse conditions of reception when compared to other cities in the world, due to its large amount of buildings and antennas, which generate many multipaths. The presence of a large amount of old cars and old appliances, generate impulsive noise. Brazil has the second largest fleet of helicopters in the world and also the large amount of aircrafts flying over the skies of the city, affecting the signals with doppler effect. About 90% of the population that attends TV, use some kind of antenna, which does them receive signals affected by these kind of interference. / O objetivo deste trabalho é estudar e avaliar as condições de recepção de um sinal de TV Digital modulado no padrão brasileiro e recebido com o uso de uma antena interna e externa, e analisar e estudar as interferências que afetam o mesmo. Comparar as condições de recepção do modelo teórico de Okumura Hata com dados reais coletados em testes de campo. São realizados testes de campo em determinados pontos da cidade de São Paulo, para coleta de dados, que serão posteriormente analisados. Utilizar-se-á um processo de captura dos sinais, no qual os sinais digitais são gravados em um hard-disk e através do uso de equipamentos de laboratório e com o auxílio de softwares como Matlab e EDX, os dados são analisados levando-se em consideração sua resposta impulsiva, a quantidade de multipercursos presentes no sinal e a sensibilidade ao efeito doppler. Foi escolhida a cidade de São Paulo pois a mesma apresenta condições de recepção muito adversas quando comparada a outras cidades do mundo. Devido a sua ampla quantidade de prédios e antenas, geram-se muitos multipercursos. A presença de inúmeros automóveis e eletrodomésticos antigos contribui com ruído impulsivo. Tem-se a segunda maior frota de helicópteros do mundo, bem como a grande quantidade de aviões que sobrevoam os céus da cidade, afetando os sinais com efeito doppler. Cerca de 90% da população que assiste TV, usa algum tipo de antena, o que ocasiona a recepção de sinais afetados por esses tipos de interferências.

Objetivo: Estudar as medidas de espessura da camada de fibras nervosas da retina(CFNR) peripapilar obtidas com as tomografias de coerência óptia (oCT) time domain (TD) e spectral domain (SD) em pacientes com perda assimétrica glaucomatosa de hemicampo visual, compará-las entre si e com aquelas de controles normais. Métodos: Trinta e seis pacientes com glaucoma primário de ângulo aberto e perda de campo visual em um hemicampo (afetado) e ausência de perda no hemicampo oposto (não afetado), e 36 controles pareados por idade tiveram o olho de estudo examinado com Stratus-OCT (Carl Zeiss Meditec Inc., Dublin, Califoprnia, USA) e o 3DOCT-1000 (Topcdon, Tokyo, Japan). As medidas de espessura da CFNR peripapilar e a classificação normativa fornecida pelos aparelhos foram registrados para análise. A média aritmética dos valores do mapa total deviation em cada hemicampo (mean deviation do hemicampo) foi calculada para cada indivíduo. \"Ìndices de assimetria\" para o campo visual e para a CFNR foram calculados como a razão entre o mean deviation dos hemicampos afetado e não-afetado, e como razão entre a espessura da CFNR das hemirretinas afetada e não-afetada, respectivamente. As variáveis contínuas foram comparadas usando os testes de Mann-Whitney, Kruskal-Wallis ou Wilcoxon, quando apropriados. As variáveis categóricas foram comparadas usando o teste qui-quadrado de Pearson. O coeficiente de correlação de Spearman foi usado para testar as correlações entre as medidas de espessura da CFNR fornecidas pelos OCTs. A presença de afinamento da CFNR foi estabelecida com base nos dados normativos fornecidos pelos softwares dos OCTs. As espessuras de CFNR fora do intervalo de previsão de 95% para a mesma faixa etária foram consideradas anormais. Resultados: As medidas de CFNR corespondentes a hemicampos não-afetados [média (DP) 87,0 (17,1) um e 84,3 (20,2) um, para TD e SD-OCT, respectivamente] foram menores do que as dos controles [média (DP) 119,0 (122,2)um e 117,0 (17,7) um, para TD e SD-OCT, respectivamente, P < 0,001, para ambos]. O banco de dados normativo classificou como alterado 42% e 67% das hemirretinas correspondentes a hemicampos não-acometidos com TD e SD-OCT, respectivamente (P = 0,01). As medidas da CFNR foram consistentemente mais espessas com TD comparadas com SD-OCT. Os índices de assimetria da CFNR em pacientes com glaucoma foram semelhantes entre TD [média (DP) 0,76 (0,17)] e SD-OCT [média (DP) 0,79 (0,12), P = 0,89] e significantemente maiores do que o índice de assimetria do campo visual [média (DP) 0,36 (0,20), P < 0,001]. Conclusões: Os hemicampos normais de pacientes com glaucoma apresentaram CFNR mais fina do que de olhos saudáveis. As medidas da CFNR foram mais espessas com TD do que com SD-OCT, o qual por sua vez detectou anormalidades na espessura da CFNR mais frequentemente do que o TD-OCT / Objective: To study the peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained with time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) in glaucomatous patients with asymmetric visual hemifield loss, to compare themselves and with those obtained from normal controls. Methods : Thirty -six patients with primary open-angle glaucoma with visual primary open-angle glaucoma with visual field loss in one hemifield (affected ) and absence of loss in other (non-affected), and 36 age-matched healthy controls had the eye study imaged with Stratus-OCT (Carl Zeiss Meditec Inc., Dublin, Califoprnia, USA) and 3D OCT-1000 (Topcon , Tokyo, Japan). Peripapillary RNFL thickness measurements and normative classification were recorded for analysis. Total deviation values were averaged for each hemifield (hemifield mean deviation) for ecch subject. Visual field and RNFL \"asymmetry indexes\" were calculated as the ratio between the mean deviation of affected versus non-affected hemifields and RNFL thickness between as affected versus non-affected hemiretinas, respectively. Continuous variables were compared using the Mann-Whitney, Kruskal-Wallis or Wilcoxon tests, when appropriate. Categorical variables were compared using the Pearson\'s chi-square test. The Spearman\'s rank correlation coefficient was used to test correlations between RNFL thickness measurements provided by both OCTs . The presence of RNFL thinning was establised based on normative data provided by the OCT\'s software. The RNFL thicknesses outside the prediction interval of 95% for the same age group were considered abnormal. Results: The RNFL measurements in non-affected hemifields [mean (SD 87.0 (17.1) e 84.3(20.2) um, for TD and SD-OCT, respectively] were thinner than those of normal controls [mean (SD) 119.0 (12.2) um and 117.0 (17.7) um, for TD and SD-OCT, respectively, P < 0.001 for both ] . The OCT normative database classified 42 % and 67% of hemiretinas corresponding to non-affected hemifields as abnormal in TD and SD-OCT, respectively (P =0.01). The RNFL measurements were consistently thicker with TD compared with SD -OCT. The RNFL thickness asymetry index in patients with glaucoma was similar with TD [ mean (SD) 0.76 ( 0.17 ) ] and SD-OCT [ mean (SD)0.79(0.12), P = 0,89] and significantly greater than the visual field asymmetry index [ mean (SD ) 0.36 (0.20 ), P < 0.001]. Conclusions: Normal hemifields of glaucoma patients had thinner RNFL measurements than healthy eyes, as measured by TD and SD-OCT. The RNFL measurements were thicker with TD than SD-OCT, SD-OCT detected abnormal RNFL more often than TD-OCT

Objetivo: Estudar as medidas de espessura da camada de fibras nervosas da retina(CFNR) peripapilar obtidas com as tomografias de coerência óptia (oCT) time domain (TD) e spectral domain (SD) em pacientes com perda assimétrica glaucomatosa de hemicampo visual, compará-las entre si e com aquelas de controles normais. Métodos: Trinta e seis pacientes com glaucoma primário de ângulo aberto e perda de campo visual em um hemicampo (afetado) e ausência de perda no hemicampo oposto (não afetado), e 36 controles pareados por idade tiveram o olho de estudo examinado com Stratus-OCT (Carl Zeiss Meditec Inc., Dublin, Califoprnia, USA) e o 3DOCT-1000 (Topcdon, Tokyo, Japan). As medidas de espessura da CFNR peripapilar e a classificação normativa fornecida pelos aparelhos foram registrados para análise. A média aritmética dos valores do mapa total deviation em cada hemicampo (mean deviation do hemicampo) foi calculada para cada indivíduo. \"Ìndices de assimetria\" para o campo visual e para a CFNR foram calculados como a razão entre o mean deviation dos hemicampos afetado e não-afetado, e como razão entre a espessura da CFNR das hemirretinas afetada e não-afetada, respectivamente. As variáveis contínuas foram comparadas usando os testes de Mann-Whitney, Kruskal-Wallis ou Wilcoxon, quando apropriados. As variáveis categóricas foram comparadas usando o teste qui-quadrado de Pearson. O coeficiente de correlação de Spearman foi usado para testar as correlações entre as medidas de espessura da CFNR fornecidas pelos OCTs. A presença de afinamento da CFNR foi estabelecida com base nos dados normativos fornecidos pelos softwares dos OCTs. As espessuras de CFNR fora do intervalo de previsão de 95% para a mesma faixa etária foram consideradas anormais. Resultados: As medidas de CFNR corespondentes a hemicampos não-afetados [média (DP) 87,0 (17,1) um e 84,3 (20,2) um, para TD e SD-OCT, respectivamente] foram menores do que as dos controles [média (DP) 119,0 (122,2)um e 117,0 (17,7) um, para TD e SD-OCT, respectivamente, P < 0,001, para ambos]. O banco de dados normativo classificou como alterado 42% e 67% das hemirretinas correspondentes a hemicampos não-acometidos com TD e SD-OCT, respectivamente (P = 0,01). As medidas da CFNR foram consistentemente mais espessas com TD comparadas com SD-OCT. Os índices de assimetria da CFNR em pacientes com glaucoma foram semelhantes entre TD [média (DP) 0,76 (0,17)] e SD-OCT [média (DP) 0,79 (0,12), P = 0,89] e significantemente maiores do que o índice de assimetria do campo visual [média (DP) 0,36 (0,20), P < 0,001]. Conclusões: Os hemicampos normais de pacientes com glaucoma apresentaram CFNR mais fina do que de olhos saudáveis. As medidas da CFNR foram mais espessas com TD do que com SD-OCT, o qual por sua vez detectou anormalidades na espessura da CFNR mais frequentemente do que o TD-OCT / Objective: To study the peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained with time domain (TD) and spectral domain (SD) optical coherence tomography (OCT) in glaucomatous patients with asymmetric visual hemifield loss, to compare themselves and with those obtained from normal controls. Methods : Thirty -six patients with primary open-angle glaucoma with visual primary open-angle glaucoma with visual field loss in one hemifield (affected ) and absence of loss in other (non-affected), and 36 age-matched healthy controls had the eye study imaged with Stratus-OCT (Carl Zeiss Meditec Inc., Dublin, Califoprnia, USA) and 3D OCT-1000 (Topcon , Tokyo, Japan). Peripapillary RNFL thickness measurements and normative classification were recorded for analysis. Total deviation values were averaged for each hemifield (hemifield mean deviation) for ecch subject. Visual field and RNFL \"asymmetry indexes\" were calculated as the ratio between the mean deviation of affected versus non-affected hemifields and RNFL thickness between as affected versus non-affected hemiretinas, respectively. Continuous variables were compared using the Mann-Whitney, Kruskal-Wallis or Wilcoxon tests, when appropriate. Categorical variables were compared using the Pearson\'s chi-square test. The Spearman\'s rank correlation coefficient was used to test correlations between RNFL thickness measurements provided by both OCTs . The presence of RNFL thinning was establised based on normative data provided by the OCT\'s software. The RNFL thicknesses outside the prediction interval of 95% for the same age group were considered abnormal. Results: The RNFL measurements in non-affected hemifields [mean (SD 87.0 (17.1) e 84.3(20.2) um, for TD and SD-OCT, respectively] were thinner than those of normal controls [mean (SD) 119.0 (12.2) um and 117.0 (17.7) um, for TD and SD-OCT, respectively, P < 0.001 for both ] . The OCT normative database classified 42 % and 67% of hemiretinas corresponding to non-affected hemifields as abnormal in TD and SD-OCT, respectively (P =0.01). The RNFL measurements were consistently thicker with TD compared with SD -OCT. The RNFL thickness asymetry index in patients with glaucoma was similar with TD [ mean (SD) 0.76 ( 0.17 ) ] and SD-OCT [ mean (SD)0.79(0.12), P = 0,89] and significantly greater than the visual field asymmetry index [ mean (SD ) 0.36 (0.20 ), P < 0.001]. Conclusions: Normal hemifields of glaucoma patients had thinner RNFL measurements than healthy eyes, as measured by TD and SD-OCT. The RNFL measurements were thicker with TD than SD-OCT, SD-OCT detected abnormal RNFL more often than TD-OCT

金融科技在近年來已成為企業界與學術界所討論的顯學，但如何有效兼顧監理、法令遵循與促進產業發展，並因應創新商業模式，設計出法規與監理措施，已成為一道難題。基於上述背景，監理沙盒的概念與制度應運而生。我國版的金融監理沙盒，已於2018年1月31日公布。然而，除了金融科技創新，其他產業同樣有創新的必要，在面臨既有法規的限制，同樣有所掣肘。金融科技以外的領域，是否有類似「監理沙盒」的機制，在不分產業別的狀況下，應用在創新的實驗？日本在2014年1月20日起施行的「產業競爭力強化法」，用於創新技術或服務的「企業實證特例制度」及「灰色地帶消除制度」兩項機制，即為不限金融科技領域，適用於各個產業的沙盒制度。 本研究透過檢視日本產業競爭力強化法，深究其內容及機制的優缺點，與推行實績及具體的兩個個案後，據以反思我國是否可透過參考「灰色地帶消除制度」、「企業實證特例制度」的運作，與各產業內的潛在創新者更緊密合作，以有利於未來當主管機關面臨創新與法規的衝撞時，掌握對於各產業的影響。回歸我國法制，本研究針對「金融科技發展與創新實驗條例草案」，包括立法目的、概要，條例中的申請及審查、監督及管理，及實驗期間法令之排除適用及法律責任豁免等議題進行研析，並針對日本推動新事業活動特例措施，與我國金融科技發展與創新實驗條例，進行比較。同時亦將監理沙盒模擬演練的過程中，針對演練的架構、步驟、實際狀況、回饋與心得，提出歸納成果，並針對業者與主管機關進行協商與溝通的階段，歸納出具有邏輯性與合理性的執行步驟與方法論，做為當業者在準備階段與主管機關往返溝通與提案時的參考。 本研究認為，當創新與科技在與金融結合時，創新服務與法規監管的本質不同，所造成的緊張與衝突在所難免，也因此更應該體認到數位時代下主管機關對於法規調適與鬆綁之必要性。在臚列我國於發展第三方支付立法的經驗作為前車之鑑，及剖析日本產業競爭強化法的制度與實績作為他山之石後，本研究認為新創事業無論在籌備階段、實驗階段、營運階段，對於法規的特例需求的確不同於一般事業。因此政府應秉持以下三項原則予以協助：(一)法規對新創企業應更友善且主動輔導、(二)抱持產業永續發展的思維看待新創產業、(三)消費者權益維護與企業營運必須兼顧。 本研究的另一研究結果為，經過個案模擬演練的操作後，歸納並提出七個執行步驟，並建議業者可針對此七個步驟進行腦力激盪與預先演練模擬，在有限的時間內以最高的效率備齊相關文件，以減少審核等待期。最後，本研究認為，業者與主管機關在議題協商時須充分考量有關於創新、業務、消保、法遵等四個面向的議題，且以公私協力的前提下，隨時調整並良性溝通。而主管機關更應加速金融科技的法規革新速度，並適度鬆綁不適用的法規，創造一個對於新創產業相對友善的法規環境，協助新創業者在業務上的發展，使我國能在金融科技戰場上決勝。 / In recent years, financial technology, aka FinTech, has become a significant study discussed by industries and academics. However, how to effectively manage supervisory, compliance with laws and promote industrial development, and how to design regulatory and supervisory measures in response to innovative business models have become a big challenge. Based on the abovementioned facts, the concept of Regulatory Sandbox came into being. Taiwan’s Act on Financial Technology Innovations and Experiments was released on January 31, 2018. Besides FinTech, innovation is equally necessary and indispensable for other industries that also restrained by the limitations of the existing laws and regulations. Are there any mechanisms similar with Regulatory Sandbox for those innovators in other industries? Japan released the Act on Strengthening Industrial Competitiveness on January 20, 2014, which provided two mechanisms, Special System for Corporate Field Tests and System to Remove Gray Zone Areas, for innovative technologies and services for all industries. This essay targets Japan’s and Taiwan’s Acts on Financial Technology Innovations as research objectives, discusses the investigations in both countuires, and provides suggestions for future works. Firstly, this study explores the strengths and weaknesses of its contents and mechanisms by examining Japan’s Act on Strengthening Industrial Competitiveness, and aims at extending the practical angle to Taiwan for the future when facing the conflict between innovation and regulation. Secondly, the essay aims at studying Taiwan’s Act on Financial Technology Innovations and Experiments, and comparing the differences between Japan’s and Taiwan’s Acts. Finally, by observing the results of sandbox simulation exercises, this study elaborates implemental procedures, and logical methodologies as a reference for practitioners to communicate with and submit proposals to the authorities during the preparatory phase. Due to the nature difference of innovation technology and financial supervision, it is considered that the tensions and conflicts are inevitable. Therefore, it is more necessary to amend the existing regulations or even deregulate for start-up. Furthermore, by learning from Taiwan's experience in developing third-party payment legislation and Japan's legislations and actual practices released, this study obtains that deregulation and coordination from government agencies considered highly important to startup operators in every stage. In terms of industry development, further suggestions are concluded in this research for government agencies, including (1) laws and regulations should be more friendly for new start-up, (2) to maintain the sustainable development of start-up industries and operators, and (3)-to achieve balance between the protection of consumer rights and business continuity. After conducting sandbox case simulation exercises, this essay proposes seven procedures for start-up to efficiently go through with internal brainstorming while in preparation stage under a limited time. The last part of the study sets out four topics for practitioners and the competent authorities that are related to innovation, business, consumer protection and law compliance when negotiating the regulatory issues during experiments, hoping to provide a solid methodology beneficial to FinTech practitioners.